{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T23:36:39Z","timestamp":1786318599762,"version":"build-2736575974"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Community of Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016658","name":"National Plan on Drugs","doi-asserted-by":"publisher","award":["2021I043"],"award-info":[{"award-number":["2021I043"]}],"id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005367","name":"National Distance Education University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007480","name":"Universidad de Castilla-La Mancha","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.neuint.2025.106015","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T12:32:36Z","timestamp":1752582756000},"page":"106015","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Combined administration of cocaine and alcohol alters the expression of brain peptide\/protein profiles in rats: a MALDI imaging mass spectrometry approach"],"prefix":"10.1016","volume":"188","author":[{"given":"Alberto","family":"Marcos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Alberdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-5485","authenticated-orcid":false,"given":"Carlos A.","family":"Castillo-Sarmiento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Ballesteros-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2025.106015_bib1","series-title":"Co-Immunoprecipitation Methods for Brain Tissue","first-page":"65","article-title":"The histoblot technique: a reliable approach to analyze expression profile of proteins and to predict their molecular association","author":"Aguado","year":"2019"},{"key":"10.1016\/j.neuint.2025.106015_bib2","first-page":"725","article-title":"Histoblot: a sensitive method to quantify the expression of proteins in normal and pathological conditions","volume":"38","author":"Aguado","year":"2023","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.neuint.2025.106015_bib3","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuint.2025.106015_bib4","doi-asserted-by":"crossref","first-page":"15897","DOI":"10.1074\/jbc.M112185200","article-title":"Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis","volume":"277","author":"Blumer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.106015_bib5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0896-6273(04)00159-X","article-title":"Activator of G-protein signaling 3: a gatekeeper of cocaine sensitization and drug-seeking","volume":"42","author":"Bowers","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2025.106015_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0376-8716(95)01128-L","article-title":"Features of cocaine dependence with concurrent alcohol abuse","volume":"39","author":"Brady","year":"1995","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuint.2025.106015_bib7","series-title":"The Nociceptin\/Orphanin FQ Peptide Receptor","first-page":"141","article-title":"Regulation of the genes encoding the ppN\/OFQ and NOP receptor","author":"Caputi","year":"2019"},{"key":"10.1016\/j.neuint.2025.106015_bib8","first-page":"77","article-title":"Pharmacologic interventions for alcohol- and cocaine-abusing individuals: a pilot study of disulfiram vs. naltrexone","volume":"2","author":"Carroll","year":"1993","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.neuint.2025.106015_bib9","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1530-0277.2010.01148.x","article-title":"Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas","volume":"34","author":"Chang","year":"2010","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuint.2025.106015_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13041-021-00800-y","article-title":"Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation","volume":"14","author":"Cole","year":"2021","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuint.2025.106015_bib11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3389\/fnins.2020.00569","article-title":"One is not enough: understanding and modeling polysubstance use","volume":"14","author":"Crummy","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuint.2025.106015_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuint.2015.12.006","article-title":"Cocaine and mitochondria-related signaling in the brain: a mechanistic view and future directions","volume":"92","author":"de Oliveira","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2025.106015_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuropharm.2009.04.005","article-title":"Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction","volume":"57","author":"del Castillo","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2025.106015_bib14","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/jms.1926","article-title":"High spatial resolution imaging mass spectrometry and classical histology on a single tissue section","volume":"46","author":"Deutskens","year":"2011","journal-title":"J. Mass Spectrom."},{"issue":"Suppl. 1","key":"10.1016\/j.neuint.2025.106015_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuropharm.2004.06.032","article-title":"Dopamine and drug addiction: the nucleus accumbens shell connection","volume":"47","author":"Di Chiara","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2025.106015_bib17","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.3390\/ijms25052933","article-title":"Association between RMTg neuropeptide genes and negative effect during alcohol withdrawal in mice","volume":"25","author":"Fu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2025.106015_bib18","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1530-0277.2007.00480.x","article-title":"Reinstatement of ethanol-seeking behavior following intravenous self-administration in wistar rats","volume":"31","author":"Gass","year":"2007","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuint.2025.106015_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2006.04.025","article-title":"Use of surface enhanced laser desorption\/ionization-time of flight mass spectrometry (SELDI-TOF MS) to study protein expression in a rat model of cocaine withdrawal","volume":"158","author":"Geng","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuint.2025.106015_bib20","first-page":"304","article-title":"Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism","volume":"26","author":"Gianoulakis","year":"2001","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neuint.2025.106015_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1568026043451573","article-title":"Endogenous