{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:22:47Z","timestamp":1790342567909,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2020YJZX0110"],"award-info":[{"award-number":["2020YJZX0110"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2022XD059"],"award-info":[{"award-number":["2022XD059"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830029"],"award-info":[{"award-number":["81830029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970879"],"award-info":[{"award-number":["81970879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192862"],"award-info":[{"award-number":["82192862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20MC1920200"],"award-info":[{"award-number":["20MC1920200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.neuint.2023.105587","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T23:28:33Z","timestamp":1690241313000},"page":"105587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Glutamate-aspartate transporter dysfunction enhances aminoglycoside-induced cochlear hair cell death via NMDA receptor activation"],"prefix":"10.1016","volume":"169","author":[{"given":"Jin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-4307","authenticated-orcid":false,"given":"Shan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2023.105587_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2021.108243","article-title":"Neonatal exposure to monosodium glutamate results in impaired auditory brainstem structure and function","volume":"405","author":"Altaher","year":"2021","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuint.2023.105587_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.toxlet.2018.04.007","article-title":"Neuronal erythropoietin overexpression is protective against kanamycin-induced hearing loss in mice","volume":"291","author":"Bachinger","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neuint.2023.105587_bib3","first-page":"1","article-title":"Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice","volume":"4","author":"Bertocchi","year":"2021","journal-title":"Communications Biology"},{"key":"10.1016\/j.neuint.2023.105587_bib4","doi-asserted-by":"crossref","first-page":"11904","DOI":"10.1523\/JNEUROSCI.1658-16.2016","article-title":"Temporal profiling of astrocyte precursors reveals parallel roles for asef during development and after injury","volume":"36","author":"Chaboub","year":"2016","journal-title":"J. Neurosci.: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.neuint.2023.105587_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41586-021-03240-9","article-title":"Glutamate transporters have a chloride channel with two hydrophobic gates","volume":"591","author":"Chen","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2023.105587_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134861","article-title":"miR-182 prevented ototoxic deafness induced by co-administration of kanamycin and furosemide in rats","volume":"723","author":"Chen","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2023.105587_bib7","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1038\/s41467-018-06307-w","article-title":"Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation","volume":"9","author":"Corns","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2023.105587_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12640-013-9384-5","article-title":"Salicylate selectively kills cochlear spiral ganglion neurons by paradoxically up-regulating superoxide","volume":"24","author":"Deng","year":"2013","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuint.2023.105587_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2021.108358","article-title":"Excitotoxic damage to auditory nerve afferents and spiral ganglion neurons is correlated with developmental upregulation of AMPA and KA receptors","volume":"411","author":"Ding","year":"2021","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuint.2023.105587_bib10","first-page":"E320","article-title":"Net amino acid transport between plasma and erythrocytes and perfused dog brain","volume":"233","author":"Drewes","year":"1977","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neuint.2023.105587_bib11","first-page":"dev162263","volume":"147","author":"Driver","year":"2020"},{"key":"10.1016\/j.neuint.2023.105587_bib12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2019.11.051","article-title":"Noise-induced cochlear synaptopathy with and without sensory cell loss","volume":"427","author":"Fernandez","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2023.105587_bib13","doi-asserted-by":"crossref","first-page":"7581","DOI":"10.7150\/thno.44306","article-title":"Single-cell transcriptome profiling reveals dermal and epithelial cell fate decisions during embryonic hair follicle development","volume":"10","author":"Ge","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.neuint.2023.105587_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/cmdc.201500527","article-title":"Bioavailability studies and in vitro profiling of the selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor UCPH-102","volume":"11","author":"Haym","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.neuint.2023.105587_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3989201","article-title":"N-Methyl-D-Aspartate receptors involvement in the gentamicin-induced hearing loss and pathological changes of ribbon synapse in the mouse cochlear inner hair cells","volume":"2018","author":"Hong","year":"2018","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuint.2023.105587_bib16","first-page":"1123","article-title":"Functional and morphological analysis of different aminoglycoside treatment regimens inducing hearing loss in mice","volume":"18","author":"Horvath","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.neuint.2023.105587_bib17","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1073\/pnas.1914247117","article-title":"Protection of cochlear synapses from noise-induced excitotoxic trauma by blockade of Ca2+-permeable AMPA receptors","volume":"117","author":"Hu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neuint.2023.105587_bib18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1097\/WNR.0b013e32833017ce","article-title":"Glutamate agonist causes irreversible degeneration of inner hair cells","volume":"20","author":"Hyodo","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2023.105587_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3109\/00016488109138538","article-title":"Labyrinthine