{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:54:23Z","timestamp":1791633263893,"version":"4.3.4"},"reference-count":125,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.neuint.2023.105630","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T04:35:54Z","timestamp":1697690154000},"page":"105630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Mechanisms and treatments of chronic pain after traumatic brain injury"],"prefix":"10.1016","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-1423","authenticated-orcid":false,"given":"QiLiang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimala","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen-Amanda","family":"Irvine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. David","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2023.105630_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110121","article-title":"Neuropathic pain increases spontaneous and noxious-evoked activity of locus coeruleus neurons","volume":"105","author":"Alba-Delgado","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2023.105630_bib2","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1007\/s11999-013-3031-6","article-title":"Does additional head trauma affect the long-term outcome after upper extremity trauma in multiple traumatized patients: is there an additional effect of traumatic brain injury?","volume":"471","author":"Andruszkow","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.neuint.2023.105630_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pain.2010.04.003","article-title":"Sensitization in patients with painful knee osteoarthritis","volume":"149","author":"Arendt-Nielsen","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jpain.2015.10.009","article-title":"Disruption of spinal noradrenergic activation delays recovery of acute incision-induced hypersensitivity and increases spinal glial activation in the rat","volume":"17","author":"Arora","year":"2016","journal-title":"J. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s10194-020-01136-z","article-title":"Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study","volume":"21","author":"Ashina","year":"2020","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib6","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.neubiorev.2009.03.011","article-title":"Persistent cognitive dysfunction after traumatic brain injury: a dopamine hypothesis","volume":"33","author":"Bales","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuint.2023.105630_bib7","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1097\/j.pain.0000000000000240","article-title":"Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations","volume":"156","author":"Bannister","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032911","article-title":"Role of running-activated neural stem cells in the anatomical and functional recovery after traumatic brain injury in p21 knock-out mice","volume":"24","author":"Battistini","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2023.105630_bib9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0301-0082(95)00009-K","article-title":"Functional characteristics of the midbrain periaqueductal gray","volume":"46","author":"Behbehani","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuint.2023.105630_bib10","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1080\/02699052.2018.1493535","article-title":"Do postconcussive symptoms from traumatic brain injury in combat veterans predict risk for receiving opioid therapy for chronic pain?","volume":"32","author":"Bertenthal","year":"2018","journal-title":"Brain Inj."},{"key":"10.1016\/j.neuint.2023.105630_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s10194-005-0251-5","article-title":"Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life","volume":"7","author":"Bettucci","year":"2006","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14051105","article-title":"Impact of magnesium on oxytocin receptor function","volume":"14","author":"Bharadwaj","year":"2022","journal-title":"Pharmaceutics"},{"issue":"10","key":"10.1016\/j.neuint.2023.105630_bib13","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.jpain.2023.05.015","article-title":"Effect of voluntary exercise on endogenous pain control systems and post-traumatic headache in mice","volume":"24","author":"Bharadwaj","year":"2023","journal-title":"J. Pai."},{"key":"10.1016\/j.neuint.2023.105630_bib14","article-title":"Traumatic brain injuries","volume":"2","author":"Blennow","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.neuint.2023.105630_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2017.09.041","article-title":"Oxytocin and pain perception: from animal models to human research","volume":"387","author":"Boll","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2023.105630_bib16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/ana.26463","article-title":"Brain connectivity predicts chronic pain in acute mild traumatic brain injury","volume":"92","author":"Bosak","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2023.105630_bib17","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1089\/neu.2012.2740","article-title":"Effects of acute intrathecal baclofen in an animal model of TBI-induced spasticity, cognitive, and balance