{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:41:32Z","timestamp":1778643692056,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.neuint.2025.105989","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T19:09:06Z","timestamp":1746558546000},"page":"105989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The effect of Fibulin-5 on early brain injury after subarachnoid hemorrhage in mice"],"prefix":"10.1016","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-395X","authenticated-orcid":false,"given":"Yume","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Nampei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Oinaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2025.105989_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/104454904323145254","article-title":"Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells","volume":"23","author":"Albig","year":"2004","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.neuint.2025.105989_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.31083\/j.jin2102062","article-title":"Osteopontin in post-subarachnoid hemorrhage pathologies","volume":"21","author":"Asada","year":"2022","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.neuint.2025.105989_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0300-9084(99)80076-5","article-title":"Induction of apoptosis in porcine thyroid follicles by transforming growth factor beta1 and epidermal growth factor","volume":"81","author":"Bechtner","year":"1999","journal-title":"Biochimie"},{"key":"10.1016\/j.neuint.2025.105989_bib4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ceb.2003.10.009","article-title":"Mechanisms of caspase activation","volume":"15","author":"Boatright","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neuint.2025.105989_bib5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.jcbfm.9600283","article-title":"Mechanisms of early brain injury after subarachnoid hemorrhage","volume":"26","author":"Cahill","year":"2006","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuint.2025.105989_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2025.105989_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41983-020-00264-2","article-title":"Ischemia-modified albumin and fibulin-5 as diagnostic and prognostic markers for acute cerebrovascular disease","volume":"57","author":"Elshony","year":"2021","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"10.1016\/j.neuint.2025.105989_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/excr.1996.0014","article-title":"Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice","volume":"222","author":"F\u00e4ssler","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.neuint.2025.105989_bib9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/physrev.00008.2011","article-title":"Matricellular proteins in cardiac adaptation and disease","volume":"92","author":"Frangogiannis","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuint.2025.105989_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-0674(99)80028-3","article-title":"Organization and regulation of mitogen-activated protein kinase signaling pathways","volume":"11","author":"Garrington","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neuint.2025.105989_bib11","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1007\/s12035-015-9222-2","article-title":"Overexpression of fibulin-5 attenuates ischemia\/reperfusion injury after middle cerebral artery occlusion in rats","volume":"53","author":"Guo","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2025.105989_bib12","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/ene.13013","article-title":"Fibulin\u20105: a novel biomarker for evaluating severity and predicting prognosis in patients with acute intracerebral haemorrhage","volume":"23","author":"Hu","year":"2016","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neuint.2025.105989_bib13","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1007\/s13311-021-01050-5","article-title":"Clarithromycin ameliorates early brain injury after subarachnoid hemorrhage via suppressing periostin-related pathway in mice","volume":"18","author":"Kanamaru","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuint.2025.105989_bib14","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4103\/NRR.NRR-D-24-00124","article-title":"Therapeutic potential of stem cells in subarachnoid hemorrhage","volume":"20","author":"Kanamaru","year":"2025","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.neuint.2025.105989_bib15","first-page":"462","article-title":"Anti-apoptotic effects of AMPA receptor antagonist perampanel in early brain injury after subarachnoid hemorrhage in mice","volume":"15","author":"Kawakita","year":"2024","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.neuint.2025.105989_bib16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/01.RES.84.10.1166","article-title":"EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature","volume":"84","author":"Kowal","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.neuint.2025.105989_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0736-5748(94)00062-8","article-title":"Neural functions of the transforming growth factors beta","volume":"13","author":"Krieglstein","year":"1995","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuint.2025.105989_bib18","doi-asserted-by":"crossref","first-page":"C1412","DOI":"10.1152\/ajpcell.00087.2006","article-title":"Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity","volume":"291","author":"Kuang","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neuint.2025.105989_bib19","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/01.WCB.0000125886.48838.7E","article-title":"Signaling pathways for early brain injury after subarachnoid hemorrhage","volume":"24","author":"Kusaka","year":"2004","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.neuint.2025.105989_bib20","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/carcin\/bgn199","article-title":"Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism","volume":"29","author":"Lee","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.neuint.2025.105989_bib21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3109\/02713683.2012.665561","article-title":"Overexpression of fibulin-5 in retinal pigment epithelial cells inhibits cell proliferation and migration and downregulates VEGF, CXCR4, and TGFB1 expression in cocultured choroidal endothelial cells","volume":"37","author":"Li","year":"2012","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.neuint.2025.105989_bib22","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1007\/s12035-015-9386-9","article-title":"Anti-vascular endothelial growth factor treatment suppresses early brain injury after subarachnoid hemorrhage in mice","volume":"53","author":"Liu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2025.105989_bib23","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0898-6568(02)00058-X","article-title":"Integration of the TGF-beta pathway into the cellular signaling network","volume":"14","author":"Lutz","year":"2002","journal-title":"Cell. Signal."