{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:10Z","timestamp":1790974870557,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2017MC052"],"award-info":[{"award-number":["ZR2017MC052"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870985"],"award-info":[{"award-number":["81870985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271432"],"award-info":[{"award-number":["82271432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171142"],"award-info":[{"award-number":["81171142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.neuint.2024.105885","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T14:54:25Z","timestamp":1729349665000},"page":"105885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury"],"prefix":"10.1016","volume":"180","author":[{"given":"Qixuan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2024.105885_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.831062","article-title":"Why has the ability to regenerate following CNS injury been repeatedly lost over the course of evolution?","volume":"16","author":"Blackshaw","year":"2022","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.neuint.2024.105885_bib2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species","volume":"40","author":"Bordt","year":"2017","journal-title":"Dev. Cell"},{"issue":"7859","key":"10.1016\/j.neuint.2024.105885_bib3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/d41586-021-01173-x","article-title":"Revolutionary view of two ways to split a mitochondrion","volume":"593","author":"Chakrabarti","year":"2021","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.neuint.2024.105885_bib4","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/cvr\/cvad171","article-title":"Targeting the apelin system for the treatment of cardiovascular diseases","volume":"119","author":"Chapman","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"352","key":"10.1016\/j.neuint.2024.105885_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf2304","article-title":"Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration","volume":"8","author":"Fan","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.neuint.2024.105885_bib6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal cell death","volume":"98","author":"Fricker","year":"2018","journal-title":"Physiol. Rev."},{"issue":"8","key":"10.1016\/j.neuint.2024.105885_bib7","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00726-021-03028-1","article-title":"Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria","volume":"53","author":"Guan","year":"2021","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.neuint.2024.105885_bib8","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s12035-023-03710-3","article-title":"Spinal cord injury model mitochondria connect altered function with defects of mitochondrion morphology: an ultrastructural study","volume":"61","author":"Hassanzadeh","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2024.105885_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.lfs.2018.03.020","article-title":"Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells","volume":"199","author":"He","year":"2018","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.neuint.2024.105885_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuron.2021.10.007","article-title":"An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury","volume":"110","author":"Hilton","year":"2022","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.neuint.2024.105885_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111535","article-title":"De novo establishment of circuit modules restores locomotion after spinal cord injury in adult zebrafish","volume":"41","author":"Huang","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.neuint.2024.105885_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12989-023-00556-4","article-title":"Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK\/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo","volume":"20","author":"Huang","year":"2023","journal-title":"Part. Fibre Toxicol."},{"issue":"284","key":"10.1016\/j.neuint.2024.105885_bib13","first-page":"124","article-title":"Reactive oxygen species - sources, functions, oxidative damage","volume":"48","author":"Jakubczyk","year":"2020","journal-title":"Pol. Merkur. Lek."},{"issue":"2","key":"10.1016\/j.neuint.2024.105885_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/1874467213666200602133032","article-title":"Apelin\/Apelin receptor system: molecular characteristics, physiological roles, and prospects as a target for disease prevention and pharmacotherapy","volume":"14","author":"Kinjo","year":"2021","journal-title":"Curr. Mol. Pharmacol."},{"issue":"29","key":"10.1016\/j.neuint.2024.105885_bib15","doi-asserted-by":"crossref","first-page":"12066","DOI":"10.1073\/pnas.1300894110","article-title":"MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS","volume":"110","author":"Lee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.neuint.2024.105885_bib16","first-page":"2005","article-title":"Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen Res"},{"issue":"5","key":"10.1016\/j.neuint.2024.105885_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.21037\/atm.2020.02.07","article-title":"Apelin\/Elabela-APJ: a novel therapeutic target in the cardiovascular system","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"4","key":"10.1016\/j.neuint.2024.105885_bib18","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051606","article-title":"OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential","volume":"22","author":"Liu","year":"2021","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.neuint.2024.105885_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12974-022-02518-7","article-title":"Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2024.105885_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157134","article-title":"Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1\/JNK signaling pathway in primary mouse neurons","volume":"844","author":"Liu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.neuint.2024.105885_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174801","article-title":"XMU-MP-1 protects heart from ischemia\/reperfusion injury in mice through modulating Mst1\/AMPK pathway","volume":"919","author":"Liu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neuint.2024.105885_bib22","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41467-022-28844-1","article-title":"Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing","volume":"13","author":"Ma","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2024.105885_bib23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1083\/jcb.201611194","article-title":"A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space","volume":"217","author":"Mattie","year":"2018","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.neuint.2024.105885_bib24","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.1007\/s12035-022-03003-1","article-title":"Antagonism of the muscarinic acetylcholine type 1 receptor enhances mitochondrial membrane potential and expression of respiratory chain components via AMPK in human neuroblastoma SH-SY5Y cells and primary neurons","volume":"59","author":"Naznin","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2024.105885_bib25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2147\/OTT.S193787","article-title":"Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK-Drp1 axis","volume":"12","author":"Ouyang","year":"2019","journal-title":"OncoTargets Ther."