{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:15:17Z","timestamp":1789247717907,"version":"build-2803163510"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19lk0201096h0001"],"award-info":[{"award-number":["19lk0201096h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20lk0201096h0002"],"award-info":[{"award-number":["20lk0201096h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.neuint.2021.105015","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T23:52:48Z","timestamp":1616802768000},"page":"105015","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Diagnostic and prognostic blood biomarkers in vascular dementia: From the viewpoint of ischemic stroke"],"prefix":"10.1016","volume":"146","author":[{"given":"Satoshi","family":"Hosoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaka","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-4048","authenticated-orcid":false,"given":"Masafumi","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2021.105015_bib1","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1161\/01.STR.0000127420.10990.76","article-title":"Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease","volume":"35","author":"Adair","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib3","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1373\/clinchem.2005.053942","article-title":"PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke","volume":"51","author":"Allard","year":"2005","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neuint.2021.105015_bib4","doi-asserted-by":"crossref","first-page":"683920","DOI":"10.1155\/2013\/683920","article-title":"Neuroprotective function of DJ-1 in Parkinson's disease","volume":"2013","author":"Ariga","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.neuint.2021.105015_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/STROKEAHA.110.595553","article-title":"Prevalence of early dementia after first-ever stroke: a 24-year population-based study","volume":"42","author":"B\u00e9jot","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.clineuro.2009.04.001","article-title":"The complexity of neurobiological processes in acute ischemic stroke","volume":"111","author":"Brouns","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.neuint.2021.105015_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00045391-200311000-00018","article-title":"Increased serum malondialdehyde and decreased nitric oxide within 24 hours of thrombotic stroke onset","volume":"10","author":"Cano","year":"2003","journal-title":"Am. J. Therapeut."},{"key":"10.1016\/j.neuint.2021.105015_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/01.STR.0000046764.57344.31","article-title":"Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke","volume":"34","author":"Castellanos","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004647-200101000-00002","article-title":"Reactive oxygen radicals in signaling and damage in the ischemic brain","volume":"21","author":"Chan","year":"2001","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuint.2021.105015_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112500","article-title":"A mini-review of the NADPH oxidases in vascular dementia: correlation with NOXs and risk factors for VaD","volume":"18","author":"Choi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib11","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1161\/01.HYP.29.6.1296","article-title":"Shear stress augments expression of C-type natriuretic peptide and adrenomedullin","volume":"29","author":"Chun","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.neuint.2021.105015_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20112812","article-title":"Emerging biomarkers in vascular cognitive impairment and dementia: from pathophysiological pathways to clinical application","volume":"20","author":"Cipollini","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1749-6632.2002.tb04831.x","article-title":"Endothelial cell activation is associated with cerebral white matter lesions in patients with cerebrovascular disease","volume":"977","author":"de Leeuw","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrd3403","article-title":"Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets","volume":"10","author":"Drummond","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuint.2021.105015_bib15","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1001\/jama.2017.14585","article-title":"Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer","volume":"318","author":"Ehteshami Bejnordi","year":"2017","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.neuint.2021.105015_bib16","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1023\/A:1007677003387","article-title":"Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)","volume":"25","author":"Eng","year":"2000","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2021.105015_bib17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.17219\/acem\/78360","article-title":"Serum asymmetric dimethylarginine and nitric oxide levels in Turkish patients with acute ischemic stroke","volume":"28","author":"Ercan","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.neuint.2021.105015_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/neurintsurg-2017-013355","article-title":"Deep learning guided stroke management: a review of clinical applications","volume":"10","author":"Feng","year":"2018","journal-title":"J. Neurointerventional Surg."},{"key":"10.1016\/j.neuint.2021.105015_bib19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrneurol.2009.175","article-title":"Changing perspectives regarding late-life dementia","volume":"5","author":"Fotuhi","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jns.2015.04.031","article-title":"S100B and ADMA in cerebral small vessel disease and cognitive dysfunction","volume":"354","author":"Gao","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib21","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/gps.5136","article-title":"Cognitive screening instruments to identify vascular cognitive impairment: a systematic review","volume":"34","author":"Ghafar","year":"2019","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.neuint.2021.105015_bib22","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib23","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/brain\/awg040","article-title":"Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis","volume":"126","author":"Hassan","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2021.105015_bib24","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1212\/01.wnl.0000435301.64776.37","article-title":"Pulse wave