{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:20:32Z","timestamp":1792858832288,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.neuint.2024.105861","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:20:31Z","timestamp":1726849231000},"page":"105861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation"],"prefix":"10.1016","volume":"180","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5143-0826","authenticated-orcid":false,"given":"Xiuwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.neuint.2024.105861_bib1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/bdra.20610","article-title":"Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: analysis using Hspa1a\/a1b knockout mice","volume":"85","author":"Barrier","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"20","key":"10.1016\/j.neuint.2024.105861_bib2","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1056\/NEJM199911113412001","article-title":"Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative project for neural tube defect prevention","volume":"341","author":"Berry","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuint.2024.105861_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.gene.2018.04.087","article-title":"The expression and function of PAX3 in development and disease","volume":"666","author":"Boudjadi","year":"2018","journal-title":"Gene"},{"issue":"23","key":"10.1016\/j.neuint.2024.105861_bib4","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1093\/hmg\/ddn262","article-title":"Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function","volume":"17","author":"Burren","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib5","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1515\/biol-2022-0504","article-title":"Abnormal methylation caused by folic acid deficiency in neural tube defects","volume":"17","author":"Cao","year":"2022","journal-title":"Open Life Sci."},{"issue":"6","key":"10.1016\/j.neuint.2024.105861_bib6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(00)81732-8","article-title":"Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development","volume":"94","author":"Cecconi","year":"1998","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12958-019-0506-7","article-title":"Downregulation of miR-322 promotes apoptosis of GC-2 cell by targeting Ddx3x","volume":"17","author":"Che","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2","key":"10.1016\/j.neuint.2024.105861_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1242\/dev.104.2.285","article-title":"A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects","volume":"104","author":"Copp","year":"1988","journal-title":"Development"},{"issue":"10","key":"10.1016\/j.neuint.2024.105861_bib9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nrg1181","article-title":"The genetic basis of mammalian neurulation","volume":"4","author":"Copp","year":"2003","journal-title":"Nat. Rev. Genet."},{"issue":"1\u20132","key":"10.1016\/j.neuint.2024.105861_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11010-014-2222-0","article-title":"Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation","volume":"398","author":"Dong","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"7","key":"10.1016\/j.neuint.2024.105861_bib11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/bdra.20286","article-title":"Integrity of the methylation cycle is essential for mammalian neural tube closure","volume":"76","author":"Dunlevy","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"5","key":"10.1016\/j.neuint.2024.105861_bib12","doi-asserted-by":"crossref","first-page":"e1559","DOI":"10.1002\/wsbm.1559","article-title":"Pathogenesis of neural tube defects: the regulation and disruption of cellular processes underlying neural tube closure","volume":"14","author":"Engelhardt","year":"2022","journal-title":"WIREs Mech Dis"},{"issue":"4","key":"10.1016\/j.neuint.2024.105861_bib13","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0092-8674(91)90071-6","article-title":"Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3","volume":"67","author":"Epstein","year":"1991","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.neuint.2024.105861_bib14","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.2337\/diabetes.48.12.2454","article-title":"Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy","volume":"48","author":"Fine","year":"1999","journal-title":"Diabetes"},{"issue":"5372","key":"10.1016\/j.neuint.2024.105861_bib15","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1126\/science.280.5372.2107","article-title":"Embryonic folate metabolism and mouse neural tube defects","volume":"280","author":"Fleming","year":"1998","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.neuint.2024.105861_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/hmg\/9.4.575","article-title":"A genetic risk factor for mouse neural tube defects: defining the embryonic basis","volume":"9","author":"Fleming","year":"2000","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s42003-022-03280-5","article-title":"Excess S-adenosylmethionine inhibits methylation via catabolism to adenine","volume":"5","author":"Fukumoto","year":"2022","journal-title":"Commun. Biol."},{"issue":"5","key":"10.1016\/j.neuint.2024.105861_bib18","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/j.1460-2075.1991.tb08054.x","article-title":"Pax-3, a novel murine DNA binding protein expressed during early neurogenesis","volume":"10","author":"Goulding","year":"1991","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.neuint.2024.105861_bib19","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/ajmg.a.38325","article-title":"Neural tube defects in Waardenburg syndrome: a case report and review of the literature","volume":"173","author":"Hart","year":"2017","journal-title":"Am. J. Med. Genet."},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/jmg.32.1.52","article-title":"A frameshift mutation in the gene for PAX3 in a girl with spina bifida and mild signs of Waardenburg syndrome","volume":"32","author":"Hol","year":"1995","journal-title":"J. Med. Genet."