},{"issue":"7","key":"10.1016\/j.neuint.2024.105885_bib26","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/nau.10147","article-title":"Urinary bladder hyperreflexia: a rat animal model","volume":"22","author":"Shaker","year":"2003","journal-title":"Neurourol. Urodyn."},{"issue":"2","key":"10.1016\/j.neuint.2024.105885_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10735-018-09809-5","article-title":"Sepsis-related myocardial injury is associated with Mst1 upregulation, mitochondrial dysfunction and the Drp1\/F-actin signaling pathway","volume":"50","author":"Shang","year":"2019","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.neuint.2024.105885_bib28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: oxidative eustress","volume":"11","author":"Sies","year":"2017","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.neuint.2024.105885_bib29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00018-022-04261-x","article-title":"Mitochondrial function in spinal cord injury and regeneration","volume":"79","author":"Slater","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuint.2024.105885_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115909","article-title":"Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK\/GSK3\u03b2(Ser9)\/Nrf2 signaling pathway","volume":"169","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.neuint.2024.105885_bib31","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/jcp.29070","article-title":"Proinflammation effect of Mst1 promotes BV-2 cell death via augmenting Drp1-mediated mitochondrial fragmentation and activating the JNK pathway","volume":"235","author":"Tian","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.neuint.2024.105885_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2021.10.029","article-title":"Central nervous system regeneration","volume":"185","author":"Varadarajan","year":"2022","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.neuint.2024.105885_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11064-021-03448-1","article-title":"Research progress on mechanism of neuroprotective roles of apelin-13 in prevention and treatment of Alzheimer's disease","volume":"47","author":"Wan","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2024.105885_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-018-0085-1","article-title":"Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway","volume":"23","author":"Wang","year":"2018","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.neuint.2024.105885_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108822","article-title":"Apelin\/APJ system in inflammation","volume":"109","author":"Wang","year":"2022","journal-title":"Int. Immunopharm."},{"issue":"4","key":"10.1016\/j.neuint.2024.105885_bib36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3390\/cells9040958","article-title":"PC12 cell line: cell types, coating of culture vessels, differentiation and other culture conditions","volume":"9","author":"Wiatrak","year":"2020","journal-title":"Cells"},{"issue":"18","key":"10.1016\/j.neuint.2024.105885_bib37","doi-asserted-by":"crossref","first-page":"8993","DOI":"10.7150\/thno.62302","article-title":"Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.neuint.2024.105885_bib38","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.3390\/ijms21113994","article-title":"Clinical trials of stem cell treatment for spinal cord injury","volume":"21","author":"Yamazaki","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2024.105885_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6687185","article-title":"Antioxidants targeting mitochondrial oxidative stress: promising neuroprotectants for epilepsy","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.neuint.2024.105885_bib40","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.devcel.2021.02.022","article-title":"Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation","volume":"56","author":"Yang","year":"2021","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.neuint.2024.105885_bib41","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chembiol.2023.02.002","article-title":"Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction","volume":"30","author":"Yang","year":"2023","journal-title":"Cell Chem. Biol."},{"issue":"3","key":"10.1016\/j.neuint.2024.105885_bib42","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chembiol.2023.02.002","article-title":"Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction","volume":"30","author":"Yang","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.neuint.2024.105885_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134948","article-title":"Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosiS","volume":"728","author":"Yin","year":"2020","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.neuint.2024.105885_bib44","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling","volume":"150","author":"Yu","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.neuint.2024.105885_bib45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/jnc.14154","article-title":"Mst-1 deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux","volume":"143","author":"Zhang","year":"2017","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.neuint.2024.105885_bib46","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1159\/000493653","article-title":"Apelin-13 administration protects against LPS-induced acute lung injury by inhibiting NF-\u03baB pathway and NLRP3 inflammasome activation","volume":"49","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"7","key":"10.1016\/j.neuint.2024.105885_bib47","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002159R","article-title":"G protein-coupled receptors can control the Hippo\/YAP pathway through Gq signaling","volume":"35","author":"Zindel","year":"2021","journal-title":"Faseb. J."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018624002122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018624002122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T13:52:16Z","timestamp":1731592336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018624002122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":47,"alternative-id":["S0197018624002122"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2024.105885","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2024.105885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105885"}}