{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:11:49Z","timestamp":1778537509558,"version":"3.51.4"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministry of Education Youth and Sports of the Czech Republic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006533","name":"Ministerstvo Zem\u011bd\u011blstv\u00ed","doi-asserted-by":"publisher","award":["QK1910264"],"award-info":[{"award-number":["QK1910264"]}],"id":[{"id":"10.13039\/501100006533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MZ CR AZV NU20-04-00136"],"award-info":[{"award-number":["MZ CR AZV NU20-04-00136"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"GA\u010cR","doi-asserted-by":"publisher","award":["GACR 19-01747S"],"award-info":[{"award-number":["GACR 19-01747S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.neuint.2021.105147","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T04:57:50Z","timestamp":1627448270000},"page":"105147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Mitophagy in Huntington's disease"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-0244","authenticated-orcid":false,"given":"I.","family":"\u0160onsk\u00fd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vodi\u010dka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Vodi\u010dkov\u00e1 Kepkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-225X","authenticated-orcid":false,"given":"H.","family":"Hans\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2021.105147_bib1","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1080\/15548627.2016.1240856","article-title":"Human Atg8-cardiolipin interactions in mitophagy: specific properties of LC3B, GABARAPL2 and GABARAP","volume":"12","author":"Ant\u00f3n","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2005.06.005","article-title":"p53 mediates cellular dysfunction and behavioral abnormalities in huntington's disease","volume":"47","author":"Bae","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2021.105147_bib3","doi-asserted-by":"crossref","first-page":"15259","DOI":"10.1073\/pnas.1305687110","article-title":"Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex","volume":"110","author":"Baird","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2021.105147_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ncb3560","article-title":"Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin","volume":"19","author":"Ban","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/nbdi.1998.0168","article-title":"Intranuclear neuronal inclusions in huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions andIT15CAG triplet repeat length","volume":"4","author":"Becher","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2021.105147_bib6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1080\/15548627.2019.1569919","article-title":"Autophagy promotes visceral aging in wild-type C. elegans","volume":"15","author":"Benedetto","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib7","doi-asserted-by":"crossref","first-page":"7186","DOI":"10.1021\/acs.jmedchem.5b00602","article-title":"Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the keap1\u2013Nrf2 protein\u2013protein interaction","volume":"58","author":"Bertrand","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib8","doi-asserted-by":"crossref","first-page":"e1009083","DOI":"10.1371\/journal.pgen.1009083","article-title":"Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila","volume":"16","author":"Bjedov","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib9","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1007\/s12035-015-9188-0","article-title":"Mutant huntingtin and elusive defects in oxidative metabolism and mitochondrial calcium handling","volume":"53","author":"Brustovetsky","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2021.105147_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tcb.2009.01.005","article-title":"Huntingtin as an essential integrator of intracellular vesicular trafficking","volume":"19","author":"Caviston","year":"2009","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib11","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2009.08.005","article-title":"Importing mitochondrial proteins: machineries and mechanisms","volume":"138","author":"Chacinska","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib12","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib13","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ncb2837","article-title":"Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells","volume":"15","author":"Chu","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1\u03b1 by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib15","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.chembiol.2014.09.019","article-title":"PMI: a \u0394\u03a8m independent pharmacological regulator of mitophagy","volume":"21","author":"East","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0278-6915(99)00082-4","article-title":"Antioxidant functions of sulforaphane: a potent inducer of phase II detoxication enzymes","volume":"37","author":"Fahey","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.neuint.2021.105147_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer's disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib18","first-page":"1","article-title":"Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease","author":"Franco-Iborra","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib19","author":"Franco-Iborra"},{"key":"10.1016\/j.neuint.2021.105147_bib20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/MCB.25.1.162-171.2005","article-title":"BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase","volume":"25","author":"Furukawa","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib21","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1091\/mbc.e07-12-1287","article-title":"The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells","volume":"19","author":"Gandre-Babbe","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib22","doi-asserted-by":"crossref","first-page":"12297","DOI":"10.1074\/jbc.M900573200","article-title":"ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy","volume":"284","author":"Ganley","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-07679-7","article-title":"Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy","volume":"7","author":"Georgakopoulos","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2021.105147_bib24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nchembio.2287","article-title":"The pharmacological regulation of cellular mitophagy","volume":"13","author":"Georgakopoulos","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms14405","article-title":"Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease","volume":"8","author":"Gomez-Pastor","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2021.105147_bib26","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/embor.2012.14","article-title":"Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment","volume":"13","author":"Greene","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neuint.2021.105147_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.410390317","article-title":"Mitochondrial defect in Huntington's disease caudate nucleus","volume":"39","author":"Gu","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2021.105147_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nbd.2015.09.008","article-title":"Mitochondrial