{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:42:22Z","timestamp":1790264542561,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15H01422"],"award-info":[{"award-number":["15H01422"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17H05555"],"award-info":[{"award-number":["17H05555"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.neuint.2019.02.005","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T22:12:41Z","timestamp":1549750361000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP"],"prefix":"10.1016","volume":"125","author":[{"given":"Hiroki","family":"Kurosaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1195-1955","authenticated-orcid":false,"given":"Kohei","family":"Man-yoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2019.02.005_bib1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","article-title":"Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations","volume":"20","author":"Bernheimer","year":"1973","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2019.02.005_bib2","first-page":"166","volume":"1986","author":"Birkmayer","year":"1986"},{"key":"10.1016\/j.neuint.2019.02.005_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/321970","article-title":"Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia","volume":"69","author":"Bonafe","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuint.2019.02.005_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF01244661","article-title":"In-vivo measurements of tryptophan and tyrosine hydroxylase activities in mouse brain","volume":"34","author":"Carlsson","year":"1973","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.neuint.2019.02.005_bib5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0006-8993(86)91050-4","article-title":"The mechanism of action of MPTP and MPP+ on endogenous dopamine release from the rat corpus striatum superfused in vitro","volume":"368","author":"Chang","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2019.02.005_bib6","first-page":"463","article-title":"Therapeutic efficacy of tetrahydrobiopterin in Parkinson's disease","volume":"40","author":"Curtius","year":"1984","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neuint.2019.02.005_bib7","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.freeradbiomed.2008.02.008","article-title":"Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease","volume":"44","author":"Drechsel","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2019.02.005_bib8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.6610213","article-title":"Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice","volume":"224","author":"Heikkila","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.neuint.2019.02.005_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-8993(85)91631-2","article-title":"Inhibition of tyrosine hydroxylation in tissue slices of the rat striatum by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"337","author":"Hirata","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2019.02.005_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0304-3940(86)90150-3","article-title":"Early and late effects of systemically administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on tyrosine hydroxylase activity in vitro and on tyrosine hydroxylation in tissue slices of mouse striatum","volume":"68","author":"Hirata","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2019.02.005_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/jnc.12287","article-title":"The role of tetrahydrobiopterin and catecholamines in the developmental regulation of the tyrosine hydroxylase level in the brain","volume":"126","author":"Homma","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2019.02.005_bib12","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0022-3565(25)39572-8","article-title":"Autoradiographic distribution of [14C]tetrahydrobiopterin and its developmental change in mice","volume":"267","author":"Hoshiga","year":"1993","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2019.02.005_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ng1194-236","article-title":"Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene","volume":"8","author":"Ichinose","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuint.2019.02.005_bib14","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.7233193","article-title":"Peripherally administered reduced pterins do enter the brain","volume":"212","author":"Kapatos","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.neuint.2019.02.005_bib15","doi-asserted-by":"crossref","first-page":"10289","DOI":"10.1523\/JNEUROSCI.19-23-10289.1999","article-title":"Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration","volume":"19","author":"Kuhn","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2019.02.005_bib16","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1124\/mol.64.4.946","article-title":"Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide","volume":"64","author":"Kuhn","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuint.2019.02.005_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pbb.2004.03.006","article-title":"Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease","volume":"78","author":"Kurosaki","year":"2004","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.neuint.2019.02.005_bib18","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1172\/JCI200314172","article-title":"Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension","volume":"111","author":"Landmesser","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuint.2019.02.005_bib19","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.neuint.2019.02.005_bib20","series-title":"Abstract of the 7th International Symposium on Parkinson's Disease","first-page":"83","author":"LeWitt","year":"1982"},{"key":"10.1016\/j.neuint.2019.02.005_bib21","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","article-title":"Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease","volume":"5","author":"Liberatore","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuint.2019.02.005_bib22","doi-asserted-by":"crossref","first-page":"38581","DOI":"10.1074\/jbc.M005385200","article-title":"The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity","volume":"275","author":"Lotharius","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2019.02.005_bib23","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/oxfordjournals.jbchem.a135401","article-title":"Stereochemistry of biopterin cofactor and facile methods for the determination of the stereochemistry of a biologically active 5,6,7,8-tetrahydropterin","volume":"98","author":"Matsuura","year":"1985","journal-title":"J. Biochem."},{"key":"10.1016\/j.neuint.2019.02.005_bib24","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1093\/brain\/awu179","article-title":"Parkinson's disease in GTP cyclohydrolase 1 mutation carriers","volume":"137","author":"Mencacci","year":"2014","journal-title":"Brain : J. Neurol."