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Psychiatry Neurosci."},{"key":"10.1016\/j.neuint.2021.105053_bib66","doi-asserted-by":"crossref","first-page":"5916451","DOI":"10.1155\/2018\/5916451","article-title":"Apocynum venetum leaf extract exerts antidepressant-like effects and inhibits hippocampal and cortical apoptosis of rats exposed to chronic unpredictable mild stress","author":"Wu","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.neuint.2021.105053_bib67","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.expneurol.2017.09.001","article-title":"Prenatal stress-induced impairments of cognitive flexibility and bidirectional synaptic plasticity are possibly associated with autophagy in adolescent male-offspring","volume":"298","author":"Zhang","year":"2017","journal-title":"Exp. 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