{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:00:01Z","timestamp":1783400401733,"version":"3.54.6"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.neuint.2021.105068","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T21:46:05Z","timestamp":1621460765000},"page":"105068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Suggesting 7,8-dihydroxyflavone as a promising nutraceutical against CNS disorders"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-9266","authenticated-orcid":false,"given":"Rajib","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-6715","authenticated-orcid":false,"given":"Joyobrato","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-8308","authenticated-orcid":false,"given":"Satinath","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-1164","authenticated-orcid":false,"given":"Muhammed Khairujjaman","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banashree Chetia","family":"Phukan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubina","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2867-1650","authenticated-orcid":false,"given":"Pallab","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-5367","authenticated-orcid":false,"given":"Anupom","family":"Borah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.neuint.2021.105068_bib1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3233\/JAD-190049","article-title":"Dysregulation of BDNF in prefrontal cortex in alzheimer's disease","volume":"69","author":"Aarons","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"10.1016\/j.neuint.2021.105068_bib2","first-page":"862\u2010872","article-title":"Flavonoid derivative DHF attenuates TBI pathology via TrkB activation","volume":"1852","author":"Agrawal","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.neuint.2021.105068_bib3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1515\/revneuro-2019-0099","article-title":"Insights into the neuropathology of cerebral ischemia and its mechanisms","volume":"31","author":"Ahad","year":"2020","journal-title":"Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib5","doi-asserted-by":"crossref","first-page":"185\u2010188","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"issue":"16","key":"10.1016\/j.neuint.2021.105068_bib6","doi-asserted-by":"crossref","first-page":"1589\u20101599","DOI":"10.1001\/jama.2019.4782","article-title":"Diagnosis and management of dementia: review","volume":"322","author":"Arvanitakis","year":"2019","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.neuint.2021.105068_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2018.02.045","article-title":"Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease","volume":"828","author":"Aytan","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/brain\/awy323","article-title":"Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder","volume":"142","author":"Banerjee","year":"2019","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.expneurol.2010.12.018","article-title":"Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration","volume":"228","author":"Baydyuk","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2021.105068_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5539\/jps.v7n1p19","article-title":"A review of medicinal uses and pharmacological activities of Tridax procumbens (L.)","volume":"7","author":"Beck","year":"2018","journal-title":"J. Plant Stud."},{"issue":"36","key":"10.1016\/j.neuint.2021.105068_bib12","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1523\/JNEUROSCI.1309-11.2011","article-title":"Vulnerability to depression: from brain neuroplasticity to identification of biomarkers","volume":"31","author":"Blugeot","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2021.105068_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2013.09.029","article-title":"7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice","volume":"257","author":"Bollen","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"11","key":"10.1016\/j.neuint.2021.105068_bib14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/cns.12175","article-title":"Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action","volume":"19","author":"Borah","year":"2013","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuint.2021.105068_bib15","doi-asserted-by":"crossref","first-page":"563\u2010574","DOI":"10.1016\/j.neubiorev.2016.06.033","article-title":"Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome","volume":"68","author":"Bostrom","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.conb.2007.04.009","article-title":"Do thin spines learn to be mushroom spines that remember?","volume":"17","author":"Bourne","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib17","first-page":"1677\u20101684","article-title":"7,8-Dihydroxyflavone activates Nrf2\/HO-1 signaling pathways and protects against osteoarthritis","volume":"18","author":"Cai","year":"2019","journal-title":"Exp Ther Med"},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib18","first-page":"213\u2010238","article-title":"Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management","volume":"104","author":"Capizzi","year":"2020","journal-title":"Med. Clin."