dynamics and quality control in Huntington's disease","volume":"90","author":"Guedes-Dias","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2021.105147_bib29","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington's disease\u2013associated neurodegeneration","volume":"123","author":"Guo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuint.2021.105147_bib30","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbadis.2016.11.026","article-title":"VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease","volume":"1863","author":"Guo","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2021.105147_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12646","article-title":"VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease","volume":"7","author":"Guo","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2021.105147_bib32","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/jnc.14852","article-title":"Mutant huntingtin fails to directly impair brain mitochondria","volume":"151","author":"Hamilton","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2021.105147_bib33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN\/NDP52 recruitment and TBK1 activation to promote mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.expneurol.2016.10.017","article-title":"Mitochondrial cristae remodelling is associated with disrupted OPA1 oligomerisation in the Huntington's disease R6\/2 fragment model","volume":"288","author":"Hering","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2021.105147_bib35","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1091\/mbc.e08-12-1248","article-title":"Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy","volume":"20","author":"Hosokawa","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/tx100389r","article-title":"Modification of Keap1 cysteine residues by sulforaphane","volume":"24","author":"Hu","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.neuint.2021.105147_bib37","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.15252\/emmm.201505256","article-title":"Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease","volume":"7","author":"Hwang","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neuint.2021.105147_bib38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ng0696-196","article-title":"Expanded polyglutamine in the Machado\u2013Joseph disease protein induces cell death in vitro and in vivo","volume":"13","author":"Ikeda","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00103","article-title":"Mitochondrial dysfunction in huntington's disease; interplay between HSF1, p53 and PGC-1\u03b1 transcription factors","volume":"13","author":"Intihar","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib40","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ydbio.2014.04.005","article-title":"Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells","volume":"391","author":"Ismailoglu","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.abb.2003.12.002","article-title":"The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis","volume":"423","author":"Iverson","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neuint.2021.105147_bib42","doi-asserted-by":"crossref","first-page":"22576","DOI":"10.1074\/jbc.M110.118976","article-title":"p62\/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription","volume":"285","author":"Jain","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib43","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1471-4159.2005.03411.x","article-title":"Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease","volume":"95","author":"Jenkins","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2021.105147_bib44","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.4161\/auto.26122","article-title":"The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2\/Parkin-mediated mitophagy of polarized mitochondria","volume":"9","author":"Jin","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms4496","article-title":"Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52","volume":"5","author":"Jo","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2021.105147_bib46","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1016\/j.febslet.2014.06.036","article-title":"Sulforaphane induces autophagy through ERK activation in neuronal cells","volume":"588","author":"Jo","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuint.2021.105147_bib47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.yjmcc.2018.12.004","article-title":"Drp1\/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease","volume":"127","author":"Joshi","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.neuint.2021.105147_bib48","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1091\/mbc.e08-12-1249","article-title":"ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery","volume":"20","author":"Jung","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib49","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.4161\/cc.20946","article-title":"Toward an integrative view of Optineurin functions","volume":"11","author":"Kachaner","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neuint.2021.105147_bib50","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1111\/j.1471-4159.2009.06255.x","article-title":"Polyglutamine expansion in huntingtin alters its interaction with phospholipids","volume":"110","author":"Kegel","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2021.105147_bib51","doi-asserted-by":"crossref","first-page":"e1617","DOI":"10.1038\/cddis.2014.581","article-title":"PINK1-induced mitophagy promotes neuroprotection in Huntington's disease","volume":"6","author":"Khalil","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuint.2021.105147_bib52","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.bbrc.2008.10.104","article-title":"PINK1 controls mitochondrial localization of Parkin through direct phosphorylation","volume":"377","author":"Kim","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2021.105147_bib53","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrn2417","article-title":"Mitochondrial fragmentation in neurodegeneration","volume":"9","author":"Knott","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib54","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.120080","article-title":"PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65","volume":"2","author":"Kondapalli","year":"2012","journal-title":"Open Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib55","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nature13392","article-title":"Ubiquitin is phosphorylated by PINK1 to activate parkin","volume":"510","author":"Koyano","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2021.105147_bib56","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","article-title":"NAD+ in brain aging and neurodegenerative disorders","volume":"30","author":"Lautrup","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.neuint.2021.105147_bib57","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2021.105147_bib58","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nature20555","article-title":"Multiple dynamin family members collaborate to drive mitochondrial