{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:45:29Z","timestamp":1791549929703,"version":"4.3.4"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"National Council of Science and Technology, Mexico","doi-asserted-by":"publisher","award":["255317"],"award-info":[{"award-number":["255317"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"National Council of Science and Technology, Mexico","doi-asserted-by":"publisher","award":["573686"],"award-info":[{"award-number":["573686"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universidad Autonoma de Nuevo Leon, College of Medicine"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.neuint.2019.03.009","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:17:57Z","timestamp":1552609077000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Inflammatory domains modulate autism spectrum disorder susceptibility during maternal nutritional programming"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-0219","authenticated-orcid":false,"given":"Roger","family":"Maldonado-Ruiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Garza-Oca\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2019.03.009_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201278","article-title":"Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny","volume":"13","author":"Adam","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2019.03.009_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00787-017-1027-6","article-title":"Maternal body mass index before pregnancy as a risk factor for ADHD and autism in children","volume":"27","author":"Andersen","year":"2017","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/genes8060150","article-title":"Maternal factors that induce epigenetic changes contribute to neurological disorders in offspring","volume":"8","author":"Banik","year":"2017","journal-title":"Genes"},{"key":"10.1016\/j.neuint.2019.03.009_bib4","doi-asserted-by":"crossref","first-page":"e434","DOI":"10.1038\/tp.2014.80","article-title":"Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain","volume":"4","author":"Basil","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41398-018-0167-x","article-title":"Prenatal immune activation alters the adult neural epigenome but can be partly stabilised by a n-3 polyunsaturated fatty acid diet","volume":"8","author":"Basil","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib6","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/nn.3560","article-title":"TGF-\u03b2 signaling regulates neuronal C1q expression and developmental synaptic refinement","volume":"16","author":"Bialas","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib7","doi-asserted-by":"crossref","first-page":"e1276","DOI":"10.1542\/peds.2013-1188","article-title":"Maternal prenatal weight gain and autism spectrum disorders","volume":"132","author":"Bilder","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuint.2019.03.009_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12659","article-title":"Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb","volume":"7","author":"Breton-Provencher","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2019.03.009_bib10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.mehy.2011.02.038","article-title":"A proposed mechanism for autism: an aberrant neuroimmune response manifested as a psychiatric disorder","volume":"76","author":"Buehler","year":"2011","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.neuint.2019.03.009_bib11","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.cell.2016.06.001","article-title":"Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring","volume":"165","author":"Buffington","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2019.03.009_bib12","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1749-6632.2011.06388.x","article-title":"Hypothalamic inflammation: a double-edged sword to nutritional diseases","volume":"1243","author":"Cai","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2019.03.009_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12986-018-0279-6","article-title":"Maternal overnutrition by hypercaloric diets programs hypothalamic mitochondrial fusion and metabolic dysfunction in rat male offspring","volume":"15","author":"Cardenas-Perez","year":"2018","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.neuint.2019.03.009_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.biopsych.2016.10.020","article-title":"Maternal immune activation and autism spectrum disorder: from rodents to nonhuman and human primates","volume":"81","author":"Careaga","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbr.2015.08.035","article-title":"Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: a systematic review and meta-analysis","volume":"296","author":"Chen","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2019.03.009_bib16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2019.03.009_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6503a1","article-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8 Years \u2014 autism and developmental disabilities monitoring network, 11 sites, United States, 2012","volume":"65","author":"Christensen","year":"2016","journal-title":"MMWR. Surveill. Summ."},{"key":"10.1016\/j.neuint.2019.03.009_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pone.0199359","article-title":"Tcf4 regulates dendritic spine density and morphology in the adult brain","volume":"13","author":"Crux","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2019.03.009_bib19","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"De Souza","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuint.2019.03.009_bib20","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1093\/hmg\/ddr416","article-title":"Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder","volume":"20","author":"Dempster","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2019.03.009_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbi.2016.09.015","article-title":"Sensory deprivation increases phagocytosis of adult-born neurons by activated microglia in the olfactory bulb","volume":"60","author":"Denizet","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib22","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.20091419","article-title":"Regulation of learning and memory by meningeal immunity: a key role for IL-4","volume":"207","author":"Derecki","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neuint.2019.03.009_bib23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature10907","article-title":"Wild-type microglia arrest pathology in a mouse model of Rett syndrome","volume":"484","author":"Derecki","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2019.03.009_bib24","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/mp.2013.65","article-title":"Microbiota is essential for social development in the mouse","volume":"19","author":"Desbonnet","year":"2014","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2019.03.009_bib25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuroscience.2018.01.060","article-title":"Gut microbiota, inflammation, and probiotics on neural development in autism spectrum disorder","volume":"374","author":"Doenyas","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2019.03.009_bib26","first-page":"1","article-title":"PDGFR\u03b2 cells rapidly relay inflammatory signal from the circulatory system to neurons via chemokine CCL2","author":"Duan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2019.03.009_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biopsych.2016.08.031","article-title":"Autoimmunity, autoantibodies, and autism spectrum disorder","volume":"81","author":"Edmiston","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: implications for neuropsychiatric disorders","author":"Estes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuint.2019.03.009_bib29","first-page":"19","article-title":"Complement C3 expression is decreased in autism spectrum disorder subjects and contributes to behavioral deficits in rodents","volume":"3","author":"Fagan","year":"2017","journal-title":"Mol. Neuropsychiatry."