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091453","article-title":"7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss","volume":"9","author":"Castello","year":"2014","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.neuint.2021.105068_bib20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2174\/1570159X18666200114125628","article-title":"Evaluation of anti-inflammatory nutraceuticals in LPS-induced mouse neuroinflammation model: an update","volume":"18","author":"Catorce","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neulet.2011.05.054","article-title":"Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity","volume":"499","author":"Chen","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/rej.2013.1519","article-title":"7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction","volume":"17","author":"Chen","year":"2014","journal-title":"Rejuvenation Res."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib22","doi-asserted-by":"crossref","first-page":"578\u2010583","DOI":"10.1073\/pnas.1718683115","article-title":"The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease","volume":"115","author":"Chen","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib23","doi-asserted-by":"crossref","first-page":"181\u2010185","DOI":"10.1016\/j.neulet.2011.05.054","article-title":"Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity","volume":"499","author":"Chen","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib25","doi-asserted-by":"crossref","first-page":"1810\u20101825","DOI":"10.1039\/C9FO02704A","article-title":"Formation, structural characterization, stability and in vitro bioaccessibility of 7,8-dihydroxyflavone loaded zein-\/sophorolipid composite nanoparticles: effect of sophorolipid under two blending sequences","volume":"11","author":"Chen","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.neuint.2021.105068_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijbiomac.2019.12.251","article-title":"Fabrication and characterization of zein\/lactoferrin composite nanoparticles for encapsulating 7,8-dihydroxyflavone: enhancement of stability, water solubility and bioaccessibility","volume":"146","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.neuint.2021.105068_bib27","doi-asserted-by":"crossref","first-page":"21087","DOI":"10.3390\/ijms160921087","article-title":"Exploring the molecular interactions of 7,8-dihydroxyflavone and its derivatives with TrkB and VEGFR2 proteins","volume":"16","author":"Chitranshi","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib28","doi-asserted-by":"crossref","first-page":"85\u201091","DOI":"10.4062\/biomolther.2018.202","article-title":"7,8-Dihydroxyflavone protects high glucose-damaged neuronal cells against oxidative stress","volume":"27","author":"Cho","year":"2019","journal-title":"Biomol Ther (Seoul)"},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib29","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0025-15.2015","article-title":"ER\u03b1 signaling is required for TrkB-mediated hippocampal neuroprotection in female neonatal mice after hypoxic ischemic encephalopathy(1,2,3)","volume":"3","author":"Cikla","year":"2016","journal-title":"eNeuro"},{"issue":"5","key":"10.1016\/j.neuint.2021.105068_bib30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/dar.13062","article-title":"Methamphetamine use, health and criminal justice system outcomes: a systematic review","volume":"39","author":"Cumming","year":"2020","journal-title":"Drug Alcohol Rev."},{"issue":"6","key":"10.1016\/j.neuint.2021.105068_bib31","doi-asserted-by":"crossref","first-page":"627\u2010640","DOI":"10.2174\/1570159X14666160104142223","article-title":"Nutraceuticals against neurodegeneration: a mechanistic insight","volume":"14","author":"Dadhania","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib33","doi-asserted-by":"crossref","first-page":"259\u2010274","DOI":"10.1038\/npp.2012.179","article-title":"An evaluation of the evidence that methamphetamine abuse causes cognitive decline in humans","volume":"38","author":"Dean","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib35","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/npp.2011.191","article-title":"7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease","volume":"37","author":"Devi","year":"2012","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.neuint.2021.105068_bib36","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","article-title":"The role of oxidative stress in Parkinson's disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.neuint.2021.105068_bib37","doi-asserted-by":"crossref","first-page":"170\u2010180","DOI":"10.1016\/j.neuint.2015.07.021","article-title":"7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders","volume":"89","author":"Du","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2021.105068_bib38","first-page":"1","article-title":"Treatment with the flavonoid 7,8-Dihydroxyflavone: a promising strategy for a constellation of body and brain disorders","volume":"11","author":"Emili","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"4","key":"10.1016\/j.neuint.2021.105068_bib39","doi-asserted-by":"crossref","first-page":"a033118","DOI":"10.1101\/cshperspect.a033118","article-title":"Clinical neurology and epidemiology of the major neurodegenerative diseases","volume":"10","author":"Erkkinen","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib43","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/jnc.13432","article-title":"TrkB activation by 7,8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer\u2019s disease","volume":"136","author":"Gao","year":"2016","journal-title":"J. Neurochem."