{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:41:44Z","timestamp":1780616504627,"version":"3.54.1"},"reference-count":220,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.neuint.2023.105486","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T02:32:28Z","timestamp":1673404348000},"page":"105486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Structural fingerprinting of pleiotropic flavonoids for multifaceted Alzheimer's disease"],"prefix":"10.1016","volume":"163","author":[{"given":"Amisha","family":"Punmiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3637-8964","authenticated-orcid":false,"given":"Arati","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"381","key":"10.1016\/j.neuint.2023.105486_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-013-1659-x","article-title":"Neuroprotective effect of quercetin in ectoenzymes and acetylcholinesterase activities in cerebral cortex synaptosomes of cadmium-exposed rats","volume":"3811","author":"Abdalla","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.neuint.2023.105486_bib2","first-page":"NP11","article-title":"Antioxidative properties and effect of quercetin and its glycosylated form (rutin) on acetylcholinesterase and Butyrylcholinesterase activities. J. Evidence-based complement","volume":"21","author":"Ademosun","year":"2016","journal-title":"Alternative Med."},{"key":"10.1016\/j.neuint.2023.105486_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24234255","article-title":"Anthocyanins potentially contribute to defense against Alzheimer's disease","volume":"24","author":"Afzal","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijbiomac.2021.03.032","article-title":"Potential of Pueraria tuberosa (Willd.) DC. to rescue cognitive decline associated with BACE1 protein of Alzheimer's disease on Drosophila model: an integrated molecular modeling and in vivo approach","volume":"179","author":"Ahuja","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.neuint.2023.105486_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neulet.2008.08.052","article-title":"Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein","volume":"444","author":"Akaishi","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2023.105486_bib214","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2018.10.053","article-title":"Therapeutic potential of luteolin in transgenic Drosophila model of Alzheimer\u2019s disease","volume":"692","author":"Ali","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2023.105486_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2021.102200","article-title":"GSK-3\u03b2 as a target for apigenin-induced neuroprotection against A\u03b2 25\u201335 in a rat model of Alzheimer's disease","volume":"90","author":"Alsadat","year":"2021","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neuint.2023.105486_bib7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/revneuro-2018-0080","article-title":"Application of quercetin in neurological disorders: from nutrition to nanomedicine","volume":"30","author":"Amanzadeh","year":"2019","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neuint.2023.105486_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.598617","article-title":"Quercetin-conjugated Superparamagnetic iron oxide nanoparticles protect AlCl3-induced neurotoxicity in a rat model of alzheimer's disease via antioxidant genes, APP gene, and miRNA-101","volume":"14","author":"Amanzadeh Jajin","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuint.2023.105486_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136509","article-title":"Designing second generation anti-Alzheimer compounds as inhibitors of Human acetylcholinesterase: computational screening of synthetic molecules and dietary phytochemicals","volume":"10","author":"Amat-Ur-Rasool","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2023.105486_bib10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2174\/092986707780090954","article-title":"SAR and QSAR of the antioxidant activity of flavonoids","volume":"14","author":"Amic","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib11","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1096\/fj.07-8627rev","article-title":"Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators","volume":"22","author":"Amit","year":"2008","journal-title":"FASEB J"},{"issue":"28","key":"10.1016\/j.neuint.2023.105486_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1022389503105","article-title":"Discussion of the role of the extracellular signal-regulated kinase-phospholipase A2 pathway in production of reactive oxygen species in alzheimer's disease","volume":"282","author":"Andersen","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib13","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1111\/1750-3841.14317","article-title":"Quercetin in food: possible mechanisms of its effect on memory","volume":"83","author":"Babaei","year":"2018","journal-title":"J. Food Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1023\/B:BIRY.0000016355.19999.93","article-title":"Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula","volume":"69","author":"Bagchi","year":"2004","journal-title":"Biochemistry. (Mosc)."},{"key":"10.1016\/j.neuint.2023.105486_bib15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11596-020-2142-z","article-title":"Epigallocatechin-3-gallate alleviates cognitive deficits in APP\/PS1 mice","volume":"40","author":"Bao","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib16","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cbpa.2008.02.019","article-title":"Metals in Alzheimer's and Parkinson's diseases","volume":"12","author":"Barnham","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.neuint.2023.105486_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/133.10.3248S","article-title":"Overview of dietary flavonoids: nomenclature, occurrence and intake","volume":"133","author":"Beecher","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.neuint.2023.105486_bib18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(94)90131-7","article-title":"Hydrogen peroxide mediates amyloid \u03b2 protein toxicity","volume":"77","author":"Behl","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2023.105486_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2010.08.023","article-title":"Regulation of tau pathology by the microglial fractalkine receptor","volume":"68","author":"Bhaskar","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2023.105486_bib20","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1080\/09168451.2017.1282805","article-title":"Quercetin inhibits advanced glycation end product formation via chelating metal ions, trapping methylglyoxal, and trapping reactive oxygen species","volume":"81","author":"Bhuiyan","year":"2017","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.neuint.2023.105486_bib21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1017\/S135561771700100X","article-title":"Alzheimer's disease: past, present, and future","volume":"23","author":"Bondi","year":"2017","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.neuint.2023.105486_bib22","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3233\/JAD-151020","article-title":"Clearing amyloid-\u03b2 through PPAR\u03b3\/ApoE activation by genistein is a treatment of experimental alzheimer's disease","volume":"51","author":"Bonet-Costa","year":"2016","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.neuint.2023.105486_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4684-5730-8_25","article-title":"Radical