{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:54:32Z","timestamp":1793325272926,"version":"4.5.0"},"reference-count":293,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.neuint.2025.105962","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:57:14Z","timestamp":1741348634000},"page":"105962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Biochemical and medical aspects of vitamin B1 research"],"prefix":"10.1016","volume":"185","author":[{"given":"Alexander F.","family":"Makarchikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Wins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-6789","authenticated-orcid":false,"given":"Lucien","family":"Bettendorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2025.105962_bib1","first-page":"829","article-title":"Mechanisms of non-coenzyme action of thiamine: protein targets and medical significance","volume":"84","author":"Aleshin","year":"2019","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuint.2025.105962_bib2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.biocel.2008.04.005","article-title":"Transketolase: observations in alcohol-related brain damage research","volume":"41","author":"Alexander-Kaufman","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1750-1172-8-83","article-title":"Biotin-responsive basal ganglia disease should be renamed biotin-thiamine-responsive basal ganglia disease: a retrospective review of the clinical, radiological and molecular findings of 18 new cases","volume":"8","author":"Alfadhel","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-0037-1607191","article-title":"SLC19A3 gene defects sorting the phenotype and acronyms: review","volume":"49","author":"Alfadhel","year":"2018","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neuint.2025.105962_bib5","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s13277-013-0784-1","article-title":"The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis","volume":"34","author":"Alho","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0925-4439(95)00024-X","article-title":"Mitochondrial decay in aging","volume":"1271","author":"Ames","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib7","first-page":"1161","article-title":"Pharmacological doses of thiamine benefit patients with the charcot-marie-tooth neuropathy by changing thiamine diphosphate levels and affecting regulation of thiamine-dependent enzymes","volume":"89","author":"Artiukhov","year":"2024","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuint.2025.105962_bib8","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.2147\/NDT.S130078","article-title":"Korsakoff's syndrome: a critical review","volume":"13","author":"Arts","year":"2017","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.neuint.2025.105962_bib9","first-page":"543","article-title":"Nucleotide specificity of rat liver thiamine pyrophosphokinase","volume":"44","author":"Artsukevich","year":"1979","journal-title":"Biokhimiya"},{"key":"10.1016\/j.neuint.2025.105962_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2020.106258","article-title":"Movement disorders associated with thiamine pyrophosphokinase deficiency: intrafamilial variability in the phenotype","volume":"199","author":"Au","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.neuint.2025.105962_bib11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0969-2126(01)00615-3","article-title":"The crystal structure of yeast thiamin pyrophosphokinase","volume":"9","author":"Baker","year":"2001","journal-title":"Structure"},{"key":"10.1016\/j.neuint.2025.105962_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/jn\/89.2.127","article-title":"Tissue and intracellular distribution of radioactive thiamine in normal and thiamine-deficient rats","volume":"89","author":"Balaghi","year":"1966","journal-title":"J. Nutr."},{"key":"10.1016\/j.neuint.2025.105962_bib13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/j.1469-8749.2009.03541.x","article-title":"Pyruvate dehydrogenase complex deficiency: four neurological phenotypes with differing pathogenesis","volume":"52","author":"Barnerias","year":"2010","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.neuint.2025.105962_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176234","article-title":"Harnessing the neuroprotective effect of oral administration of benfotiamine in MPTP induced Parkinson's disease in rats","volume":"962","author":"Bashir","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2025.105962_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/bmc.3544","article-title":"Ion pair liquid chromatography method for the determination of thiamine (vitamin B1) homeostasis","volume":"30","author":"Basiri","year":"2016","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.neuint.2025.105962_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1897208","article-title":"Running after ghosts: are dead bacteria the dark matter of the human gut microbiota?","volume":"13","author":"Bellali","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neuint.2025.105962_bib17","series-title":"Introduction to Nutrition and Metabolism","author":"Bender","year":"2021"},{"key":"10.1016\/j.neuint.2025.105962_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1471-4159.1975.tb07662.x","article-title":"Thiamine phosphate metabolism and possible coenzyme-independent functions of thiamine in brain","volume":"24","author":"Berman","year":"1975","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2025.105962_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411296","article-title":"Synthetic thioesters of thiamine: promising tools for slowing progression of neurodegenerative diseases","volume":"24","author":"Bettendorff","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib20","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3390\/biom11111645","article-title":"Update on thiamine triphosphorylated derivatives and metabolizing enzymatic complexes","volume":"11","author":"Bettendorff","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuint.2025.105962_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0197-0186(94)00123-C","article-title":"Thiamine homeostasis in neuroblastoma cells","volume":"26","author":"Bettendorff","year":"1995","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2025.105962_bib22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0167-4889(94)90019-1","article-title":"The compartmentation of phosphorylated thiamine derivatives in cultured neuroblastoma cells","volume":"1222","author":"Bettendorff","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0378-4347(00)83533-1","article-title":"Determination of thiamine and its phosphate esters in human blood serum at femtomole levels","volume":"382","author":"Bettendorff","year":"1986","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.neuint.2025.105962_bib24","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s11011-014-9509-4","article-title":"Thiamine triphosphate: a ubiquitous molecule in search of a physiological role","volume":"29","author":"Bettendorff","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1471-4159.1996.66010250.x","article-title":"Thiamine, thiamine phosphates, and their metabolizing enzymes in human brain","volume":"66","author":"Bettendorff","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2025.105962_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1471-4159.1987.tb02891.x","article-title":"Thiamine triphosphate and membrane-associated thiamine phosphatases in the electric organ of Electrophorus electricus","volume":"49","author":"Bettendorff","year":"1987","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2025.105962_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0003-2697(91)90505-N","article-title":"Determination of thiamin and its phosphate esters in cultured neurons and astrocytes using an ion-pair reversed-phase high-performance liquid chromatographic method","volume":"198","author":"Bettendorff","year":"1991","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib28","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1111\/febs.12498","article-title":"Thiamine triphosphatase and the CYTH superfamily of proteins","volume":"280","author":"Bettendorff","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.neuint.2025.105962_bib29","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1111\/j.1742-4658.2009.07019.x","article-title":"Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors","volume":"276","author":"Bettendorff","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.neuint.2025.105962_bib30","first-page":"37","article-title":"Thiamine derivatives in excitable tissues: metabolism, deficiency and neurodegenerative diseases","volume":"2","author":"Bettendorff","year":"1999","journal-title":"Recent Res. Devel. Neurochem"},{"key":"10.1016\/j.neuint.2025.105962_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-4889(94)90018-3","article-title":"Subcellular localization and compartmentation of thiamine derivatives in rat brain","volume":"1222","author":"Bettendorff","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nchembio867","article-title":"Discovery of a natural thiamine adenine nucleotide","volume":"3","author":"Bettendorff","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/TACG.S125962","article-title":"Maple syrup urine disease: mechanisms and management","volume":"10","author":"Blackburn","year":"2017","journal-title":"Appl. Clin. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0378-4347(00)84100-6","article-title":"Determination of thiamine and thiamine phosphates in excitable tissues as thiochrome derivatives by reversed-phase high-performance liquid chromatography on octadecyl silica","volume":"307","author":"Bontemps","year":"1984","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.neuint.2025.105962_bib35","first-page":"95","article-title":"Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms","volume":"50","author":"Bottini","year":"2002","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.neuint.2025.105962_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.896263","article-title":"Delayed impact of 2-oxoadipate dehydrogenase inhibition on the rat brain metabolism is linked to protein glutarylation","volume":"9","author":"Boyko","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.neuint.2025.105962_bib37","doi-asserted-by":"crossref","first-page":"13086","DOI":"10.1074\/jbc.M806563200","article-title":"Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex","volume":"284","author":"Brautigam","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib38","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/jcm8070991","article-title":"Utility of whole blood thiamine pyrophosphate evaluation in TPK1-related diseases","volume":"8","author":"Bugiardini","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.neuint.2025.105962_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/jnc.15576","article-title":"Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo","volume":"161","author":"Bunik","year":"2022","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2025.105962_bib40","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/prot.21766","article-title":"Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins","volume":"71","author":"Bunik","year":"2007","journal-title":"Proteins"},{"key":"10.1016\/j.neuint.2025.105962_bib41","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/BF00965326","article-title":"Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase","volume":"11","author":"Butterworth","year":"1986","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib42","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1530-0277.1993.tb05668.x","article-title":"Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome","volume":"17","author":"Butterworth","year":"1993","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0006-8993(00)02933-4","article-title":"Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism","volume":"885","author":"Calingasan","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2025.105962_bib44","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1749-6632.2000.tb06386.x","article-title":"Vascular endothelium is a site of free radical production and inflammation in areas of neuronal loss in thiamine-deficient brain","volume":"903","author":"Calingasan","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib45","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/jnen\/59.3.207","article-title":"Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism","volume":"59","author":"Calingasan","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuint.2025.105962_bib46","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.4c00113","article-title":"Exploring the therapeutic potential of benfotiamine in a sporadic alzheimer\u2019s-like disease rat model: insights into insulin signaling and cognitive function","author":"Cardinali","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuint.2025.105962_bib47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000343109","article-title":"The discovery of thiamin","volume":"61","author":"Carpenter","year":"2012","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.neuint.2025.105962_bib48","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.bbapap.2016.07.001","article-title":"Low molecular weight protein tyrosine phosphatase: multifaceted functions of an evolutionarily conserved enzyme","volume":"1864","author":"Caselli","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib49","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1042\/BST0350876","article-title":"The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids","volume":"35","author":"Casteels","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neuint.2025.105962_bib50","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/jnc.13836","article-title":"Reductions in the mitochondrial enzyme \u03b1-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?","volume":"139","author":"Chen","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2025.105962_bib51","doi-asserted-by":"crossref","first-page":"9983","DOI":"10.1073\/pnas.1314939111","article-title":"OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin","volume":"111","author":"Chen","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2025.105962_bib52","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/136.1.243S","article-title":"Lessons from genetic disorders of branched-chain amino acid metabolism","volume":"136","author":"Chuang","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.neuint.2025.105962_bib53","doi-asserted-by":"crossref","first-page":"36905","DOI":"10.1074\/jbc.C200430200","article-title":"The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase","volume":"277","author":"Chuang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib54","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1749-6632.1982.tb31196.x","article-title":"The enzymatic synthesis of thiamin triphosphate","volume":"378","author":"Cooper","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib55","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00964146","article-title":"The role of thiamine in nervous tissue","volume":"4","author":"Cooper","year":"1979","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib56","first-page":"257","article-title":"Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer","volume":"51","author":"Coy","year":"2005","journal-title":"Clin. Lab."},{"key":"10.1016\/j.neuint.2025.105962_bib57","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/geno.1996.0124","article-title":"Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes","volume":"32","author":"Coy","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.neuint.2025.105962_bib58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41421-022-00508-w","article-title":"Molecular mechanism of substrate recognition by folate transporter SLC19A1","volume":"8","author":"Dang","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.neuint.2025.105962_bib59","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.ajhg.2012.10.006","article-title":"DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria","volume":"91","author":"Danhauser","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib292","first-page":"333","article-title":"Contents in rat tissue of thiamine and its phosphates during dietary thiamine deificiency","volume":"31","author":"De Caro","year":"1961","journal-title":"Int. Z Vitaminforsch"},{"key":"10.1016\/j.neuint.2025.105962_bib60","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1001\/archneurol.2009.293","article-title":"Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations","volume":"67","author":"Debs","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuint.2025.105962_bib61","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1016\/j.bbagen.2013.05.014","article-title":"Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase","volume":"1830","author":"Delvaux","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib62","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12900-018-0099-y","article-title":"The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases","volume":"19","author":"Deshpande","year":"2019","journal-title":"BMC Struct. Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fpsyt.2019.00207","article-title":"Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults","volume":"10","author":"Dhir","year":"2019","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.neuint.2025.105962_bib64","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/10385","article-title":"Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome","volume":"22","author":"Diaz","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib65","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/acer.14843","article-title":"What is the optimum thiamine dose to treat or prevent Wernicke's encephalopathy or Wernicke-Korsakoff syndrome? Results of a randomized controlled trial","volume":"46","author":"Dingwall","year":"2022","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib66","doi-asserted-by":"crossref","first-page":"31925","DOI":"10.1074\/jbc.274.45.31925","article-title":"Cloning of the human thiamine transporter, a member of the folate transporter family","volume":"274","author":"Dutta","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib67","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1042\/bj1051307","article-title":"Organic pyrophosphates as substrates for human alkaline phosphatases","volume":"105","author":"Eaton","year":"1967","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuint.2025.105962_bib68","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1515\/bchm2.1964.338.1-2.286","article-title":"Uber eine ATP:thiaminediphosphat-phosphotransferase \u2014 Aktivit\u00e4t im Nervengewebe","volume":"338","author":"Eckert","year":"1964","journal-title":"Physiol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib69","doi-asserted-by":"crossref","first-page":"12960","DOI":"10.1002\/anie.201205886","article-title":"One hundred years of vitamins-a success story of the natural sciences","volume":"51","author":"Eggersdorfer","year":"2012","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.neuint.2025.105962_bib70","first-page":"385","article-title":"Content of thiamin phosphate esters in mammalian tissues - an extremely high concentration of thiamin triphosphate in pig skeletal muscle","volume":"12","author":"Egi","year":"1986","journal-title":"Biochem. Int."