},{"key":"10.1016\/j.neuint.2019.02.005_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00967976","article-title":"Tetrahydrobiopterin administration to Rhesus Macaques. Its Appearance in CSF and effect on neurotransmitter synthesis","volume":"11","author":"Miller","year":"1986","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2019.02.005_bib26","series-title":"Abstract of the 7th International Symposium on PD","first-page":"82","author":"Nagatsu","year":"1982"},{"key":"10.1016\/j.neuint.2019.02.005_bib27","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ng.3043","article-title":"Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease","volume":"46","author":"Nalls","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuint.2019.02.005_bib28","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.bi.54.070185.003501","article-title":"Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin","volume":"54","author":"Nichol","year":"1985","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neuint.2019.02.005_bib29","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0006-8993(01)02238-7","article-title":"Release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP(+)) into the striatum is associated with hydroxyl free radical generation","volume":"906","author":"Obata","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2019.02.005_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neulet.2006.03.031","article-title":"Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity","volume":"401","author":"Ogawa","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2019.02.005_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11010-017-3060-7","article-title":"Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess","volume":"435","author":"Ohashi","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.neuint.2019.02.005_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ymgme.2010.09.005","article-title":"Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis","volume":"102","author":"Ohashi","year":"2011","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.neuint.2019.02.005_bib33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neulet.2004.03.072","article-title":"Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease","volume":"363","author":"Park","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2019.02.005_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3940(85)90229-0","article-title":"Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse","volume":"60","author":"Perry","year":"1985","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2019.02.005_bib35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.2042-7158.1985.tb04947.x","article-title":"Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on dopamine metabolism in mouse and rat striatum","volume":"37","author":"Pileblad","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.neuint.2019.02.005_bib36","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1073\/pnas.93.10.4565","article-title":"Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity","volume":"93","author":"Przedborski","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2019.02.005_bib37","doi-asserted-by":"crossref","first-page":"12551","DOI":"10.1073\/pnas.0806065105","article-title":"Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia","volume":"105","author":"Sato","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuint.2019.02.005_bib38","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1046\/j.1471-4159.1995.64020936.x","article-title":"Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice","volume":"64","author":"Schulz","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2019.02.005_bib39","doi-asserted-by":"crossref","first-page":"19099","DOI":"10.1074\/jbc.M400101200","article-title":"1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide","volume":"279","author":"Shang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2019.02.005_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2013.05.001","article-title":"Glutathione metabolism and Parkinson's disease","volume":"62","author":"Smeyne","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.neuint.2019.02.005_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0006-8993(96)01271-1","article-title":"Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice","volume":"749","author":"Sriram","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2019.02.005_bib42","doi-asserted-by":"crossref","first-page":"41150","DOI":"10.1074\/jbc.M102237200","article-title":"Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice","volume":"276","author":"Sumi-Ichinose","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2019.02.005_bib43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bbrc.2008.01.028","article-title":"A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease","volume":"367","author":"Takazawa","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2019.02.005_bib44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0378-4347(93)80495-P","article-title":"Analysis of 6R- and 6S-tetrahydrobiopterin and other pterins by reversed-phase ion-pair liquid-chromatography with fluorimetric detection by post-column sodium nitrite oxidation","volume":"617","author":"Tani","year":"1993","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.neuint.2019.02.005_bib45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/syn.21889","article-title":"Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease","volume":"70","author":"Thiollier","year":"2016","journal-title":"Synapse"},{"issue":"Pt 1","key":"10.1016\/j.neuint.2019.02.005_bib46","first-page":"1","article-title":"Tetrahydrobiopterin biosynthesis, regeneration and functions","volume":"347","author":"Th\u00f6ny","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuint.2019.02.005_bib47","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ejphar.2011.09.171","article-title":"Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice","volume":"670","author":"Tsai","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2019.02.005_bib48","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/bj3620733","article-title":"The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study","volume":"362","author":"V\u00e1squez-Vivar","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuint.2019.02.005_bib49","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/BJ20110293","article-title":"Tetrahydrobiopterin: biochemistry and pathophysiology","volume":"438","author":"Werner","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuint.2019.02.005_bib50","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1073\/pnas.0937239100","article-title":"NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease","volume":"100","author":"Wu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018618305540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018618305540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:43:57Z","timestamp":1759311837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018618305540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":50,"alternative-id":["S0197018618305540"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2019.02.005","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2019.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}