chemistry of flavonoid antioxidants","volume":"264","author":"Bors","year":"1990","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuint.2023.105486_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on alzheimer's disease: causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2009.08.031","article-title":"Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors","author":"Brunden","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2023.105486_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/01.wad.0000201847.29836.a5","article-title":"Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date","volume":"20","author":"Bullock","year":"2006","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neuint.2023.105486_bib27","first-page":"296","article-title":"Flavonoids and their antioxidant properties","volume":"19","author":"Burak","year":"1999","journal-title":"Turkiye Klin Tip Bil Derg"},{"key":"10.1016\/j.neuint.2023.105486_bib28","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0891-5849(96)00351-6","article-title":"Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships","volume":"22","author":"Cao","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s12640-020-00243-8","article-title":"Genistein and galantamine combinations decrease \u03b2-amyloid peptide (1\u201342)\u2013induced genotoxicity and cell death in SH-SY5Y cell line: an in vitro and in silico approach for mimic of alzheimer's disease","volume":"38","author":"Castillo","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foodchem.2015.11.118","article-title":"Metal chelation, radical scavenging and inhibition of A\u03b242 fibrillation by food constituents in relation to Alzheimer's disease","volume":"199","author":"Chan","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1179\/1476830515Y.0000000038","article-title":"Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons","volume":"19","author":"Chesser","year":"2016","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neuint.2023.105486_bib219","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s12272-014-0351-3","article-title":"The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer\u2019s disease, anti-diabetic, and anti-inflammatory activities","volume":"37","author":"Choi","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1089\/jmf.2014.3292","article-title":"The n-Butanol fraction and rutin from tartary Buckwheat improve cognition and memory in an in vivo model of amyloid-\u03b2-induced alzheimer's disease","volume":"18","author":"Choi","year":"2015","journal-title":"J. Med. Food"},{"key":"10.1016\/j.neuint.2023.105486_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules25184320","article-title":"The effects of flavonoids in cardiovascular diseases","volume":"25","author":"Ciumarnean","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib34","doi-asserted-by":"crossref","first-page":"9758","DOI":"10.1073\/pnas.1218402110","article-title":"Proliferation of amyloid-\u03b242 aggregates occurs through a secondary nucleation mechanism","volume":"110","author":"Cohen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuint.2023.105486_bib35","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bcp.2006.07.016","article-title":"Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship","volume":"72","author":"Comalada","year":"2006","journal-title":"Biochem. Pharmacol."},{"issue":"38","key":"10.1016\/j.neuint.2023.105486_bib36","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1007\/s11064-013-1085-1","article-title":"Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?","volume":"389","author":"Costa","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib37","first-page":"573","article-title":"Anthocyanidines as inhibitors of xanthine oxidase","volume":"50","author":"Costantino","year":"1995","journal-title":"Pharmazie"},{"key":"10.1016\/j.neuint.2023.105486_bib38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0223-5234(96)85878-8","article-title":"A rational approach to the design of flavones as xanthine oxidase inhibitors","volume":"31","author":"Costantino","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0891-5849(95)02014-4","article-title":"Antioxidant properties of hydroxy-flavones","volume":"20","author":"Cotelle","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1055\/s-0043-120662","article-title":"Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation","volume":"68","author":"Crasc\u00ec","year":"2018","journal-title":"Drug Res."},{"key":"10.1016\/j.neuint.2023.105486_bib41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/abbi.1997.0455","article-title":"Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-density lipoprotein by quercetin and quercetin monoglucosides","volume":"349","author":"Da Silva","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neuint.2023.105486_bib42","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1212\/WNL.59.4.563","article-title":"Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months","volume":"59","author":"Darreh-Shori","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2023.105486_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3940(01)01586-5","article-title":"Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease","volume":"300","author":"Davidsson","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2023.105486_bib44","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.2174\/0929867323666161213101126","article-title":"Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment","volume":"25","author":"dos Santos Picanco","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2100","article-title":"Study on the neuroprotective effects of Genistein on Alzheimer's disease","volume":"11","author":"Duan","year":"2021","journal-title":"Brain Behav"},{"key":"10.1016\/j.neuint.2023.105486_bib46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/np990352n","article-title":"Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships","volume":"63","author":"Dugas","year":"2000","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.neuint.2023.105486_bib47","article-title":"The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: Quercetin","volume":"9","author":"El-Saber Batiha","year":"2020","journal-title":"Foods"},{"key":"10.1016\/j.neuint.2023.105486_bib48","series-title":"Flavonoids in the Living System. Advances in Experimental Medicine and Biology","first-page":"175","article-title":"Effect of plant flavonoids on immune and inflammatory cell function","author":"Elliott","year":"1998"},{"key":"10.1016\/j.neuint.2023.105486_bib209","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14030576","article-title":"A brain-targeted approach to ameliorate memory disorders in a sporadic alzheimer\u2019s disease mouse model via intranasal luteolin-loaded nanobilosomes","volume":"14","author":"Elsheikh","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.neuint.2023.105486_bib49","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1007\/s12035-019-01849-6","article-title":"Epigallocatechin-3-Gallate (EGCG) improves cognitive deficits aggravated by an obesogenic diet through modulation of unfolded protein response in APPswe\/PS1dE9 mice","volume":"57","author":"Ettcheto","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2023.105486_bib50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1159\/000008243","article-title":"A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease","volume":"44","author":"Farlow","year":"2000","journal-title":"Eur. Neurol."