{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:44:34Z","timestamp":1788183874161,"version":"build-2803163510"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.neuint.2022.105381","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T19:08:52Z","timestamp":1656184132000},"page":"105381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Neuroprotection against supra-lethal \u2018stroke in a dish\u2019 insults by an anti-excitotoxic receptor antagonist cocktail"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-0487","authenticated-orcid":false,"given":"Joseph S.","family":"Tauskela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Brunette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Aylsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xigeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2022.105381_bib1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(03)01017-1","article-title":"A key role for TRPM7 channels in anoxic neuronal death","volume":"115","author":"Aarts","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2022.105381_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00441-011-1218-2","article-title":"Validation of organotypical hippocampal slice cultures as an ex vivo model of brain ischemia: different roles of NMDA receptors in cell death signalling after exposure to NMDA or oxygen and glucose deprivation","volume":"345","author":"Ahlgren","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neuint.2022.105381_bib3","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1113\/jphysiol.2012.234476","article-title":"Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons","volume":"590","author":"Aiba","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2022.105381_bib4","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1152\/jn.00654.2004","article-title":"Blocking the anoxic depolarization protects without functional compromise following simulated stroke in cortical brain slices","volume":"93","author":"Anderson","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2022.105381_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0006-8993(98)01051-8","article-title":"Neuroprotective interaction effects of NMDA and AMPA receptor antagonists in an in vitro model of cerebral ischemia","volume":"816","author":"Arias","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nbd.2011.12.051","article-title":"Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+\/Ca2+ exchanger","volume":"46","author":"Brittain","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2022.105381_bib7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1523\/JNEUROSCI.11-04-01049.1991","article-title":"The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats","volume":"11","author":"Buchan","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0006-8993(03)02758-6","article-title":"Microtubule-associated protein 2 (MAP2) associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose deprivation","volume":"978","author":"Buddle","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1471-4159.2004.02732.x","article-title":"Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones","volume":"91","author":"Chinopoulos","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2022.105381_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1523\/JNEUROSCI.08-01-00185.1988","article-title":"Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists","volume":"8","author":"Choi","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41583-021-00488-y","article-title":"Brain vulnerability and viability after ischaemia","volume":"22","author":"Daniele","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib12","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1073\/pnas.88.14.6368","article-title":"Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures","volume":"88","author":"Dawson","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuint.2022.105381_bib13","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1523\/JNEUROSCI.16-08-02479.1996","article-title":"Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice","volume":"16","author":"Dawson","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib14","series-title":"New Strategies in Stroke Intervention: Ion Transporters, Pumps, and New Channels","first-page":"13","article-title":"Why have ionotropic and metabotropic glutamate antagonists failed in stroke therapy","author":"Di Renzo","year":"2010"},{"key":"10.1016\/j.neuint.2022.105381_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0896-6273(93)90241-I","article-title":"GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA\/kainate receptor responses","volume":"10","author":"Donevan","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2022.105381_bib16","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1523\/JNEUROSCI.15-11-07071.1995","article-title":"An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death","volume":"15","author":"Dubinsky","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1471-4159.1989.tb07327.x","article-title":"Direct evidence that excitotoxicity in cultured neurons is mediated via N-methyl-D-aspartate (NMDA) as well as non-NMDA receptors","volume":"53","author":"Frandsen","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2022.105381_bib18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0028-3908(99)00168-9","article-title":"Differential effects of NMDA-receptor antagonists on long-term potentiation and hypoxic\/hypoglycaemic excitotoxicity in hippocampal slices","volume":"39","author":"Frankiewicz","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2022.105381_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neures.2004.06.013","article-title":"Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures","volume":"50","author":"Fujimoto","year":"2004","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuint.2022.105381_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2010.12.018","article-title":"Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-D-aspartate receptor channels","volume":"177","author":"Gavazzo","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2022.105381_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-8993(90)91276-M","article-title":"Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures","volume":"506","author":"Giffard","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib22","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1471-4159.2009.05997.x","article-title":"Simultaneous