disabilities","volume":"30","author":"Bose","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neuint.2023.105630_bib18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/0333102416681571","article-title":"Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: implications for mechanisms of post-traumatic headache","volume":"38","author":"Bree","year":"2018","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2023.105630_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.expneurol.2006.04.008","article-title":"Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats","volume":"201","author":"Browne","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2023.105630_bib20","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1124\/jpet.112.199489","article-title":"The antinociceptive effect of milnacipran in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition","volume":"344","author":"Burnham","year":"2013","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2023.105630_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainresbull.2016.09.016","article-title":"Chemokine receptor CXCR2 in dorsal root ganglion contributes to the maintenance of inflammatory pain","volume":"127","author":"Cao","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2023.105630_bib22","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/pm\/pnz058","article-title":"An exploratory study of endogenous pain modulatory function in patients following mild traumatic brain injury","volume":"20","author":"Carey","year":"2019","journal-title":"Pain Med."},{"key":"10.1016\/j.neuint.2023.105630_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/02699052.2023.2165155","article-title":"Effectiveness of exercise in improving quality of life in patients with traumatic brain injury: a systematic review and meta-analysis","volume":"37","author":"Chang","year":"2023","journal-title":"Brain Inj."},{"key":"10.1016\/j.neuint.2023.105630_bib24","article-title":"Shifting the balance: how top-down and bottom-up input modulate pain via the rostral ventromedial medulla","volume":"3","author":"Chen","year":"2022","journal-title":"Front. Pain Res. (Lausanne)"},{"key":"10.1016\/j.neuint.2023.105630_bib25","series-title":"Mild Traumatic Brain Injury-Induced Augmented Postsurgical Pain Is Driven by Central Serotonergic Pain-Facilitatory Signaling","author":"Chen","year":"2023"},{"key":"10.1016\/j.neuint.2023.105630_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114181","article-title":"Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats","volume":"438","author":"Chiariello","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2023.105630_bib27","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1177\/0333102419861726","article-title":"Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain","volume":"39","author":"Christensen","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2023.105630_bib28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1682\/JRRD.2013.01.0006","article-title":"Traumatic brain injury, posttraumatic stress disorder, and pain diagnoses in OIF\/OEF\/OND Veterans","volume":"50","author":"Cifu","year":"2013","journal-title":"J. Rehabil. Res. Dev."},{"key":"10.1016\/j.neuint.2023.105630_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/ALN.0000000000001340","article-title":"Preclinical pain research: can we do better?","volume":"125","author":"Clark","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuint.2023.105630_bib30","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s13311-022-01230-x","article-title":"The arrival of anti-CGRP monoclonal antibodies in migraine","volume":"19","author":"Cohen","year":"2022","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuint.2023.105630_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fnana.2017.00047","article-title":"Lower functional connectivity of the periaqueductal gray is related to negative affect and clinical manifestations of fibromyalgia","volume":"11","author":"Coulombe","year":"2017","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neuint.2023.105630_bib32","doi-asserted-by":"crossref","first-page":"9794","DOI":"10.1523\/JNEUROSCI.0806-21.2021","article-title":"Brainstem mechanisms of pain modulation: a within-subjects 7T fMRI study of placebo analgesic and nocebo hyperalgesic responses","volume":"41","author":"Crawford","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2023.105630_bib33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/head.13451","article-title":"Gabapentin and tricyclics in the treatment of post-concussive headache, a retrospective cohort study","volume":"59","author":"Cushman","year":"2019","journal-title":"Headache"},{"key":"10.1016\/j.neuint.2023.105630_bib34","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jpain.2014.05.001","article-title":"Repetitive transcranial magnetic stimulation increases the corticospinal inhibition and the brain-derived neurotrophic factor in chronic myofascial pain syndrome: an explanatory double-blinded, randomized, sham-controlled trial","volume":"15","author":"Dall'Agnol","year":"2014","journal-title":"J. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurom.2022.04.049","article-title":"Spinal cord stimulation paradigms and pain relief: a preclinical systematic review on modulation of the central inflammatory response in neuropathic pain","volume":"26","author":"de Geus","year":"2023","journal-title":"Neuromodulation"},{"key":"10.1016\/j.neuint.2023.105630_bib36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1179\/2042618613Y.0000000053","article-title":"Chronic post-traumatic headache: clinical findings and possible mechanisms","volume":"22","author":"Defrin","year":"2014","journal-title":"J. Man. Manip. Ther."},{"key":"10.1016\/j.neuint.2023.105630_bib37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/neu.2014.3359","article-title":"Deficient pain modulatory systems in patients with mild traumatic brain and chronic post-traumatic headache: implications for its mechanism","volume":"32","author":"Defrin","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neuint.2023.105630_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jpain.2021.07.003","article-title":"Pupillary reflexes in complex regional pain syndrome: asymmetry to arousal stimuli suggests an ipsilateral locus coeruleus deficit","volume":"23","author":"Drummond","year":"2022","journal-title":"J. Pain"},{"issue":"7-8","key":"10.1016\/j.neuint.2023.105630_bib39","doi-asserted-by":"crossref","first-page":"e2118","DOI":"10.1093\/milmed\/usad026","article-title":"Self-reported symptoms in U.S. Marines following blast- and impact-related concussion","volume":"188","author":"Englert","year":"2023","journal-title":"Mil. Med."},{"key":"10.1016\/j.neuint.2023.105630_bib40","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1089\/neu.2009.1091","article-title":"Treatment for depression after traumatic brain injury: a systematic review","volume":"26","author":"Fann","year":"2009","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neuint.2023.105630_bib41","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuint.2023.105630_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113079","article-title":"Inhibition of nociceptive dural input to the trigeminocervical complex through oxytocinergic transmission","volume":"323","author":"Garcia-Boll","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2023.105630_bib43","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3109\/10826084.2013.796988","article-title":"Prescription opioid initiation, correlates, and consequences among a sample of OEF\/OIF military personnel","volume":"48","author":"Golub","year":"2013","journal-title":"Subst. Use Misuse"},{"key":"10.1016\/j.neuint.2023.105630_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17114024","article-title":"The relation between persistent post-traumatic headache and PTSD: similarities and possible differences","volume":"17","author":"Guglielmetti","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.neuint.2023.105630_bib45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/ner.12685","article-title":"The efficacy and safety of dorsal root ganglion stimulation as a treatment for neuropathic pain: a literature review","volume":"21","author":"Harrison","year":"2018","journal-title":"Neuromodulation"},{"key":"10.1016\/j.neuint.2023.105630_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/00325481.2020.1769393","article-title":"Mechanisms and mode of action of spinal cord stimulation in chronic neuropathic pain","volume":"132","author":"Heijmans","year":"2020","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.neuint.2023.105630_bib47","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211043965","article-title":"A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation","volume":"17","author":"Heijmans","year":"2021","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11206224","article-title":"A systematic review of treatments of post-concussion symptoms","volume":"11","author":"Heslot","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.neuint.2023.105630_bib49","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/pme.12388","article-title":"Persistent pain and comorbidity among operation enduring freedom\/operation Iraqi freedom\/operation new dawn veterans","volume":"15","author":"Higgins","year":"2014","journal-title":"Pain Med."},{"key":"10.1016\/j.neuint.2023.105630_bib50","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/0333102418756863","article-title":"The role of the brainstem in migraine: potential brainstem effects of CGRP and CGRP receptor activation in animal models","volume":"39","author":"Holland","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2023.105630_bib51","article-title":"Voluntary exercise to reduce anxiety behaviour in traumatic brain injury shown to alleviate inflammatory brain response in mice","volume":"24","author":"Hu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2023.105630_bib52","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/pm\/pnx153","article-title":"Chronic pain after traumatic brain injury: pathophysiology and pain mechanisms","volume":"19","author":"Irvine","year":"2018","journal-title":"Pain Med."