},{"issue":"1","key":"10.1016\/j.neuint.2023.105486_bib51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer\u2019s disease: targeting the cholinergic system","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib52","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pbb.2014.09.005","article-title":"Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats","volume":"126","author":"Fu","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2023.105486_bib53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0306-3623(98)00220-1","article-title":"Flavonoids and the inhibition of PKC and PI 3-kinase","volume":"32","author":"Gamet-Payrastre","year":"1999","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jsps.2016.04.025","article-title":"The pharmacological potential of rutin","volume":"25","author":"Ganeshpurkar","year":"2017","journal-title":"Saudi Pharmaceut. J."},{"key":"10.1016\/j.neuint.2023.105486_bib55","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1471-4159.2006.04368.x","article-title":"Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein","volume":"101","author":"Gr\u00fcnblatt","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2023.105486_bib56","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.freeradbiomed.2005.04.022","article-title":"Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway","volume":"39","author":"Guo","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib57","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/WNR.0000000000000803","article-title":"(-)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer's disease","volume":"28","author":"Guo","year":"2017","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2023.105486_bib58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/asia.201601291","article-title":"Flavonoids and their glycosides as anti-amyloidogenic compounds: a\u03b21-42 interaction studies to gain new insights on their potential for Alzheimer's disease prevention and therapy","volume":"12","author":"Guzzi","year":"2017","journal-title":"Chem. An Asaian J."},{"key":"10.1016\/j.neuint.2023.105486_bib218","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neuint.2007.10.005","article-title":"Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model","volume":"52","author":"Ha","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2023.105486_bib59","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1501244","article-title":"Neuroscience: an anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer's disease","volume":"2","author":"Habchi","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuint.2023.105486_bib60","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1006\/bbrc.1997.7016","article-title":"Peroxynitrite scavenging by flavonoids","volume":"236","author":"Haenen","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2023.105486_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0227631","article-title":"Naringenin protects AlCl3\/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress","volume":"15","author":"Haider","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2023.105486_bib62","first-page":"1","article-title":"The anthocyanins","author":"Harborne","year":"1988","journal-title":"The Flavonoids"},{"key":"10.1016\/j.neuint.2023.105486_bib63","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1021\/np50056a030","article-title":"Inhibition of cow's milk xanthine oxidase by flavonoids","volume":"51","author":"Hayashi","year":"1988","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.neuint.2023.105486_bib64","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","article-title":"Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships","volume":"13","author":"Heim","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neuint.2023.105486_bib65","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1021\/bi061540x","article-title":"The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure","volume":"46","author":"Hirohata","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuint.2023.105486_bib66","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/BPL-200098","article-title":"Flavonoids as an intervention for alzheimer's disease: progress and hurdles towards defining a mechanism of action","volume":"6","author":"Hole","year":"2020","journal-title":"Brain Plast."},{"key":"10.1016\/j.neuint.2023.105486_bib67","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12272-015-0662-z","article-title":"Hesperidin attenuates learning and memory deficits in APP\/PS1 mice through activation of Akt\/Nrf2 signaling and inhibition of RAGE\/NF-\u03baB signaling","volume":"41","author":"Hong","year":"2018","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.neuint.2023.105486_bib68","first-page":"291","article-title":"The free radical scavenging activity of four flavonoids determined by the comet assay","volume":"50","author":"Horv\u00e1thov\u00e1","year":"2003","journal-title":"Neoplasma"},{"issue":"47","key":"10.1016\/j.neuint.2023.105486_bib69","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02790134","article-title":"Structure-activity relationship of flavonoids with superoxide scavenging activity","volume":"471","author":"Hu","year":"1995","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules23092357","article-title":"Effects of tea catechins on Alzheimer's disease: recent updates and perspectives","volume":"23","author":"Ide","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib71","doi-asserted-by":"crossref","first-page":"6293","DOI":"10.1007\/s12035-019-1512-7","article-title":"Hesperetin confers neuroprotection by regulating nrf2\/TLR4\/NF-\u03baB signaling in an A\u03b2 mouse model","volume":"56","author":"Ikram","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2023.105486_bib72","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1212\/01.WNL.0000115115.98960.37","article-title":"Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain","volume":"62","author":"Ingelsson","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2023.105486_bib212","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1073\/pnas.0802865105","article-title":"Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1","volume":"105","author":"Jang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2023.105486_bib73","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neuroscience.2012.02.046","article-title":"Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type","volume":"210","author":"Javed","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2023.105486_bib74","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1016\/j.bmcl.2003.09.018","article-title":"Green tea catechins as a BACE1 (\u03b2-Secretase) inhibitor","volume":"13","author":"Jeon","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neuint.2023.105486_bib75","first-page":"537","article-title":"Antioxidant and chemosensitizing effects of flavonoids with hydroxy and\/or methoxy groups and structure-activity relationship","volume":"10","author":"Jeong","year":"2007","journal-title":"J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib76","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/jf025551i","article-title":"Antioxidant activity of anthocyanins and their aglycons","volume":"51","author":"K\u00e4hk\u00f6nen","year":"2003","journal-title":"J. Agric. Food Chem."