},{"issue":"16","key":"10.1016\/j.neuint.2021.105068_bib44","first-page":"3144","article-title":"7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington\u2019s disease mouse model through specific activation of the PLC\u03b31 pathway","volume":"26","author":"Garc\u00eda-D\u00edaz Barriga","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"2\u20133","key":"10.1016\/j.neuint.2021.105068_bib45","first-page":"117\u2010154","article-title":"Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review","volume":"156","author":"Geyer","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.neuint.2021.105068_bib46","doi-asserted-by":"crossref","first-page":"499\u2010502","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis Model Mech"},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib47","first-page":"175\u2010184","article-title":"Multiple sclerosis review","volume":"37","author":"Goldenberg","year":"2012","journal-title":"P T"},{"key":"10.1016\/j.neuint.2021.105068_bib48","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.neuint.2021.105068_bib49","doi-asserted-by":"crossref","first-page":"17065","DOI":"10.1038\/nrdp.2017.65","article-title":"Fragile X syndrome","volume":"3","author":"Hagerman","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.neuint.2021.105068_bib50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuint.2013.10.018","article-title":"Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity","volume":"64","author":"Han","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2021.105068_bib51","doi-asserted-by":"crossref","first-page":"34339","DOI":"10.1038\/srep34339","article-title":"Neuroprotective effects of 7, 8-dihydroxyflavone on midbrain dopaminergic neurons in MPP(+)-treated monkeys","volume":"6","author":"He","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/exnr.2000.7483","article-title":"Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra","volume":"166","author":"Howells","year":"2000","journal-title":"Exp. Neurol."},{"issue":"49","key":"10.1016\/j.neuint.2021.105068_bib54","doi-asserted-by":"crossref","first-page":"16207","DOI":"10.1523\/JNEUROSCI.0747-14.2014","article-title":"Social interaction rescues memory deficit in an animal model of Alzheimer's disease by increasing BDNF-dependent hippocampal neurogenesis","volume":"34","author":"Hsiao","year":"2014","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.neuint.2021.105068_bib55","doi-asserted-by":"crossref","first-page":"2275\u20102283","DOI":"10.1161\/STROKEAHA.113.001552","article-title":"Thyroxin treatment protects against white matter injury in the immature brain via brain-derived neurotrophic factor","volume":"44","author":"Hung","year":"2013","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.neuint.2021.105068_bib56","doi-asserted-by":"crossref","first-page":"7169\u20107177","DOI":"10.4049\/jimmunol.0901906","article-title":"Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes","volume":"183","author":"J\u00e4ger","year":"2009","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.neuint.2021.105068_bib57","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.0913572107","article-title":"A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone","volume":"107","author":"Jang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.neuint.2021.105068_bib58","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1093\/hmg\/ddt098","article-title":"Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease","volume":"22","author":"Jiang","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.neuint.2021.105068_bib59","doi-asserted-by":"crossref","first-page":"704\u2010710","DOI":"10.1152\/japplphysiol.01361.2011","article-title":"7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome","volume":"112","author":"Johnson","year":"2012","journal-title":"J. Appl. Physiol."},{"issue":"6","key":"10.1016\/j.neuint.2021.105068_bib60","doi-asserted-by":"crossref","first-page":"1204\u20101213","DOI":"10.1016\/j.bbadis.2017.03.007","article-title":"7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: implications for early brain trauma recovery","volume":"1863","author":"Krishna","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/brainsci10010043","article-title":"Therapeutic advances for huntington\u2019s disease","volume":"10","author":"Kumar","year":"2020","journal-title":"Brain Sci."},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib62","doi-asserted-by":"crossref","first-page":"195\u2010203","DOI":"10.1016\/j.pharep.2014.09.004","article-title":"A review on Alzheimer's disease pathophysiology and its management: an update","volume":"67","author":"Kumar","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuint.2021.105068_bib63","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fnins.2015.00469","article-title":"Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuint.2021.105068_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2278-0521.151402","article-title":"Flavonoids as novel neuroprotective nutraceuticals","volume":"4","author":"Latif","year":"2015","journal-title":"Saudi J. Health Sci."