{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:00:26Z","timestamp":1780542026116,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671398"],"award-info":[{"award-number":["81671398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2019JJ50912"],"award-info":[{"award-number":["2019JJ50912"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.neuint.2020.104685","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T11:43:37Z","timestamp":1578656617000},"page":"104685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Estrogen protects neuroblastoma cell from amyloid-\u03b2 42 (A\u03b242)-induced apoptosis via TXNIP\/TRX axis and AMPK signaling"],"prefix":"10.1016","volume":"135","author":[{"given":"Qiong","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyun","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2020.104685_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ana.24135","article-title":"Sex modifies the APOE-related risk of developing Alzheimer disease","volume":"75","author":"Altmann","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2020.104685_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbagen.2010.06.011","article-title":"Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system","volume":"1810","author":"Aon-Bertolino","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2020.104685_bib3","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1523\/JNEUROSCI.6498-10.2011","article-title":"Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice","volume":"31","author":"Blouet","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2020.104685_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nbd.2008.11.017","article-title":"Enhanced expression of ERalpha in astrocytes modifies the response of cortical neurons to beta-amyloid toxicity","volume":"33","author":"Carbonaro","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2020.104685_bib5","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1346-8138.2006.00156.x","article-title":"Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases","volume":"33","author":"Chung","year":"2006","journal-title":"J. Dermatol."},{"key":"10.1016\/j.neuint.2020.104685_bib6","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/j.1468-1331.2006.01520.x","article-title":"The number of pregnancies is a risk factor for Alzheimer's disease","volume":"13","author":"Colucci","year":"2006","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neuint.2020.104685_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1532-5415.2002.50006.x","article-title":"Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study","volume":"50","author":"Di Carlo","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.neuint.2020.104685_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12432","article-title":"Sex hormone decline and amyloid beta synthesis, transport and clearance in the brain","volume":"28","author":"Duarte","year":"2016","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neuint.2020.104685_bib9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/archneur.62.6.953","article-title":"Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment","volume":"62","author":"Fleisher","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuint.2020.104685_bib10","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/ptj\/78.12.1325","article-title":"An overview of the etiology, diagnosis, and treatment of Alzheimer disease","volume":"78","author":"Forsyth","year":"1998","journal-title":"Phys. Ther."},{"key":"10.1016\/j.neuint.2020.104685_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbr.2015.06.045","article-title":"Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer's disease","volume":"293","author":"Gao","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2020.104685_bib12","series-title":"TXNIP, the major player in insulin resistance, is early over-expressed in the brain of the 5XFAD Alzheimer's mice model and is induced by A\u03b2 in vitro: emerging role of TXNIP and inflammation in Alzheimer's Disease progression","author":"Gouget","year":"2011"},{"key":"10.1016\/j.neuint.2020.104685_bib13","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.neurobiolaging.2010.04.033","article-title":"Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans","volume":"31","author":"Hua","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuint.2020.104685_bib14","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s12035-014-8766-x","article-title":"Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice","volume":"51","author":"Ishrat","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2020.104685_bib15","first-page":"233","article-title":"Exploring potential biomarkers underlying pathogenesis of Alzheimer's disease by differential Co-expression analysis","volume":"10","author":"Izadi","year":"2018","journal-title":"Avicenna J. Med. Biotechnol. (AJMB)"},{"key":"10.1016\/j.neuint.2020.104685_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0197-4580(00)00125-1","article-title":"The role of cerebral ischemia in Alzheimer's disease","volume":"21","author":"Kalaria","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuint.2020.104685_bib17","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/bpa.12599","article-title":"Higher levels of kallikrein-8 in female brain may increase the risk for Alzheimer's disease","volume":"28","author":"Keyvani","year":"2018","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neuint.2020.104685_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.tem.2012.03.002","article-title":"miRNAs and estrogen action","volume":"23","author":"Klinge","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.neuint.2020.104685_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.mce.2015.01.035","article-title":"miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets","volume":"418","author":"Klinge","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neuint.2020.104685_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186636","article-title":"In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells","volume":"12","author":"Krishtal","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2020.104685_bib21","doi-asserted-by":"crossref","first-page":"10318","DOI":"10.1038\/s41598-017-10442-7","article-title":"Estradiol regulates txnip and prevents intermittent hypoxia-induced vascular injury","volume":"7","author":"Lan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2020.104685_bib22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5498\/wjp.v6.i1.54","article-title":"Sex differences in cognitive impairment in Alzheimer's disease","volume":"6","author":"Laws","year":"2016","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.neuint.2020.104685_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.expneurol.2016.11.009","article-title":"The inhibition of spinal synaptic plasticity mediated by activation of AMP-activated protein kinase signaling alleviates the acute pain induced by oxaliplatin","volume":"288","author":"Ling","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2020.104685_bib24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ygeno.2007.08.005","article-title":"Gene expression profiling in the adult Down syndrome brain","volume":"90","author":"Lockstone","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.neuint.2020.104685_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.mcn.2018.02.004","article-title":"Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser(396)) and (Ser(262)) via AMPK but not mTOR signaling pathway","volume":"88","author":"Majd","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2020.104685_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11095-017-2276-2","article-title":"Verapamil inhibits ser202\/thr205 phosphorylation of tau by blocking TXNIP\/ROS\/p38 MAPK pathway","volume":"35","author":"Melone","year":"2018","journal-title":"Pharm. Res."