{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:42:41Z","timestamp":1768635761099,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"am","delay-in-days":301,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.neuint.2021.105148","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T11:36:43Z","timestamp":1627385803000},"page":"105148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8668-3222","authenticated-orcid":false,"given":"Irina N.","family":"Gaisina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry M.","family":"Hushpulian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsen M.","family":"Gaisin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliot H.","family":"Kazakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navneet","family":"Ammal Kaidery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuj","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey A.","family":"Poloznikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina G.","family":"Gazaryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory R.J.","family":"Thatcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-9726","authenticated-orcid":false,"given":"Bobby","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2021.105148_bib1","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1523\/JNEUROSCI.0426-16.2016","article-title":"Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced experimental Parkinson's-like disease","volume":"36","author":"Ahuja","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2021.105148_bib2","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1021\/tx7002257","article-title":"Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection","volume":"20","author":"Dunlap","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.neuint.2021.105148_bib3","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1021\/tx3003609","article-title":"Quinone-induced activation of Keap1\/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide","volume":"25","author":"Dunlap","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.neuint.2021.105148_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100942","article-title":"Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases","volume":"54","author":"Fao","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neuint.2021.105148_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.673205","article-title":"Challenges and limitations of targeting the Keap1-Nrf2 pathway for neurotherapeutics: Bach1 de-repression to the rescue","volume":"13","author":"Hushpulian","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuint.2021.105148_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejmech.2015.08.049","article-title":"Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators","volume":"103","author":"Jain","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.neuint.2021.105148_bib7","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1021\/jm5000529","article-title":"Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis","volume":"57","author":"Jiang","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.neuint.2021.105148_bib8","article-title":"Synthesis and characterization of an aspirin-fumarate prodrug that inhibits NFkappaB activity and breast cancer stem cells","volume":"119","author":"Kastrati","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neuint.2021.105148_bib9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1186\/s12885-015-1868-7","article-title":"A novel aspirin prodrug inhibits NFkappaB activity and breast cancer stem cell properties","volume":"15","author":"Kastrati","year":"2015","journal-title":"BMC Canc."},{"key":"10.1016\/j.neuint.2021.105148_bib10","first-page":"180","article-title":"Quantitative analysis of cell-based luciferase fusion reporters","author":"Khristichenko","year":"2009","journal-title":"Moscow Univ. Chem. Bull."},{"key":"10.1016\/j.neuint.2021.105148_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1021\/acsmedchemlett.9b00631","article-title":"Synthesis and evaluation of noncovalent naphthalene-based KEAP1-NRF2 inhibitors","volume":"11","author":"Lazzara","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.neuint.2021.105148_bib12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/bbrc.2000.4106","article-title":"Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells","volume":"280","author":"Lee","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2021.105148_bib13","article-title":"Aspirin use on incident dementia and mild cognitive decline: a systematic review and meta-analysis","volume":"12","author":"Li","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuint.2021.105148_bib14","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.bmc.2013.04.019","article-title":"Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism","volume":"21","author":"Marcotte","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.neuint.2021.105148_bib15","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1021\/jm801094c","article-title":"Discovery of a \"true\" aspirin prodrug","volume":"51","author":"Moriarty","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.neuint.2021.105148_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10555-017-9675-z","article-title":"Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention","volume":"36","author":"Ornelas","year":"2017","journal-title":"Canc. Metastasis Rev."},{"key":"10.1016\/j.neuint.2021.105148_bib17","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/acs.chemrestox.6b00115","article-title":"Prodrugs bioactivated to quinones target NF-kappaB and multiple protein networks: identification of the quinonome","volume":"29","author":"Pierce","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.neuint.2021.105148_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00228-018-2561-y","article-title":"Non-steroidal anti-inflammatory drugs and risk of Parkinson's disease in the elderly population: a meta-analysis","volume":"75","author":"Poly","year":"2019","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.neuint.2021.105148_bib19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.chembiol.2011.03.013","article-title":"Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators","volume":"18","author":"Smirnova","year":"2011","journal-title":"Chem. Biol."},{"key":"10.1016\/j.neuint.2021.105148_bib20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1074\/mcp.O116.065219","article-title":"A proteomic approach to analyze the aspirin-mediated lysine acetylome","volume":"16","author":"Tatham","year":"2017","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.neuint.2021.105148_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1021\/tx100292n","article-title":"Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent","volume":"24","author":"West","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.neuint.2021.105148_bib22","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.2147\/OTT.S164670","article-title":"Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo","volume":"11","author":"Zhang","year":"2018","journal-title":"OncoTargets Ther."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621001947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018621001947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:58:41Z","timestamp":1759312721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018621001947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":22,"alternative-id":["S0197018621001947"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105148","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2021.105148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105148"}}