velocity is associated with \u03b2-amyloid deposition in the brains of very elderly adults","volume":"81","author":"Hughes","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2021.105015_bib25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2021.105015_bib26","doi-asserted-by":"crossref","first-page":"978761","DOI":"10.4061\/2011\/978761","article-title":"Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes","volume":"2011","author":"Ihara","year":"2011","journal-title":"J Aging Res"},{"key":"10.1016\/j.neuint.2021.105015_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jns.2007.01.045","article-title":"Neuropathological evaluation of mixed dementia","volume":"257","author":"Jellinger","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib28","doi-asserted-by":"crossref","first-page":"19429","DOI":"10.1038\/s41598-019-54542-y","article-title":"Differential expression of circulating exosomal microRNAs in refractory intracranial atherosclerosis associated with antiangiogenesis","volume":"9","author":"Jiang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2021.105015_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0197-4580(00)00125-1","article-title":"The role of cerebral ischemia in Alzheimer's disease","volume":"21","author":"Kalaria","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuint.2021.105015_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jns.2012.07.032","article-title":"Does vascular pathology contribute to Alzheimer changes?","volume":"322","author":"Kalaria","year":"2012","journal-title":"J. Neurol. Sci."},{"issue":"Suppl. 3","key":"10.1016\/j.neuint.2021.105015_bib31","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1097\/00002093-199912003-00017","article-title":"Overlap between pathology of Alzheimer disease and vascular dementia","volume":"13","author":"Kalaria","year":"1999","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neuint.2021.105015_bib32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrneurol.2013.164","article-title":"Dementia: vascular and neurodegenerative pathways-will they meet?","volume":"9","author":"Kalaria","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ana.22553","article-title":"Evolving role of biomarkers in acute cerebrovascular disease","volume":"71","author":"Kernagis","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aat4285","article-title":"The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing \u03b1-synuclein","volume":"11","author":"Kim","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuint.2021.105015_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1046\/j.1365-2826.2002.00778.x","article-title":"Cerebral endothelial cells are a major source of adrenomedullin","volume":"14","author":"Kis","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neuint.2021.105015_bib36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neulet.2007.02.021","article-title":"Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease","volume":"417","author":"Kitaguchi","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2021.105015_bib37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3389\/fimmu.2020.00759","article-title":"Brain ischemia significantly alters microRNA expression in human peripheral blood natural killer cells","volume":"11","author":"Kong","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuint.2021.105015_bib38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.5551\/jat.29967","article-title":"Adrenomedullin-RAMP2 system in vascular endothelial cells","volume":"22","author":"Koyama","year":"2015","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.neuint.2021.105015_bib39","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3233\/JAD-160901","article-title":"Association between mid-regional proadrenomedullin levels and progression of deep white matter lesions in the brain accompanying cognitive decline","volume":"56","author":"Kuriyama","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuint.2021.105015_bib40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cca.2014.03.007","article-title":"Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke","volume":"433","author":"Leung","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neuint.2021.105015_bib41","first-page":"1729","article-title":"miR-134-5p\/Foxp2\/Syn1 is involved in cognitive impairment in an early vascular dementia rat model","volume":"44","author":"Liu","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neuint.2021.105015_bib42","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2021.105015_bib43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/1471-2377-13-178","article-title":"Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans","volume":"13","author":"Long","year":"2013","journal-title":"BMC Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib44","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jns.2015.10.034","article-title":"Serum neuron specific enolase level as a predictor of prognosis in acute ischemic stroke patients after intravenous thrombolysis","volume":"359","author":"Lu","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib45","first-page":"35","article-title":"Heart - type fatty acid binding protein in prognosis of ischemic stroke at the hospital stage","volume":"91","author":"Lyang","year":"2019","journal-title":"Ter. Arkh."},{"key":"10.1016\/j.neuint.2021.105015_bib46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1161\/01.STR.0000105927.62344.4C","article-title":"Novel diagnostic test for acute stroke","volume":"35","author":"Lynch","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib47","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1096\/fj.05-3839fje","article-title":"SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain","volume":"19","author":"Madeira","year":"2005","journal-title":"Faseb. J."