},{"key":"10.1016\/j.neuint.2025.105962_bib71","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1006\/mgme.2000.3112","article-title":"Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes","volume":"71","author":"Eudy","year":"2000","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.neuint.2025.105962_bib72","article-title":"Vitamin B 1 enhancement in the endosperm of rice through thiamine sequestration","volume":"14348","author":"Fitzpatrick","year":"2024","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.neuint.2025.105962_bib73","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/mgme.2001.3241","article-title":"Characterization of a murine high-affinity thiamine transporter, Slc19a2","volume":"74","author":"Fleming","year":"2001","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.neuint.2025.105962_bib74","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/10379","article-title":"The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter","volume":"22","author":"Fleming","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib75","article-title":"Thiamine disulfide derivatives in thiol redox regulation: role of thioredoxin and glutathione systems","author":"Folda","year":"2024","journal-title":"Biofactors"},{"key":"10.1016\/j.neuint.2025.105962_bib76","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1073\/pnas.96.18.10039","article-title":"Purification, molecular cloning, and expression of 2-hydroxyphytanoyl- CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3- methyl-branched fatty acids","volume":"96","author":"Foulon","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuint.2025.105962_bib77","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.bbapap.2011.06.007","article-title":"Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase","volume":"1814","author":"Fraccascia","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2091-8-10","article-title":"Presence of thiamine pyrophosphate in mammalian peroxisomes","volume":"8","author":"Fraccascia","year":"2007","journal-title":"BMC Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib79","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/0148607114565245","article-title":"Thiamin in clinical practice","volume":"39","author":"Frank","year":"2015","journal-title":"JPEN - J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.neuint.2025.105962_bib80","first-page":"66","article-title":"Thiamine pyrophosphokinase deficiency causes a Leigh Disease like phenotype in a sibling pair: identification through whole exome sequencing and management strategies","volume":"1","author":"Fraser","year":"2014","journal-title":"Mol. Genet Metab. Rep."},{"key":"10.1016\/j.neuint.2025.105962_bib81","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1111\/j.1742-4658.2009.07040.x","article-title":"Thiaminylated adenine nucleotides. Chemical synthesis, structural characterization and natural occurrence","volume":"276","author":"Fr\u00e9d\u00e9rich","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.neuint.2025.105962_bib82","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1113\/jphysiol.1911.sp001481","article-title":"On the chemical nature of the substance which cures polyneuritis in birds induced by a diet of polished rice","volume":"43","author":"Funk","year":"1911","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2025.105962_bib83","first-page":"141","article-title":"Metabolic genes in cancer: their roles in tumor progression and clinical implications","volume":"1805","author":"Furuta","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib84","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1468-1331.2010.03153.x","article-title":"EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy","volume":"17","author":"Galvin","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neuint.2025.105962_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013616","article-title":"Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells","volume":"5","author":"Gangolf","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.105962_bib86","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1074\/jbc.M109.054379","article-title":"Thiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chain","volume":"285","author":"Gangolf","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib87","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/dmd.116.073338","article-title":"Interaction of 2,4-diaminopyrimidine-containing drugs including fedratinib and trimethoprim with thiamine transporters","volume":"45","author":"Giacomini","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neuint.2025.105962_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.1033272","article-title":"Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease","volume":"9","author":"Gibson","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.neuint.2025.105962_bib89","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mcn.2012.09.001","article-title":"Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes","volume":"55","author":"Gibson","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2025.105962_bib90","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/srep01071","article-title":"An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate","volume":"3","author":"Gigliobianco","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2025.105962_bib91","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1471-2180-10-148","article-title":"Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress","volume":"10","author":"Gigliobianco","year":"2010","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.neuint.2025.105962_bib92","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/19.6.349","article-title":"Nucleoside diphosphatase and thiamine pyrophosphatase activities in the endoplasmic reticulum and golgi apparatus","volume":"19","author":"Goldfischer","year":"1971","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.neuint.2025.105962_bib93","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/nyas.14569","article-title":"Thiamine deficiency unrelated to alcohol consumption in high-income countries: a literature review","volume":"1498","author":"Gomes","year":"2021","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib94","first-page":"1201","article-title":"Bovine kidney low molecular weight acid phosphatase: FMN-dependent kinetics","volume":"41","author":"Granjeiro","year":"1997","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.neuint.2025.105962_bib95","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.nu.08.070188.002411","article-title":"Thiamin and the brain","volume":"8","author":"Haas","year":"1988","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.neuint.2025.105962_bib96","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s10545-015-9841-9","article-title":"Genetic basis of alpha-aminoadipic and alpha-ketoadipic aciduria","volume":"38","author":"Hagen","year":"2015","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012403","article-title":"The \u03b1-ketoglutarate dehydrogenase complex as a hub of plasticity in neurodegeneration and regeneration","volume":"23","author":"Hansen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib98","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0065-2571(90)90021-S","article-title":"Regulation of the branched-chain alpha-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease","volume":"30","author":"Harris","year":"1990","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.neuint.2025.105962_bib99","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.3390\/molecules27103229","article-title":"Synthesis of mixed dinucleotides by mechanochemistry","volume":"27","author":"Hayat","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2025.105962_bib100","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11011-020-00644-w","article-title":"Region-selective permeability of the blood-brain barrier to \u03b1-aminoisobutyric acid during thiamine deficiency and following its reversal","volume":"36","author":"Hazell","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib101","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/alcalc\/agn120","article-title":"Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation","volume":"44","author":"Hazell","year":"2009","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuint.2025.105962_bib102","first-page":"287","article-title":"Thiamine deprivation produces a liver ATP deficit and metabolic and genomic effects in mice: findings are parallel to those of biotin deficiency and have implications for energy disorders","volume":"9","author":"Hernandez-Vazquez","year":"2016","journal-title":"J. Nutrigenet. Nutrigenomics"},{"key":"10.1016\/j.neuint.2025.105962_bib103","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1074\/jbc.M308172200","article-title":"Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components","volume":"279","author":"Hiromasa","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib104","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1021\/acs.orglett.6b01466","article-title":"Chemoselective dimerization of phosphates","volume":"18","author":"Hofer","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.neuint.2025.105962_bib105","doi-asserted-by":"crossref","DOI":"10.1002\/pld3.258","article-title":"On the nature of thiamine triphosphate in Arabidopsis","volume":"4","author":"Hofmann","year":"2020","journal-title":"Plant Direct"},{"key":"10.1016\/j.neuint.2025.105962_bib106","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0003-2697(79)90345-2","article-title":"Analysis of thiamine and its phosphate esters by high-performance liquid chromatography","volume":"97","author":"Ishii","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib107","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0021-9673(01)83586-X","article-title":"Improved high-performance liquid chromatographic determination of thiamine and its phosphate esters in animal tissues","volume":"450","author":"Iwata","year":"1988","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.neuint.2025.105962_bib108","first-page":"1686","article-title":"[Central nervous system diseases associated with alcoholism]","volume":"46","author":"Iwata","year":"1988","journal-title":"Nippon Rinsho"},{"key":"10.1016\/j.neuint.2025.105962_bib109","first-page":"1390","article-title":"On the isolation of anti-beriberi vitamin","volume":"29","author":"Jansen","year":"1926","journal-title":"Proc. K. Ned. Akad. Wet."