},{"key":"10.1016\/j.neuint.2019.03.009_bib30","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: pathological role of the cerebellum in Autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"Cerebellum"},{"key":"10.1016\/j.neuint.2019.03.009_bib31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbi.2016.09.028","article-title":"Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring","volume":"63","author":"Fern\u00e1ndez de Coss\u00edo","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2014.07.050","article-title":"Interactions of innate and adaptive immunity in brain development and function","volume":"1617","author":"Filiano","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2019.03.009_bib33","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.immuni.2018.04.016","article-title":"The microglial innate immune receptor TREM2 is required for synapse elimination and normal brain connectivity","volume":"48","author":"Filipello","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.neuint.2019.03.009_bib34","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s40263-015-0279-2","article-title":"Maternal anti-fetal brain IgG autoantibodies and autism spectrum disorders: current knowledge and its implications for potential therapeutics","volume":"29","author":"Fox-edmiston","year":"2016","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuint.2019.03.009_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2013.05.005","article-title":"Immunological and autoimmune considerations of autism spectrum disorders","volume":"44","author":"Gesundheit","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.neuint.2019.03.009_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbi.2018.05.005","article-title":"Maternal immune activation with staphylococcal enterotoxin A produces unique behavioral changes in C57BL\/6 mouse offspring","volume":"75","author":"Glass","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2040-2392-2-13","article-title":"Increased midgestational IFN-\u03b3, IL-4 and IL-5 in women bearing a child with autism: a case-control study","volume":"2","author":"Goines","year":"2011","journal-title":"Mol. Autism."},{"key":"10.1016\/j.neuint.2019.03.009_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.31887\/DCNS.2017.19.1\/mleboyer","article-title":"Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti-NMDA-receptor autoantibody","volume":"19","author":"Gr\u00e9a","year":"2017","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib39","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2015.08.023","article-title":"Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity","volume":"51","author":"Hao","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib40","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"Heijtz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.neuint.2019.03.009_bib41","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.4049\/jimmunol.1402183","article-title":"Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM","volume":"194","author":"Huai","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.neuint.2019.03.009_bib43","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/glia.23284","article-title":"Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome","volume":"66","author":"Jawaid","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.neuint.2019.03.009_bib44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2016.06.005","article-title":"Maternal infection during pregnancy and risk of autism spectrum disorders: a systematic review and meta-analysis","volume":"58","author":"Jiang","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib45","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/mp.2016.77","article-title":"Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation","volume":"22","author":"Jones","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2019.03.009_bib46","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-9-4","article-title":"Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study","volume":"9","author":"Jyonouchi","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2019.03.009_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192606","article-title":"Maternal high-fat diet associated with altered gene expression, DNA methylation, and obesity risk in mouse offspring","volume":"13","author":"Keleher","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2019.03.009_bib48","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1016\/j.celrep.2016.08.004","article-title":"Tcf4 regulates synaptic plasticity, DNA methylation, and memory function","volume":"16","author":"Kennedy","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuint.2019.03.009_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type Associated with restricting development of alzheimer \u2019 s disease article a unique microglia type Associated with restricting development of alzheimer \u2019 s disease","volume":"169","author":"Keren-shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2019.03.009_bib50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbi.2015.02.018","article-title":"Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala","volume":"46","author":"Kigar","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib51","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature23910","article-title":"Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring","volume":"549","author":"Kim","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2019.03.009_bib52","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuint.2019.03.009_bib54","article-title":"Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease","volume":"26","author":"Krajmalnik-Brown","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.neuint.2019.03.009_bib55","doi-asserted-by":"crossref","first-page":"e1121","DOI":"10.1542\/peds.2011-2583","article-title":"Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders","volume":"129","author":"Krakowiak","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuint.2019.03.009_bib56","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2017.01.019","article-title":"Developmental microglial priming in postmortem autism spectrum disorder temporal cortex","volume":"62","author":"Lee","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib57","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuron.2018.09.017","article-title":"CD47 protects synapses from excess microglia-mediated pruning during development","volume":"100","author":"Lehrman","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2019.03.009_bib58","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-2206","article-title":"The association of maternal