},{"key":"10.1016\/j.neuint.2021.105015_bib48","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/STROKEAHA.110.603399","article-title":"Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice","volume":"42","author":"Maki","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib49","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/01.STR.0000169924.60783.d4","article-title":"Markers of endothelial and hemostatic activation and progression of cerebral white matter hyperintensities: longitudinal results of the Austrian Stroke Prevention Study","volume":"36","author":"Markus","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12916-017-0779-7","article-title":"Post-stroke dementia - a comprehensive review","volume":"15","author":"Mijajlovi\u0107","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.neuint.2021.105015_bib51","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2021.105015_bib52","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1210\/en.2005-1038","article-title":"The neuroprotective and vasculo-neuro-regenerative roles of adrenomedullin in ischemic brain and its therapeutic potential","volume":"147","author":"Miyashita","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuint.2021.105015_bib53","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1447-0594.2010.00686.x","article-title":"Relationship between interleukin-6 and cerebral deep white matter and periventricular hyperintensity in elderly women","volume":"11","author":"Nagai","year":"2011","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.neuint.2021.105015_bib54","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ajh.2012.85","article-title":"Association of prothrombotic status with markers of cerebral small vessel disease in elderly hypertensive patients","volume":"25","author":"Nagai","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.neuint.2021.105015_bib55","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/jb\/mvz017","article-title":"Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke","volume":"165","author":"Nakamura","year":"2019","journal-title":"J. Biochem."},{"key":"10.1016\/j.neuint.2021.105015_bib56","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1006\/bbrc.1998.8131","article-title":"Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells","volume":"243","author":"Nakayama","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2021.105015_bib57","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1161\/STROKEAHA.110.581686","article-title":"A mouse model characterizing features of vascular dementia with hippocampal atrophy","volume":"41","author":"Nishio","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib58","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrcardio.2010.161","article-title":"The relationship between blood pressure and cognitive function","volume":"7","author":"Novak","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.neuint.2021.105015_bib59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00401-011-0925-9","article-title":"Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts","volume":"123","author":"Okamoto","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuint.2021.105015_bib60","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1161\/01.STR.0000133340.37712.9b","article-title":"Soluble thrombomodulin and brain infarction: case-control and prospective study","volume":"35","author":"Olivot","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib61","first-page":"127","article-title":"Purification and characterization of human neuron-specific enolase: radioimmunoassay development","volume":"5","author":"P\u00e5hlman","year":"1984","journal-title":"Tumour Biol"},{"key":"10.1016\/j.neuint.2021.105015_bib62","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/CCM.0b013e3181b788ab","article-title":"Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury","volume":"38","author":"Papa","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.neuint.2021.105015_bib63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/STROKEAHA.119.024148","article-title":"Clinical relevance of cerebral small vessel diseases","volume":"51","author":"Pasi","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib64","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.pjnns.2018.08.004","article-title":"sP- and sE-selectin in stroke patients with metabolic disorders","volume":"52","author":"Pawelczyk","year":"2018","journal-title":"Neurol. Neurochir. Pol."},{"key":"10.1016\/j.neuint.2021.105015_bib65","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(09)70236-4","article-title":"Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis","volume":"8","author":"Pendlebury","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib66","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S1474-4422(18)30442-3","article-title":"Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study","volume":"18","author":"Pendlebury","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib67","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1161\/STROKEAHA.109.557116","article-title":"Association of plasma ADMA levels with MRI markers of vascular brain injury: framingham offspring study","volume":"40","author":"Pikula","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib68","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/10715760290019273","article-title":"Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome","volume":"36","author":"Polidori","year":"2002","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neuint.2021.105015_bib69","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/ageing\/afx090","article-title":"Circulating microRNAs as potential biomarkers for the identification of vascular dementia due to cerebral small vessel disease","volume":"46","author":"Prabhakar","year":"2017","journal-title":"Age Ageing"},{"key":"10.1016\/j.neuint.2021.105015_bib70","first-page":"527","article-title":"Expression and short-term prognostic value of miR-126 and miR-182 in patients with acute stroke","volume":"19","author":"Qi","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.neuint.2021.105015_bib71","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ijcard.2007.11.031","article-title":"Elevated soluble intercellular adhesion molecule-1 levels are associated with poor short-term prognosis in middle-aged patients with acute ischaemic stroke","volume":"132","author":"Rallidis","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.neuint.2021.105015_bib72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuropharm.2018.07.006","article-title":"Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: opportunities, challenges and future directions for cerebral stroke management","volume":"139","author":"Rana","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2021.105015_bib73","doi-asserted-by":"crossref","first-page":"24588","DOI":"10.1038\/srep24588","article-title":"Assessment of serum UCH-L1 and GFAP in acute stroke patients","volume":"6","author":"Ren","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2021.105015_bib74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12950-015-0106-z","article-title":"E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases","volume":"12","author":"Richard","year":"2015","journal-title":"J. Inflamm."