{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:23:41Z","timestamp":1783722221904,"version":"3.55.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PDUK","award":["501431"],"award-info":[{"award-number":["501431"]}]},{"name":"MRC","award":["RCBM523"],"award-info":[{"award-number":["RCBM523"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.neuint.2017.01.016","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T17:33:09Z","timestamp":1485538389000},"page":"114-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?"],"prefix":"10.1016","volume":"106","author":[{"given":"Sophie V.","family":"Precious","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rike","family":"Zietlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Dunnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Rosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neuint.2017.01.016_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/096368970000900108","article-title":"Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease","volume":"9","author":"Armstrong","year":"2000","journal-title":"Cell Transpl."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.016_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/exnr.2002.7889","article-title":"The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease","volume":"175","author":"Armstrong","year":"2002","journal-title":"Exp. Neurol."},{"issue":"9246","key":"10.1016\/j.neuint.2017.01.016_bib3","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(00)03310-9","article-title":"Motor and cognitive improvements in patients with Huntington's disease after neural transplantation","volume":"356","author":"Bachoud-L\u00e9vi","year":"2000","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.neuint.2017.01.016_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1474-4422(06)70381-7","article-title":"Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study","volume":"5","author":"Bachoud-L\u00e9vi","year":"2006","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.neuint.2017.01.016_bib5","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neurol.2014.10.007","article-title":"Regenerative medicine in Huntington's disease: current status on fetal grafts and prospects for the use of pluripotent stem cell","volume":"170","author":"Bachoud-L\u00e9vi","year":"2014","journal-title":"Rev. Neurol."},{"issue":"8","key":"10.1016\/j.neuint.2017.01.016_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1440-1681.1995.tb02066.x","article-title":"Regulation of neural precursor differentiation in the embryonic and adult forebrain","volume":"22","author":"Bartlett","year":"1995","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neuint.2017.01.016_bib7","article-title":"Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: where have we been and what have we learned?","author":"Bartus","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.neuint.2017.01.016_bib8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/88158","article-title":"Growth factors regulate the survival and fate of cells derived from human neurospheres","volume":"19","author":"Caldwell","year":"2001","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.neuint.2017.01.016_bib9","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.drudis.2014.02.012","article-title":"Cell-based therapies for Huntington's disease","volume":"19","author":"Chen","year":"2014","journal-title":"Drug Discov. Today"},{"issue":"7","key":"10.1016\/j.neuint.2017.01.016_bib10","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/biot.201300560","article-title":"Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease","volume":"9","author":"Choi","year":"2014","journal-title":"Biotechnol. J."},{"issue":"19","key":"10.1016\/j.neuint.2017.01.016_bib11","doi-asserted-by":"crossref","first-page":"7869","DOI":"10.1523\/JNEUROSCI.18-19-07869.1998","article-title":"Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2","volume":"18","author":"Ciccolini","year":"1998","journal-title":"J.\u00a0Neurosci."},{"issue":"7220","key":"10.1016\/j.neuint.2017.01.016_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature07404","article-title":"Generation of pluripotent stem cells from adult human testis","volume":"456","author":"Conrad","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2017.01.016_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0006-8993(94)90526-6","article-title":"The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence","volume":"668","author":"Deacon","year":"1994","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1242\/dev.084608","article-title":"Deveopmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons","volume":"140","author":"Delli Carri","year":"2013","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.neuint.2017.01.016_bib15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0014-4886(03)00028-1","article-title":"Motor training effects on recovery of function after striatal lesions and striatal grafts","volume":"184","author":"D\u00f6br\u00f6ssy","year":"2003","journal-title":"Exp. Neurol."},{"issue":"6338","key":"10.1016\/j.neuint.2017.01.016_bib16","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/352809a0","article-title":"Requirement for mast cell growth factor for primordial germ cell survival in culture","volume":"352","author":"Dolci","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2017.01.016_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.nbd.2013.05.004","article-title":"Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease","volume":"61","author":"Dunnett","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"6","key":"10.1016\/j.neuint.2017.01.016_bib19","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/MOT.0b013e32834c2356","article-title":"Clinical translation of cell transplantation in the brain","volume":"16","author":"Dunnett","year":"2011","journal-title":"Curr. Opin. Organ Transpl."