obesity and diabetes with autism and other developmental disabilities","volume":"137","author":"Li","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuint.2019.03.009_bib59","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jneuroim.2008.12.002","article-title":"Elevated immune response in the brain of autistic patients","volume":"207","author":"Li","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuint.2019.03.009_bib60","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0140-6736(18)31129-2","article-title":"Autism spectrum disorder","volume":"392","author":"Lord","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2019.03.009_bib61","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1172\/JCI90603","article-title":"Understanding the functions and relationships of the glymphatic system and meningeal lymphatics","volume":"127","author":"Louveau","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neuint.2019.03.009_bib62","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3597209","article-title":"Neuroinflammation in autism: plausible role of maternal inflammation, dietary omega 3, and microbiota","author":"Madore","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuint.2019.03.009_bib63","first-page":"e00016","article-title":"Maternal immunoreactivity to herpes simplex virus 2 and risk of autism spectrum disorder in male offspring","volume":"2","author":"Mahic","year":"2017","journal-title":"mSphere"},{"key":"10.1016\/j.neuint.2019.03.009_bib64","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7949582","article-title":"Central modulation of neuroinflammation by neuropeptides and energy-sensing hormones during obesity","author":"Maldonado-Ruiz","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.neuint.2019.03.009_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-017-0176-2","article-title":"Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder","volume":"8","author":"Masi","year":"2017","journal-title":"Mol. Autism."},{"key":"10.1016\/j.neuint.2019.03.009_bib66","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/8061389","article-title":"Maternal overnutrition programs central inflammation and addiction-like behavior in offspring","author":"Montalvo-Mart\u00ednez","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.neuint.2019.03.009_bib69","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1523\/JNEUROSCI.3617-10.2011","article-title":"Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis","volume":"31","author":"Moriyama","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib70","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/nn.3233","article-title":"Neural progenitor cells regulate microglia functions and activity","volume":"15","author":"Mosher","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib71","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbi.2017.09.010","article-title":"Activation of IL-17 receptor leads to increased oxidative inflammation in peripheral monocytes of autistic children","volume":"67","author":"Nadeem","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib72","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbi.2016.12.024","article-title":"Toll-like receptor 4 signaling is associated with upregulated NADPH oxidase expression in peripheral T cells of children with autism","volume":"61","author":"Nadeem","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib73","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1093\/cercor\/bhx250","article-title":"Dysregulation of cortical neuron DNA methylation profile in autism spectrum disorder","volume":"27","author":"Nardone","year":"2017","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuint.2019.03.009_bib74","doi-asserted-by":"crossref","first-page":"e433","DOI":"10.1038\/tp.2014.70","article-title":"DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways","volume":"4","author":"Nardone","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib75","first-page":"1","article-title":"The innate immune receptors TLR2\/4 mediate repeated social defeat stress-induced social avoidance through prefrontal microglial activation","author":"Nie","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2019.03.009_bib76","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbi.2012.01.015","article-title":"Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response","volume":"26","author":"Oskvig","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib77","doi-asserted-by":"crossref","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.neuint.2019.03.009_bib78","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.3390\/nu6114706","article-title":"The influence of early life nutrition on epigenetic regulatory mechanisms of the immune system","volume":"6","author":"Paparo","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.neuint.2019.03.009_bib79","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/jamapsychiatry.2013.896","article-title":"Gestational influenza and bipolar disorder in adult offspring","volume":"70","author":"Parboosing","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-016-0115-7","article-title":"Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study","volume":"8","author":"Pardo","year":"2017","journal-title":"Mol. Autism."},{"key":"10.1016\/j.neuint.2019.03.009_bib81","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2019.03.009_bib82","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/eji.200838105","article-title":"DNA methylation controls Foxp3 gene expression","volume":"38","author":"Polansky","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.neuint.2019.03.009_bib83","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbi.2015.07.009","article-title":"Microbes & neurodevelopment - absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala","volume":"50","author":"R.M.","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib84","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbi.2013.08.013","article-title":"Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire","volume":"35","author":"Radjavi","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2019.03.009_bib85","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI58644","article-title":"Innate immunity in the central nervous system","volume":"122","author":"Ransohoff","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neuint.2019.03.009_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.54","article-title":"CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice","volume":"3","author":"Rattazzi","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib87","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jp.2014.80","article-title":"Maternal obesity and increased risk for autism and developmental delay among very preterm infants","volume":"34","author":"Reynolds","year":"2014","journal-title":"J. Perinatol."