},{"issue":"28","key":"10.1016\/j.neuint.2023.105486_bib77","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00044-019-02330-8","article-title":"Exploration of synthetic antioxidant flavonoid analogs as acetylcholinesterase inhibitors: an approach towards finding their quantitative structure\u2013activity relationship","volume":"285","author":"Karmakar","year":"2019","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib78","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00004714-199912000-00005","article-title":"Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans","volume":"19","author":"Kennedy","year":"1999","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib79","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cbi.2009.06.024","article-title":"Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies","volume":"181","author":"Khan","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neuint.2023.105486_bib80","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.biopha.2018.03.007","article-title":"Flavonoids as acetylcholinesterase inhibitors: current therapeutic standing and future prospects","volume":"101","author":"Khan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neuint.2023.105486_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox9070609","article-title":"Antioxidant and anti\u2010inflammatory effects of citrus flavonoid hesperetin: special focus on neurological disorders","volume":"9","author":"Khan","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.neuint.2023.105486_bib82","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/biom10010059","article-title":"Neuroprotective effects of quercetin in alzheimer's disease","volume":"10","author":"Khan","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuint.2023.105486_bib83","first-page":"8537","article-title":"Effects of naturally occurring compounds on fibril formation and oxidative stress of","volume":"53","author":"Kim","year":"2005","journal-title":"Amyloid"},{"key":"10.1016\/j.neuint.2023.105486_bib84","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbrc.2018.08.182","article-title":"Crystal structure of GSK3\u03b2 in complex with the flavonoid, morin","volume":"504","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2023.105486_bib220","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12565-019-00486-2","article-title":"The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes","volume":"94","author":"Kim","year":"2019","journal-title":"Anat. Sci. Int."},{"key":"10.1016\/j.neuint.2023.105486_bib85","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.3390\/molecules26175192","article-title":"Apigenin ameliorates Scopolamine-induced cognitive dysfunction and neuronal damage in mice","volume":"26","author":"Kim","year":"2021","journal-title":"Mol"},{"key":"10.1016\/j.neuint.2023.105486_bib86","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0031-9422(03)00438-2","article-title":"Analysis and biological activities of anthocyanins","volume":"64","author":"Kong","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.neuint.2023.105486_bib217","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41401-021-00702-8","article-title":"Luteolin alleviates cognitive impairment in Alzheimer\u2019s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation","volume":"43","author":"Kou","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neuint.2023.105486_bib87","doi-asserted-by":"crossref","DOI":"10.17116\/jnevro20151156103-114","article-title":"Molecular aspects of the pathogenesis and current approaches to pharmacological correction of Alzheimer's disease","author":"Kukharsky","year":"2015","journal-title":"Zhurnal Nevrol. i Psihiatr. Im. S.S. Korsakova."},{"key":"10.1016\/j.neuint.2023.105486_bib88","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: an overview Shashank","volume":"2013","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.neuint.2023.105486_bib89","doi-asserted-by":"crossref","DOI":"10.15406\/japlr.2018.07.00230","article-title":"Pathophysiology and management of alzheimer's disease: an overview","volume":"7","author":"Kumar Thakur","year":"2018","journal-title":"J. Anal. Pharm. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26237175","article-title":"Antioxidant properties and structure-antioxidant activity relationship of allium species leaves","volume":"26","author":"Kurnia","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib91","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.exger.2017.05.014","article-title":"Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease","volume":"95","author":"Kwon","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neuint.2023.105486_bib92","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.abb.2010.06.013","article-title":"The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention","volume":"501","author":"Lambert","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neuint.2023.105486_bib93","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer's disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neuint.2023.105486_bib94","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2008.10.012","article-title":"Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of \u03b2-amyloid generation and memory deficiency","volume":"1250","author":"Lee","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2023.105486_bib95","doi-asserted-by":"crossref","first-page":"416","DOI":"10.14348\/molcells.2015.2268","article-title":"Nrf2 expression and apoptosis in quercetin-treated malignant mesothelioma cells","volume":"38","author":"Lee","year":"2015","journal-title":"Mol. Cells"},{"key":"10.1016\/j.neuint.2023.105486_bib96","article-title":"Design, synthesis and evaluation of hesperetin derivatives as potential multifunctional anti-Alzheimer agents","volume":"22","author":"Li","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib97","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0006-291X(02)00442-4","article-title":"Molecular modeling of flavonoids that inhibits xanthine oxidase","volume":"294","author":"Lin","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2023.105486_bib98","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1039\/C8FO01696H","article-title":"The in silico and in vivo evaluation of puerarin against Alzheimer's disease","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.neuint.2023.105486_bib210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3233\/JAD-2010-101593","article-title":"The flavonoid apigenin protects brain neurovascular coupling against amyloid-\u03b2\u2082\u2085\u208b\u2083\u2085-induced toxicity in mice","volume":"24","author":"Liu","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuint.2023.105486_bib99","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bcp.2008.06.001","article-title":"Effect of flavonoids on rat splenocytes, a structure\u2013activity relationship study","volume":"76","author":"L\u00f3pez-Posadas","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib206","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s11064-012-0872-4","article-title":"Genistein inhibits A\u03b2\u2082\u2085\u208b\u2083\u2085 -induced neurotoxicity in PC12 cells via PKC signaling pathway","volume":"37","author":"Luo","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib207","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/jmf.2014.3150","article-title":"Genistein alleviates \u03b2-amyloid-induced inflammatory damage through regulating Toll-like receptor 4\/nuclear factor \u03baB","volume":"18","author":"Ma","year":"2015","journal-title":"J. Med. Food"},{"key":"10.1016\/j.neuint.2023.105486_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomag.2013.11.001","article-title":"Pyrethroid deltamethrin-induced developmental neurodegenerative cerebral injury and ameliorating effect of dietary glycoside naringin in male wistar rats","volume":"4","author":"Magendira Mani","year":"2014","journal-title":"Biomed. Aging Pathol."