{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:59:40Z","timestamp":1792519180134,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009383","name":"Tzu Chi University","doi-asserted-by":"publisher","award":["TCMRC-P-111007"],"award-info":[{"award-number":["TCMRC-P-111007"]}],"id":[{"id":"10.13039\/100009383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009383","name":"Tzu Chi University","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-075B-002"],"award-info":[{"award-number":["NSTC 112-2314-B-075B-002"]}],"id":[{"id":"10.13039\/100009383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH112-101"],"award-info":[{"award-number":["KSVGH112-101"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.neuint.2024.105926","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:17:39Z","timestamp":1735298259000},"page":"105926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Celecoxib paradoxically induces COX-2 expression and astrocyte activation through the ERK\/JNK\/AP-1 signaling pathway in the cerebral cortex of rats"],"prefix":"10.1016","volume":"183","author":[{"given":"Kai-Che","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-9200","authenticated-orcid":false,"given":"Chia-Ho","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2024.105926_bib1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joca.2008.04.022","article-title":"Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis","volume":"16","author":"Alvarez-Soria","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.neuint.2024.105926_bib2","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s11095-023-03571-4","article-title":"Challenges and opportunities for celecoxib repurposing","volume":"40","author":"B\u0105k","year":"2023","journal-title":"Pharmaceut. Res."},{"key":"10.1016\/j.neuint.2024.105926_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11302-009-9137-3","article-title":"Different properties of P2X 7 receptor in hippocampal and cortical astrocytes","volume":"5","author":"Bianco","year":"2009","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.neuint.2024.105926_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2004-5-9-241","article-title":"The cyclooxygenases","volume":"5","author":"Chandrasekharan","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.neuint.2024.105926_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.canlet.2005.08.026","article-title":"Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor","volume":"239","author":"Chen","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neuint.2024.105926_bib6","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1007\/s10620-009-0828-y","article-title":"Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells","volume":"55","author":"Cho","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.neuint.2024.105926_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2867-12-53","article-title":"Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in vitro and in vivo","volume":"12","author":"Dai","year":"2012","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.neuint.2024.105926_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ijc.10330","article-title":"The MEK\/ERK pathway mediates COX\u20102\u2010selective NSAID\u2010induced apoptosis and induced COX\u20102 protein expression in colorectal carcinoma cells","volume":"99","author":"Elder","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neuint.2024.105926_bib9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2024.105926_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2013.02.041","article-title":"Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats","volume":"240","author":"Fan","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2024.105926_bib11","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1681\/ASN.V10112261","article-title":"NS-398 upregulates constitutive cyclooxygenase-2 expression in the M-1 cortical collecting duct cell line","volume":"10","author":"Ferguson","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.neuint.2024.105926_bib12","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.4049\/jimmunol.174.8.5033","article-title":"Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury","volume":"174","author":"Fukunaga","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.neuint.2024.105926_bib13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neulet.2014.01.018","article-title":"Epidermal growth factor increases the expression of Nestin in rat reactive astrocytes through the Ras\u2013Raf\u2013ERK pathway","volume":"562","author":"Gao","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2024.105926_bib14","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1212\/01.wnl.0000260269.93245.d2","article-title":"Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial","volume":"68","author":"Group","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2024.105926_bib15","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.4049\/jimmunol.1601330","article-title":"The AP-1 transcription factor c-Jun promotes arthritis by regulating cyclooxygenase-2 and arginase-1 expression in macrophages","volume":"198","author":"Hannemann","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.neuint.2024.105926_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/mcne.1998.0731","article-title":"Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system","volume":"13","author":"Hirst","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2024.105926_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108348","article-title":"Protectin DX promotes the inflammatory resolution via activating COX-2\/L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome","volume":"102","author":"Hu","year":"2022","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.neuint.2024.105926_bib18","first-page":"2129","article-title":"MAPK\/ERK signal pathway involved expression of COX-2 and VEGF by IL-1\u03b2 induced in human endometriosis stromal cells in vitro","volume":"6","author":"Huang","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.neuint.2024.105926_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-8-66","article-title":"Enhanced sensitivity of celecoxib in human glioblastoma cells: induction of DNA damage leading to p53-dependent G 1 cell cycle arrest and autophagy","volume":"8","author":"Kang","year":"2009","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.neuint.2024.105926_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2021.577744","article-title":"Salivary GFAP as a potential biomarker for diagnosis of mild cognitive impairment and Alzheimer's disease and its correlation with neuroinflammation and apoptosis","volume":"361","author":"Katsipis","year":"2021","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuint.2024.105926_bib21","first-page":"613","article-title":"Cyclooxygenase-2 expression is induced by celecoxib treatment in lung cancer cells and is transferred to neighbor cells via exosomes","volume":"52","author":"Kim","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.neuint.2024.105926_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/f56711b9-78f1-49ed-9116-872913e98867","article-title":"TNF-\u03b1 induces cytosolic phospholipase A2 expression in human lung epithelial cells via JNK1\/2-and p38 MAPK-dependent AP-1 activation","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2024.105926_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1478-811X-11-8","article-title":"Up-regulation of COX-2\/PGE 2 by endothelin-1 via MAPK-dependent NF-\u03baB pathway in mouse brain microvascular endothelial cells","volume":"11","author":"Lin","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.neuint.2024.105926_bib24","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.3390\/cells9122585","article-title":"Role of HMGB1\/TLR4 axis in ischemia\/reperfusion-impaired