opioids and addiction to alcohol and other drugs of abuse","volume":"4","author":"Gianoulakis","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.neuint.2025.106015_bib22","first-page":"719","article-title":"The influence of ethanol on the functional status of GABA(A) receptors","volume":"67","author":"Golovko","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuint.2025.106015_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/npp.2013.182","article-title":"Proteomic approaches and identification of novel therapeutic targets for alcoholism","volume":"39","author":"Gorini","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuint.2025.106015_bib24","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1360-0443.2006.01497.x","article-title":"Concurrent use and order of use of cocaine and alcohol: behavioural differences between users of crack cocaine and cocaine powder","volume":"101","author":"Gossop","year":"2006","journal-title":"Addiction"},{"key":"10.1016\/j.neuint.2025.106015_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.drugalcdep.2011.02.014","article-title":"Associations between polysubstance use and psychiatric problems in a criminal justice population in Sweden","volume":"118","author":"Hakansson","year":"2011","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuint.2025.106015_bib26","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.bbapap.2014.12.026","article-title":"Spatial neuroproteomics using imaging mass spectrometry","volume":"1854","author":"Hanrieder","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2025.106015_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108748","article-title":"Circuit and neuropeptide mechanisms of the paraventricular thalamus across stages of alcohol and drug use","volume":"198","author":"Hartmann","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2025.106015_bib28","first-page":"1","article-title":"Evaluation of prodynorphin gene polymorphisms and their association with heroin addiction in a sample of the southeast Iranian population","volume":"7","author":"Hashemi","year":"2018","journal-title":"Mol. Biol. Res. Commun."},{"key":"10.1016\/j.neuint.2025.106015_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/oxfordjournals.alcalc.a044989","article-title":"Alcohol and membrane-associated signal transduction","volume":"25","author":"Hoek","year":"1990","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuint.2025.106015_bib30","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.redox.2017.04.020","article-title":"Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome","volume":"12","author":"Hoyt","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.neuint.2025.106015_bib31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0091-3057(02)00738-4","article-title":"Intravenous ethanol\/cocaine self-administration initiates high intake of intravenous ethanol alone","volume":"72","author":"Ikegami","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2025.106015_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108359","article-title":"The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol coabuse","volume":"183","author":"James","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2025.106015_bib33","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/0024-3205(91)90217-Y","article-title":"Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion","volume":"48","author":"Jatlow","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/j.neuint.2025.106015_bib34","first-page":"381","article-title":"Psychoactive drugs\u2014from chemical structure to oxidative stress related to dopaminergic neurotransmission","volume":"10","author":"J\u00eetc\u0103","year":"2021","journal-title":"A Review, Antioxidants (Basel)"},{"key":"10.1016\/j.neuint.2025.106015_bib35","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0006-8993(88)90656-7","article-title":"Alterations and recovery of dendritic spine density in rat hippocampus following long-term ethanol ingestion","volume":"459","author":"King","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2025.106015_bib36","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/nn1105-1442","article-title":"Plasticity of reward neurocircuitry and the \u201cdark side\u201d of drug addiction","volume":"8","author":"Koob","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2025.106015_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuint.2025.106015_bib38","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0006-8993(97)01205-5","article-title":"Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains1","volume":"778","author":"Kosten","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2025.106015_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0924-977X(98)00025-X","article-title":"Effects of calcium channel blockade on intravenous self-administration of ethanol in rats","volume":"9","author":"Kuzmin","year":"1999","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuint.2025.106015_bib40","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/adb.12429","article-title":"Intravenous self-administration of alcohol in rats\u2014problems with translation to humans","volume":"22","author":"L\u00ea","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuint.2025.106015_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/7854_2020_187","article-title":"GABAB receptors and drug addiction: psychostimulants and other drugs of abuse","volume":"52","author":"Li","year":"2022","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.neuint.2025.106015_bib42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.drugalcdep.2018.07.025","article-title":"The importance of considering polysubstance use: lessons from cocaine research","volume":"192","author":"Liu","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neuint.2025.106015_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0091-3057(92)90465-R","article-title":"Influence of dopaminergic and serotonergic neurons on intravenous ethanol self-administration in the rat","volume":"42","author":"Lyness","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2025.106015_bib44","first-page":"2","article-title":"Factors related