},{"key":"10.1016\/j.neuint.2023.105630_bib53","series-title":"Chronic Pain after Traumatic Brain Injury: Pathophysiology and Pain Mechanisms. Pain Medicine","author":"Irvine","year":"2017"},{"key":"10.1016\/j.neuint.2023.105630_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.112976","article-title":"Enhanced descending pain facilitation in acute traumatic brain injury","volume":"320","author":"Irvine","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2023.105630_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113428","article-title":"Loss of diffuse noxious inhibitory control after traumatic brain injury in rats: a chronic issue","volume":"333","author":"Irvine","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2023.105630_bib56","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1089\/neu.2017.5411","article-title":"Traumatic brain injury disrupts pain signaling in the brainstem and spinal cord","volume":"35","author":"Irvine","year":"2018","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neuint.2023.105630_bib57","article-title":"Relation between injury of the periaqueductal gray and central pain in patients with mild traumatic brain injury: observational study","volume":"95","author":"Jang","year":"2016","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.neuint.2023.105630_bib58","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1124\/jpet.111.187724","article-title":"Epigenetic augmentation of the macrophage inflammatory protein 2\/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain","volume":"340","author":"Kiguchi","year":"2012","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2023.105630_bib59","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/PHM.0000000000001580","article-title":"Reduced brainstem volume after mild traumatic brain injury","volume":"100","author":"Kim","year":"2021","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.neuint.2023.105630_bib60","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1177\/0333102420981688","article-title":"CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache","volume":"41","author":"Kopruszinski","year":"2021","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2023.105630_bib61","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroscience.2016.06.057","article-title":"Antidepressants and gabapentinoids in neuropathic pain: mechanistic insights","volume":"338","author":"Kremer","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2023.105630_bib62","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s10194-019-1051-7","article-title":"Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review","volume":"20","author":"Larsen","year":"2019","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib63","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00002508-199709000-00003","article-title":"Possible deficiencies of pain modulation in fibromyalgia","volume":"13","author":"Lautenbacher","year":"1997","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12101357","article-title":"Update on non-pharmacological interventions for treatment of post-traumatic headache","volume":"12","author":"Lee","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.neuint.2023.105630_bib65","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuchi.2020.02.002","article-title":"Definition and epidemiology of mild traumatic brain injury","volume":"67","author":"Lefevre-Dognin","year":"2021","journal-title":"Neurochirurgie"},{"key":"10.1016\/j.neuint.2023.105630_bib66","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1682\/JRRD.2009.01.0006","article-title":"Prevalence of chronic pain, posttraumatic stress disorder, and persistent postconcussive symptoms in OIF\/OEF veterans: polytrauma clinical triad","volume":"46","author":"Lew","year":"2009","journal-title":"J. Rehabil. Res. Dev."},{"key":"10.1016\/j.neuint.2023.105630_bib67","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917730212","article-title":"The chemokine receptor CXCR2 supports nociceptive sensitization after traumatic brain injury","volume":"13","author":"Liang","year":"2017","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/ner.12228","article-title":"One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain","volume":"18","author":"Liem","year":"2015","journal-title":"Neuromodulation"},{"key":"10.1016\/j.neuint.2023.105630_bib69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jts.21979","article-title":"Deployment-related psychiatric and behavioral conditions and their association with functional disability in OEF\/OIF\/OND veterans","volume":"28","author":"Lippa","year":"2015","journal-title":"J. Trauma Stress"},{"key":"10.1016\/j.neuint.2023.105630_bib70","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/bjsports-2017-097699","article-title":"Consensus statement on concussion in sport-the 5(th) international conference on concussion in sport held in Berlin, October 2016","volume":"51","author":"McCrory","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.neuint.2023.105630_bib71","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/head.13248","article-title":"Intranasal oxytocin attenuates reactive and ongoing, chronic pain in a model of mild traumatic brain injury","volume":"58","author":"Meidahl","year":"2018","journal-title":"Headache"},{"key":"10.1016\/j.neuint.2023.105630_bib72","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1523\/JNEUROSCI.1647-17.2017","article-title":"Brainstem pain-control circuitry connectivity in chronic neuropathic pain","volume":"38","author":"Mills","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2023.105630_bib73","article-title":"Concussion\/mild traumatic brain injury-related chronic pain in males and females: a diagnostic modelling study","volume":"96","author":"Mollayeva","year":"2017","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.neuint.2023.105630_bib74","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s42826-022-00128-1","article-title":"Role of animal models in biomedical research: a review","volume":"38","author":"Mukherjee","year":"2022","journal-title":"Lab. Anim Res."