division","volume":"540","author":"Lee","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2021.105147_bib59","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib60","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/378398a0","article-title":"A huntingtin-associated protein enriched in brain with implications for pathology","volume":"378","author":"Li","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2021.105147_bib61","doi-asserted-by":"crossref","first-page":"e1004987","DOI":"10.1371\/journal.pgen.1004987","article-title":"Proteotoxic stress induces phosphorylation of p62\/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates","volume":"11","author":"Lim","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib62","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1471-4159.2008.05398.x","article-title":"Characterization of PINK1 processing, stability, and subcellular localization","volume":"106","author":"Lin","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2021.105147_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002537","article-title":"Parkinson's disease\u2013associated kinase PINK1 regulates miro protein level and axonal transport of mitochondria","volume":"8","author":"Liu","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib64","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","article-title":"Mitophagy and neuroprotection","volume":"26","author":"Lou","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuint.2021.105147_bib65","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib66","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1074\/jbc.M115.680181","article-title":"Distinct splice variants of dynamin-related protein 1 differentially utilize mitochondrial fission factor as an effector of cooperative GTPase activity","volume":"291","author":"Macdonald","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib67","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00064","article-title":"Neuronal mitophagy in neurodegenerative diseases","volume":"10","author":"Martinez-Vicente","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib69","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nn.2528","article-title":"Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease","volume":"13","author":"Martinez-Vicente","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib70","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.200910140","article-title":"PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy","volume":"189","author":"Matsuda","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib71","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1093\/hmg\/ddv179","article-title":"TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62\/SQSTM1 phosphorylation","volume":"24","author":"Matsumoto","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib72","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.molcel.2011.07.039","article-title":"Serine 403 phosphorylation of p62\/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins","volume":"44","author":"Matsumoto","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib73","doi-asserted-by":"crossref","first-page":"21592","DOI":"10.1074\/jbc.M300931200","article-title":"Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression","volume":"278","author":"McMahon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib74","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1074\/jbc.M113.536912","article-title":"Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy","volume":"289","author":"Mealer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib75","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1471-4159.2011.07253.x","article-title":"The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking","volume":"117","author":"Meissner","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2021.105147_bib76","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2007.05.021","article-title":"Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion","volume":"130","author":"Nakatogawa","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib77","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4161\/auto.6.8.13426","article-title":"p62\/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both","volume":"6","author":"Narendra","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib78","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib79","doi-asserted-by":"crossref","first-page":"16889","DOI":"10.1073\/pnas.1420103111","article-title":"Potential function for the Huntingtin protein as a scaffold for selective autophagy","volume":"111","author":"Ochaba","year":"2014","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.neuint.2021.105147_bib80","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0092-8674(00)80464-X","article-title":"Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse","volume":"91","author":"Ordway","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2021.105147_bib81","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1523\/JNEUROSCI.0106-08.2008","article-title":"N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking","volume":"28","author":"Orr","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib82","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1242\/jcs.185165","article-title":"Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission","volume":"129","author":"Osellame","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neuint.2021.105147_bib83","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1083\/jcb.201007152","article-title":"Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells","volume":"191","author":"Otera","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib84","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.4161\/auto.26557","article-title":"The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells","volume":"9","author":"Padman","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib85","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/embor.2011.54","article-title":"MiD49 and MiD51, new components of the mitochondrial fission machinery","volume":"12","author":"Palmer","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neuint.2021.105147_bib86","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib87","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-021115-105011","article-title":"Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function","volume":"78","author":"Pernas","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuint.2021.105147_bib88","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1073\/pnas.91.12.5355","article-title":"Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases","volume":"91","author":"Perutz","year":"1994","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.neuint.2021.105147_bib89","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2021.105147_bib90","first-page":"789","article-title":"A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity","volume":"126","author":"Qi","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neuint.2021.105147_bib91","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.chembiol.2016.05.015","article-title":"SIRT2- and NRF2-targeting thiazole-containing compound with therapeutic activity in huntington's disease models","volume":"23","author":"Quinti","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib92","doi-asserted-by":"crossref","first-page":"E4676","DOI":"10.1073\/pnas.1614943114","article-title":"KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients","volume":"114","author":"Quinti","year":"2017","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.neuint.2021.105147_bib93","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1523\/JNEUROSCI.20-10-03705.2000","article-title":"Wild-type huntingtin protects from apoptosis upstream of caspase-3","volume":"20","author":"Rigamonti","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib94","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1080\/15548627.2015.1039219","article-title":"HTT\/Huntingtin in selective autophagy and Huntington disease: a foe or a friend within?","volume":"11","author":"Rui","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib95","first-page":"1269","article-title":"Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochimica et Biophysica Acta (BBA)","volume":"1813","author":"Scarpulla","year":"2011","journal-title":"Mol. Cell Res."