},{"key":"10.1016\/j.neuint.2025.105962_bib110","article-title":"Variability and heritability of thiamine pharmacokinetics with focus on OCT1 effects on membrane transport and pharmacokinetics in humans","author":"Jensen","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.neuint.2025.105962_bib111","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/0260106019830847","article-title":"Thiamin deficiency in low- and middle-income countries: disorders, prevalences, previous interventions and current recommendations","volume":"25","author":"Johnson","year":"2019","journal-title":"Nutr. Health"},{"key":"10.1016\/j.neuint.2025.105962_bib112","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-4165(68)90107-4","article-title":"Studies on the physiological functions of thiamine. 3. The phosphorylation of thiamine in brain","volume":"156","author":"Johnson","year":"1968","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib113","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2407-15-2","article-title":"TKTL1 expression in human malign and benign cell lines","volume":"15","author":"K\u00e4mmerer","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neuint.2025.105962_bib114","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11095-013-1144-y","article-title":"Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins","volume":"31","author":"Kato","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib115","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1007\/s11095-014-1608-8","article-title":"Involvement of organic cation transporters in the clearance and milk secretion of thiamine in mice","volume":"32","author":"Kato","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib116","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/ajmg.10529","article-title":"Amish lethal microcephaly: a new metabolic disorder with severe congenital microcephaly and 2-ketoglutaric aciduria","volume":"112","author":"Kelley","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib117","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/1721187a0","article-title":"Thiamine triphosphate in bakers' yeast","volume":"172","author":"Kiessling","year":"1953","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2025.105962_bib118","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jchromb.2019.05.037","article-title":"Development of an IPRP-LC-MS\/MS method to determine the fate of intracellular thiamine in cancer cells","volume":"1124","author":"Kim","year":"2019","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib119","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/34.3.3005391","article-title":"Thiamine monophosphatase: a genuine marker for transganglionic regulation of primary sensory neurons","volume":"34","author":"Knyihar-Csillik","year":"1986","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.neuint.2025.105962_bib120","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.bbapap.2014.06.003","article-title":"Structure and functioning mechanism of transketolase","volume":"1844","author":"Kochetov","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib121","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1124\/pr.118.015578","article-title":"Organic cation transporters in health and disease","volume":"72","author":"Koepsell","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuint.2025.105962_bib122","doi-asserted-by":"crossref","first-page":"39","DOI":"10.15407\/ubj86.06.039","article-title":"Identification of thiamine monophosphate hydrolyzing enzymes in chicken liver","volume":"86","author":"Kolas","year":"2014","journal-title":"Ukr.Biochem.J."},{"key":"10.1016\/j.neuint.2025.105962_bib123","series-title":"Modern Problems of Biochemistry and Molecular Biology","first-page":"233","article-title":"Molecular identification of thiamine monophosphatase","author":"Kolas","year":"2018"},{"key":"10.1016\/j.neuint.2025.105962_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2024.108307","article-title":"Pyruvate dehydrogenase-E1\u03b1 deficiency presenting as generalized dystonia: a genetic diagnosis with important clinical implications","volume":"241","author":"Kowalska","year":"2024","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.neuint.2025.105962_bib125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02080928","article-title":"Neuropathology of thiamine deficiency disorders","volume":"11","author":"Kril","year":"1996","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib126","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/10372","article-title":"Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness","volume":"22","author":"Labay","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib127","doi-asserted-by":"crossref","first-page":"13771","DOI":"10.1074\/jbc.M111241200","article-title":"Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues","volume":"277","author":"Lakaye","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib128","doi-asserted-by":"crossref","first-page":"17142","DOI":"10.1074\/jbc.M313569200","article-title":"Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation","volume":"279","author":"Lakaye","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib129","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02674735","article-title":"Increased cerebral free radical production during thiamine deficiency","volume":"12","author":"Langlais","year":"1997","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib130","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/hmg\/ddaa037","article-title":"DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo","volume":"29","author":"Leandro","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib131","series-title":"Thiamine, Biosynthesis and Function","author":"Leder","year":"1975"},{"key":"10.1016\/j.neuint.2025.105962_bib132","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/cge.13713","article-title":"Genetic heterogeneity in Leigh syndrome: highlighting treatable and novel genetic causes","volume":"97","author":"Lee","year":"2020","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib133","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2012.02.028","article-title":"Thiamine is a substrate of organic cation transporters in Caco-2 cells","volume":"682","author":"Lemos","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2025.105962_bib134","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1038\/s41467-019-10375-x","article-title":"APC\/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2025.105962_bib135","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1021\/acs.molpharmaceut.5b00501","article-title":"Metformin is a substrate and inhibitor of the human thiamine transporter, THTR-2 (SLC19A3)","volume":"12","author":"Liang","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.neuint.2025.105962_bib136","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2002907","article-title":"Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content","volume":"16","author":"Liang","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib137","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13073-023-01258-4","article-title":"Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity","volume":"15","author":"Lin","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.neuint.2025.105962_bib138","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0607661103","article-title":"Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia","volume":"103","author":"Lindhurst","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2025.105962_bib139","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.1074\/jbc.M510951200","article-title":"Pyrithiamine as a substrate for thiamine pyrophosphokinase","volume":"281","author":"Liu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib140","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1046\/j.1471-4159.2003.01888.x","article-title":"Evaluation of blood-brain barrier thiamine efflux using the in situ rat brain perfusion method","volume":"86","author":"Lockman","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2025.105962_bib141","first-page":"188","article-title":"Untersuchungen \u00fcber die Cocarboxylase","volume":"294","author":"Lohmann","year":"1937","journal-title":"Biochem. Z."},{"key":"10.1016\/j.neuint.2025.105962_bib142","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1373\/clinchem.2007.099077","article-title":"Rapid HPLC measurement of thiamine and its phosphate esters in whole blood","volume":"54","author":"Lu","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib143","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/jm200607g","article-title":"Low molecular weight phosphotyrosine protein phosphatases as emerging targets for the design of novel therapeutic agents","volume":"55","author":"Maccari","year":"2012","journal-title":"J. Med. Chem."},{"issue":"1999","key":"10.1016\/j.neuint.2025.105962_bib144","first-page":"26","article-title":"[The rate of molecular evolution of mammalian soluble thiamine triphosphatase]","volume":"81","author":"Makarchikov","year":"2009","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.neuint.2025.105962_bib145","first-page":"75","article-title":"Thiamine triphosphate hydrolysis in non-excitable tissues: purification and properties of thiamine triphosphatase from bovine kidney","volume":"5","author":"Makarchikov","year":"2001","journal-title":"J. Biochem. Mol. Biol. Biophys."