{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:26:00Z","timestamp":1786994760783,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,29]],"date-time":"2018-12-29T00:00:00Z","timestamp":1546041600000},"content-version":"am","delay-in-days":362,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Program","doi-asserted-by":"publisher","award":["W81XWH-08-2-0018"],"award-info":[{"award-number":["W81XWH-08-2-0018"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Program","doi-asserted-by":"publisher","award":["W81XWH-11-2-0127"],"award-info":[{"award-number":["W81XWH-11-2-0127"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.neuint.2017.07.014","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T15:01:02Z","timestamp":1501513262000},"page":"234-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Defective methionine metabolism in the brain after repeated blast exposures might contribute to increased oxidative stress"],"prefix":"10.1016","volume":"112","author":[{"given":"Peethambaran","family":"Arun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Rittase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Wilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene D.","family":"Gist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2017.07.014_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.freeradbiomed.2013.02.029","article-title":"Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast","volume":"60","author":"Abdul-Muneer","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2017.07.014_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/brb3.208","article-title":"N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities","volume":"4","author":"Bavarsad Shahripour","year":"2014","journal-title":"Brain Behav."},{"key":"10.1016\/j.neuint.2017.07.014_bib3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1089\/neu.2013.3144","article-title":"Diffusion tensor imaging reveals white matter injury in a rat model of repetitive blast-induced traumatic brain injury","volume":"31","author":"Calabrese","year":"2014","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.nbd.2010.10.025","article-title":"The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice","volume":"41","author":"Cernak","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2017.07.014_bib5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/00005373-200104000-00017","article-title":"Ultrastructural and functional characteristics of blast injury-induced neurotrauma","volume":"50","author":"Cernak","year":"2001","journal-title":"J.\u00a0Trauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib6","doi-asserted-by":"crossref","first-page":"716458","DOI":"10.1155\/2008\/716458","article-title":"Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine","volume":"2008","author":"Chen","year":"2008","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.neuint.2017.07.014_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroscience.2013.08.037","article-title":"Blast induces oxidative stress, inflammation, neuronal loss and subsequent short-term memory impairment in rats","volume":"253","author":"Cho","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2017.07.014_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11010-013-1777-5","article-title":"Methionine and methionine sulfoxide alter parameters of oxidative stress in the liver of young rats: in\u00a0vitro and in\u00a0vivo studies","volume":"384","author":"Costa","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.neuint.2017.07.014_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fnsys.2016.00036","article-title":"Traumatic brain injury alters methionine metabolism: implications for pathophysiology","volume":"10","author":"Dash","year":"2016","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neuint.2017.07.014_bib10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0021-9673(00)00166-7","article-title":"Dehydroascorbic acid","volume":"881","author":"Deutsch","year":"2000","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.neuint.2017.07.014_bib11","doi-asserted-by":"crossref","first-page":"4159357","DOI":"10.1155\/2016\/4159357","article-title":"Ameliorative effects of antioxidants on the hippocampal accumulation of pathologic tau in a rat model of blast-induced traumatic brain injury","volume":"2016","author":"Du","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.neuint.2017.07.014_bib12","doi-asserted-by":"crossref","first-page":"e90617","DOI":"10.1371\/journal.pone.0090617","article-title":"Efficacy of N-acetyl cysteine in traumatic brain injury","volume":"9","author":"Eakin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2017.07.014_bib13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0304-4165(77)90238-0","article-title":"The pathways of oxalate formation from phenylalanine, tyrosine, tryptophan and ascorbic acid in the rat","volume":"499","author":"Gambardella","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2017.07.014_bib14","doi-asserted-by":"crossref","first-page":"e54163","DOI":"10.1371\/journal.pone.0054163","article-title":"Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study","volume":"8","author":"Hoffer","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2017.07.014_bib15","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/10715760410001700497","article-title":"Oxidative decomposition of vitamin C in drinking water","volume":"38","author":"Jansson","year":"2004","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neuint.2017.07.014_bib16","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1089\/neu.2013.2862","article-title":"Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats","volume":"30","author":"Kochanek","year":"2013","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1682\/JRRD.2008.08.0100","article-title":"Pathology of blast-related brain injury","volume":"46","author":"Kocsis","year":"2009","journal-title":"J.\u00a0Rehabil. Res. Dev."