},{"key":"10.1016\/j.neuint.2019.03.009_bib88","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/mp.2010.136","article-title":"Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis","volume":"17","author":"Rossignol","year":"2012","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2019.03.009_bib89","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41593-018-0128-y","article-title":"Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring","volume":"21","author":"Rudolph","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib90","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2019.03.009_bib91","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020545","article-title":"Microglia function in central nervous system development and plasticity","volume":"7","author":"Schafer","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuint.2019.03.009_bib92","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/hmg\/ddr044","article-title":"Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes","volume":"20","author":"Schaible","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2019.03.009_bib93","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1038\/tp.2013.16","article-title":"Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice","volume":"3","author":"Schwartzer","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuint.2019.03.009_bib94","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1399-5618.2010.00849.x","article-title":"Prenatal exposure to influenza and major affective disorder","volume":"12","author":"Selten","year":"2010","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neuint.2019.03.009_bib96","first-page":"1","article-title":"Reversing behavioural abnormalities in mice exposed to maternal inflammation","author":"Shin Yim","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2019.03.009_bib97","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/15592294.2016.1161873","article-title":"Arachidonic and oleic acid exert distinct effects on the DNA methylome","volume":"11","author":"Silva-Mart\u00ednez","year":"2016","journal-title":"Epigenetics"},{"key":"10.1016\/j.neuint.2019.03.009_bib98","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuint.2018.08.005","article-title":"Unhealthy gut, unhealthy brain: the role of the intestinal microbiota in neurodegenerative diseases","volume":"120","author":"Spielman","year":"2018","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2019.03.009_bib99","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/cge.13450","article-title":"Neurodevelopmental phenotype caused by a de novo PTPN4 single nucleotide variant disrupting protein localization in neuronal dendritic spines","volume":"94","author":"Szcza\u0142uba","year":"2018","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neuint.2019.03.009_bib100","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s10803-012-1513-0","article-title":"Microglia in the cerebral cortex in autism","volume":"42","author":"Tetreault","year":"2012","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.neuint.2019.03.009_bib101","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.autrev.2013.06.018","article-title":"The \u201cmissing link\u201d in autoimmunity and autism: extracellular mitochondrial components secreted from activated live mast cells","volume":"12","author":"Theoharides","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.neuint.2019.03.009_bib102","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/5584_2015_145","article-title":"Inflammatory activity in autism spectrum disorder","volume":"861","author":"Tonhajzerova","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuint.2019.03.009_bib103","first-page":"239","volume":"vol. 15","author":"Tsilioni","year":"2018"},{"key":"10.1016\/j.neuint.2019.03.009_bib104","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nn.3358","article-title":"Layer v cortical neurons require microglial support for survival during postnatal development","volume":"16","author":"Ueno","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib105","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.celrep.2014.11.018","article-title":"Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function","volume":"9","author":"Valdearcos","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuint.2019.03.009_bib106","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9498247","article-title":"Autism-like behaviours and memory deficits result from a western diet in mice","author":"Veniaminova","year":"2017","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuint.2019.03.009_bib107","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/glia.23261","article-title":"Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism","volume":"66","author":"Vogel Ciernia","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.neuint.2019.03.009_bib108","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrg.2017.4","article-title":"Autism genetics: opportunities and challenges for clinical translation","volume":"18","author":"Vorstman","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neuint.2019.03.009_bib110","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm.2353","article-title":"B lymphocytes promote insulin resistance through modulation of T lymphocytes and production of pathogenic IgG antibody","volume":"17","author":"Winer","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuint.2019.03.009_bib111","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/mp.2013.41","article-title":"Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits","volume":"19","author":"Wong","year":"2014","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2019.03.009_bib112","first-page":"686","article-title":"High-fat-diet exposure induces IgG accumulation in hypothalamic microglia","volume":"5","author":"Yi","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.neuint.2019.03.009_bib113","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nn.3641","article-title":"Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior","volume":"17","author":"Zhan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2019.03.009_bib114","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1742-2094-7-80","article-title":"Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children","volume":"7","author":"Zhang","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2019.03.009_bib115","article-title":"Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2019.03.009_bib116","doi-asserted-by":"crossref","first-page":"11697","DOI":"10.1038\/s41598-017-12003-4","article-title":"Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis","volume":"7","author":"Zheng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2019.03.009_bib117","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1128\/MCB.16.6.2898","article-title":"B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB","volume":"16","author":"Zhuang","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.neuint.2019.03.009_bib118","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuroscience.2016.01.070","article-title":"High-fat diet exacerbates cognitive rigidity and social deficiency in the BTBR mouse model of autism","volume":"345","author":"Zilkha","year":"2017","journal-title":"Neuroscience"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018618306569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018618306569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:46:20Z","timestamp":1759311980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018618306569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":112,"alternative-id":["S0197018618306569"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2019.03.009","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory domains modulate autism spectrum disorder susceptibility during maternal nutritional programming","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2019.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}