{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:00:15Z","timestamp":1774238415426,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007029","name":"State Committee of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.neuint.2020.104838","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T21:18:23Z","timestamp":1598303903000},"page":"104838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Embryonic proteoglycans regulate monoamines in the rat frontal cortex and hippocampus in Alzheimer's disease-like pathology"],"prefix":"10.1016","volume":"140","author":[{"given":"Vergine","family":"Chavushyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senik","family":"Matinyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-7066","authenticated-orcid":false,"given":"Margarita","family":"Danielyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Aghajanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Yenkoyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2020.104838_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104531","article-title":"Alzheimer's disease-like pathology-triggered oxidative stress, alterations in monoamines levels, and structural damage of locus coeruleus neurons are partially recovered by a mix of proteoglycans of embryonic genesis","volume":"131","author":"Aghajanov","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2020.104838_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnsyn.2013.00011","article-title":"Target-cell-specific short-term plasticity in local circuits","volume":"5","author":"Blackman","year":"2013","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.neuint.2020.104838_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1124\/jpet.117.241653","article-title":"Sembragiline: a novel, selective monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease","volume":"362","author":"Borroni","year":"2017","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2020.104838_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuint.2020.104838_bib5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbrc.2016.09.088","article-title":"Emerging pathways driving early synaptic pathology in Alzheimer's disease","volume":"483","author":"Briggs","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2020.104838_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1515\/tnsci-2015-0013","article-title":"Perception of emotions in mild cognitive impairment and Alzheimer's dementia: does intensity matter?","volume":"6","author":"Elferink","year":"2015","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.neuint.2020.104838_bib7","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0896-6273(02)01106-6","article-title":"Interaction of postsynaptic receptor saturation with presynaptic mechanisms produces a reliable synapse","volume":"36","author":"Foster","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2020.104838_bib8","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1176\/appi.ajp.161.6.1096","article-title":"Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression","volume":"161","author":"Hendricksen","year":"2004","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.neuint.2020.104838_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1515\/REVNEURO.2005.16.3.181","article-title":"Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies","volume":"16","author":"H\u00f6lscher","year":"2005","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neuint.2020.104838_bib10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4103\/1673-5374.250625","article-title":"Glutamate receptor delocalization in postsynaptic membrane and reduced hippocampal synaptic plasticity in the early stage of Alzheimer's disease","volume":"14","author":"Li","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuint.2020.104838_bib11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2174\/157015909790031193","article-title":"Neuroplasticity regulation by noradrenaline in mammalian brain","volume":"7","author":"Marzo","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neuint.2020.104838_bib12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(96)00710-X","article-title":"Reversion of \u03b225\u201335-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists","volume":"731","author":"Maurice","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2020.104838_bib13","article-title":"Neuroprotective, neurogenic, and amyloid beta reducing effect of a novel alpha 2-Adrenoblocker, mesedin, on astroglia and neuronal progenitors upon hypoxia and glutamate exposure","volume":"19","author":"Melkonyan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2020.104838_bib14","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006338","article-title":"Neurotoxicity of amyloid \u03b2-protein: synaptic and network dysfunction","volume":"2","author":"Mucke","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neuint.2020.104838_bib15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's Disease with plaques and tangles: intracellular A\u03b2 and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2020.104838_bib16","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.neuint.2020.104838_bib17","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005702","article-title":"Short-term presynaptic plasticity","volume":"4","author":"Regehr","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuint.2020.104838_bib18","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neuint.2020.104838_bib19","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2990.2009.01038.x","article-title":"Does Alzheimer's disease begin in the brainstem?","volume":"35","author":"Simic","year":"2009","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neuint.2020.104838_bib20","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.neubiorev.2013.05.008","article-title":"Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care","volume":"37","author":"Trillo","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuint.2020.104838_bib21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid \u03b2 protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2020.104838_bib22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pnpbp.2018.05.013","article-title":"The role of monoamines in the development of Alzheimer's disease and neuroprotective effect of a proline rich polypeptide","volume":"86","author":"Yenkoyan","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2020.104838_bib23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.brainresbull.2011.08.003","article-title":"Neuroprotective action of proline-rich polypeptide-1 in \u03b2-amyloid induced neurodegeneration in rats","volume":"86","author":"Yenkoyan","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2020.104838_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuint.2008.12.010","article-title":"Effects of beta-amyloid on behavioral and amino acids spectrum in rats' brain and their modulation by embryonic proteins","volume":"54","author":"Yenkoyan","year":"2009","journal-title":"Neurochem. Int."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018620302291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018620302291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:51:38Z","timestamp":1759312298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018620302291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":24,"alternative-id":["S0197018620302291"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2020.104838","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Embryonic proteoglycans regulate monoamines in the rat frontal cortex and hippocampus in Alzheimer's disease-like pathology","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2020.104838","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104838"}}