},{"key":"10.1016\/j.neuint.2025.105962_bib146","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2091-8-17","article-title":"Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate","volume":"8","author":"Makarchikov","year":"2007","journal-title":"BMC Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib147","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0304-4165(92)90032-P","article-title":"Purification and characterization of thiamine triphosphatase from bovine brain","volume":"1117","author":"Makarchikov","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2022.130086","article-title":"Synthesis, physico-chemical properties and effect of adenosine thiamine triphosphate on vitamin B1 metabolism in the liver of alloxan diabetic rats","volume":"1866","author":"Makarchikov","year":"2022","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.neuint.2025.105962_bib149","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s00018-003-3098-4","article-title":"Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals","volume":"60","author":"Makarchikov","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib150","doi-asserted-by":"crossref","first-page":"52","DOI":"10.15407\/ubj90.04.052","article-title":"Adenosine thiamine triphosphate and adenosine thiamine triphosphate hydrolase activity in animal tissues","volume":"90","author":"Makarchikov","year":"2018","journal-title":"Ukrainian Biochem. J."},{"key":"10.1016\/j.neuint.2025.105962_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2020.04.009","article-title":"Novel p.P298L SURF1 mutation in thiamine deficient Leigh syndrome patients compromises cytochrome c oxidase activity","author":"Mani","year":"2020","journal-title":"Mitochondrion"},{"key":"10.1016\/j.neuint.2025.105962_bib152","article-title":"Impaired thiamine metabolism in amyotrophic lateral sclerosis and its potential treatment with benfotiamine: a case report and a review of the literature","volume":"15","author":"Mann","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.neuint.2025.105962_bib153","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.jbchem.a127064","article-title":"Studies on enzymatic synthesis of cocarboxylase in animal tissue. III. Purification and properties of thiaminokinase from rat liver","volume":"47","author":"Mano","year":"1960","journal-title":"J. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib154","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jimd.12125","article-title":"Genetic defects of thiamine transport and metabolism: a review of clinical phenotypes, genetics, and functional studies","volume":"42","author":"Marc\u00e9-Grau","year":"2019","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib155","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ana.410390507","article-title":"Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease","volume":"39","author":"Mastrogiacomo","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2025.105962_bib156","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ajhg.2011.11.007","article-title":"Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway","volume":"89","author":"Mayr","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib157","series-title":"Thiamine Deficiency and Associated Clinical Disorders","author":"McCandless","year":"2010"},{"key":"10.1016\/j.neuint.2025.105962_bib158","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/apt.16465","article-title":"Review article: the aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies","volume":"54","author":"McGing","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.neuint.2025.105962_bib159","first-page":"413","volume":"vol. 25","author":"Menon","year":"2024"},{"key":"10.1016\/j.neuint.2025.105962_bib160","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbadis.2012.12.004","article-title":"Is transketolase-like protein, TKTL1, transketolase?","volume":"1832","author":"Meshalkina","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib161","doi-asserted-by":"crossref","DOI":"10.1124\/dmd.120.000170","article-title":"Differences in metformin and thiamine uptake between human and mouse organic cation transporter OCT1:structural determinants and potential consequences for intrahepatic concentrations","author":"Meyer","year":"2020","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.neuint.2025.105962_bib162","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.bbalip.2017.06.004","article-title":"Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase","volume":"1862","author":"Mezzar","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib163","doi-asserted-by":"crossref","first-page":"31559","DOI":"10.1074\/jbc.M110.149955","article-title":"The crystal structure of human transketolase and new insights into its mode of action","volume":"285","author":"Mitschke","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102161","article-title":"Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3","volume":"298","author":"Miyake","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib165","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/oxfordjournals.jbchem.a123192","article-title":"Evidence for in vivo synthesis of thiamin triphosphate by cytosolic adenylate kinase in chicken skeletal muscle","volume":"108","author":"Miyoshi","year":"1990","journal-title":"J. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib166","doi-asserted-by":"crossref","DOI":"10.1038\/srep12583","article-title":"Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis","volume":"5","author":"Mkrtchyan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2025.105962_bib167","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25235492","article-title":"Synthesis of 5\u2019-thiamine-capped RNA","volume":"25","author":"M\u00f6hler","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2025.105962_bib168","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/labmed\/lmac040","article-title":"Whole-exome sequencing revealed a pathogenic nonsense variant in the SLC19A2 gene in an Iranian family with thiamine-responsive megaloblastic anemia","volume":"53","author":"Mohsen-Pour","year":"2022","journal-title":"Lab. Med."},{"key":"10.1016\/j.neuint.2025.105962_bib169","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/0016-5085(92)90043-X","article-title":"Thiamine transport by basolateral rat liver plasma membrane vesicles","volume":"103","author":"Moseley","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuint.2025.105962_bib170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-510X(99)00055-6","article-title":"Dynamic changes in glucose metabolism induced by thiamine deficiency and its replenishment as revealed by a positron autoradiography technique using rat living brain slices","volume":"164","author":"Murata","year":"1999","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib171","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1074\/jbc.M113.528257","article-title":"Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter","volume":"289","author":"Nabokina","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib172","doi-asserted-by":"crossref","first-page":"G389","DOI":"10.1152\/ajpgi.00151.2012","article-title":"A high-affinity and specific carrier-mediated mechanism for uptake of thiamine pyrophosphate by human colonic epithelial cells","volume":"303","author":"Nabokina","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.neuint.2025.105962_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2021.129889","article-title":"Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: implications for the overall hKGDHc structure","volume":"1865","author":"Nagy","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.neuint.2025.105962_bib174","doi-asserted-by":"crossref","first-page":"R985","DOI":"10.1152\/ajpregu.00537.2001","article-title":"Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice","volume":"282","author":"Navarro","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuint.2025.105962_bib175","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2017.11.018","article-title":"The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species","volume":"115","author":"Nemeria","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2025.105962_bib176","doi-asserted-by":"crossref","first-page":"8213","DOI":"10.3390\/ijms23158213","article-title":"Functional versatility of the human 2-oxoadipate dehydrogenase in the L-lysine degradation pathway toward its non-cognate substrate 2-oxopimelic acid","volume":"23","author":"Nemeria","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib177","doi-asserted-by":"crossref","first-page":"11871","DOI":"10.1016\/S0021-9258(17)44313-4","article-title":"Enzyme system involved in the synthesis of thiamin triphosphate. I. Purification and characterization of protein-bound thiamin diphosphate: ATP phosphoryltransferase","volume":"258","author":"Nishino","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib178","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.1038\/s41467-024-51939-w","article-title":"Phospholipid scrambling induced by an ion channel\/metabolite transporter complex","volume":"15","author":"Niu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2025.105962_bib179","doi-asserted-by":"crossref","first-page":"34129","DOI":"10.1074\/jbc.274.48.34129","article-title":"Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA","volume":"274","author":"Nosaka","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib180","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/alcalc\/agac032","article-title":"SLC19A1 genetic variation leads to altered thiamine diphosphate transport: implications for the risk of developing wernicke-korsakoff\u2019s syndrome","volume":"57","author":"O'Brien","year":"2022","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuint.2025.105962_bib181","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1749-6632.1982.tb31197.x","article-title":"Recent findings on ultracytochemistry of thiamin phosphatases","volume":"378","author":"Ogawa","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib182","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1432-1033.1980.tb04992.x","article-title":"Purification and characterization of nucleoside diphosphatase from rat-liver microsomes. Evidence for metalloenzyme and glycoprotein","volume":"112","author":"Ohkubo","year":"1980","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib183","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/mgme.2001.3184","article-title":"Slc19a2: cloning and characterization of the murine thiamin transporter cDNA and genomic sequence, the orthologue of the human TRMA