},{"issue":"10","key":"10.1016\/j.neuint.2017.01.016_bib20","doi-asserted-by":"crossref","first-page":"e3531","DOI":"10.1371\/journal.pone.0003531","article-title":"Reprogramming primordial germ cells into pluripotent stem cells","volume":"3","author":"Durcova-Hills","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2017.01.016_bib21","first-page":"106529","article-title":"Molecular regulation of striatal development: a review","author":"Evans","year":"2012","journal-title":"Anat. Res. Int."},{"issue":"8","key":"10.1016\/j.neuint.2017.01.016_bib22","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.fertnstert.2009.09.047","article-title":"Glial cell line-derived neurotrophic factor (GDNF) and its receptors in human ovaries from fetuses, girls, and women","volume":"93","author":"Farhi","year":"2010","journal-title":"Fertil. Steril."},{"issue":"14","key":"10.1016\/j.neuint.2017.01.016_bib24","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1523\/JNEUROSCI.19-14-05990.1999","article-title":"Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain","volume":"19","author":"Fricker","year":"1995","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.neuint.2017.01.016_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000360583","article-title":"Human striatum remodelling after neurotransplantation in Huntington's disease","volume":"92","author":"Gallina","year":"2014","journal-title":"Stereotact. Funct. Neurosurg."},{"issue":"10","key":"10.1016\/j.neuint.2017.01.016_bib26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/molehr\/gam059","article-title":"Novel germ cell markers characterize testicular seminoma and fetal testis","volume":"13","author":"Gashaw","year":"2007","journal-title":"Mol. Hum. Reprod."},{"issue":"3","key":"10.1016\/j.neuint.2017.01.016_bib27","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1095\/biolreprod.108.072728","article-title":"Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium\/protein kinase C and NFKB1","volume":"80","author":"Ge","year":"2009","journal-title":"Biol. reproduction"},{"issue":"6338","key":"10.1016\/j.neuint.2017.01.016_bib28","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/352807a0","article-title":"Effects of the steel gene product on mouse primordial germ cells in culture","volume":"352","author":"Godin","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2017.01.016_bib29","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1523\/JNEUROSCI.09-09-03250.1989","article-title":"Intrastriatal grafts derived from fetal striatal primordia. 1. Phenotypy and modular organization","volume":"9","author":"Graybiel","year":"1989","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuint.2017.01.016_bib30","article-title":"The need for new approaches in CNS drug discovery: why drugs have failed, and what can Be done to improve outcomes","author":"Gribkoff","year":"2016","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.neuint.2017.01.016_bib31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s11373-007-9185-z","article-title":"Fibroblast-like cells derived from the gonadal ridges and dorsal mesenteries of human embryos as feeder cells for the culture of human embryonic germ cells","volume":"14","author":"He","year":"2007","journal-title":"J.\u00a0Biomed. Sci."},{"issue":"10","key":"10.1016\/j.neuint.2017.01.016_bib32","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/stem.198","article-title":"Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem\/progenitor cells through Smad2\/3 and Oct-4 activation","volume":"27","author":"He","year":"2009","journal-title":"Stem Cells."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.016_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2015.05.015","article-title":"Quantification of retinogenesis in 3D cultures reveals epigenetic memory and higher efficiency in iPSCs derived from rod photoreceptors","volume":"17","author":"Hiler","year":"2015","journal-title":"Cell Stem Cell."},{"issue":"6","key":"10.1016\/j.neuint.2017.01.016_bib34","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1177\/096368970000900601","article-title":"Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease","volume":"9","author":"Hurelbrink","year":"2000","journal-title":"Cell Transpl."},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib35","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1095\/biolreprod.103.017012","article-title":"Long-term proliferation in culture and germline transmission of mouse male germline stem cells","volume":"69","author":"Kanatsu-Shinohara","year":"2003","journal-title":"Biol. reproduction"},{"issue":"4","key":"10.1016\/j.neuint.2017.01.016_bib36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3727\/096368910X546580","article-title":"Medical terminations of pregnancy: a viable source of tissue for cell replacement therapy for neurodegenerative disorders","volume":"20","author":"Kelly","year":"2011","journal-title":"Cell Transpl."},{"issue":"Pt 5","key":"10.1016\/j.neuint.2017.01.016_bib37","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/brain\/awm053","article-title":"Striatal graft projections are influenced by donor cell type and not the immunogenic background","volume":"130","author":"Kelly","year":"2007","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.neuint.2017.01.016_bib40","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1634\/stemcells.2008-0379","article-title":"CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells","volume":"26","author":"Kim","year":"2008","journal-title":"Stem cells"},{"issue":"11","key":"10.1016\/j.neuint.2017.01.016_bib41","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1242\/dev.120.11.3197","article-title":"Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines","volume":"120","author":"Labosky","year":"1994","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.neuint.2017.01.016_bib42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00441-004-0990-7","article-title":"Human embryonic germ cells isolation from early stages of post-implantation embryos","volume":"318","author":"Liu","year":"2004","journal-title":"Cell tissue Res."