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Lett."},{"key":"10.1016\/j.neuint.2021.105050_bib123","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1248\/bpb.b12-00411","article-title":"Very long chain fatty acid \u03b2-oxidation in astrocytes: contribution of the ABCD1-dependent and -independent pathways","volume":"35","author":"Morita","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neuint.2021.105050_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MOL.0000000000000656","article-title":"Nonesterified fatty acids, cognitive decline, and dementia","volume":"31","author":"Mukamal","year":"2020","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.neuint.2021.105050_bib125","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/jnc.14000","volume":"141","author":"Murphy","year":"2017","journal-title":"J. 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