},{"key":"10.1016\/j.neuint.2020.104685_bib27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1212\/WNL.58.2.209","article-title":"Incidence of AD may decline in the early 90s for men, later for women: the Cache County study","volume":"58","author":"Miech","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2020.104685_bib28","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3233\/JAD-180735","article-title":"Metabolic syndrome, brain insulin resistance, and Alzheimer's disease: Thioredoxin interacting protein (TXNIP) and inflammasome as core amplifiers","volume":"66","author":"Nasoohi","year":"2018","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.neuint.2020.104685_bib29","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4696","article-title":"Palmitic acid induces neurotoxicity and gliatoxicity in SH-SY5Y human neuroblastoma and T98G human glioblastoma cells","volume":"6","author":"Ng","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.neuint.2020.104685_bib30","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2020.104685_bib31","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2018.03.020","article-title":"Downregulation of TXNIP leads to high proliferative activity and estrogen-dependent cell growth in breast cancer","volume":"498","author":"Park","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2020.104685_bib32","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/jama.1994.03510410028015","article-title":"Alzheimer's disease, apolipoprotein E4, and gender","volume":"271","author":"Payami","year":"1994","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.neuint.2020.104685_bib33","first-page":"734956","article-title":"The complexity of sporadic Alzheimer's disease pathogenesis: the role of RAGE as therapeutic target to promote neuroprotection by inhibiting neurovascular dysfunction","volume":"2012","author":"Perrone","year":"2012","journal-title":"Int. J. Alzheimer's Dis."},{"key":"10.1016\/j.neuint.2020.104685_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10522-009-9223-5","article-title":"Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?","volume":"11","author":"Pun","year":"2010","journal-title":"Biogerontology"},{"key":"10.1016\/j.neuint.2020.104685_bib35","first-page":"131","article-title":"Modifications to the in situ TUNEL method for detection of apoptosis in paraffin-embedded tissue sections","volume":"28","author":"Rao","year":"1998","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.neuint.2020.104685_bib36","doi-asserted-by":"crossref","first-page":"985845","DOI":"10.1155\/2015\/985845","article-title":"Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress","volume":"2015","author":"Rosales-Corral","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.neuint.2020.104685_bib37","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/1471-0528.12828","article-title":"Impact of a premature menopause on cognitive function in later life","volume":"121","author":"Ryan","year":"2014","journal-title":"BJOG"},{"key":"10.1016\/j.neuint.2020.104685_bib38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1471-4159.2011.07331.x","article-title":"AMP\u2010activated protein kinase: a potential player in Alzheimer's disease","volume":"118","author":"Salminen","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2020.104685_bib39","first-page":"151","article-title":"Alcohol and Alzheimer's disease-does alcohol dependence contribute to beta-amyloid deposition, neuroinflammation and neurodegeneration in Alzheimer's disease?","volume":"52","author":"Venkataraman","year":"2017","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuint.2020.104685_bib41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000337428","article-title":"Risk of Alzheimer's disease in relation to diabetes: a population-based cohort study","volume":"38","author":"Wang","year":"2012","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neuint.2020.104685_bib40","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1089\/ars.2017.7440","article-title":"Dl-3-n-Butylphthalide inhibits NLRP3 inflammasome and mitigates alzheimer\u2019s-like pathology via nrf2-TXNIP-TrX Axis","volume":"30","author":"Wang","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.neuint.2020.104685_bib42","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1385-299X(98)00020-8","article-title":"TUNEL, Hoechst and immunohistochemistry triple-labelling: an improved method for detection of apoptosis in tissue sections--an update","volume":"3","author":"Whiteside","year":"1998","journal-title":"Brain Res Brain Res Protoc"},{"key":"10.1016\/j.neuint.2020.104685_bib43","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fimmu.2013.00514","article-title":"Thioredoxin\/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases","volume":"4","author":"Yoshihara","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuint.2020.104685_bib44","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1212\/WNL.45.6.1161","article-title":"Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study","volume":"45","author":"Yoshitake","year":"1995","journal-title":"Neurology"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018619302839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018619302839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:47:57Z","timestamp":1759312077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018619302839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":44,"alternative-id":["S0197018619302839"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2020.104685","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estrogen protects neuroblastoma cell from amyloid-\u03b2 42 (A\u03b242)-induced apoptosis via TXNIP\/TRX axis and AMPK signaling","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2020.104685","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104685"}}