},{"issue":"16","key":"10.1016\/j.neuint.2017.01.016_bib43","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1523\/JNEUROSCI.20-16-06063.2000","article-title":"Origin and molecular specification of striatal interneurons","volume":"20","author":"Marin","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuint.2017.01.016_bib44","article-title":"Insights in Spacio-temporal characterization of human fetal neural stem cells","author":"Mart\u00edn-Ib\u00e1\u00f1ez","year":"2016","journal-title":"Expt Neurology press"},{"issue":"3","key":"10.1016\/j.neuint.2017.01.016_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/jme.2005.013169","article-title":"Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson's disease","volume":"33","author":"Master","year":"2007","journal-title":"J.\u00a0Med. Ethics"},{"issue":"6346","key":"10.1016\/j.neuint.2017.01.016_bib46","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/353750a0","article-title":"Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture","volume":"353","author":"Matsui","year":"1991","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.neuint.2017.01.016_bib47","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1111\/j.1460-9568.2009.07006.x","article-title":"Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington's disease","volume":"30","author":"Mazzocchi-Jones","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2017.01.016_bib48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/cne.20176","article-title":"Human neural stem cell transplants improve motor function in a rat model of Huntington's disease","volume":"475","author":"McBride","year":"2004","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"12","key":"10.1016\/j.neuint.2017.01.016_bib49","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3727\/096368912X658809","article-title":"Transplantation of GABAergic cells derived from bioreactor-expanded human neural precursor cells restores motor and cognitive behavioral deficits in a rodent model of Huntington's disease","volume":"22","author":"McLeod","year":"2013","journal-title":"Cell Transpl."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.016_bib51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ydbio.2012.02.014","article-title":"The proto-oncogene Ret is required for male foetal germ cell survival","volume":"365","author":"Miles","year":"2012","journal-title":"Dev. Biol."},{"issue":"51","key":"10.1016\/j.neuint.2017.01.016_bib52","doi-asserted-by":"crossref","first-page":"32635","DOI":"10.1074\/jbc.271.51.32635","article-title":"Dual Oncostatin M (OSM) Receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation","volume":"271","author":"Mosley","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"issue":"4","key":"10.1016\/j.neuint.2017.01.016_bib53","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jnr.490250404","article-title":"Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in\u00a0vitro","volume":"25","author":"Murphy","year":"1990","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"12","key":"10.1016\/j.neuint.2017.01.016_bib54","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1242\/dev.120.12.3519","article-title":"FGF2 regulates proliferation of neural crest cells, with subsequent neuronal differentiation regulated by LIF or related factors","volume":"120","author":"Murphy","year":"1994","journal-title":"Development"},{"issue":"7048","key":"10.1016\/j.neuint.2017.01.016_bib55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature03813","article-title":"Blimp1 is a critical determinant of the germ cell lineage in mice","volume":"436","author":"Ohinata","year":"2005","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.neuint.2017.01.016_bib56","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0306-4522(95)00325-D","article-title":"Projection neurons on fetal striatal transplants are predominantly derived from the lateral ganglionic eminence","volume":"69","author":"Olsson","year":"1995","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.neuint.2017.01.016_bib57","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0306-4522(97)00532-0","article-title":"Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence","volume":"84","author":"Olsson","year":"1998","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib58","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bbrc.2004.11.168","article-title":"In\u00a0vitro neuronal differentiation of cultured human embryonic germ cells","volume":"327","author":"Pan","year":"2005","journal-title":"Biochem. biophysical Res. Commun."},{"issue":"9","key":"10.1016\/j.neuint.2017.01.016_bib59","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/jnnp-2013-306533","article-title":"Fetal striatal grafting slows motor and cognitive decline of Huntington's disease","volume":"85","author":"Paganini","year":"2014","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.neuint.2017.01.016_bib61","doi-asserted-by":"crossref","first-page":"e39088","DOI":"10.1371\/journal.pone.0039088","article-title":"Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells","volume":"7","author":"Pashai","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2017.01.016_bib62","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fncel.2012.00016","article-title":"Restoration of the striatal circuitry: from developmental aspects toward clinical applications","volume":"6","author":"Pauly","year":"2012","journal-title":"Front. Cell Neurosci."},{"issue":"4","key":"10.1016\/j.neuint.2017.01.016_bib63","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1258\/ebm.2011.011359","article-title":"Producing striatal phenotypes for transplantation in Huntington's disease","volume":"237","author":"Precious","year":"2012","journal-title":"Exp. Biol. Med."