extracellular glutamate clearance in primary astrocytes","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neuint.2024.105926_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/ejn.12383","article-title":"Stimulating ERK\/PI3K\/NF\u03baB signaling pathways upon activation of mGluR2\/3 restores OGD\u2010induced impairment in glutamate clearance in astrocytes","volume":"39","author":"Lin","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2024.105926_bib26","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","article-title":"Astrocyte crosstalk in CNS inflammation","volume":"108","author":"Linnerbauer","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2024.105926_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.clpt.2005.11.007","article-title":"Accumulation of celecoxib with a 7\u2010fold higher drug exposure in individuals homozygous for CYP2C9\u2217 3","volume":"79","author":"Lundblad","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.neuint.2024.105926_bib28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuroscience.2017.12.046","article-title":"Celecoxib prevents cognitive impairment and neuroinflammation in soluble amyloid \u03b2-treated rats","volume":"372","author":"Mhillaj","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2024.105926_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s40266-015-0239-z","article-title":"Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer's disease: a systematic review and meta-analysis of treatment effect","volume":"32","author":"Miguel-\u00c1lvarez","year":"2015","journal-title":"Drugs Aging"},{"key":"10.1016\/j.neuint.2024.105926_bib30","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1523\/JNEUROSCI.4531-05.2006","article-title":"Prostaglandin D2-mediated microglia\/astrocyte interaction enhances astrogliosis and demyelination in twitcher","volume":"26","author":"Mohri","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2024.105926_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.703810","article-title":"Diversity of reactive astrogliosis in CNS pathology: heterogeneity or plasticity?","volume":"15","author":"Moulson","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2024.105926_bib32","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1096\/fj.00-0716fje","article-title":"Celecoxib loses its anti\u2010inflammatory efficacy at high doses through activation of NF\u2010\u03baB","volume":"15","author":"Niederberger","year":"2001","journal-title":"Faseb. J."},{"key":"10.1016\/j.neuint.2024.105926_bib33","doi-asserted-by":"crossref","first-page":"28173","DOI":"10.1074\/jbc.M002329200","article-title":"Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase: mediation through different signaling pathways","volume":"275","author":"Paik","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2024.105926_bib34","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.4049\/jimmunol.170.2.1043","article-title":"Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors","volume":"170","author":"Pang","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.neuint.2024.105926_bib35","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuint.2024.105926_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/0192623308329474","article-title":"Pathophysiology of cyclooxygenase inhibition in animal models","volume":"37","author":"Radi","year":"2009","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.neuint.2024.105926_bib37","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.3390\/ijms21093195","article-title":"Limited proteolysis of cyclooxygenase-2 enhances cell proliferation","volume":"21","author":"Saadi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2024.105926_bib38","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/cvr\/cvp400","article-title":"PPAR\u03b3 agonists inhibit angiogenesis by suppressing PKC\u03b1-and CREB-mediated COX-2 expression in the human endothelium","volume":"86","author":"Scoditti","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neuint.2024.105926_bib39","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/glia.23212","article-title":"Reactive astrocyte COX2\u2010PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury","volume":"65","author":"Shiow","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.neuint.2024.105926_bib40","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.4049\/jimmunol.173.3.2011","article-title":"Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-\u03baB activation through inhibition of activation of I\u03baB\u03b1 kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis","volume":"173","author":"Shishodia","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.neuint.2024.105926_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.dmpk.2018.06.001","article-title":"Celecoxib is a substrate of CYP2D6: impact on celecoxib metabolism in individuals with CYP2C9\u2217 3 variants","volume":"33","author":"Siu","year":"2018","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.neuint.2024.105926_bib42","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/neuonc\/not062","article-title":"Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress","volume":"15","author":"Suzuki","year":"2013","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.neuint.2024.105926_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.69","article-title":"Induction of COX-2-PGE2 synthesis by activation of the MAPK\/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia","volume":"6","author":"Xia","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuint.2024.105926_bib44","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1158\/1535-7163.MCT-10-0415","article-title":"Celecoxib can induce vascular endothelial growth factor expression and tumor angiogenesis","volume":"10","author":"Xu","year":"2011","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.neuint.2024.105926_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-019-1487-3","article-title":"TRPV1 mediates astrocyte activation and interleukin-1\u03b2 release induced by hypoxic ischemia (HI)","volume":"16","author":"Yang","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2024.105926_bib46","first-page":"6419","article-title":"Celecoxib and LLW-3-6 reduce survival of human glioma cells independently and synergistically with sulfasalazine","volume":"35","author":"Yerokun","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.neuint.2024.105926_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/etm.2021.10150","article-title":"Chrysoeriol ameliorates COX-2 expression through NF-\u03baB, AP-1 and MAPK regulation via the TLR4\/MyD88 signaling pathway in LPS-stimulated murine macrophages","volume":"22","author":"Yoon","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.neuint.2024.105926_bib48","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20192139","article-title":"Neuromedin B mediates IL-6 and COX-2 expression through NF-\u03baB\/P65 and AP-1\/C-JUN activation in human primary myometrial cells","volume":"39","author":"Zhu","year":"2019","journal-title":"Biosci. Rep."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018624002535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018624002535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:44:04Z","timestamp":1777527844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018624002535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":48,"alternative-id":["S0197018624002535"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2024.105926","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Celecoxib paradoxically induces COX-2 expression and astrocyte activation through the ERK\/JNK\/AP-1 signaling pathway in the cerebral cortex of rats","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2024.105926","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105926"}}