single neuron recording of O2 consumption, [Ca2+]i and mitochondrial membrane potential in glutamate toxicity","volume":"109","author":"Gleichmann","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2022.105381_bib23","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0022-3565(25)24075-7","article-title":"Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia","volume":"245","author":"Goldberg","year":"1988","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2022.105381_bib24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/sj.bjp.0706199","article-title":"D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons","volume":"145","author":"Gong","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuint.2022.105381_bib25","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1046\/j.1440-1681.2002.03767.x","article-title":"Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective","volume":"29","author":"Green","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neuint.2022.105381_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0022-3565(25)12433-6","article-title":"Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison","volume":"253","author":"Grigg","year":"1990","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2022.105381_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/str.33.1.306","article-title":"Neuroprotection is unlikely to be effective in humans using current trial designs","volume":"33","author":"Grotta","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2022.105381_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0306-4522(95)00232-8","article-title":"Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro","volume":"68","author":"Gwag","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2022.105381_bib29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0031-6997(25)06942-X","article-title":"The pharmacology of mechanogated membrane ion channels","volume":"48","author":"Hamill","year":"1996","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuint.2022.105381_bib30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2021.02.021","article-title":"Synaptic and network contributions to anoxic depolarization in mouse hippocampal slices","volume":"461","author":"Heit","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2022.105381_bib31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0197-4580(89)90149-8","article-title":"The role of neuronal energy in the neurotoxicity of excitatory amino acids","volume":"10","author":"Henneberry","year":"1989","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuint.2022.105381_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuropharm.2008.05.023","article-title":"Bioenergetics of cerebral ischemia: a cellular perspective","volume":"55","author":"Hertz","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2022.105381_bib33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0006-8993(93)91078-7","article-title":"Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-D-aspartate neurotoxicity","volume":"625","author":"Hewett","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib34","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.2899909","article-title":"Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists","volume":"241","author":"Honor\u00e9","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.neuint.2022.105381_bib35","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1074\/jbc.M109.040485","article-title":"Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels","volume":"285","author":"Inoue","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2022.105381_bib36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/cercor\/11.3.249","article-title":"Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices","volume":"11","author":"Jarvis","year":"2001","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuint.2022.105381_bib37","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1152\/jn.2001.85.1.414","article-title":"Imaging anoxic depolarization during ischemia-like conditions in the mouse hemi-brain slice","volume":"85","author":"Joshi","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2022.105381_bib38","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1126\/science.8389056","article-title":"Neuroprotective effects of glutamate antagonists and extracellular acidity","volume":"260","author":"Kaku","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neuint.2022.105381_bib39","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0006-8993(91)90214-G","article-title":"Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose","volume":"554","author":"Kaku","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1989.sp017638","article-title":"Protection of hippocampal slices from young rats against anoxic transmission damage is due to better maintenance of ATP","volume":"413","author":"Kass","year":"1989","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2022.105381_bib41","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.3390\/ijms15033596","article-title":"Non-specific inhibition of ischemia- and acidosis-induced intracellular calcium elevations and membrane currents by \u03b1-phenyl-N-tert-butylnitrone, butylated hydroxytoluene and trolox","volume":"15","author":"Katnik","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2022.105381_bib42","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1124\/jpet.104.070912","article-title":"Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices","volume":"311","author":"Katsuki","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2022.105381_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1113\/jphysiol.1987.sp016450","article-title":"Identification of sodium-calcium exchange current in single ventricular cells of Guinea-pig","volume":"384","author":"Kimura","year":"1987","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2022.105381_bib44","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0022-3565(24)37397-5","article-title":"Role of glutamate receptors and voltage-dependent calcium and sodium channels in the extracellular glutamate\/aspartate accumulation and subsequent neuronal injury induced by oxygen\/glucose deprivation in cultured hippocampal