},{"key":"10.1016\/j.neuint.2021.105147_bib96","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1073\/pnas.96.8.4604","article-title":"Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology","volume":"96","author":"Scherzinger","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neuint.2021.105147_bib97","doi-asserted-by":"crossref","first-page":"22780","DOI":"10.1074\/jbc.M001500200","article-title":"Phorbol esters and cytokines regulate the expression of theNEMO-related protein, a molecule involved in a NF-\u03baB-independent pathway","volume":"275","author":"Schwamborn","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib98","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S1474-4422(18)30238-2","article-title":"Selective autophagy as a potential therapeutic target for neurodegenerative disorders","volume":"17","author":"Scrivo","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuint.2021.105147_bib99","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1207\/s15327914nc5501_7","article-title":"Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study","volume":"55","author":"Shapiro","year":"2006","journal-title":"Nutr. Canc."},{"key":"10.1016\/j.neuint.2021.105147_bib100","first-page":"1091","article-title":"Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol","volume":"7","author":"Shapiro","year":"1998","journal-title":"Biomark. Prev."},{"key":"10.1016\/j.neuint.2021.105147_bib101","doi-asserted-by":"crossref","first-page":"23760","DOI":"10.1073\/pnas.1912868116","article-title":"Rhes, a striatal-enriched protein, promotes mitophagy via Nix","volume":"116","author":"Sharma","year":"2019","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.neuint.2021.105147_bib102","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib103","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/hmg\/ddr475","article-title":"Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease","volume":"21","author":"Shirendeb","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib104","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ncb2979","article-title":"Cargo recognition and trafficking in selective autophagy","volume":"16","author":"Stolz","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib105","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1126\/science.1172871","article-title":"Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity","volume":"324","author":"Subramaniam","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuint.2021.105147_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005114","article-title":"NF-\u03baB mediates tumor necrosis factor \u03b1-induced expression of optineurin, a negative regulator of NF-\u03baB","volume":"4","author":"Sudhakar","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.neuint.2021.105147_bib107","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2010.00139","article-title":"Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease","volume":"2","author":"Vos","year":"2010","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib108","series-title":"Elucidation of Protein Translocation Pathways (Part I)","first-page":"1075","article-title":"Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria. Journal of molecular biology","volume":"427","author":"Waegemann","year":"2015"},{"key":"10.1016\/j.neuint.2021.105147_bib109","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bbadis.2013.12.015","article-title":"p53 and mitochondrial function in neurons","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2021.105147_bib110","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/hmg\/ddi165","article-title":"Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo","volume":"14","author":"Warby","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2021.105147_bib111","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature14879","article-title":"Mechanism of phospho-ubiquitin-induced PARKIN activation","volume":"524","author":"Wauer","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2021.105147_bib112","first-page":"2784","article-title":"Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Biochimica et Biophysica Acta (BBA) - molecular Cell Research","volume":"1853","author":"Wei","year":"2015","journal-title":"Mitophagy"},{"key":"10.1016\/j.neuint.2021.105147_bib113","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1523\/JNEUROSCI.1870-13.2014","article-title":"The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation","volume":"34","author":"Wong","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib114","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nn.3721","article-title":"Inhibition of mitochondrial protein import by mutant huntingtin","volume":"17","author":"Yano","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2021.105147_bib115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/B978-0-12-394305-7.00005-7","article-title":"Cellular and molecular biology OF optineurin","volume":"294","author":"Ying","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.neuint.2021.105147_bib116","doi-asserted-by":"crossref","first-page":"18947","DOI":"10.1074\/jbc.M113.466870","article-title":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase c\u03b4 (PKC\u03b4) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury","volume":"288","author":"Yogalingam","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2021.105147_bib117","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/cdd.2009.16","article-title":"Role OF BNIP3 and NIX IN cell death, autophagy, and mitophagy","volume":"16","author":"Zhang","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neuint.2021.105147_bib118","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1073\/pnas.89.6.2399","article-title":"A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure","volume":"89","author":"Zhang","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621001935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621001935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:32:45Z","timestamp":1778535165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018621001935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":118,"alternative-id":["S0197018621001935"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105147","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitophagy in Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105147"}}