},{"key":"10.1016\/j.neuint.2023.105486_bib101","article-title":"Topical apigenin alleviates cutaneous inflammation in murine models. Evidence-based Complement","author":"Man","year":"2012","journal-title":"Alternative Med."},{"key":"10.1016\/j.neuint.2023.105486_bib102","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.freeradbiomed.2022.03.021","article-title":"The multimodal action of genistein in Alzheimer's and other age-related diseases","volume":"183","author":"Mas-Bargues","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib103","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1515\/pac-2017-0201","article-title":"Synthesis and effects of flavonoid structure variation on amyloid-\u03b2 aggregation","volume":"89","author":"Matos","year":"2017","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib104","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/0006-291X(92)90792-J","article-title":"The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs","volume":"186","author":"Matter","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2023.105486_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25173809","article-title":"Anthocyanins: a comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases","volume":"25","author":"Mattioli","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib106","doi-asserted-by":"crossref","first-page":"8913","DOI":"10.1007\/s13277-015-3634-5","article-title":"Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention","volume":"36","author":"Maurya","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.neuint.2023.105486_bib107","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.ijbiomac.2018.06.190","article-title":"In vitro neuroprotective effects of naringenin nanoemulsion against \u03b2-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation","volume":"118","author":"Md","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.neuint.2023.105486_bib108","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1021\/jf9806661","article-title":"Evidence of iron association with emulsion droplets and its impact on lipid oxidation","volume":"46","author":"Mei","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib109","first-page":"1067","article-title":"Evidence for antiradical and antioxidant properties of four biologically active N,N-diethylamioethyl ethers of flavanone oximes: a comparison with natural polyphenolic flavonoid (rutin) action","volume":"41","author":"Metodiewa","year":"1997","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.neuint.2023.105486_bib110","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0006-8993(02)03731-9","article-title":"Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40)","volume":"958","author":"Miguel-Hidalgo","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2023.105486_bib111","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.toxlet.2013.10.010","article-title":"Rutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced neurotoxicity in rats","volume":"224","author":"Moghbelinejad","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neuint.2023.105486_bib112","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0891-5849(02)01241-8","article-title":"Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers","volume":"34","author":"Moridani","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib211","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.phrs.2017.10.008","article-title":"Apigenin as neuroprotective agent: of mice and men","volume":"128","author":"Nabavi","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib113","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/WNR.0000000000000594","article-title":"Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients","volume":"27","author":"Nakagawa","year":"2016","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2023.105486_bib114","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.2147\/DDDT.S289473","article-title":"Epigallocatechin-3-Gallate provides protection against alzheimer's disease-induced learning and memory impairments in rats","volume":"15","author":"Nan","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.neuint.2023.105486_bib115","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/156720509787313961","article-title":"Different cholinesterase inhibitor effects on CSF cholinesterases in alzheimer patients","volume":"6","author":"Nordberg","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neuint.2023.105486_bib116","doi-asserted-by":"crossref","DOI":"10.4161\/pri.22118","article-title":"Alzheimer disease: a tale of two prions","author":"Nussbaum","year":"2013"},{"key":"10.1016\/j.neuint.2023.105486_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2017.02.016","article-title":"The protective role of plant biophenols in mechanisms of Alzheimer's disease","volume":"47","author":"Omar","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neuint.2023.105486_bib118","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.foodchem.2008.09.001","article-title":"Chemical studies of anthocyanins: a review","volume":"113","author":"Ovando","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib119","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jnutbio.2018.02.014","article-title":"Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer's type","volume":"56","author":"Pacheco","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neuint.2023.105486_bib120","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4397340","article-title":"Flavonoids as putative inducers of the transcription factors Nrf2, FoxO, and PPAR \u03b3","author":"Pallauf","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neuint.2023.105486_bib121","first-page":"1","article-title":"Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-\u03b2 clearance","volume":"5","author":"Pan","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuint.2023.105486_bib122","doi-asserted-by":"crossref","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: an overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib123","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/bdd.1956","article-title":"Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin","volume":"36","author":"Paredes-Gonzalez","year":"2015","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.neuint.2023.105486_bib124","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4062\/biomolther.2016.026","article-title":"Quercetin-3-O-\u03b2-D-glucuronide suppresses lipopolysaccharide-induced JNK and ERK phosphorylation in LPS-challenged RAW264.7 cells","volume":"24","author":"Park","year":"2016","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.neuint.2023.105486_bib125","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/j.1471-4159.2010.06875.x","article-title":"Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies","volume":"114","author":"Pasinetti","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2023.105486_bib126","doi-asserted-by":"crossref","DOI":"10.3390\/biom12030371","article-title":"Epigallocatechin-3-Gallate (EGCG): new therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age","volume":"12","author":"Payne","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuint.2023.105486_bib127","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/jnnp.48.2.196","article-title":"Dementia: a Survey of the syndrome of dementia","volume":"48","author":"Pearce","year":"1985","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neuint.2023.105486_bib128","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/ptr.6560","article-title":"Genistein protects against amyloid-beta-induced toxicity in SH-SY5Y cells by regulation of Akt and Tau phosphorylation","volume":"34","author":"Petry","year":"2020","journal-title":"Phyther. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib129","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040756","article-title":"Polyphenols modulate alzheimer's amyloid beta aggregation in a structure-dependent manner","volume":"11","author":"Phan","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuint.2023.105486_bib130","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/np9904509","article-title":"Flavonoids as antioxidants","volume":"63","author":"Pietta","year":"2000","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.neuint.2023.105486_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105314","article-title":"Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease","volume":"148","author":"Pinheiro","year":"2020","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib132","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/10715760600602894","article-title":"Are the biological properties of kaempferol determined by its oxidation products?","volume":"40","author":"Pirker","year":"2006","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib133","article-title":"Catechins as tools to understand the molecular basis of neurodegeneration","volume":"25","author":"Pomier","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib134","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.3390\/molecules19022226","article-title":"Structure and antioxidant activity relationships of isoflavonoids from Dalbergia parviflora","volume":"19","author":"Promden","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib135","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2014.02.045","article-title":"Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease","volume":"76","author":"Qiang","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib136","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainresbull.2016.04.020","article-title":"Effects of naringin on learning and memory dysfunction induced by gp120 in rats","volume":"124","author":"Qin","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2023.105486_bib137","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1111\/bph.12725","article-title":"Rutin protects against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion","volume":"171","author":"Qu","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib138","series-title":"Alzheimer's Disease","author":"Querfurth","year":"2010"},{"key":"10.1016\/j.neuint.2023.105486_bib139","doi-asserted-by":"crossref","first-page":"379","DOI":"10.7326\/0003-4819-148-5-200803040-00009","article-title":"Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline","volume":"148","author":"Raina","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cbi.2017.02.021","article-title":"Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice","volume":"268","author":"Rajput","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neuint.2023.105486_bib141","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/07391102.2020.1814868","article-title":"Deciphering inhibitory activity of flavonoids against tau protein kinases: a coupled molecular docking and quantum chemical study","volume":"40","author":"Rasouli","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.neuint.2023.105486_bib142","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1021\/ja962309h","article-title":"A model of the interaction of substrates and inhibitors with xanthine oxidase","volume":"119","author":"Rastelli","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.neuint.2023.105486_bib216","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-5-41","article-title":"Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression","volume":"5","author":"Rezai-Zadeh","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2023.105486_bib143","series-title":"Handbook of Toxicologic Pathology","first-page":"2391","article-title":"Endocrine system","author":"Rosol","year":"2013"},{"key":"10.1016\/j.neuint.2023.105486_bib144","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-2952(02)01621-0","article-title":"Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action","volume":"65","author":"Sadik","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061305","article-title":"The therapeutic potential of apigenin","volume":"20","author":"Salehi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib146","first-page":"217","article-title":"Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach","author":"Salkovic-Petrisic","year":"2007","journal-title":"J. Neural. Transm. Suppl."},{"key":"10.1016\/j.neuint.2023.105486_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104602","article-title":"Development of genistein-O-alkylamines derivatives as multifunctional agents for the treatment of Alzheimer's disease","volume":"107","author":"Sang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib148","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fct.2014.07.038","article-title":"The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway","volume":"72","author":"Saw","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.neuint.2023.105486_bib149","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2023.105486_bib213","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1055\/s-0028-1088314","article-title":"Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin","volume":"74","author":"Seelinger","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.neuint.2023.105486_bib150","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1021\/jf025671q","article-title":"Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechins","volume":"50","author":"Seeram","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib151","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-140-8-200404200-00047","article-title":"Alzheimer disease: mechanistic understanding predicts novel therapies","volume":"140","author":"Selkoe","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib152","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.phrs.2017.11.030","article-title":"Phytochemicals as inhibitors of NF-\u03baB for treatment of Alzheimer's disease","volume":"129","author":"Seo","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib153","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neuint.2023.105486_bib154","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0024-3205(00)01005-5","article-title":"Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment","volume":"68","author":"Sharma","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib155","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bbagen.2008.01.017","article-title":"Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features","volume":"1780","author":"Shimmyo","year":"2008","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.neuint.2023.105486_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.110086","article-title":"In vitro anti-inflammatory properties of honey flavonoids: a review","volume":"141","author":"Silva","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.neuint.2023.105486_bib157","article-title":"Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)","volume":"15","author":"Singh","year":"2016","journal-title":"Nutr. J."