neurons","volume":"285","author":"Kimura","year":"1998","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2022.105381_bib45","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0006-8993(93)91673-G","article-title":"Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia","volume":"612","author":"Kral","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib46","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molmed.2010.12.008","article-title":"Stroke intervention pathways: NMDA receptors and beyond","volume":"17","author":"Lai","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuint.2022.105381_bib47","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12975-011-0074-4","article-title":"Emerging therapies: pleiotropic multi-target drugs to treat stroke victims","volume":"2","author":"Lapchak","year":"2011","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.neuint.2022.105381_bib48","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0026-895X(25)11422-3","article-title":"Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site","volume":"35","author":"Lester","year":"1989","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuint.2022.105381_bib49","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/aps.2011.47","article-title":"Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury","volume":"32","author":"Li","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neuint.2022.105381_bib50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.brainres.2006.01.016","article-title":"Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices","volume":"1077","author":"Lipski","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib51","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1523\/JNEUROSCI.13-11-04861.1993","article-title":"Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage","volume":"13","author":"Lobner","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib52","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0022-3565(25)09637-5","article-title":"Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists","volume":"273","author":"Lynch","year":"1995","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2022.105381_bib53","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1093\/brain\/awq284","article-title":"The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells","volume":"133","author":"Madry","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2022.105381_bib54","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1046\/j.1471-4159.1995.65020652.x","article-title":"Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies","volume":"65","author":"Maier","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2022.105381_bib55","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1152\/jn.00458.2019","article-title":"Rapid exchange of synaptic and extrasynaptic NMDA receptors in hippocampal CA1 neurons","volume":"123","author":"McQuate","year":"2020","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2022.105381_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105071","article-title":"NMDA receptors sustain but do not initiate neuronal depolarization in spreading depolarization","volume":"145","author":"Mei","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2022.105381_bib57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0006-8993(94)91911-9","article-title":"Vulnerability to excitotoxic stimuli of cultured rat hippocampal neurons containing the calcium-binding proteins calretinin and calbindin D28K","volume":"648","author":"M\u00f6ckel","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0014-4886(91)90140-8","article-title":"Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina","volume":"113","author":"Mosinger","year":"1991","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2022.105381_bib59","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1161\/STROKEAHA.110.598458","article-title":"Brain protection: maybe yes, maybe no","volume":"41","author":"Moskowitz","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2022.105381_bib60","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0028-3908(94)90153-8","article-title":"Rapid desensitization determines the pharmacology of glutamate neurotoxicity","volume":"33","author":"Moudy","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2022.105381_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(98)00812-9","article-title":"Inhibition of major cationic inward currents prevents spreading depression-like hypoxic depolarization in rat hippocampal tissue slices","volume":"812","author":"M\u00fcller","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib62","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1046\/j.1471-4159.2003.02049.x","article-title":"Primary cortical neuronal cultures reduce cellular energy utilization during anoxic energy deprivation","volume":"87","author":"Munns","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2022.105381_bib63","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00000542-199108000-00016","article-title":"Lack of protection by the N-methyl-D-aspartate receptor blocker dizocilpine (MK-801) after transient severe cerebral ischemia in the rat","volume":"75","author":"Nellg\u00e5rd","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuint.2022.105381_bib64","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.expneurol.2006.04.038","article-title":"Neuroprotective effect of topiramate on hypoxic ischemic brain injury in neonatal rats","volume":"201","author":"Noh","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2022.105381_bib65","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(88)90765-2","article-title":"Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced","volume":"451","author":"Novelli","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib66","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1046\/j.1460-9568.1998.00358.x","article-title":"Spreading depression determines acute cellular damage in the hippocampal slice during oxygen\/glucose deprivation","volume":"10","author":"Obeidat","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib67","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00004647-200002000-00024","article-title":"Glutamate does not mediate acute neuronal damage after spreading depression induced by O2\/glucose deprivation in the hippocampal