{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:12:38Z","timestamp":1780434758336,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860217"],"award-info":[{"award-number":["81860217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560219"],"award-info":[{"award-number":["81560219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200853"],"award-info":[{"award-number":["81200853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31560276"],"award-info":[{"award-number":["31560276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570735"],"award-info":[{"award-number":["81570735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Scientist Training Object of Jiangxi Province","award":["20153BCB23030"],"award-info":[{"award-number":["20153BCB23030"]}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20171BAB205025"],"award-info":[{"award-number":["20171BAB205025"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.neuint.2018.09.002","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T13:23:50Z","timestamp":1536240230000},"page":"206-212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Knockdown the P2X3 receptor in the stellate ganglia of rats relieved the diabetic cardiac autonomic neuropathy"],"prefix":"10.1016","volume":"120","author":[{"given":"Xuan","family":"Sheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangdong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2018.09.002_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00006676-200104000-00014","article-title":"Streptozotocin-Induced diabetes mellitus is associated with increased pancreatic tissue levels of noradrenaline and adrenaline in the rat","volume":"22","author":"Adeghate","year":"2001","journal-title":"Pancreas"},{"key":"10.1016\/j.neuint.2018.09.002_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pneurobio.2005.02.002","article-title":"Plasticity of synaptic transmission in autonomic ganglia","volume":"75","author":"Alkadhi","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuint.2018.09.002_bib3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4239\/wjd.v6.i1.80","article-title":"Diabetes and cardiac autonomic neuropathy: clinical manifestations, cardiovascular consequences, diagnosis and treatment","volume":"6","author":"Balcioglu","year":"2015","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.neuint.2018.09.002_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejphar.2013.01.078","article-title":"Purinergic mechanisms and pain--an update","volume":"716","author":"Burnstock","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2018.09.002_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11302-013-9359-2","article-title":"Purinergic signalling and diabetes","volume":"9","author":"Burnstock","year":"2013","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.neuint.2018.09.002_bib6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1758-5996-5-54","article-title":"Cardiovascular autonomic neuropathy in type 2 diabetes mellitus patients with peripheral artery disease","volume":"5","author":"Canani","year":"2013","journal-title":"Diabetol. Metab. Syndrome"},{"key":"10.1016\/j.neuint.2018.09.002_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diacare.8.5.491","article-title":"The value of cardiovascular autonomic function tests: 10 years experience in diabetes","volume":"8","author":"Ewing","year":"1985","journal-title":"Diabetes Care"},{"key":"10.1016\/j.neuint.2018.09.002_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s10286-006-0345-4","article-title":"Decreased heart rate variability may predict the progression of carotid atherosclerosis in type 2 diabetes","volume":"16","author":"Gottsater","year":"2006","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.neuint.2018.09.002_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2202-12-69","article-title":"The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons","volume":"12","author":"Hughes","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neuint.2018.09.002_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155978","article-title":"Trajectories of metabolic risk factors and biochemical markers prior to the onset of cardiovascular disease - the doetinchem cohort study","volume":"11","author":"Hulsegge","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2018.09.002_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.brainresbull.2011.01.011","article-title":"Effects of oxymatrine on sympathoexcitatory reflex induced by myocardial ischemic signaling mediated by P2X(3) receptors in rat SCG and DRG","volume":"84","author":"Li","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2018.09.002_bib12","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/jnr.24000","article-title":"Co-expression changes of lncRNAs and mRNAs in the cervical sympathetic ganglia in diabetic cardiac autonomic neuropathic rats","volume":"95","author":"Li","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuint.2018.09.002_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainresbull.2012.10.002","article-title":"Effects of neferine on CCL5 and CCR5 expression in SCG of type 2 diabetic rats","volume":"90","author":"Li","year":"2013","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2018.09.002_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11302-013-9367-2","article-title":"Sensory-sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor","volume":"9","author":"Liu","year":"2013","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.neuint.2018.09.002_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.neuint.2018.09.002_bib16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00276-003-0113-2","article-title":"The sympathetic contributions to the cardiac plexus","volume":"25","author":"Pather","year":"2003","journal-title":"Surg. Radiol. Anat."},{"key":"10.1016\/j.neuint.2018.09.002_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.intimp.2016.02.027","article-title":"Anti-inflammatory effects of royal poinciana through inhibition of toll-like receptor 4 signaling pathway","volume":"34","author":"Patra","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.neuint.2018.09.002_bib18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fphar.2017.00363","article-title":"IL-1beta inhibition in cardiovascular complications associated to diabetes mellitus","volume":"8","author":"Peiro","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuint.2018.09.002_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuropharm.2012.11.011","article-title":"Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation","volume":"67","author":"Prado","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2018.09.002_bib20","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1007\/s00125-015-3771-9","article-title":"Role of the renal sympathetic nerve in renal glucose metabolism during the development of type 2 diabetes in rats","volume":"58","author":"Rafiq","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.neuint.2018.09.002_bib21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neulet.2008.08.087","article-title":"Pressure pain precedes development of type 2 disease in Zucker rat model of diabetes","volume":"445","author":"Romanovsky","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2018.09.002_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroscience.2014.11.020","article-title":"Muscle hyperalgesia induced by peripheral P2X3 receptors is modulated by inflammatory mediators","volume":"285","author":"Schiavuzzo","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2018.09.002_bib23","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuint.2018.09.002_bib24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.acthis.2007.02.005","article-title":"Exploration of P2X3 in the rat stellate ganglia after myocardial ischemia","volume":"109","author":"Shao","year":"2007","journal-title":"Acta Histochem."},{"key":"10.1016\/j.neuint.2018.09.002_bib25","article-title":"Involvement of MAPK\/NF-kappaB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2018.09.002_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pain.2006.10.007","article-title":"Enhanced excitability of nociceptive trigeminal ganglion neurons by satellite glial cytokine following peripheral inflammation","volume":"129","author":"Takeda","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2018.09.002_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jdi.12042","article-title":"Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease","volume":"4","author":"Vinik","year":"2013","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.neuint.2018.09.002_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(98)00774-5","article-title":"Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia","volume":"256","author":"Xiang","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2018.09.002_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainresbull.2011.10.007","article-title":"Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons","volume":"87","author":"Xu","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2018.09.002_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1471-2334-12-177","article-title":"Short hairpin RNA targeting 2B gene of coxsackievirus B3 exhibits potential antiviral effects both in vitro and in vivo","volume":"12","author":"Yao","year":"2012","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.neuint.2018.09.002_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresbull.2017.01.002","article-title":"A317491 relieved HIV gp120-associated neuropathic pain involved in P2X3 receptor in dorsal root ganglia","volume":"130","author":"Yi","year":"2017","journal-title":"Brain Res. Bull."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018618300524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018618300524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T18:01:46Z","timestamp":1537812106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018618300524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":31,"alternative-id":["S0197018618300524"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2018.09.002","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown the P2X3 receptor in the stellate ganglia of rats relieved the diabetic cardiac autonomic neuropathy","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2018.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}