},{"key":"10.1016\/j.neuint.2017.07.014_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/15216540051081056","article-title":"Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation","volume":"50","author":"Levine","year":"2000","journal-title":"IUBMB Life"},{"key":"10.1016\/j.neuint.2017.07.014_bib19","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1089\/152308601317203594","article-title":"GSH is required to recycle ascorbic acid in cultured liver cell lines","volume":"3","author":"Li","year":"2001","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.neuint.2017.07.014_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/B978-0-444-52892-6.00011-8","article-title":"Brain injury from explosive blast: description and clinical management","volume":"127","author":"Ling","year":"2015","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.neuint.2017.07.014_bib21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1089\/neu.2008.0748","article-title":"Blast overpressure in rats: recreating a battlefield injury in the laboratory","volume":"26","author":"Long","year":"2009","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib22","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2017.07.014_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.trsl.2015.08.005","article-title":"Amelioration of nicotinamide adenine dinucleotide phosphate-oxidase mediated stress reduces cell death after blast-induced traumatic brain injury","volume":"166","author":"Lucke-Wold","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.neuint.2017.07.014_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s11910-012-0303-6","article-title":"Neuropathology of explosive blast traumatic brain injury","volume":"12","author":"Magnuson","year":"2012","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.neuint.2017.07.014_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa9585","article-title":"Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction","volume":"8","author":"Meabon","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuint.2017.07.014_bib26","doi-asserted-by":"crossref","first-page":"021008","DOI":"10.1115\/1.4026364","article-title":"The mechanics of traumatic brain injury: a review of what we know and what we need to know for reducing its societal burden","volume":"136","author":"Meaney","year":"2014","journal-title":"J.\u00a0Biomech. Eng."},{"key":"10.1016\/j.neuint.2017.07.014_bib27","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1016\/S0021-9258(17)36891-6","article-title":"Glutathione-ascorbic acid antioxidant system in animals","volume":"269","author":"Meister","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuint.2017.07.014_bib28","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bbrc.2006.06.136","article-title":"Protection of GroEL by its methionine residues against oxidation by hydrogen peroxide","volume":"347","author":"Melkani","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2017.07.014_bib29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbapap.2004.09.003","article-title":"Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases","volume":"1703","author":"Moskovitz","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2017.07.014_bib30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature13136","article-title":"Cystathionine gamma-lyase deficiency mediates neurodegeneration in Huntington's disease","volume":"509","author":"Paul","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2017.07.014_bib31","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1002\/jnr.22510","article-title":"Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury","volume":"88","author":"Readnower","year":"2010","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuint.2017.07.014_bib32","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/nbm.2805","article-title":"Blast-induced neurotrauma leads to neurochemical changes and neuronal degeneration in the rat hippocampus","volume":"25","author":"Sajja","year":"2012","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuint.2017.07.014_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/089771502753594945","article-title":"Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise","volume":"19","author":"Saljo","year":"2002","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbapap.2004.08.010","article-title":"Methionine oxidation and aging","volume":"1703","author":"Stadtman","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2017.07.014_bib35","first-page":"795","article-title":"Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure","volume":"69","author":"Svetlov","year":"2010","journal-title":"J.\u00a0Trauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0891-5849(99)00107-0","article-title":"Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader","volume":"27","author":"Wang","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2017.07.014_bib37","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1089\/neu.2011.1990","article-title":"Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice","volume":"28","author":"Wang","year":"2011","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib38","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1089\/neu.1999.16.1067","article-title":"Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats","volume":"16","author":"Xiong","year":"1999","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2004.10.055","article-title":"N-acetylcysteine attenuates early induction of heme oxygenase-1 following traumatic brain injury","volume":"1033","author":"Yi","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2017.07.014_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/neu.2006.23.86","article-title":"Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine","volume":"23","author":"Yi","year":"2006","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuint.2017.07.014_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12031-012-9948-5","article-title":"The expression changes of cystathionine-beta-synthase in brain cortex after traumatic brain injury","volume":"51","author":"Zhang","year":"2013","journal-title":"J.\u00a0Mol. Neurosci."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018617303674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018617303674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:43:25Z","timestamp":1759311805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018617303674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":41,"alternative-id":["S0197018617303674"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2017.07.014","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defective methionine metabolism in the brain after repeated blast exposures might contribute to increased oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2017.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}