},{"issue":"2","key":"10.1016\/j.neuint.2024.105861_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/15548627.2021.1924038","article-title":"AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner","volume":"18","author":"Huang","year":"2022","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.neuint.2024.105861_bib22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/md19060322","article-title":"Okadaic acid exposure induced neural tube defects in chicken (Gallus gallus) embryos","volume":"19","author":"Jiao","year":"2021","journal-title":"Mar. Drugs"},{"issue":"11","key":"10.1016\/j.neuint.2024.105861_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23455","article-title":"Micronutrient imbalance and common phenotypes in neural tube defects","volume":"59","author":"Kakebeen","year":"2021","journal-title":"Genesis"},{"issue":"5","key":"10.1016\/j.neuint.2024.105861_bib24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/(SICI)1097-4547(19990601)56:5<518::AID-JNR7>3.0.CO;2-8","article-title":"Pax-3 regulates neurogenesis in neural crest-derived precursor cells","volume":"56","author":"Koblar","year":"1999","journal-title":"J. Neurosci. Res."},{"issue":"Pt 3","key":"10.1016\/j.neuint.2024.105861_bib25","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/brain\/115.3.935","article-title":"Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase","volume":"115","author":"Lee","year":"1992","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.neuint.2024.105861_bib26","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1242\/dev.126.11.2495","article-title":"Transgenic rescue of congenital heart disease and spina bifida in Splotch mice","volume":"126","author":"Li","year":"1999","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41538-023-00212-3","article-title":"Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice","volume":"7","author":"Li","year":"2023","journal-title":"NPJ Sci Food"},{"issue":"2","key":"10.1016\/j.neuint.2024.105861_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/cge.13421","article-title":"Linking genetics to epigenetics: the role of folate and folate-related pathways in neurodevelopmental disorders","volume":"95","author":"Lintas","year":"2019","journal-title":"Clin. Genet."},{"issue":"4","key":"10.1016\/j.neuint.2024.105861_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1357-2725(99)00139-9","article-title":"S-Adenosylmethionine","volume":"32","author":"Lu","year":"2000","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.neuint.2024.105861_bib30","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41390-021-01908-6","article-title":"Folate deficiency disturbs PEG10 methylation modifications in human spina bifida","volume":"92","author":"Lu","year":"2022","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.neuint.2024.105861_bib31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4149\/neo_2019_190429N378","article-title":"PAX3 silencing suppresses gastric cancer proliferation and angiogenesis via MET\/PI3K signaling","volume":"67","author":"Lv","year":"2020","journal-title":"Neoplasma"},{"issue":"5","key":"10.1016\/j.neuint.2024.105861_bib32","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2337\/diabetes.50.5.1193","article-title":"Diabetic embryopathy in C57BL\/6J mice. Altered fetal sex ratio and impact of the splotch allele","volume":"50","author":"Machado","year":"2001","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.neuint.2024.105861_bib33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0301-0082(95)00024-P","article-title":"Apoptosis in the developing CNS","volume":"47","author":"Naruse","year":"1995","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.neuint.2024.105861_bib34","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.devcel.2013.11.015","article-title":"Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells","volume":"27","author":"Nonomura","year":"2013","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.neuint.2024.105861_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23445","article-title":"Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities","volume":"59","author":"Palmer","year":"2021","journal-title":"Genesis"},{"issue":"6","key":"10.1016\/j.neuint.2024.105861_bib36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1101\/gad.969302","article-title":"Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis","volume":"16","author":"Pani","year":"2002","journal-title":"Genes Dev."},{"issue":"7","key":"10.1016\/j.neuint.2024.105861_bib37","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2337\/diab.46.7.1189","article-title":"Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis","volume":"46","author":"Phelan","year":"1997","journal-title":"Diabetes"},{"issue":"8760","key":"10.1016\/j.neuint.2024.105861_bib38","first-page":"131","article-title":"MRC Vitamin study Research group","volume":"338","year":"1991","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.neuint.2024.105861_bib39","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1016\/j.celrep.2017.11.092","article-title":"S-adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1","volume":"21","author":"Shima","year":"2017","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.neuint.2024.105861_bib40","doi-asserted-by":"crossref","first-page":"dmm042234","DOI":"10.1242\/dmm.042234","article-title":"Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid","volume":"12","author":"Sudiwala","year":"2019","journal-title":"Dis Model Mech"},{"issue":"2","key":"10.1016\/j.neuint.2024.105861_bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.devbrainres.2003.07.002","article-title":"Region of caspase-3 activation and programmed cell death in the early development of the mouse forebrain","volume":"145","author":"Urase","year":"2003","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuint.2024.105861_bib42","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fcell.2019.00300","article-title":"One-carbon metabolism regulates embryonic stem cell fate through epigenetic DNA and histone modifications: implications for transgenerational metabolic disorders in adults","volume":"7","author":"Van Winkle","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.neuint.2024.105861_bib43","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3945\/ajcn.2009.28858","article-title":"Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects","volume":"91","author":"Wang","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"issue":"8","key":"10.1016\/j.neuint.2024.105861_bib44","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/jat.2901","article-title":"Role of methotrexate exposure in apoptosis and proliferation during early neurulation","volume":"34","author":"Wang","year":"2014","journal-title":"J. Appl. Toxicol."