},{"key":"10.1016\/j.neuint.2021.105015_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023111","article-title":"Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injury","volume":"6","author":"Rojo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2021.105015_bib76","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/YCO.0000000000000239","article-title":"Interaction between cerebrovascular disease and Alzheimer pathology","volume":"29","author":"Saito","year":"2016","journal-title":"Curr. Opin. Psychiatr."},{"key":"10.1016\/j.neuint.2021.105015_bib77","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1504327","article-title":"Incidence of dementia over three decades in the framingham heart study","volume":"374","author":"Satizabal","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuint.2021.105015_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jstrokecerebrovasdis.2005.09.005","article-title":"Increased von Willebrand factor in acute stroke patients with atrial fibrillation","volume":"15","author":"Sato","year":"2006","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.neuint.2021.105015_bib79","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2021.105015_bib80","first-page":"19471","article-title":"Serum somatostatin and neuron-specific enolase might be biochemical markers of vascular dementia in the early stage","volume":"8","author":"Shen","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.neuint.2021.105015_bib81","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1161\/01.CIR.101.19.2309","article-title":"Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature","volume":"101","author":"Shindo","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.neuint.2021.105015_bib82","first-page":"1452","article-title":"miR-335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke","volume":"43","author":"Si","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neuint.2021.105015_bib83","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","article-title":"Brain infarction and the clinical expression of Alzheimer disease. The Nun Study","volume":"277","author":"Snowdon","year":"1997","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.neuint.2021.105015_bib84","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.omtn.2018.08.020","article-title":"miR-409 inhibits human non-small-cell lung cancer progression by directly targeting SPIN1","volume":"13","author":"Song","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.neuint.2021.105015_bib85","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1212\/WNL.0000000000000837","article-title":"Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden","volume":"83","author":"Staals","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2021.105015_bib86","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1161\/01.STR.0000029007.32244.40","article-title":"Soluble intercellular adhesion molecule-1 and risk of future ischemic stroke: a nested case-control study from the Bezafibrate Infarction Prevention (BIP) study cohort","volume":"33","author":"Tanne","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166688","article-title":"Plasma MicroRNA-16 is a biomarker for diagnosis, stratification, and prognosis of hyperacute cerebral infarction","volume":"11","author":"Tian","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2021.105015_bib88","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jocn.2004.06.013","article-title":"Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction","volume":"12","author":"Tombul","year":"2005","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.neuint.2021.105015_bib89","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1164\/ajrccm.160.1.9810006","article-title":"Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome","volume":"160","author":"Ueda","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neuint.2021.105015_bib90","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/jnnp.74.3.312","article-title":"Raised plasma oxidised LDL in acute cerebral infarction","volume":"74","author":"Uno","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"Suppl. 12","key":"10.1016\/j.neuint.2021.105015_bib91","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1097\/00005344-199204002-00018","article-title":"Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis","volume":"20","author":"Vallance","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.neuint.2021.105015_bib92","doi-asserted-by":"crossref","first-page":"18003","DOI":"10.1038\/nrdp.2018.3","article-title":"Vascular cognitive impairment","volume":"4","author":"van der Flier","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.neuint.2021.105015_bib93","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.expneurol.2015.05.006","article-title":"Models and mechanisms of vascular dementia","volume":"272","author":"Venkat","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib94","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/01.STR.0000068408.82115.D2","article-title":"Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study","volume":"34","author":"Vermeer","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib95","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1474-4422(07)70170-9","article-title":"Silent brain infarcts: a systematic review","volume":"6","author":"Vermeer","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib96","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa022066","article-title":"Silent brain infarcts and the risk of dementia and cognitive decline","volume":"348","author":"Vermeer","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuint.2021.105015_bib97","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1212\/01.wnl.0000341271.90478.8e","article-title":"Vascular risk factors and dementia: how to move forward?","volume":"72","author":"Viswanathan","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2021.105015_bib98","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/ene.13497","article-title":"Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke","volume":"25","author":"Wang","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib99","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/STROKEAHA.116.014816","article-title":"Association of oxidized low-density lipoprotein with prognosis of stroke and stroke subtypes","volume":"48","author":"Wang","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib100","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000488365","article-title":"Diagnosis of hyperacute and acute ischaemic stroke: the potential utility of exosomal MicroRNA-21-5p and MicroRNA-30a-5p","volume":"45","author":"Wang","year":"2018","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.neuint.2021.105015_bib101","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1002\/jcb.27281","article-title":"Association of serum neuron-specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large-artery atherosclerotic strokes","volume":"119","author":"Wang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.neuint.2021.105015_bib102","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/STROKEAHA.107.511261","article-title":"Blood biomarkers in the diagnosis of ischemic stroke: a systematic review","volume":"39","author":"Whiteley","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib103","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1080\/15476286.2016.1236172","article-title":"Toward the promise of microRNAs - enhancing reproducibility and rigor in microRNA research","volume":"13","author":"Witwer","year":"2016","journal-title":"RNA Biol."