{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:25:05Z","timestamp":1787826305128,"version":"build-2784847793"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"College of Art and Science at Kent State University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.neuint.2017.10.011","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T13:47:36Z","timestamp":1509025656000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Dysregulation of methionine metabolism in multiple sclerosis"],"prefix":"10.1016","volume":"112","author":[{"given":"N.K.","family":"Singhal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-0808","authenticated-orcid":false,"given":"E.","family":"Arning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Clements","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Bottiglieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2017.10.011_bib1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/1531-8249(200012)48:6<893::AID-ANA10>3.0.CO;2-B","article-title":"Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl-aspartate in chronic multiple sclerosis patients","volume":"48","author":"Bjartmar","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2017.10.011_bib2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0404.2006.00615.x","article-title":"Grey matter pathology in multiple sclerosis","volume":"183","author":"B\u00f6","year":"2006","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1016\/j.neuint.2017.10.011_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0404.1994.tb05405.x","article-title":"S-adenosylmethionine levels in psychiatric and neurological disorders: a review","volume":"154","author":"Bottiglieri","year":"1994","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1016\/j.neuint.2017.10.011_bib4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbadis.2011.01.012","article-title":"Analysis of the mitochondrial proteome in multiple sclerosis cortex","volume":"1812","author":"Broadwater","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2017.10.011_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00221-008-1317-9","article-title":"Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue","volume":"187","author":"Clements","year":"2008","journal-title":"Exp Brain Res."},{"key":"10.1016\/j.neuint.2017.10.011_bib7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1515\/CCLM.2006.178","article-title":"A\u00a0robust liquid chromatography tandem mass spectrometry method for total plasma homocysteine determination in clinical practice","volume":"44","author":"Ducros","year":"2006","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.neuint.2017.10.011_bib8","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ana.20736","article-title":"Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients","volume":"59","author":"Dutta","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2017.10.011_bib21","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1073\/pnas.87.17.6777","article-title":"Changed distribution of sodium channels along demyelinated axons","volume":"87","author":"England","year":"1990","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.neuint.2017.10.011_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ana.21436","article-title":"Gray matter atrophy in multiple sclerosis: a longitudinal study","volume":"64","author":"Fisher","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2017.10.011_bib10","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/elps.201200536","article-title":"LC-MS\/MS identification of the one-carbon cycle metabolites in human plasma","volume":"34","author":"Gardner","year":"2013","journal-title":"Electrophoresis"},{"key":"10.1016\/j.neuint.2017.10.011_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3892\/mco.2012.53","article-title":"S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells","volume":"1","author":"Ham","year":"2013","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.neuint.2017.10.011_bib12","first-page":"17,121","article-title":"Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains","author":"Huynh","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2017.10.011_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/1471-2407-13-389","article-title":"Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore","volume":"13","author":"Inoue-Choi","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neuint.2017.10.011_bib14","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1007\/s12035-016-9966-3","article-title":"DNA Methylation: a new player in multiple sclerosis","volume":"54","author":"Li","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2017.10.011_bib15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2015.08.024","article-title":"Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism","volume":"22","author":"Mentch","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuint.2017.10.011_bib16","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJM200009283431307","article-title":"Multiple sclerosis","volume":"343","author":"Noseworthy","year":"2000","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuint.2017.10.011_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jns.2009.01.009","article-title":"Impaired regulation of electron transport chain subunit genes by nuclear respiratory factor 2 in multiple sclerosis","volume":"279","author":"Pandit","year":"2009","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neuint.2017.10.011_bib18","doi-asserted-by":"crossref","first-page":"15170","DOI":"10.1523\/JNEUROSCI.4349-14.2015","article-title":"Changes in methionine metabolism and histone H3 trimethylation are linked to mitochondrial defects in multiple sclerosis","volume":"35","author":"Singhal","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuint.2017.10.011_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0022-510X(02)00427-6","article-title":"Primary and secondary progressive multiple sclerosis","volume":"206","author":"Vukusic","year":"2003","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neuint.2017.10.011_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molmed.2013.11.007","article-title":"Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis","volume":"20","author":"Witte","year":"2014","journal-title":"Trends Mol.\u00a0Med."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018617302620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018617302620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T12:26:21Z","timestamp":1530015981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018617302620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":20,"alternative-id":["S0197018617302620"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2017.10.011","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulation of methionine metabolism in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2017.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}