gene","volume":"73","author":"Oishi","year":"2001","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.neuint.2025.105962_bib184","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3177\/jnsv.49.156","article-title":"Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase","volume":"49","author":"Onozuka","year":"2003","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.neuint.2025.105962_bib185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.117482","article-title":"Wernicke-Korsakoff syndrome despite no alcohol abuse: a summary of systematic reports","volume":"426","author":"Oudman","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib293","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1079\/BJN19890027","article-title":"Brain glutamate and gamma-aminobutyrate (GABA) metabolism in thiamine-deficient rats","volume":"62","author":"Page","year":"1989","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.neuint.2025.105962_bib186","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3390\/biom10040655","article-title":"Diseases caused by mutations in mitochondrial carrier genes SLC25: a review","volume":"10","author":"Palmieri","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuint.2025.105962_bib187","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/brain\/awq069","article-title":"Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein\/presenilin-1 transgenic mice","volume":"133","author":"Pan","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2025.105962_bib188","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1017\/S0007114518001666","article-title":"Thiamine status, metabolism and application in dairy cows: a review","volume":"120","author":"Pan","year":"2018","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.neuint.2025.105962_bib189","article-title":"Enhanced activities of blood thiamine diphosphatase and monophosphatase in Alzheimer's disease","volume":"12","author":"Pan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.105962_bib190","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.3390\/nu14102078","article-title":"Dietary vitamin B1 intake influences gut microbial community and the consequent production of short-chain fatty acids","volume":"14","author":"Park","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.neuint.2025.105962_bib191","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0047-6374(01)00336-0","article-title":"Co-culture with astrocytes or microglia protects metabolically impaired neurons","volume":"123","author":"Park","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neuint.2025.105962_bib192","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1021\/bi4015743","article-title":"Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies","volume":"53","author":"Patel","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuint.2025.105962_bib193","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ymgme.2011.09.032","article-title":"The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients","volume":"105","author":"Patel","year":"2012","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.neuint.2025.105962_bib194","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BST0340217","article-title":"Regulation of the pyruvate dehydrogenase complex","volume":"34","author":"Patel","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neuint.2025.105962_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2021.129980","article-title":"Thiamine deficiency in rats affects thiamine metabolism possibly through the formation of oxidized thiamine pyrophosphate","author":"Pavlova","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.neuint.2025.105962_bib196","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/osp4.541","article-title":"Human adipose tissue gene expression of solute carrier family 19 member 3 (SLC19A3); relation to obesity and weight\u2010loss","volume":"8","author":"Pereira","year":"2021","journal-title":"Obes. Sci. Pract."},{"key":"10.1016\/j.neuint.2025.105962_bib197","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0140-6736(01)28025-8","article-title":"The biochemical lesion in vitamin B1 deficiency. Application of modern biochemical analysis in its diagnosis","volume":"1","author":"Peters","year":"1936","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2025.105962_bib198","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0005-2744(75)90127-8","article-title":"Partial purification and properties of thiamine pyrophosphokinase from pig brain","volume":"397","author":"Peterson","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2022.102441","article-title":"Frontiers in the enzymology of thiamin diphosphate-dependent enzymes","volume":"76","author":"Prajapati","year":"2022","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113986","article-title":"In FUS[1\u2212359]\u2010tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome","volume":"156","author":"Probert","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neuint.2025.105962_bib201","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1158\/0008-5472.CAN-07-1651","article-title":"Prostatic acid phosphatase is not a prostate specific target","volume":"67","author":"Quintero","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuint.2025.105962_bib202","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0925-4439(01)00073-4","article-title":"SLC19A3 encodes a second thiamine transporter ThTr2","volume":"1537","author":"Rajgopal","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105799","article-title":"Alzheimer's disease is associated with disruption in thiamin transport physiology: a potential role for neuroinflammation","volume":"171","author":"Ramamoorthy","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib204","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00018-002-8481-z","article-title":"Low molecular weight protein tyrosine phosphatases: small, but smart","volume":"59","author":"Raugei","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib205","doi-asserted-by":"crossref","first-page":"38329","DOI":"10.1074\/jbc.R100026200","article-title":"A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes","volume":"276","author":"Reed","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib206","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1053\/j.gastro.2009.10.042","article-title":"Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice","volume":"138","author":"Reidling","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuint.2025.105962_bib207","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0006-8993(84)91240-X","article-title":"Nervous tissue thiamine metabolism in vivo. II. Thiamine and its phosphoesters dynamics in different brain regions and sciatic nerve of the rat","volume":"293","author":"Rindi","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2025.105962_bib208","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/jn\/94.4.447","article-title":"Thiamine monophosphate, a normal constituent of rat plasma","volume":"94","author":"Rindi","year":"1968","journal-title":"J. Nutr."},{"key":"10.1016\/j.neuint.2025.105962_bib209","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-8993(80)90619-8","article-title":"Thiamine content and turnover rates of some rat nervous regions, using labeled thiamine as a tracer","volume":"181","author":"Rindi","year":"1980","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2025.105962_bib210","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/BF01971788","article-title":"Monophosphate, the only phosphoric ester of thiamin in the cerebro-spinal fluid","volume":"37","author":"Rindi","year":"1981","journal-title":"Experientia"},{"key":"10.1016\/j.neuint.2025.105962_bib211","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1126\/science.116.3026.711","article-title":"On the presence of the triphosphothiamine (TPT) in the liver","volume":"116","author":"Rossi-Fanelli","year":"1952","journal-title":"Science"},{"key":"10.1016\/j.neuint.2025.105962_bib212","article-title":"Identification of novel mutations in TPK1 and SLC19A3 genes in families exhibiting thiamine metabolism dysfunction syndrome","volume":"10","author":"Rostami","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.neuint.2025.105962_bib213","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1055\/s-0040-1715628","article-title":"Thiamine pyrophosphokinase deficiency due to mutations in the TPK1 gene: a rare, treatable neurodegenerative disorder","volume":"52","author":"R\u00fcsch","year":"2021","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neuint.2025.105962_bib214","doi-asserted-by":"crossref","first-page":"G36","DOI":"10.1152\/ajpgi.00065.2024","article-title":"Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology","volume":"327","author":"Sabui","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.neuint.2025.105962_bib215","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.adh2771","article-title":"Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis","volume":"383","author":"Sahu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.neuint.2025.105962_bib216","doi-asserted-by":"crossref","first-page":"G491","DOI":"10.1152\/ajpgi.00361.2003","article-title":"Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine","volume":"286","author":"Said","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.neuint.2025.105962_bib217","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0005-2736(02)00606-5","article-title":"Cellular and molecular aspects of thiamin uptake by human liver cells: studies with cultured HepG2 cells","volume":"1567","author":"Said","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib218","series-title":"GeneReviews\u00ae [Internet]","article-title":"Thiamine-responsive megaloblastic anemia syndrome","author":"Sako","year":"2022"},{"key":"10.1016\/j.neuint.2025.105962_bib219","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3390\/biomedicines8090361","article-title":"Dibenzoylthiamine has powerful antioxidant and anti-inflammatory properties in cultured cells and in mouse models of stress and neurodegeneration","volume":"8","author":"Sambon","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.neuint.2025.105962_bib220","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01710","article-title":"Thiamine and benfotiamine protect neuroblastoma cells against paraquat and \u03b2-amyloid toxicity by a coenzyme-independent mechanism","volume":"5","author":"Sambon","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.neuint.2025.105962_bib221","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2021.130071","article-title":"Product inhibition of mammalian thiamine pyrophosphokinase is an important mechanism for maintaining thiamine diphosphate homeostasis","volume":"1866","author":"Sambon","year":"2022","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.neuint.2025.105962_bib222","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MCD.0000000000000411","article-title":"Clinical and genetic studies of thiamine metabolism dysfunction syndrome-4: case series and review of the literature","volume":"31","author":"Samur","year":"2022","journal-title":"Clin. Dysmorphol."