},{"key":"10.1016\/j.neuint.2023.105486_bib158","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","article-title":"Alzheimer's disease","volume":"167","author":"Soria Lopez","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.neuint.2023.105486_bib159","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/01616412.2016.1244374","article-title":"In vitro antiaggregation and deaggregation potential of Rhizophora mucronata and its bioactive compound (+)- catechin against Alzheimer's beta amyloid peptide (25\u201335)","volume":"38","author":"Suganthy","year":"2016","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1254\/jjp.89.7","article-title":"Research and development of Donepezil hydrochloride, a new type of acetylcholinesterase inhibitor","volume":"89","author":"Sugimoto","year":"2002","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib161","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02182-3","article-title":"Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease","volume":"18","author":"Sun","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2023.105486_bib162","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.1074\/jbc.M408714200","article-title":"Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins","volume":"280","author":"Taniguchi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib163","first-page":"5196","article-title":"Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray","volume":"62","author":"Thimmulappa","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuint.2023.105486_bib164","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/aps.2017.203","article-title":"Cyanidin attenuates A\u03b2 25-35 -induced neuroinflammation by suppressing NF-\u03baB activity downstream of TLR4\/NOX4 in human neuroblastoma cells","volume":"39","author":"Thummayot","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neuint.2023.105486_bib165","doi-asserted-by":"crossref","first-page":"13952","DOI":"10.1039\/C7NJ03497K","article-title":"A comparative: in vitro and in silico study of the biological potential and chemical fingerprints of Dorcycinum pentapyllum subsp. haussknechtii using three extraction procedures","volume":"41","author":"Uysal","year":"2017","journal-title":"New J. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib166","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1021\/tx9600964","article-title":"A quantum chemical explanation of the antioxidant activity of flavonoids","volume":"9","author":"Van Acker","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.neuint.2023.105486_bib167","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0361-9230(99)00093-3","article-title":"Methionine residue 35 is important in amyloid \u03b2-peptide-associated free radical oxidative stress","volume":"50","author":"Varadarajan","year":"1999","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2023.105486_bib168","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1073\/pnas.97.10.5129","article-title":"Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure","volume":"97","author":"Von Bergen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuint.2023.105486_bib169","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1097-2765(05)00089-4","article-title":"Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine","volume":"6","author":"Walker","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuint.2023.105486_bib170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pbb.2012.03.013","article-title":"Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease","volume":"102","author":"Wang","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2023.105486_bib171","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10571-014-0098-x","article-title":"Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease","volume":"34","author":"Wang","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2023.105486_bib172","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s11064-014-1343-x","article-title":"Effects of long-term treatment with quercetin on cognition and mitochondrial function in a mouse model of Alzheimer's disease","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib173","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.3892\/mmr.2016.5052","article-title":"Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuint.2023.105486_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109489","article-title":"Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease","volume":"342","author":"Wang","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neuint.2023.105486_bib175","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jnutbio.2004.05.002","article-title":"Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases","volume":"15","author":"Weinreb","year":"2004","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neuint.2023.105486_bib176","series-title":"Open Peer Review Current Understanding of Alzheimer's Disease Diagnosis and Treatment [version 1; Referees: 2 Approved","author":"Weller","year":"2018"},{"key":"10.1016\/j.neuint.2023.105486_bib177","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.nbt.2011.05.003","article-title":"Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity","volume":"28","author":"Weng","year":"2011","journal-title":"N. Biotech."},{"issue":"1","key":"10.1016\/j.neuint.2023.105486_bib178","first-page":"48","volume":"28","author":"Williams","year":"2016","journal-title":"Natural products as a source of Alzheimer\u2019s drug leads"},{"key":"10.1016\/j.neuint.2023.105486_bib179","series-title":"The Green Tea Polyphenol (\u00c0)-Epigallocatechin Gallate Prevents the Aggregation of Tau Protein into Toxic Oligomers at Substoichiometric Ratios","author":"Wobst","year":"2014"},{"key":"10.1016\/j.neuint.2023.105486_bib180","doi-asserted-by":"crossref","DOI":"10.3390\/nu10101554","article-title":"Bioactive compounds in Kimchi improve the cognitive and memory functions impaired by amyloid beta","volume":"10","author":"Woo","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.neuint.2023.105486_bib181","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s12035-014-9042-9","article-title":"Naringenin suppresses neuroinflammatory responses through inducing suppressor of cytokine signaling 3 expression","volume":"53","author":"Wu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2023.105486_bib182","first-page":"224","article-title":"Protective effects of puerarin against A \u03b2 1-42-induced learning and memory impairments in mice","volume":"83","author":"Wu","year":"2017","journal-title":"Planta Med."},{"key":"10.1016\/j.neuint.2023.105486_bib183","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbr.2014.02.002","article-title":"Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A\u03b2 oligomer level and attenuating oxidative stress and neuroinflammation","volume":"264","author":"Xu","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2023.105486_bib184","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/ptr.6305","article-title":"Naringenin promotes microglial M2 polarization and A\u03b2 degradation enzyme expression","volume":"33","author":"Yang","year":"2019","journal-title":"Phyther. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib185","doi-asserted-by":"crossref","first-page":"9081","DOI":"10.3892\/mmr.2017.7702","article-title":"Puerarin inhibits \u03b2-amyloid peptide 1-42-induced tau hyperphosphorylation via the Wnt\/\u03b2-catenin signaling pathway","volume":"16","author":"Yao","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuint.2023.105486_bib208","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.4103\/1673-5374.215260","article-title":"Genistein protects hippocampal neurons against injury by regulating calcium\/calmodulin dependent protein kinase IV protein levels in Alzheimer\u2019s disease model rats","volume":"12","author":"Ye","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib186","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5603\/FHC.a2021.0006","article-title":"Genistein exerts a cell-protective effect via nrf2\/ho-1\/\/pi3k signaling in ab25-35-induced alzheimer's disease models in vitro","volume":"59","author":"Yi","year":"2021","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.neuint.2023.105486_bib187","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1089\/jmf.2017.4068","article-title":"BACE1 inhibition by genistein: biological evaluation, kinetic analysis, and molecular docking Simulation","volume":"21","author":"Youn","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.neuint.2023.105486_bib188","doi-asserted-by":"crossref","DOI":"10.1039\/C5FO00500K","article-title":"Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress","author":"Yu","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.neuint.2023.105486_bib189","article-title":"Effect of quercetin on PC12 alzheimer's disease cell model induced by A \u03b2 25-35 and its mechanism based on Sirtuin1\/nrf2\/HO-1 pathway","author":"Yu","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.neuint.2023.105486_bib215","first-page":"6740","article-title":"Protective effects of luteolin against cognitive impairment induced by infusion of A\u03b2 peptide in rats","volume":"8","author":"Yu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.neuint.2023.105486_bib190","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.lfs.2019.03.055","article-title":"Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease","volume":"224","author":"Zaplatic","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.neuint.2023.105486_bib191","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.cellbi.2008.07.006","article-title":"Puerarin protects PC12 cells against \u03b2-amyloid-induced cell injury","volume":"32","author":"Zhang","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.neuint.2023.105486_bib192","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.intimp.2015.05.024","article-title":"Apigenin protects blood\u2013brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats","volume":"28","author":"Zhang","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.neuint.2023.105486_bib193","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1080\/14786419.2015.1062377","article-title":"Isolation and identification of polyphenols from Marsilea quadrifolia with antioxidant properties in vitro and in vivo","volume":"30","author":"Zhang","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib194","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/0973-1296.182174","article-title":"Epicatechin plus treadmill exercise are neuroprotective against moderate-stage amyloid precursor protein\/presenilin 1 mice","volume":"12","author":"Zhang","year":"2016","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.neuint.2023.105486_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172731","article-title":"Flavonoids reduces lipopolysaccharide-induced release of inflammatory mediators in human bronchial epithelial cells: structure-activity relationship","volume":"865","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib196","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153316","article-title":"The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: a systematic review","volume":"79","author":"Zhang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuint.2023.105486_bib197","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainres.2012.11.019","article-title":"Apigenin attenuates copper-mediated \u03b2-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model","volume":"1492","author":"Zhao","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2023.105486_bib198","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.3390\/molecules18089949","article-title":"Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer's disease mouse model","volume":"18","author":"Zhao","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2023.105486_bib199","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuro.2015.10.010","article-title":"Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice","volume":"51","author":"Zhao","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuint.2023.105486_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105697","article-title":"Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: involved of inactivation of the TLR4\/NF-\u03baB signaling pathway","volume":"75","author":"Zhao","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.neuint.2023.105486_bib201","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1021\/jm900504c","article-title":"Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy","volume":"52","author":"Zheng","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.neuint.2023.105486_bib202","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3233\/JAD-142517","article-title":"Luteolin reduces BACE1 expression through NF-\u03baB and estrogen receptor mediated pathways in HEK293 and SH-SY5Y cells","volume":"45","author":"Zheng","year":"2015","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.neuint.2023.105486_bib203","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1017\/S146114571300148X","article-title":"Puerarin alleviates cognitive impairment and oxidative stress in APP\/PS1 transgenic mice","volume":"17","author":"Zhou","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuint.2023.105486_bib204","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/ptr.5083","article-title":"Puerarin: a review of pharmacological effects","volume":"28","author":"Zhou","year":"2014","journal-title":"Phyther. Res."},{"key":"10.1016\/j.neuint.2023.105486_bib205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/10715762.2012.742518","article-title":"Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3\u03b2\/Nrf2 signaling pathway","volume":"47","author":"Zou","year":"2013","journal-title":"Free Radic. Res."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623000141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623000141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:01:00Z","timestamp":1759312860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018623000141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":220,"alternative-id":["S0197018623000141"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105486","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural fingerprinting of pleiotropic flavonoids for multifaceted Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105486"}}