},{"key":"10.1016\/j.neuint.2025.105989_bib24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0140-6736(16)30668-7","article-title":"Spontaneous subarachnoid haemorrhage","volume":"389","author":"Macdonald","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2025.105989_bib25","doi-asserted-by":"crossref","first-page":"22476","DOI":"10.1074\/jbc.274.32.22476","article-title":"DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries","volume":"274","author":"Nakamura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105989_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/415171a","article-title":"Fibulin-5\/DANCE is essential for elastogenesis in vivo","volume":"415","author":"Nakamura","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2025.105989_bib27","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1161\/STROKEAHA.122.041977","article-title":"Epidermal growth factor receptor mediates neuronal apoptosis after subarachnoid hemorrhage in mice","volume":"54","author":"Nakano","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2025.105989_bib28","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s12975-020-00867-0","article-title":"Aneurysmal subarachnoid hemorrhage: the last decade. Transl","volume":"12","author":"Neifert","year":"2021","journal-title":"Stroke Res"},{"key":"10.1016\/j.neuint.2025.105989_bib29","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1161\/STROKEAHA.118.021757","article-title":"Modified citrus pectin prevents blood-brain barrier disruption in mouse subarachnoid hemorrhage by inhibiting galectin-3","volume":"49","author":"Nishikawa","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.neuint.2025.105989_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cytogfr.2004.11.002","article-title":"Dual role for TGF-beta1 in apoptosis","volume":"16","author":"S\u00e1nchez-Capelo","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.neuint.2025.105989_bib31","doi-asserted-by":"crossref","first-page":"27367","DOI":"10.1074\/jbc.M200148200","article-title":"Context-specificeffectsoffibulin-5 (DANCE\/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades","volume":"277","author":"Schiemann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105989_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-001-0479-6","article-title":"Mechanisms of TGF-\u03b2-mediated apoptosis","volume":"307","author":"Schuster","year":"2002","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neuint.2025.105989_bib33","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-b signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2025.105989_bib34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12975-014-0333-2","article-title":"Tenascin-C causes neuronal apoptosis after subarachnoid hemorrhage in rats","volume":"5","author":"Shiba","year":"2014","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.neuint.2025.105989_bib35","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/pmic.201300241","article-title":"Characterization of individual mouse cerebrospinal fluid proteomes","volume":"14","author":"Smith","year":"2014","journal-title":"Proteomics"},{"key":"10.1016\/j.neuint.2025.105989_bib36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","article-title":"A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model","volume":"167","author":"Sugawara","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuint.2025.105989_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12975-014-0380-8","article-title":"What is early brain injury? Transl","volume":"6","author":"Suzuki","year":"2015","journal-title":"Stroke Res"},{"key":"10.1016\/j.neuint.2025.105989_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315184","article-title":"Plasma fibulin-5 levels as an independent predictor of a poor outcome after an aneurysmal subarachnoid hemorrhage","volume":"23","author":"Suzuki","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2025.105989_bib39","doi-asserted-by":"crossref","first-page":"22244","DOI":"10.1074\/jbc.M116.730945","article-title":"Hypoxia and transforming growth factor beta cooperate to induce fibulin-5 expression in pancreatic cancer","volume":"291","author":"Topalovski","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.105989_bib40","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.3390\/ijms19092787","article-title":"Extracellular interactions between fibulins and transforming growth factor (TGF)-\u03b2 in physiological and pathological conditions","volume":"19","author":"Tsuda","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2025.105989_bib41","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1091\/mbc.e08-06-0621","article-title":"A shared mechanism of adhesion modulation for tenascin-C and fibulin-1","volume":"20","author":"Williams","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuint.2025.105989_bib42","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3892\/ol.2016.4650","article-title":"Fibulin-5 localisation in human endometrial cancer shifts from epithelial to stromal with increasing tumour grade, and silencing promotes endometrial epithelial cancer cell proliferation","volume":"12","author":"Winship","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.neuint.2025.105989_bib43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/415168a","article-title":"Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo","volume":"415","author":"Yanagisawa","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2025.105989_bib44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12079-009-0065-3","article-title":"Fibulin-5, an integrin-binding matricellular protein: its function in development and disease","volume":"3","author":"Yanagisawa","year":"2009","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.neuint.2025.105989_bib45","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/1440-1681.12742","article-title":"Limb remote ischaemic postconditioning\u2010induced elevation of fibulin\u20105 confers neuroprotection to rats with cerebral ischaemia\/reperfusion injury: activation of the AKT pathway","volume":"44","author":"Zhang","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neuint.2025.105989_bib46","doi-asserted-by":"crossref","first-page":"10775","DOI":"10.1007\/s11033-022-07756-9","article-title":"The role of autophagy and apoptosis in early brain injury after subarachnoid hemorrhage: an updated review","volume":"49","author":"Zhao","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.neuint.2025.105989_bib47","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0006-8993(00)02240-X","article-title":"The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat","volume":"866","author":"Zhu","year":"2000","journal-title":"Brain Res."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018625000622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018625000622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T13:51:02Z","timestamp":1762264262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018625000622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":47,"alternative-id":["S0197018625000622"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2025.105989","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of Fibulin-5 on early brain injury after subarachnoid hemorrhage in mice","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2025.105989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105989"}}