},{"key":"10.1016\/j.neuint.2021.105068_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2013.03.024","article-title":"BDNF deregulation in Rett syndrome","author":"Li","year":"2014","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.neuint.2021.105068_bib66","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/cns.12555","article-title":"7,8-dihydroxyflavone ameliorates motor deficits via suppressing \u03b1-synuclein expression and oxidative stress in the MPTP-induced mouse model of Parkinson's disease","volume":"22","author":"Li","year":"2016","journal-title":"CNS Neurosci. Ther."},{"issue":"38","key":"10.1016\/j.neuint.2021.105068_bib67","doi-asserted-by":"crossref","first-page":"15491","DOI":"10.1073\/pnas.1212899109","article-title":"Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development","volume":"109","author":"Li","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"23","key":"10.1016\/j.neuint.2021.105068_bib68","doi-asserted-by":"crossref","first-page":"8274","DOI":"10.1021\/jm101206p","article-title":"A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect","volume":"53","author":"Liu","year":"2010","journal-title":"J. Med. Chem."},{"issue":"3\u20134","key":"10.1016\/j.neuint.2021.105068_bib69","first-page":"185\u2010200","article-title":"O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity","volume":"91","author":"Liu","year":"2013","journal-title":"Pharmacology"},{"issue":"1\u20132","key":"10.1016\/j.neuint.2021.105068_bib71","first-page":"1\u201015","article-title":"Use of engineered bone marrow stem cells to deliver brain derived neurotrophic factor under the control of a tetracycline sensitive response element in experimental allergic encephalomyelitis","volume":"252","author":"Makar","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuint.2021.105068_bib70","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2016.03.042","article-title":"7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents","volume":"620","author":"Luo","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2021.105068_bib72","first-page":"83","article-title":"Phytochemical and biological overview of genus \"Bignonia","volume":"2","author":"Mahmoud","year":"2019"},{"key":"10.1016\/j.neuint.2021.105068_bib73","doi-asserted-by":"crossref","first-page":"840547","DOI":"10.1155\/2014\/840547","article-title":"Pb neurotoxicity: neuropsychological effects of lead toxicity","volume":"2014","author":"Mason","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.neuint.2021.105068_bib74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuroscience.2020.02.046","article-title":"Gait deficits and loss of striatal tyrosine hydroxlase\/trk-B are restored following 7,8-dihydroxyflavone treatment in a progressive MPTP mouse model of Parkinson\u2019s disease","volume":"433","author":"Massaquoi","year":"2020","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.neuint.2021.105068_bib75","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.mehy.2014.09.021","article-title":"Inhibition of matrix metalloproteinase-2 and 9 by Piroxicam confer neuroprotection in cerebral ischemia: an in silico evaluation of the hypothesis","volume":"83","author":"Mazumder","year":"2014","journal-title":"Med. Hypotheses"},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib76","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/cells8030230","article-title":"Microglial progranulin: involvement in alzheimer's disease and neurodegenerative diseases","volume":"8","author":"Mendsaikhan","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib77","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41598-020-57417-9","article-title":"Design and molecular dynamic investigations of 7,8-dihydroxyflavone derivatives as potential neuroprotective agents against alpha-synuclein (published correction appears in sci rep. 2020 mar 16;10(1):5085)","volume":"10","author":"Mohankumar","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib79","doi-asserted-by":"crossref","first-page":"249\u2010263","DOI":"10.1093\/toxsci\/kfq111","article-title":"Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: potential role of NMDA receptor-dependent BDNF signaling","volume":"116","author":"Neal","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.neuint.2021.105068_bib80","first-page":"9193534","article-title":"7,8-Dihydroxyflavone protects nigrostriatal dopaminergic neurons from rotenone-induced neurotoxicity in rodents","volume":"2019","author":"Nie","year":"2019","journal-title":"Parkinsons Dis"},{"key":"10.1016\/j.neuint.2021.105068_bib81","first-page":"9193534","article-title":"7,8-Dihydroxyflavone protects nigrostriatal dopaminergic neurons from rotenone-induced neurotoxicity in rodents","volume":"2019","author":"Nie","year":"2019","journal-title":"Parkinsons