},{"key":"10.1016\/j.neuint.2023.105630_bib75","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/jama.300.6.711","article-title":"Prevalence of chronic pain after traumatic brain injury: a systematic review","volume":"300","author":"Nampiaparampil","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.neuint.2023.105630_bib76","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s10194-020-01207-1","article-title":"The role of deficient pain modulatory systems in the development of persistent post-traumatic headaches following mild traumatic brain injury: an exploratory longitudinal study","volume":"21","author":"Naugle","year":"2020","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib77","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1177\/03331024221099841","article-title":"Preclinical assessment of onabotulinumtoxinA for the treatment of mild traumatic brain injury-related acute and persistent post-traumatic headache","volume":"42","author":"Navratilova","year":"2022","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2023.105630_bib78","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1177\/0333102419877662","article-title":"CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice","volume":"39","author":"Navratilova","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2023.105630_bib79","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/jnnp-2018-318886","article-title":"Disruption of periaqueductal grey-default mode network functional connectivity predicts persistent post-traumatic headache in mild traumatic brain injury","volume":"90","author":"Niu","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neuint.2023.105630_bib80","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.pain.2007.06.015","article-title":"The characteristics of chronic central pain after traumatic brain injury","volume":"131","author":"Ofek","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib81","doi-asserted-by":"crossref","first-page":"101","DOI":"10.36076\/ppj.2023.26.101","article-title":"Missed emergency department diagnosis of mild traumatic brain injury in patients with chronic pain after motor vehicle collision","volume":"26","author":"Peixoto","year":"2023","journal-title":"Pain Physician"},{"key":"10.1016\/j.neuint.2023.105630_bib82","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuint.2023.105630_bib83","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/09602011.2019.1706585","article-title":"The use of repetitive transcranial magnetic stimulation (rTMS) following traumatic brain injury (TBI): a scoping review","volume":"31","author":"Pink","year":"2021","journal-title":"Neuropsychol. Rehabil."},{"key":"10.1016\/j.neuint.2023.105630_bib84","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-20292-7","article-title":"Monoamine control of descending pain modulation after mild traumatic brain injury","volume":"12","author":"Sahbaie","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2023.105630_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55739-x","article-title":"Mild traumatic brain injury causes nociceptive sensitization through spinal chemokine upregulation","volume":"9","author":"Sahbaie","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2023.105630_bib86","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jpain.2018.06.004","article-title":"Nociceptive and cognitive changes in a murine model of polytrauma","volume":"19","author":"Sahbaie","year":"2018","journal-title":"J. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib87","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/HTR.0000000000000870","article-title":"Disparities in chronic pain experience and treatment history among persons with traumatic brain injury: a traumatic brain injury model systems study","volume":"38","author":"Sander","year":"2023","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.neuint.2023.105630_bib88","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1007\/s00701-018-3669-7","article-title":"Spinal cord stimulation modulates descending pain inhibition and temporal summation of pricking pain in patients with neuropathic pain","volume":"160","author":"Schuh-Hofer","year":"2018","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.neuint.2023.105630_bib89","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuroimage.2015.09.023","article-title":"Physiological brainstem mechanisms of trigeminal nociception: an fMRI study at 3T","volume":"124","author":"Schulte","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuint.2023.105630_bib90","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jpain.2018.03.005","article-title":"Traumatic brain injury and receipt of prescription opioid therapy for chronic pain in Iraq and Afghanistan veterans: do clinical practice guidelines matter?","volume":"19","author":"Seal","year":"2018","journal-title":"J. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib91","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/brain\/awn346","article-title":"Differential endogenous pain modulation in complex-regional pain syndrome","volume":"132","author":"Seifert","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2023.105630_bib92","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.nbd.2010.06.015","article-title":"Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury","volume":"40","author":"Semple","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2023.105630_bib93","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/jcbfm.2009.240","article-title":"Role of chemokines in CNS health and pathology: a focus on the CCL2\/CCR2 and CXCL8\/CXCR2 networks","volume":"30","author":"Semple","year":"2010","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuint.2023.105630_bib94","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/02699052.2019.1683892","article-title":"Cognitive and neural effects of exercise following traumatic brain injury: a systematic review of randomized and controlled clinical trials","volume":"34","author":"Sharma","year":"2020","journal-title":"Brain Inj."},{"key":"10.1016\/j.neuint.2023.105630_bib95","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1123\/pes.2017-0286","article-title":"Pediatric traumatic brain injury and exercise medicine: a narrative review","volume":"31","author":"Sharma","year":"2019","journal-title":"Pediatr. Exerc. Sci."},{"key":"10.1016\/j.neuint.2023.105630_bib96","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1212\/WNL.0b013e3182535d20","article-title":"Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society","volume":"78","author":"Silberstein","year":"2012","journal-title":"Neurology"},{"issue":"iii","key":"10.1016\/j.neuint.2023.105630_bib97","first-page":"1","article-title":"Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: systematic review and economic evaluation","volume":"13","author":"Simpson","year":"2009","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.neuint.2023.105630_bib98","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuroimage.2016.08.038","article-title":"Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans","volume":"146","author":"Sims-Williams","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuint.2023.105630_bib99","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/j.pain.0000000000002719","article-title":"Diffuse noxious inhibitory controls and conditioned pain modulation: a shared neurobiology within the descending pain inhibitory system?","volume":"164","author":"Sirucek","year":"2023","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib100","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/art.40749","article-title":"Central sensitization in knee osteoarthritis: relating presurgical brainstem neuroimaging and PainDETECT-based patient stratification to arthroplasty outcome","volume":"71","author":"Soni","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.neuint.2023.105630_bib101","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/HTR.0000000000000721","article-title":"Scoping review of opioid use after traumatic brain injury","volume":"36","author":"Starosta","year":"2021","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.neuint.2023.105630_bib102","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1586\/ern.12.41","article-title":"Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions","volume":"12","author":"Staud","year":"2012","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neuint.2023.105630_bib103","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jpain.2014.05.003","article-title":"Opioids enhance CXCL1 expression and function after incision in mice","volume":"15","author":"Sun","year":"2014","journal-title":"J. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib104","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/ALN.0b013e31829ce340","article-title":"Epigenetic regulation of spinal CXCR2 signaling in incisional hypersensitivity in mice","volume":"119","author":"Sun","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuint.2023.105630_bib105","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ibror.2019.10.002","article-title":"Aggravating effects of treadmill exercises during the early-onset period in a rat traumatic brain injury model: when should rehabilitation exercises be initiated?","volume":"7","author":"Taguchi","year":"2019","journal-title":"IBRO Rep."},{"key":"10.1016\/j.neuint.2023.105630_bib106","series-title":"Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects, Boca Raton (FL)","article-title":"Translational considerations for behavioral impairment and rehabilitation strategies after diffuse traumatic brain injury","author":"Thomas","year":"2015"},{"issue":"Suppl. 