slice","volume":"20","author":"Obeidat","year":"2000","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuint.2022.105381_bib68","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1749-6632.1999.tb08004.x","article-title":"High extracellular glutamate and neuronal death in neurological disorders. Cause, contribution or consequence?","volume":"890","author":"Obrenovitch","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2022.105381_bib69","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0301-0082(96)00049-4","article-title":"Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy","volume":"51","author":"Obrenovitch","year":"1997","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuint.2022.105381_bib70","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0006-8993(02)02741-5","article-title":"In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site","volume":"944","author":"Ohtani","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib71","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1113\/jphysiol.2008.162289","article-title":"Ca2+-dependent induction of TRPM2 currents in hippocampal neurons","volume":"587","author":"Olah","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2022.105381_bib72","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1021\/jm950740w","article-title":"Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor","volume":"39","author":"Pelletier","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.neuint.2022.105381_bib73","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/jcbfm.1995.108","article-title":"Correlation of CGS 19755 neuroprotection against in vitro excitotoxicity and focal cerebral ischemia","volume":"15","author":"P\u00e9rez-Pinz\u00f3n","year":"1995","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuint.2022.105381_bib74","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/01.STR.0000166023.51307.e0","article-title":"Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia","volume":"36","author":"Petzold","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2022.105381_bib75","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0006-8993(90)90772-4","article-title":"The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures","volume":"531","author":"Priestley","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib76","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0006-8993(97)00089-9","article-title":"Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischemia","volume":"755","author":"Pringle","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib77","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0028-3908(97)00072-5","article-title":"Sodium channel modulators prevent oxygen and glucose deprivation injury and glutamate release in rat neocortical cultures","volume":"36","author":"Probert","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2022.105381_bib78","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00775-007-0324-9","article-title":"Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology","volume":"13","author":"Reboucas","year":"2008","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.neuint.2022.105381_bib79","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.nbd.2016.07.019","article-title":"The earliest neuronal responses to hypoxia in the neocortical circuit are glutamate-dependent","volume":"95","author":"Revah","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2022.105381_bib80","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0361-9230(97)00102-0","article-title":"Dissociation of effects of glutamate receptor antagonists on excitotoxic and hypoxic neuronal cell death in a novel rat cortical culture system","volume":"44","author":"Rogers","year":"1997","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2022.105381_bib81","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2022.105381_bib82","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1058519","article-title":"TRP-PLIK, a bifunctional protein with kinase and ion channel activities","volume":"291","author":"Runnels","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuint.2022.105381_bib83","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1126\/science.284.5421.1845","article-title":"Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein","volume":"284","author":"Sattler","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.neuint.2022.105381_bib84","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0197-0186(94)00148-N","article-title":"Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro","volume":"26","author":"Schurr","year":"1995","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2022.105381_bib85","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-3565(24)29340-X","article-title":"Complestatin is a noncompetitive peptide antagonist of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid\/kainate receptors: secure blockade of ischemic neuronal death","volume":"299","author":"Seo","year":"2001","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2022.105381_bib86","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.2154034","article-title":"2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia","volume":"247","author":"Sheardown","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.neuint.2022.105381_bib87","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.1471-4159.1998.70010120.x","article-title":"Conditioning heat stress reduces excitotoxic and apoptotic components of oxygen-glucose deprivation-induced neuronal death in vitro","volume":"70","author":"Snider","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2022.105381_bib88","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/jcbfm.2009.64","article-title":"Rising zinc: a significant cause of ischemic neuronal death in the CA1 region of rat hippocampus","volume":"29","author":"Stork","year":"2009","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuint.2022.105381_bib89","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(95)00519-V","article-title":"Protection from neuronal damage induced by combined oxygen and glucose deprivation in organotypic hippocampal cultures by glutamate receptor