Dis"},{"issue":"40","key":"10.1016\/j.neuint.2021.105068_bib82","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib84","doi-asserted-by":"crossref","first-page":"128\u2010137","DOI":"10.1002\/bab.1570","article-title":"Biosynthesis of novel 7,8-dihydroxyflavone glycoside derivatives and in silico study of their effects on BACE1 inhibition","volume":"65","author":"Pandey","year":"2018","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"6","key":"10.1016\/j.neuint.2021.105068_bib85","doi-asserted-by":"crossref","first-page":"1827\u20101840","DOI":"10.1007\/s00213-020-05502-2","article-title":"7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence","volume":"237","author":"Pandey","year":"2020","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"10.1016\/j.neuint.2021.105068_bib87","first-page":"1146","article-title":"7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-\u03baB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells","volume":"29","author":"Park","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neuint.2021.105068_bib88","doi-asserted-by":"crossref","first-page":"104823","DOI":"10.1016\/j.neuint.2020.104823","article-title":"Lycopene - a pleiotropic neuroprotective nutraceutical: deciphering its therapeutic potentials in broad spectrum neurological disorders","volume":"140","author":"Paul","year":"2020","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib89","doi-asserted-by":"crossref","first-page":"17922","DOI":"10.1038\/s41598-017-17911-z","article-title":"Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice","volume":"7","author":"Paul","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.neuint.2021.105068_bib90","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.bbagen.2016.06.018","article-title":"L-DOPA-induced hyperhomocysteinemia in Parkinson's disease: elephant in the room","volume":"1860","author":"Paul","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2021.105068_bib91","doi-asserted-by":"crossref","first-page":"15\u201026","DOI":"10.1016\/j.neuint.2017.01.021","article-title":"Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: relevance to Parkinson's disease","volume":"108","author":"Paul","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2021.105068_bib92","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2018.03.022","article-title":"Research trends in flavonoids and health","volume":"646","author":"Perez-Vizcaino","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neuint.2021.105068_bib93","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"21","key":"10.1016\/j.neuint.2021.105068_bib94","doi-asserted-by":"crossref","first-page":"9604\u20109611","DOI":"10.1523\/JNEUROSCI.22-21-09604.2002","article-title":"Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice","volume":"22","author":"Ralph-Williams","year":"2002","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib95","doi-asserted-by":"crossref","first-page":"169\u2010180","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.neuint.2021.105068_bib96","doi-asserted-by":"crossref","first-page":"e666","DOI":"10.1038\/tp.2015.157","article-title":"BDNF-TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms","volume":"5","author":"Ren","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuint.2021.105068_bib97","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pbb.2013.03.016","article-title":"Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine","volume":"106","author":"Ren","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib98","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00213-013-3221-7","article-title":"7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine","volume":"231","author":"Ren","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuint.2021.105068_bib100","series-title":"New Therapeutics for Traumatic Brain Injury","first-page":"225","article-title":"TrkB receptor agonist 7, 8 dihydroxyflavone and its therapeutic potential for traumatic brain injury","author":"Romeika","year":"2017"},{"key":"10.1016\/j.neuint.2021.105068_bib101","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.neuroscience.2014.12.080","article-title":"Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson\u2019s disease","volume":"290","author":"Sconce","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2021.105068_bib102","doi-asserted-by":"crossref","first-page":"639\u2010677","DOI":"10.1146\/annurev.pa.33.040193.003231","article-title":"Amphetamine: effects on catecholamine systems and behavior","volume":"33","author":"Seiden","year":"1993","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuint.2021.105068_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2013.11.007","article-title":"Dynamic regulation of SCG10 in regenerating axons after injury","volume":"252","author":"Shin","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2021.105068_bib105","first-page":"97\u2010102","article-title":"Metabolic profile study of 7,8-dihydroxyflavone in monkey plasma using high performance liquid chromatography-tandem mass spectrometry","volume":"1061\u20131062","author":"Sun","year":"2017","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"5","key":"10.1016\/j.neuint.2021.105068_bib106","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.neuron.2019.01.039","article-title":"Huntingtin lowering