{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:58:51Z","timestamp":1790870331549,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"am","delay-in-days":352,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.neuint.2023.105507","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T02:29:09Z","timestamp":1676341749000},"page":"105507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Human transthyretin gene expression is markedly increased in repair Schwann cells in an in vitro model of hereditary transthyretin amyloidosis"],"prefix":"10.1016","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-6822","authenticated-orcid":false,"given":"Tatsufumi","family":"Murakami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Sango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Watabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Sunada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2023.105507_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2023.105507_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.747699","article-title":"Transthyretin promotes axon growth via regulation of microtubule dynamics and tubulin acetylation","volume":"9","author":"Eira","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neuint.2023.105507_bib3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1471-4159.2007.04828.x","article-title":"Transthyretin enhances nerve regeneration","volume":"103","author":"Fleming","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2023.105507_bib4","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1523\/JNEUROSCI.6012-08.2009","article-title":"Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity","volume":"29","author":"Fleming","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2023.105507_bib5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/13506120308999001","article-title":"Late-onset familial amyloid polyneuropathy: an autopsy study of two Japanese brothers","volume":"10","author":"Fujitake","year":"2003","journal-title":"Amyloid"},{"key":"10.1016\/j.neuint.2023.105507_bib6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.expneurol.2014.04.030","article-title":"The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model","volume":"257","author":"Goncalves","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2023.105507_bib7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ana.410250405","article-title":"Peripheral nerve pathological findings in familial amyloid polyneuropathy: a correlative study of proximal sciatic nerve and sural nerve lesions","volume":"25","author":"Hanyu","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2023.105507_bib8","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1113\/JP270874","article-title":"The repair Schwann cell and its function in regenerating nerves","volume":"594","author":"Jessen","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2023.105507_bib9","first-page":"1497","article-title":"Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy","volume":"150","author":"Kohno","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuint.2023.105507_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1212\/01.WNL.0000132966.36437.12","article-title":"Pathology of early- vs late-onset TTR Met30 familial amyloid polyneuropathy","volume":"63","author":"Koike","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2023.105507_bib11","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1212\/WNL.0000000000003362","article-title":"Schwann cell and endothelial cell damage in transthyretin familial amyloid polyneuropathy","volume":"87","author":"Koike","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2023.105507_bib12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/brain\/awu344","article-title":"In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography","volume":"138","author":"Kollmer","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2023.105507_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1827.1995.tb03373.x","article-title":"Genetic abnormalities and pathogenesis of familial amyloidotic polyneuropathy","volume":"45","author":"Murakami","year":"1995","journal-title":"Pathol. Int."},{"key":"10.1016\/j.neuint.2023.105507_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neulet.2008.03.063","article-title":"The transthyretin gene is expressed in human and rodent dorsal root ganglia","volume":"436","author":"Murakami","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2023.105507_bib15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.brainres.2010.06.017","article-title":"The transthyretin gene is expressed in Schwann cells of peripheral nerves","volume":"1348","author":"Murakami","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2023.105507_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/jnc.13068","article-title":"Schwann cells contribute to neurodegeneration in transthyretin amyloidosis","volume":"134","author":"Murakami","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2023.105507_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2022.120329","article-title":"Magnetic resonance imaging of dorsal root ganglion in a pre-symptomatic subject with familial amyloid polyneuropathy transthyretin E61K","volume":"440","author":"Murakami","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2023.105507_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/oxfordjournals.jbchem.a124705","article-title":"A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse","volume":"117","author":"Nagata","year":"1995","journal-title":"J. Biochem."},{"key":"10.1016\/j.neuint.2023.105507_bib19","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1007\/s00018-020-03516-9","article-title":"Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury","volume":"77","author":"Nocera","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuint.2023.105507_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jnnp-2013-305973","article-title":"Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation","volume":"85","author":"Oshima","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neuint.2023.105507_bib21","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1474-4422(11)70246-0","article-title":"Familial amyloid polyneuropathy","volume":"10","author":"Plante-Bordeneuve","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuint.2023.105507_bib22","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s00415-017-8708-4","article-title":"Transthyretin familial amyloid polyneuropathy: an update","volume":"265","author":"Plante-Bordeneuve","year":"2018","journal-title":"J. Neurol."},{"key":"10.1016\/j.neuint.2023.105507_bib23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1212\/WNL.34.8.1025","article-title":"Length-dependent degeneration of fibers in Portuguese amyloid polyneuropathy: a clinicopathologic study","volume":"34","author":"Said","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2023.105507_bib24","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s00415-021-10754-9","article-title":"Progressive brachial plexus enlargement in hereditary transthyretin amyloidosis","volume":"269","author":"Salvalaggio","year":"2022","journal-title":"J. Neurol."},{"key":"10.1016\/j.neuint.2023.105507_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neurobiolaging.2008.04.001","article-title":"The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems","volume":"31","author":"Santos","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuint.2023.105507_bib26","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"Pt 4","key":"10.1016\/j.neuint.2023.105507_bib27","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/brain\/113.4.903","article-title":"Type I familial amyloid polyneuropathy. A pathological study of the peripheral nervous system","volume":"113","author":"Sobue","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2023.105507_bib28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/BF00294814","article-title":"Familial amyloid polyneuropathy associated with transthyretin Gly42 mutation: a quantitative light and electron microscopic study of the peripheral nervous system","volume":"90","author":"Toyooka","year":"1995","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuint.2023.105507_bib29","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1523\/JNEUROSCI.4936-13.2014","article-title":"The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice","volume":"34","author":"Wang","year":"2014","journal-title":"J. Neurosci."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623000359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623000359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:02:08Z","timestamp":1759312928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018623000359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":29,"alternative-id":["S0197018623000359"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105507","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human transthyretin gene expression is markedly increased in repair Schwann cells in an in vitro model of hereditary transthyretin amyloidosis","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105507","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105507"}}