to simultaneous cocaine and alcohol use for clients in treatment","volume":"3","author":"Macdonald","year":"2015","journal-title":"Journal of Alcoholism and Drug Dependence"},{"key":"10.1016\/j.neuint.2025.106015_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227044","article-title":"The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats","volume":"15","author":"Marcos","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.106015_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108937","article-title":"The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats","volume":"206","author":"Marcos","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2025.106015_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464047","article-title":"Untargeted metabolomic study by liquid chromatography-mass spectrometry in brain tissues on the effects of combined cocaine and ethanol self-administration in male and female young rats","volume":"1700","author":"Marcos","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.neuint.2025.106015_bib48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1192\/bjp.176.3.285","article-title":"Psychiatric symptoms among clients seeking treatment for drug dependence. Intake data from the National Treatment Outcome Research Study","volume":"176","author":"Marsden","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neuint.2025.106015_bib49","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-3223(97)00426-5","article-title":"Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone--a multiple-dose study","volume":"44","author":"McCance-Katz","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2025.106015_bib50","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.1471-4159.2008.05240.x","article-title":"Regulation of psychostimulant-induced signaling and gene expression in the striatum","volume":"104","author":"McGinty","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2025.106015_bib51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1874473710801020239","article-title":"Role of mu and delta opioid receptors in alcohol drinking behaviour","volume":"1","author":"M\u00e9ndez","year":"2008","journal-title":"Curr. Drug Abuse Rev."},{"key":"10.1016\/j.neuint.2025.106015_bib52","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00213-007-0958-x","article-title":"Glutamate and aspartate levels in the nucleus accumbens during cocaine self-administration and extinction: a time course microdialysis study","volume":"196","author":"Migu\u00e9ns","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuint.2025.106015_bib53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/cercor\/bht200","article-title":"The effects of cocaine self-administration on dendritic spine density in the rat hippocampus are dependent on genetic background","volume":"25","author":"Migu\u00e9ns","year":"2015","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuint.2025.106015_bib54","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/ejn.15035","article-title":"Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens","volume":"53","author":"Mongi-Bragato","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2025.106015_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104584","article-title":"Neurochemical mechanisms underlying acute and chronic ethanol-mediated responses in zebrafish: the role of mitochondrial bioenergetics","volume":"131","author":"M\u00fcller","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2025.106015_bib56","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/proteomes6040050","article-title":"From synapse to function: a perspective on the role of neuroproteomics in elucidating mechanisms of drug addiction","volume":"6","author":"Natividad","year":"2018","journal-title":"Proteomes"},{"key":"10.1016\/j.neuint.2025.106015_bib57","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2015.12.039","article-title":"Reflections on: \u201cA general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function,\u201d","volume":"1645","author":"Nestler","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2025.106015_bib58","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1111\/bph.13190","article-title":"The opioid receptors as targets for drug abuse medication","volume":"172","author":"Noble","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuint.2025.106015_bib59","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1530-0277.1994.tb00118.x","article-title":"Differences between alcohol-preferring (AA) and alcohol-avoiding (ANA) rats in the prodynorphin and proenkephalin systems","volume":"18","author":"Nylander","year":"1994","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuint.2025.106015_bib60","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2017"},{"key":"10.1016\/j.neuint.2025.106015_bib61","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0024-3205(94)00747-0","article-title":"The order of drug administration: its effects on the interaction between cocaine and ethanol","volume":"55","author":"Perez-Reyes","year":"1994","journal-title":"Life Sci."},{"key":"10.1016\/j.neuint.2025.106015_bib62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.brainres.2014.10.036","article-title":"Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell","volume":"1594","author":"Peterson","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2025.106015_bib63","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0022-3565(25)27954-X","article-title":"Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed-ratio size","volume":"161","author":"Pickens","year":"1968","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.neuint.2025.106015_bib64","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ejphar.2004.07.036","article-title":"Opioid abuse and brain gene expression","volume":"500","author":"Przewlocki","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2025.106015_bib65","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jat\/3.2.59","article-title":"Identification of cocaine and its metabolites in human urine in the presence of ethyl alcohol","volume":"3","author":"Rafla","year":"1979","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.neuint.2025.106015_bib66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1037\/1064-1297.8.1.117","article-title":"Comparison of the reinforcing and anxiogenic effects