},{"key":"10.1016\/j.neuint.2021.105015_bib104","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.clineuro.2005.12.006","article-title":"Neuron-specific enolase and tau protein as neurobiochemical markers of neuronal damage are related to early clinical course and long-term outcome in acute ischemic stroke","volume":"108","author":"Wunderlich","year":"2006","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.neuint.2021.105015_bib105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jns.2004.08.005","article-title":"Release of neurobiochemical markers of brain damage is related to the neurovascular status on admission and the site of arterial occlusion in acute ischemic stroke","volume":"227","author":"Wunderlich","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib106","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1742-1241.2007.01268.x","article-title":"Plasma fibrinogen is associated with cognitive decline and risk for dementia in patients with mild cognitive impairment","volume":"62","author":"Xu","year":"2008","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.neuint.2021.105015_bib107","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1159\/000477597","article-title":"Protective effects of MicroRNA-126 on human cardiac microvascular endothelial cells against hypoxia\/reoxygenation-induced injury and inflammatory response by activating PI3K\/Akt\/eNOS signaling pathway","volume":"42","author":"Yang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.neuint.2021.105015_bib108","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1161\/STROKEAHA.117.017284","article-title":"MicroRNA-15a\/16-1 antagomir ameliorates ischemic brain injury in experimental stroke","volume":"48","author":"Yang","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2021.105015_bib109","doi-asserted-by":"crossref","first-page":"116736","DOI":"10.1016\/j.jns.2020.116736","article-title":"The role of cerebral microbleeds in the incidence of post-stroke dementia","volume":"412","author":"Yatawara","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2021.105015_bib110","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41419-019-1409-4","article-title":"LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation","volume":"10","author":"Ye","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuint.2021.105015_bib111","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.5551\/jat.32466","article-title":"High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study","volume":"23","author":"Yokota","year":"2016","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.neuint.2021.105015_bib119","doi-asserted-by":"crossref","unstructured":"Yoshimoto, T., Saito, S., Omae, K., Hattori, Y., Fukuma, K., Kitamura, K., Kakuta, R., Kita, T., Maruyama, H., Yamamoto, H., Ihara, M., n.d.. Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Phase-II Trial: AdrenoMedullin for Ischemic Stroke Study. J Stroke Cerebrovasc Dis 105761. doi:10.1016\/j.jstrokecerebrovasdis.2021.105761. In press.","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105761"},{"key":"10.1016\/j.neuint.2021.105015_bib112","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s12031-020-01597-6","article-title":"Therapeutic and diagnostic potential of microRNAs in vascular cognitive impairment","volume":"70","author":"Yuan","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neuint.2021.105015_bib113","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1046\/j.1532-5415.2002.50367.x","article-title":"Mixed dementia: epidemiology, diagnosis, and treatment","volume":"50","author":"Zekry","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.neuint.2021.105015_bib114","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1177\/0300060516665707","article-title":"Decreased plasma miR-335 expression in patients with acute ischemic stroke and its association with calmodulin expression","volume":"44","author":"Zhao","year":"2016","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.neuint.2021.105015_bib115","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12883-018-1196-z","article-title":"Increased serum exosomal miR-134 expression in the acute ischemic stroke patients","volume":"18","author":"Zhou","year":"2018","journal-title":"BMC Neurol."},{"key":"10.1016\/j.neuint.2021.105015_bib116","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/01616412.2016.1152675","article-title":"S100\u03b2 as a biomarker for differential diagnosis of intracerebral hemorrhage and ischemic stroke","volume":"38","author":"Zhou","year":"2016","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neuint.2021.105015_bib117","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.09.009","article-title":"Peripheral blood leukocyte expression of lncRNA MIAT and its diagnostic and prognostic value in ischemic stroke","volume":"27","author":"Zhu","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.neuint.2021.105015_bib118","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1074\/mcp.M300066-MCP200","article-title":"Fatty acid binding protein as a serum marker for the early diagnosis of stroke: a pilot study","volume":"3","author":"Zimmermann-Ivol","year":"2004","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621000619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621000619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:51:43Z","timestamp":1759312303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018621000619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":118,"alternative-id":["S0197018621000619"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105015","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic and prognostic blood biomarkers in vascular dementia: From the viewpoint of ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105015"}}