barriers and cochlear homeostasis","volume":"91","author":"Juhn","year":"1981","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.neuint.2023.105587_bib20","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1523\/JNEUROSCI.2228-18.2019","article-title":"Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses","volume":"39","author":"Kim","year":"2019","journal-title":"J. Neurosci.: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.neuint.2023.105587_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7513258","article-title":"The key transcription factor expression in the developing vestibular and auditory sensory organs: a comprehensive comparison of spatial and temporal patterns","volume":"2018","author":"Liu","year":"2018","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuint.2023.105587_bib22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/cells8020184","article-title":"Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release","volume":"8","author":"Mahmoud","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.neuint.2023.105587_bib23","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0006-8993(99)02265-9","article-title":"A role of glutamate in drug-induced ototoxicity: in vivo microdialysis study combined with on-line enzyme fluorometric detection of glutamate in the Guinea pig cochlea","volume":"852","author":"Matsuda","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2023.105587_bib24","first-page":"338","article-title":"Increased mitochondrial DNA copy number protects hair cells and HEI-OC1 cells against drug-induced apoptosis","volume":"21","author":"Mei","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuint.2023.105587_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.heares.2013.01.008","article-title":"Lead roles for supporting actors: critical functions of inner ear supporting cells","volume":"303","author":"Monzack","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuint.2023.105587_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/coa.13493","article-title":"A novel water occlusion test for disorders causing pulsatile tinnitus: our experience in 32 patients","volume":"45","author":"Park","year":"2020","journal-title":"Clin. Otolaryngol.: official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery"},{"key":"10.1016\/j.neuint.2023.105587_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1460-9568.2003.02429.x","article-title":"Glutamate transporters in the Guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications","volume":"17","author":"Rebillard","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2023.105587_bib28","doi-asserted-by":"crossref","first-page":"dev177188","DOI":"10.1242\/dev.177188","article-title":"Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration","volume":"146","author":"Roccio","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.neuint.2023.105587_bib29","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1523\/JNEUROSCI.3644-16.2017","article-title":"Ca2+-Permeable AMPARs mediate glutamatergic transmission and excitotoxic damage at the hair cell ribbon synapse","volume":"37","author":"Sebe","year":"2017","journal-title":"J. Neurosci.: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.neuint.2023.105587_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/srep41102","article-title":"Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation","volume":"7","author":"Sheets","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2023.105587_bib31","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2018.07.007","article-title":"Sensory neuron diversity in the inner ear is shaped by activity","volume":"174","author":"Shrestha","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2023.105587_bib32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fncel.2014.00248","article-title":"In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period","volume":"8","author":"Sun","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2023.105587_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/bs.pbr.2020.04.004","article-title":"Auditory synaptopathy in mice lacking the glutamate transporter GLAST and its impact on brain activity","volume":"262","author":"Tserga","year":"2021","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neuint.2023.105587_bib34","doi-asserted-by":"crossref","first-page":"13978","DOI":"10.1096\/fj.202001236R","article-title":"Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea","volume":"34","author":"Tserga","year":"2020","journal-title":"Faseb. J.: official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.neuint.2023.105587_bib35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/glia.23098","article-title":"Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation","volume":"65","author":"Untiet","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.neuint.2023.105587_bib36","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1523\/JNEUROSCI.0619-20.2021","article-title":"Outer hair cell glutamate signaling through type II spiral ganglion afferents activates neurons in the cochlear nucleus in response to nondamaging sounds","volume":"41","author":"Weisz","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2023.105587_bib37","article-title":"Dexmedetomidine attenuates glutamate-induced cytotoxicity by inhibiting the mitochondrial-mediated apoptotic pathway","volume":"26","author":"Zhang","year":"2020","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.neuint.2023.105587_bib38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0197-4580(03)00085-X","article-title":"Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer's disease","volume":"25","author":"Zoia","year":"2004","journal-title":"Neurobiol. Aging"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623001158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623001158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T04:13:02Z","timestamp":1736395982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018623001158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":38,"alternative-id":["S0197018623001158"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105587","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamate-aspartate transporter dysfunction enhances aminoglycoside-induced cochlear hair cell death via NMDA receptor activation","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105587"}}