},{"key":"10.1016\/j.neuint.2025.105962_bib223","author":"Sang"},{"key":"10.1016\/j.neuint.2025.105962_bib224","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0006-291X(84)91099-4","article-title":"Thiamine pyrophosphatase and nucleoside diphosphatase in rat brain","volume":"118","author":"Sano","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2025.105962_bib225","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/oxfordjournals.jbchem.a122328","article-title":"Thiamine pyrophosphatase (nucleoside diphosphatase) in the Golgi apparatus is distinct from microsomal nucleoside diphosphatase","volume":"103","author":"Sano","year":"1988","journal-title":"J. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib226","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neuro.2016.10.014","article-title":"Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat","volume":"57","author":"Sarkar","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuint.2025.105962_bib227","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/jmg.37.9.669","article-title":"A novel mutation in the thiamine responsive megaloblastic anaemia gene SLC19A2 in a patient with deficiency of respiratory chain complex I","volume":"37","author":"Scharfe","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib228","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S1357-2725(98)00095-8","article-title":"Properties and functions of the thiamin diphosphate dependent enzyme transketolase","volume":"30","author":"Schenk","year":"1998","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib229","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048321","article-title":"A \u03b438 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity","volume":"7","author":"Schneider","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.105962_bib230","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/BF00965993","article-title":"Studies on ATP: thiamine diphosphate phosphotransferase activity in rat brain","volume":"3","author":"Schrijver","year":"1978","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib231","author":"Sherrill"},{"key":"10.1016\/j.neuint.2025.105962_bib232","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0304-4165(91)90007-4","article-title":"Properties of thiamin triphosphate-synthesizing activity of chicken cytosolic adenylate kinase and the effect of adenine nucleotides","volume":"1115","author":"Shioda","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib233","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.clpt.6100275","article-title":"Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics","volume":"83","author":"Shu","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.neuint.2025.105962_bib234","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/ajmg.a.33373","article-title":"Amish microcephaly: long-term survival and biochemical characterization","volume":"152A","author":"Siu","year":"2010","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib235","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/8755122520962859","article-title":"Thiamine dosing for the treatment of alcohol-induced Wernicke's encephalopathy: a review of the literature","volume":"37","author":"Smith","year":"2021","journal-title":"J. Pharm. Technol."},{"key":"10.1016\/j.neuint.2025.105962_bib236","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1074\/jbc.M709675200","article-title":"Structural basis for the catalytic mechanism of mammalian 25-kDa thiamine triphosphatase","volume":"283","author":"Song","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib237","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10545-014-9787-3","article-title":"The spectrum of pyruvate oxidation defects in the diagnosis of mitochondrial disorders","volume":"38","author":"Sperl","year":"2015","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.neuint.2025.105962_bib238","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/0884533611426149","article-title":"Thiamine in nutrition therapy","volume":"27","author":"Sriram","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.neuint.2025.105962_bib239","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073503","article-title":"Mitochondrial uptake of thiamin pyrophosphate: physiological and cell biological aspects","volume":"8","author":"Subramanian","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.105962_bib240","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-3-031-58843-3_13","article-title":"Mitochondrial alpha-keto acid dehydrogenase complexes: recent developments on structure and function in health and disease","volume":"104","author":"Szabo","year":"2024","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib241","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbagen.2005.05.026","article-title":"Pig tissues express a catalytically inefficient 25-kDa thiamine triphosphatase: insight in the catalytic mechanisms of this enzyme","volume":"1725","author":"Szyniarowski","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.105962_bib242","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ejpn.2015.05.008","article-title":"Treatment of biotin-responsive basal ganglia disease: open comparative study between the combination of biotin plus thiamine versus thiamine alone","volume":"19","author":"Tabarki","year":"2015","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.neuint.2025.105962_bib243","series-title":"GeneReviews\u00ae [Internet]","article-title":"Biotin-thiamine-responsive basal ganglia disease","author":"Tabarki","year":"2020"},{"key":"10.1016\/j.neuint.2025.105962_bib244","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3177\/jnsv.57.192","article-title":"Adenosine thiamine triphosphate (AThTP) inhibits poly(ADP-ribose) polymerase-1 (PARP-1) activity","volume":"57","author":"Tanaka","year":"2011","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.neuint.2025.105962_bib245","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.3390\/antiox12061282","article-title":"Therapeutic potential of heterocyclic compounds targeting mitochondrial calcium homeostasis and signaling in Alzheimer's disease and Parkinson's disease","volume":"12","author":"Tapias","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.neuint.2025.105962_bib246","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1093\/hmg\/ddy201","article-title":"Benfotiamine treatment activates the Nrf2\/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy","volume":"27","author":"Tapias","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib247","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1002\/ajmg.a.63376","article-title":"Thiamine metabolism dysfunction syndrome 5 (THMD5) mimicking acute disseminated encephalomyelitis","volume":"191","author":"Thompson","year":"2023","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib248","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.2001.4727","article-title":"Crystal structure of thiamin pyrophosphokinase","volume":"310","author":"Timm","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib249","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1098\/rstb.2005.1764","article-title":"Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress","volume":"360","author":"Tretter","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib250","first-page":"304","article-title":"[2-Oxoglutarate dehydrogenase complex and its multipoint control]","volume":"57","author":"Tylicki","year":"2011","journal-title":"Postepy Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib251","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2022.103785","article-title":"Thiamine insufficiency induces Hypoxia Inducible Factor-1\u03b1 as an upstream mediator for neurotoxicity and AD-like pathology","volume":"123","author":"Valle","year":"2022","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2025.105962_bib252","first-page":"735","article-title":"Acide thiamine-triphosphorique","volume":"226","author":"Velluz","year":"1948","journal-title":"C. R. Acad. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib253","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/bpa.12188","article-title":"Thiamine deficiency-mediated brain mitochondrial pathology in alaskan huskies with mutation in SLC19A3.1","volume":"25","author":"Vernau","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neuint.2025.105962_bib254","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1021\/acs.analchem.9b05717","article-title":"The first comprehensive LC-MS\/MS method allowing dissection of the thiamine pathway in plants","volume":"92","author":"Verstraete","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib255","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.nlm.2011.01.003","article-title":"Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment","volume":"96","author":"Vetreno","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuint.2025.105962_bib256","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mcn.2017.05.005","article-title":"Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels","volume":"82","author":"Vignisse","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2025.105962_bib257","series-title":"Stress and Pathology","author":"Vinogradov","year":"2007"},{"key":"10.1016\/j.neuint.2025.105962_bib258","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2210-8-10","article-title":"Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives","volume":"8","author":"Volvert","year":"2008","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.neuint.2025.105962_bib259","series-title":"Biosynthesis, Degradation and Transport of Thiamine Phosphate Esters","author":"Voskoboev","year":"1987"},{"key":"10.1016\/j.neuint.2025.105962_bib260","first-page":"1421","article-title":"Biosynthesis of thiamine triphosphate and identification of thiamine diphosphate-binding protein of rat liver hyaloplasm","volume":"50","author":"Voskoboev","year":"1985","journal-title":"Biokhimiya"},{"key":"10.1016\/j.neuint.2025.105962_bib261","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.1982.tb31195.x","article-title":"Thiamin pyrophosphokinase: structure, properties, and role in thiamin metabolism","volume":"378","author":"Voskoboyev","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib262","first-page":"93","article-title":"[Relative reactivity of thiamine monophosphate and thiamine diphosphate upon interaction with alkaline phosphatase]","volume":"74","author":"Vovk","year":"2002","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.neuint.2025.105962_bib263","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/path.4594","article-title":"Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy","volume":"237","author":"Wade","year":"2015","journal-title":"J. Pathol."},{"key":"10.1016\/j.neuint.2025.105962_bib264","article-title":"Knock-out of DHTKD1 alters mitochondrial respiration and function, and may represent a novel pathway in cardiometabolic disease risk","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.neuint.2025.105962_bib265","first-page":"1","article-title":"High thiamine diphosphate level as a protective factor for Alzheimer's disease","author":"Wang","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neuint.2025.105962_bib266","article-title":"Benfotiamine protects MPTP-induced Parkinson's disease mouse model via activating Nrf2 signaling pathway","volume":"19","author":"Wang","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.105962_bib267","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102669","article-title":"Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death","volume":"62","author":"Weidinger","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.neuint.2025.105962_bib268","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nyas.13919","article-title":"Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs","volume":"1430","author":"Whitfield","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2025.105962_bib269","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.87.2269.559","article-title":"The chemistry and biological significance of thiamin","volume":"87","author":"Williams","year":"1938","journal-title":"Science"},{"key":"10.1016\/j.neuint.2025.105962_bib270","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1021\/ja01299a505","article-title":"Synthesis of vitamin B1","volume":"58","author":"Williams","year":"1936","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.neuint.2025.105962_bib271","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3390\/biomedicines11041153","article-title":"Physiological associations between vitamin B deficiency and diabetic kidney disease","volume":"11","author":"Wu","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.neuint.2025.105962_bib272","doi-asserted-by":"crossref","first-page":"9178","DOI":"10.1074\/jbc.M111.314963","article-title":"Structural and biochemical characterization of human mitochondrial branched-chain \u03b1-ketoacid dehydrogenase phosphatase","volume":"287","author":"Wynn","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib273","doi-asserted-by":"crossref","DOI":"10.1097\/WNR.0000000000002094","article-title":"Low expression of thiamine pyrophosphokinase-1 contributes to brain susceptibility to thiamine deficiency","author":"Xia","year":"2024","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2025.105962_bib274","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.ajhg.2012.09.018","article-title":"A nonsense mutation in DHTKD1 causes charcot-marie-tooth disease type 2 in a large Chinese pedigree","volume":"91","author":"Xu","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib275","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.013610","article-title":"pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: implications for absorption in acidic microclimates","author":"Yamashiro","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib276","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmpk.2022.100456","article-title":"Animal species differences in the pyridoxine transport function of SLC19A3: absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine","volume":"44","author":"Yamashiro","year":"2022","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.neuint.2025.105962_bib277","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1016\/S0021-9258(18)93362-4","article-title":"Allosteric properties of nucleoside diphosphatase and its identity with thiamine pyrophosphatase","volume":"243","author":"Yamazaki","year":"1968","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib278","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000185506","article-title":"Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation","volume":"22","author":"Zambuzzi","year":"2008","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.neuint.2025.105962_bib279","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn4582","article-title":"Stoichiometry and architecture of the human pyruvate dehydrogenase complex","volume":"10","author":"Zdanowicz","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuint.2025.105962_bib280","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1086\/431216","article-title":"Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3","volume":"77","author":"Zeng","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuint.2025.105962_bib281","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1038\/s41467-023-42086-9","article-title":"Structural basis of promiscuous substrate transport by Organic Cation Transporter 1","volume":"14","author":"Zeng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2025.105962_bib282","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jacc.2014.01.007","article-title":"Genetic implication of a novel thiamine transporter in human hypertension","volume":"63","author":"Zhang","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.neuint.2025.105962_bib283","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1038\/s41467-024-52792-7","article-title":"Molecular architecture of the mammalian 2-oxoglutarate dehydrogenase complex","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2025.105962_bib284","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1173787","article-title":"Thiamine pyrophosphokinase deficiency: report of two Chinese cases and a literature review","volume":"11","author":"Zhao","year":"2023","journal-title":"Front Pediatr"},{"key":"10.1016\/j.neuint.2025.105962_bib285","doi-asserted-by":"crossref","first-page":"C1512","DOI":"10.1152\/ajpcell.00547.2001","article-title":"Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells","volume":"282","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neuint.2025.105962_bib286","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1074\/jbc.M007919200","article-title":"Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells","volume":"276","author":"Zhao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105962_bib287","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.mam.2012.07.006","article-title":"Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors","volume":"34","author":"Zhao","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.neuint.2025.105962_bib288","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11302-009-9157-z","article-title":"Prostatic acid phosphatase, a neglected ectonucleotidase","volume":"5","author":"Zimmermann","year":"2009","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.neuint.2025.105962_bib289","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11302-012-9309-4","article-title":"Cellular function and molecular structure of ecto-nucleotidases","volume":"8","author":"Zimmermann","year":"2012","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.neuint.2025.105962_bib290","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13028-014-0072-0","article-title":"Interstitial lactate, lactate\/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia","volume":"56","author":"Zoremba","year":"2014","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.neuint.2025.105962_bib291","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuron.2008.08.024","article-title":"Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine","volume":"60","author":"Zylka","year":"2008","journal-title":"Neuron"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701862500035X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701862500035X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:27:14Z","timestamp":1777642034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019701862500035X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":293,"alternative-id":["S019701862500035X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2025.105962","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biochemical and medical aspects of vitamin B1 research","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2025.105962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105962"}}