antagonists","volume":"687","author":"Strasser","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib90","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/nn.2395","article-title":"Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia","volume":"12","author":"Sun","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib91","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1152\/jn.1997.78.2.891","article-title":"Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro","volume":"78","author":"Tanaka","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2022.105381_bib92","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1073\/pnas.87.16.6445","article-title":"Modulation of the N-methyl-D-aspartate channel by extracellular H+","volume":"87","author":"Tang","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuint.2022.105381_bib93","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neulet.2006.03.046","article-title":"Competing approaches to excitotoxic neuroprotection by inert and catalytic antioxidant porphyrins","volume":"401","author":"Tauskela","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2022.105381_bib94","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neulet.2006.03.046","article-title":"Competing approaches to excitotoxic neuroprotection by inert and catalytic antioxidant porphyrins","volume":"401","author":"Tauskela","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2022.105381_bib95","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/j.1471-4159.2006.03973.x","article-title":"Unconventional neuroprotection against Ca2+ -dependent insults by metalloporphyrin catalytic antioxidants","volume":"98","author":"Tauskela","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2022.105381_bib96","doi-asserted-by":"crossref","first-page":"C899","DOI":"10.1152\/ajpcell.00110.2003","article-title":"Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling","volume":"285","author":"Tauskela","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neuint.2022.105381_bib97","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1096\/fj.05-3795fje","article-title":"An alternative Ca2+-dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics","volume":"19","author":"Tauskela","year":"2005","journal-title":"Faseb. J."},{"key":"10.1016\/j.neuint.2022.105381_bib98","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0306-4522(01)00381-5","article-title":"Cross-tolerance to otherwise lethal N-methyl-D-aspartate and oxygen-glucose deprivation in preconditioned cortical cultures","volume":"107","author":"Tauskela","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2022.105381_bib99","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0014-2999(03)01371-2","article-title":"Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS","volume":"464","author":"Tauskela","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2022.105381_bib100","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1126\/science.1126241","article-title":"Ischemia opens neuronal gap junction hemichannels","volume":"312","author":"Thompson","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuint.2022.105381_bib101","doi-asserted-by":"crossref","DOI":"10.1177\/1759091415614301","article-title":"A cytotoxic, Co-operative interaction between energy deprivation and glutamate release from system xc- mediates aglycemic neuronal cell death","volume":"7","author":"Thorn","year":"2015","journal-title":"ASN neuro"},{"key":"10.1016\/j.neuint.2022.105381_bib102","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0006-8993(90)91277-N","article-title":"Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation","volume":"506","author":"Tombaugh","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib103","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pharep.2014.10.011","article-title":"Neuroprotective effect of noscapine on cerebral oxygen-glucose deprivation injury","volume":"67","author":"Vahabzadeh","year":"2015","journal-title":"Pharmacol. Rep. : PR"},{"key":"10.1016\/j.neuint.2022.105381_bib104","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/hipo.450050111","article-title":"Simultaneous blockade of non-NMDA ionotropic receptors and NMDA receptor-associated ionophore partially protects hippocampal slices from protein synthesis impairment due to simulated ischemia","volume":"5","author":"Virgili","year":"1995","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuint.2022.105381_bib105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0006-8993(91)90865-S","article-title":"Enhancement of NMDA receptor-mediated neurotoxicity in the hippocampal slice by depolarization and ischemia","volume":"555","author":"Vornov","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2022.105381_bib106","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1523\/JNEUROSCI.1267-12.2012","article-title":"Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases","volume":"32","author":"Weilinger","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2022.105381_bib107","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.neuropharm.2008.07.015","article-title":"Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current","volume":"55","author":"Welch","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2022.105381_bib108","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/jn.1997.78.2.903","article-title":"Factors that reverse the persistent depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro","volume":"78","author":"Yamamoto","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2022.105381_bib109","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4236\/health.2010.21002","article-title":"The role of intracellular Na+ in the regulation of Ca2+-mediated signaling and toxicity","volume":"2","author":"Yu","year":"2010","journal-title":"Health"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018622001061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018622001061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:01:40Z","timestamp":1759312900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018622001061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":109,"alternative-id":["S0197018622001061"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2022.105381","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotection against supra-lethal \u2018stroke in a dish\u2019 insults by an anti-excitotoxic receptor antagonist cocktail","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2022.105381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2022 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105381"}}