2","key":"10.1016\/j.neuint.2023.105630_bib107","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/head.13082","article-title":"Oxytocin and migraine headache","volume":"57","author":"Tzabazis","year":"2017","journal-title":"Headache"},{"key":"10.1016\/j.neuint.2023.105630_bib108","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0333102415618615","article-title":"Oxytocin receptor: expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders","volume":"36","author":"Tzabazis","year":"2016","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2023.105630_bib109","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s10194-019-1007-y","article-title":"The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse","volume":"20","author":"van Hoogstraten","year":"2019","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib110","first-page":"33","article-title":"A systematic review of the effect of physical exercise on cognition in stroke and traumatic brain injury patients","volume":"40","author":"Vanderbeken","year":"2017","journal-title":"NeuroRehabilitation"},{"key":"10.1016\/j.neuint.2023.105630_bib111","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jpain.2010.12.007","article-title":"Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats","volume":"12","author":"Vera-Portocarrero","year":"2011","journal-title":"J. Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib112","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/j.pain.0000000000001421","article-title":"Divergent influences of the locus coeruleus on migraine pathophysiology","volume":"160","author":"Vila-Pueyo","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib113","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12974-022-02535-6","article-title":"Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2023.105630_bib114","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1526-4610.2001.041007629.x","article-title":"Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness?","volume":"41","author":"Welch","year":"2001","journal-title":"Headache"},{"issue":"8","key":"10.1016\/j.neuint.2023.105630_bib115","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jpain.2023.03.009","article-title":"Persistent changes in mechanical nociception in rats with traumatic brain injury involving polytrauma","volume":"24","author":"Wong","year":"2023","journal-title":"J. Pain."},{"key":"10.1016\/j.neuint.2023.105630_bib116","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00221-021-06249-8","article-title":"The neuroprotection of hyperbaric oxygen therapy against traumatic brain injury via NF-kappaB\/MAPKs-CXCL1 signaling pathways","volume":"240","author":"Xia","year":"2022","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuint.2023.105630_bib117","doi-asserted-by":"crossref","DOI":"10.1177\/17448069221135743","article-title":"CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats","volume":"18","author":"Xu","year":"2022","journal-title":"Mol. Pain"},{"issue":"Suppl. 1","key":"10.1016\/j.neuint.2023.105630_bib118","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1097\/01.j.pain.0000460343.46847.58","article-title":"Role of endogenous pain modulation in chronic pain mechanisms and treatment","volume":"156","author":"Yarnitsky","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib119","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.pain.2012.02.021","article-title":"Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy","volume":"153","author":"Yarnitsky","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci7080093","article-title":"Selective serotonin reuptake inhibitors for treating neurocognitive and neuropsychiatric disorders following traumatic brain injury: an evaluation of current evidence","volume":"7","author":"Yue","year":"2017","journal-title":"Brain Sci."},{"key":"10.1016\/j.neuint.2023.105630_bib121","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.pain.2013.07.002","article-title":"Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons","volume":"154","author":"Zhang","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.neuint.2023.105630_bib122","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1089\/neu.2014.3739","article-title":"Voluntary exercise preconditioning activates multiple antiapoptotic mechanisms and improves neurological recovery after experimental traumatic brain injury","volume":"32","author":"Zhao","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neuint.2023.105630_bib123","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.2174\/1381612821666150831141931","article-title":"Chemokines and their receptors: potential therapeutic targets for bone cancer pain","volume":"21","author":"Zhou","year":"2015","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.neuint.2023.105630_bib124","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/milmed\/usaa391","article-title":"Botulinum toxin type A for the treatment of post-traumatic headache: a randomized, placebo-controlled, cross-over study","volume":"186","author":"Zirovich","year":"2021","journal-title":"Mil. Med."},{"key":"10.1016\/j.neuint.2023.105630_bib125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623001584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018623001584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:04:10Z","timestamp":1759313050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018623001584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":125,"alternative-id":["S0197018623001584"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105630","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms and treatments of chronic pain after traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2023.105630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105630"}}