strategies for disease modification in huntington\u2019s disease","volume":"101","author":"Tabrizi","year":"2019","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.neuint.2021.105068_bib107","doi-asserted-by":"crossref","first-page":"1096\u20101109","DOI":"10.1111\/ejn.13880","article-title":"TrkB-mediated activation of the phosphatidylinositol-3-kinase\/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus","volume":"47","author":"Tecuatl","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2021.105068_bib108","doi-asserted-by":"crossref","first-page":"43\u201053","DOI":"10.1016\/j.neuropharm.2014.09.006","article-title":"7,8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome","volume":"89","author":"Tian","year":"2015","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib109","doi-asserted-by":"crossref","first-page":"36\u201045","DOI":"10.1038\/nrn2294","article-title":"Glucose neurotoxicity","volume":"9","author":"Tomlinson","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2021.105068_bib110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mcn.2013.02.007","article-title":"7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathways","volume":"56","author":"Tsai","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib111","doi-asserted-by":"crossref","first-page":"360\u2010370","DOI":"10.2174\/18715273113129990061","article-title":"TrkB receptor agonist 7,8-dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia","volume":"12","author":"Uluc","year":"2013","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.neuint.2021.105068_bib112","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","article-title":"Amyotrophic lateral sclerosis","volume":"390","author":"van Es","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.neuint.2021.105068_bib113","doi-asserted-by":"crossref","first-page":"129\u2010140","DOI":"10.1007\/s10735-013-9539-y","article-title":"7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats","volume":"45","author":"Wang","year":"2014","journal-title":"J. Mol. Histol."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib114","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12929-019-0543-8","article-title":"Activation of TrkB\/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage","volume":"26","author":"Wu","year":"2019","journal-title":"J. Biomed. Sci."},{"issue":"11","key":"10.1016\/j.neuint.2021.105068_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113397","article-title":"Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K\/Akt signaling","volume":"9","author":"Wu","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib116","first-page":"7\u201012","article-title":"Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury","volume":"12","author":"Wurzelmann","year":"2017","journal-title":"Neural Regen Res"},{"issue":"10","key":"10.1016\/j.neuint.2021.105068_bib118","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S1474-4422(17)30300-9","article-title":"Traumatic brain injury: an enduring challenge","volume":"16","author":"Zafonte","year":"2017","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib119","doi-asserted-by":"crossref","first-page":"186\u2010195","DOI":"10.1093\/toxsci\/kfx210","article-title":"From the cover: 7,8-dihydroxyflavone rescues lead-induced impairment of vesicular release: a novel therapeutic approach for lead intoxicated children","volume":"161","author":"Zhang","year":"2018","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib120","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/npp.2013.243","article-title":"7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease","volume":"39","author":"Zhang","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.neuint.2021.105068_bib121","doi-asserted-by":"crossref","first-page":"1884\u20101895","DOI":"10.1007\/s12035-015-9128-z","article-title":"The role of 7,8-dihydroxyflavone in preventing dendrite degeneration in cortex after moderate traumatic brain injury","volume":"53","author":"Zhao","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.neuint.2021.105068_bib122","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/1567205012666141218124243","article-title":"No significant effect of 7,8-dihydroxyflavone on APP processing and Alzheimer-associated phenotypes","volume":"12","author":"Zhou","year":"2015","journal-title":"Curr. Alzheimer Res."},{"issue":"5\u20136","key":"10.1016\/j.neuint.2021.105068_bib123","first-page":"294\u2010330","article-title":"Role of brain-derived neurotrophic factor in Huntington's disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog. Neurobiol."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621001145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621001145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:52:57Z","timestamp":1759312377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018621001145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":109,"alternative-id":["S0197018621001145"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105068","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suggesting 7,8-dihydroxyflavone as a promising nutraceutical against CNS disorders","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105068"}}