},{"issue":"19","key":"10.1016\/j.neuint.2024.105861_bib45","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1002\/bdr2.1094","article-title":"Apoptosis, expression of PAX3 and P53, and caspase signal in fetuses with neural tube defects","volume":"109","author":"Wang","year":"2017","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.neuint.2024.105861_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.reprotox.2017.12.007","article-title":"Inhibition of thymidylate synthase affects neural tube development in mice","volume":"76","author":"Wang","year":"2018","journal-title":"Reprod. Toxicol."},{"issue":"5","key":"10.1016\/j.neuint.2024.105861_bib47","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41419-018-0563-4","article-title":"Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib48","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1515\/biol-2021-0022","article-title":"miR-299-3p suppresses cell progression and induces apoptosis by downregulating PAX3 in gastric cancer","volume":"16","author":"Wang","year":"2021","journal-title":"Open Life Sci."},{"issue":"4","key":"10.1016\/j.neuint.2024.105861_bib49","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.7150\/thno.69054","article-title":"PPAR-gamma integrates obesity and adipocyte clock through epigenetic regulation of Bmal1","volume":"12","author":"Wang","year":"2022","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.neuint.2024.105861_bib50","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.3390\/ijms24032220","article-title":"Neural tube defects and folate deficiency: is DNA repair defective?","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.neuint.2024.105861_bib51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0960-9822(06)00125-4","article-title":"Is programmed cell death required for neural tube closure?","volume":"7","author":"Weil","year":"1997","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2005.09.008","article-title":"Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients","volume":"213","author":"Wlodarczyk","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.neuint.2024.105861_bib53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2012.07.016","article-title":"From neuroepithelial cells to neurons: changes in the physiological properties of neuroepithelial stem cells","volume":"534","author":"Yamashita","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"issue":"10","key":"10.1016\/j.neuint.2024.105861_bib54","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/cbin.11421","article-title":"PAX3 silencing inhibits prostate cancer progression through the suppression of the TGF-beta\/Smad signaling axis","volume":"44","author":"Zeng","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.neuint.2024.105861_bib55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.nbd.2013.01.014","article-title":"Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects","volume":"54","author":"Zhang","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2024.105861_bib56","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fneur.2020.00242","article-title":"Ethionine suppresses mitochondria autophagy and induces apoptosis via activation of reactive oxygen species in neural tube defects","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.neuint.2024.105861_bib57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13072-021-00426-3","article-title":"Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt\/beta-catenin signaling pathway","volume":"14","author":"Zhang","year":"2021","journal-title":"Epigenet. Chromatin"},{"issue":"2","key":"10.1016\/j.neuint.2024.105861_bib58","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuro.2009.12.011","article-title":"Folic acid and soybean isoflavone combined supplementation protects the post-neural tube closure defects of rodents induced by cyclophosphamide in vivo and in vitro","volume":"31","author":"Zhao","year":"2010","journal-title":"Neurotoxicology"},{"issue":"9","key":"10.1016\/j.neuint.2024.105861_bib59","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jat.2769","article-title":"Influence of the antifolate drug Methotrexate on the development of murine neural tube defects and genomic instability","volume":"33","author":"Zhao","year":"2013","journal-title":"J. Appl. Toxicol."},{"issue":"8","key":"10.1016\/j.neuint.2024.105861_bib60","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1530-0277.2008.00722.x","article-title":"Peptidergic agonists of activity-dependent neurotrophic factor protect against prenatal alcohol-induced neural tube defects and serotonin neuron loss","volume":"32","author":"Zhou","year":"2008","journal-title":"Alcohol Clin. Exp. Res."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018624001888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018624001888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T09:46:39Z","timestamp":1730108799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018624001888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":60,"alternative-id":["S0197018624001888"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2024.105861","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2024.105861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105861"}}