},{"issue":"11","key":"10.1016\/j.neuint.2017.01.016_bib64","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1523\/JNEUROSCI.12-11-04565.1992","article-title":"A\u00a0multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes","volume":"12","author":"Reynolds","year":"1992","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.neuint.2017.01.016_bib65","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.neuroscience.2006.01.025","article-title":"Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease","volume":"139","author":"Roberts","year":"2006","journal-title":"Neuroscience"},{"issue":"R1","key":"10.1016\/j.neuint.2017.01.016_bib66","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1093\/hmg\/ddu204","article-title":"Human-induced pluripotent stem cells: potential for neurodegenerative diseases","volume":"15;23","author":"Ross","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2017.01.016_bib67","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/B978-0-444-59575-1.00016-8","article-title":"Clinical trials of neural transplantation in Huntington's disease","volume":"200","author":"Rosser","year":"2012","journal-title":"Prog. Brain Res."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.016_bib68","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nbd.2004.01.016","article-title":"Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease","volume":"16","author":"Ryu","year":"2004","journal-title":"Neurobiol. Dis."},{"issue":"256","key":"10.1016\/j.neuint.2017.01.016_bib69","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbr.2013.07.053","article-title":"Donor age dependent graft development and recovery in a rat model of Huntington's disease: histological and behavioral analysis","volume":"1","author":"Schackel","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"23","key":"10.1016\/j.neuint.2017.01.016_bib71","doi-asserted-by":"crossref","first-page":"13726","DOI":"10.1073\/pnas.95.23.13726","article-title":"Derivation of pluripotent stem cells from cultured human primordial germ cells","volume":"95","author":"Shamblott","year":"1998","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib73","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1006\/dbio.1994.1058","article-title":"Stem cells from primordial germ cells can reenter the germ line","volume":"161","author":"Stewart","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuint.2017.01.016_bib74","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroscience.2016.07.022","article-title":"Human t-DARPP is induced during striatal development","volume":"333","author":"Straccia","year":"2016","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib75","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0165-0270(98)00126-5","volume":"85","author":"Svendsen","year":"1998","journal-title":"J.\u00a0Neurosci. Methods"},{"issue":"6","key":"10.1016\/j.neuint.2017.01.016_bib76","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1530\/REP-07-0161","article-title":"Stem cell factor affects fate determination of human gonocytes in\u00a0vitro","volume":"134","author":"Tu","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.neuint.2017.01.016_bib77","series-title":"Culture of Human Stem Cells","isbn-type":"print","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/9780470167526.ch5","article-title":"Culture of the human germ cell lineage","author":"Turnpenny","year":"2007","ISBN":"https:\/\/id.crossref.org\/isbn\/9780470052464"},{"issue":"5","key":"10.1016\/j.neuint.2017.01.016_bib78","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1634\/stemcells.21-5-598","article-title":"Derivation of human embryonic germ cells: an alternative source of pluripotent stem cells","volume":"21","author":"Turnpenny","year":"2003","journal-title":"Stem Cells."},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib79","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1634\/stemcells.2005-0255","article-title":"Evaluating human embryonic germ cells: concord and conflict as pluripotent stem cells","volume":"24","author":"Turnpenny","year":"2006","journal-title":"Stem Cells."},{"issue":"Pt 19","key":"10.1016\/j.neuint.2017.01.016_bib80","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1242\/jcs.02553","article-title":"Activin\/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells","volume":"118","author":"Vallier","year":"2005","journal-title":"J.\u00a0cell Sci."},{"issue":"6","key":"10.1016\/j.neuint.2017.01.016_bib83","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0301-0082(92)90044-F","article-title":"Anatomy and connectivity of intrastriatal transplants","volume":"38","author":"Wictorin","year":"1992","journal-title":"Prog. Neurobiol."},{"issue":"11","key":"10.1016\/j.neuint.2017.01.016_bib84","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/mds.26007","article-title":"Targets for future clinical trials in Huntington's disease: what's in the pipeline?","volume":"29","author":"Wild","year":"2014","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib86","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3233\/JHD-160191","article-title":"A\u00a0longitudinal motor characterisation of the HdhQ111 mouse model of Huntington's disease","volume":"5","author":"Yhnell","year":"2016","journal-title":"J.\u00a0Huntingt. Dis."},{"issue":"2","key":"10.1016\/j.neuint.2017.01.016_bib87","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.expneurol.2012.03.010","article-title":"Long-term expansion of human foetal neural progenitors leads to reduced graft viability in the neonatal rat brain","volume":"235","author":"Zietlow","year":"2012","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.neuint.2017.01.016_bib88","first-page":"227","article-title":"The survival of neural precursor cell grafts is influenced by in\u00a0vitro expansion","volume":"207","author":"Zietlow","year":"2005","journal-title":"J.\u00a0Anat."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018617300116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018617300116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T22:40:13Z","timestamp":1658529613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018617300116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":77,"alternative-id":["S0197018617300116"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2017.01.016","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2017.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}