of intravenous cocaine and cocaethylene","volume":"8","author":"Raven","year":"2000","journal-title":"Exp. Clin. Psychopharmacol"},{"key":"10.1016\/j.neuint.2025.106015_bib67","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1208\/s12248-010-9204-2","article-title":"Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine","volume":"12","author":"Romanova","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.neuint.2025.106015_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pbb.2004.03.018","article-title":"Sex differences in the escalation of intravenous cocaine intake following long- or short-access to cocaine self-administration","volume":"78","author":"Roth","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2025.106015_bib69","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.conb.2013.01.027","article-title":"Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin\u2019?","volume":"23","author":"Rothenfluh","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuint.2025.106015_bib70","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1530-0277.2002.tb02607.x","article-title":"The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure","volume":"26","author":"Roy","year":"2002","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuint.2025.106015_bib71","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.alcohol.2008.06.002","article-title":"Chronic ethanol exposure increases the association of hippocampal mu-opioid receptors with G-protein receptor kinase 2","volume":"42","author":"Saland","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.neuint.2025.106015_bib72","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3233\/BPL-190091","article-title":"Alcohol and cocaine combined substance use on adult hypothalamic neural stem cells and neurogenesis","volume":"6","author":"Schlagal","year":"2020","journal-title":"Brain Plast."},{"key":"10.1016\/j.neuint.2025.106015_bib73","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11011-021-00797-2","article-title":"MALDI imaging mass spectrometry: an emerging tool in neurology","volume":"37","author":"Schnackenberg","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2025.106015_bib74","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuint.2025.106015_bib75","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/pmic.201500460","article-title":"The use of MALDI-MSI in the investigation of psychiatric and neurodegenerative disorders: a review","volume":"16","author":"Schubert","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.neuint.2025.106015_bib76","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/hbm.23244","article-title":"Brain GABA levels across psychiatric disorders: a systematic literature review and meta-analysis of (1) H-MRS studies","volume":"37","author":"Sch\u00fcr","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuint.2025.106015_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.561173","article-title":"Chronic alcohol exposure induces aberrant mitochondrial morphology and inhibits respiratory capacity in the medial prefrontal cortex of mice","volume":"14","author":"Shang","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuint.2025.106015_bib78","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.neuint.2025.106015_bib79","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0091-3057(82)90033-8","article-title":"Parameters of low-dose ethanol intravenous self-administration in the rat","volume":"16","author":"Sinden","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2025.106015_bib80","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuint.2025.106015_bib81","article-title":"Key substance use and mental Health indicators in the United States: results from the 2022","year":"2022","journal-title":"National Survey on Drug Use and Health"},{"key":"10.1016\/j.neuint.2025.106015_bib82","doi-asserted-by":"crossref","first-page":"33202","DOI":"10.1074\/jbc.274.47.33202","article-title":"Receptor-independent activators of heterotrimeric G-protein signaling pathways","volume":"274","author":"Takesono","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.106015_bib83","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/mp.2008.53","article-title":"Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration","volume":"15","author":"Tannu","year":"2010","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2025.106015_bib84","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/bjp.2008.30","article-title":"Neuropharmacology of alcohol addiction","volume":"154","author":"Vengeliene","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"Suppl. 6","key":"10.1016\/j.neuint.2025.106015_bib85","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/ana.10696","article-title":"GABA, gamma-hydroxybutyric acid, and neurological disease","volume":"54","author":"Wong","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2025.106015_bib86","doi-asserted-by":"crossref","first-page":"W652","DOI":"10.1093\/nar\/gkp356","article-title":"MetaboAnalyst: a web server for metabolomic data analysis and interpretation","volume":"37","author":"Xia","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuint.2025.106015_bib87","article-title":"Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders","volume":"9","author":"Ye","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.106015_bib88","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/npp.2008.187","article-title":"A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain","volume":"34","author":"Yuferov","year":"2009","journal-title":"Neuropsychopharmacology"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018625000889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018625000889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:44:33Z","timestamp":1777527873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018625000889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":87,"alternative-id":["S0197018625000889"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2025.106015","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined administration of cocaine and alcohol alters the expression of brain peptide\/protein profiles in rats: a MALDI imaging mass spectrometry approach","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2025.106015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106015"}}