{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:10:00Z","timestamp":1780413000790,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020962","name":"ACT-X","doi-asserted-by":"publisher","award":["JPMJAX222H"],"award-info":[{"award-number":["JPMJAX222H"]}],"id":[{"id":"10.13039\/501100020962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008665","name":"Osaka Medical Research Foundation for Intractable Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K15367"],"award-info":[{"award-number":["21K15367"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K14453"],"award-info":[{"award-number":["23K14453"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K17413"],"award-info":[{"award-number":["23K17413"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008884","name":"Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.neuint.2025.106048","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T06:26:30Z","timestamp":1756535190000},"page":"106048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Impaired lysosomal proteolysis in developing neurons induces protein aggregation and disrupts morphogenesis and neuromaturation"],"prefix":"10.1016","volume":"190","author":[{"given":"Yinping","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-7755","authenticated-orcid":false,"given":"Yuuki","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Shirazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Imaizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiichi","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2025.106048_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/jmcb\/mjt022","article-title":"The lysosome: from waste bag to potential therapeutic target","volume":"5","author":"Appelqvist","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.neuint.2025.106048_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41580-019-0185-4","article-title":"Lysosomes as dynamic regulators of cell and organismal homeostasis","volume":"21","author":"Ballabio","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuint.2025.106048_bib3","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1523\/JNEUROSCI.1372-16.2018","article-title":"The development of neuronal polarity: a retrospective view","volume":"38","author":"Banker","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2025.106048_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.aax3338","article-title":"Huntington's disease alters human neurodevelopment","volume":"369","author":"Barnat","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.neuint.2025.106048_bib5","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.cell.2022.04.013","article-title":"mTOR substrate phosphorylation in growth control","volume":"185","author":"Battaglioni","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2025.106048_bib6","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1056\/NEJMoa1915722","article-title":"Developmental consequences of defective ATG7-Mediated autophagy in humans","volume":"384","author":"Collier","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuint.2025.106048_bib7","doi-asserted-by":"crossref","first-page":"E762","DOI":"10.1073\/pnas.1715865115","article-title":"Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes","volume":"115","author":"Conforti","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2025.106048_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1042\/bj0600604","article-title":"Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue","volume":"60","author":"de Duve","year":"1955","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuint.2025.106048_bib9","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s12035-014-8832-4","article-title":"Genetic convergence of Parkinson's disease and lysosomal storage disorders","volume":"51","author":"Deng","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2025.106048_bib10","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1523\/JNEUROSCI.08-04-01454.1988","article-title":"The establishment of polarity by hippocampal neurons in culture","volume":"8","author":"Dotti","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2025.106048_bib11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1074\/jbc.M109.024703","article-title":"Kidins220\/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development","volume":"285","author":"Higuero","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2025.106048_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau8237","article-title":"GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA(A) receptor trafficking and social behavior","volume":"5","author":"Hui","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuint.2025.106048_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijdevneu.2006.12.001","article-title":"Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus","volume":"25","author":"Jalava","year":"2007","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuint.2025.106048_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091926","article-title":"Conventional and non-conventional roles of non-muscle Myosin II-Actin in neuronal development and degeneration","volume":"9","author":"Javier-Torrent","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neuint.2025.106048_bib15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/sj.mp.4001737","article-title":"Association of the calcyon gene (DRD1IP) with attention deficit\/hyperactivity disorder","volume":"10","author":"Laurin","year":"2005","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2025.106048_bib16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/15548627.2021.1936777","article-title":"Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders","volume":"18","author":"Linda","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2025.106048_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13229-020-00349-y","article-title":"Dysregulation of protein synthesis and dendritic spine morphogenesis in ASD: studies in human pluripotent stem cells","volume":"11","author":"Lo","year":"2020","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neuint.2025.106048_bib18","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.tcb.2022.04.012","article-title":"Non-canonical mTORC1 signaling at the lysosome","volume":"32","author":"Napolitano","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuint.2025.106048_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112399","article-title":"The emerging role of the lysosome in Parkinson's Disease","volume":"9","author":"Navarro-Romero","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neuint.2025.106048_bib20","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuint.2025.106048_bib21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","article-title":"Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases","volume":"25","author":"Nixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuint.2025.106048_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/dgd.12213","article-title":"Roles of cofilin in development and its mechanisms of regulation","volume":"57","author":"Ohashi","year":"2015","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.neuint.2025.106048_bib23","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1523\/JNEUROSCI.3522-13.2014","article-title":"Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of beta-secretase","volume":"34","author":"Olsen","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2025.106048_bib24","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.tins.2020.05.004","article-title":"Neurodevelopmental disorders: from genetics to functional pathways","volume":"43","author":"Parenti","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuint.2025.106048_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41572-018-0025-4","article-title":"Lysosomal storage diseases","volume":"4","author":"Platt","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.neuint.2025.106048_bib26","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.aax3769","article-title":"Cellular quality control by the ubiquitin-proteasome system and autophagy","volume":"366","author":"Pohl","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.neuint.2025.106048_bib27","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/npp.2011.120","article-title":"DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders","volume":"36","author":"Reif","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuint.2025.106048_bib28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuint.2025.106048_bib29","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.neuron.2018.08.017","article-title":"FoxO function is essential for maintenance of Autophagic Flux and neuronal morphogenesis in adult neurogenesis","volume":"99","author":"Schaffner","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2025.106048_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12013-010-9138-4","article-title":"Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies","volume":"60","author":"Shen","year":"2011","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.neuint.2025.106048_bib31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4161\/auto.1.2.1697","article-title":"Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy","volume":"1","author":"Tanida","year":"2005","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2025.106048_bib32","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1007\/s12035-023-03302-1","article-title":"Insights on the role of alpha- and beta-Tubulin isotypes in early brain development","volume":"60","author":"Tantry","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2025.106048_bib33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/15548627.2016.1271514","article-title":"Multistep regulation of TFEB by MTORC1","volume":"13","author":"Vega-Rubin-de-Celis","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2025.106048_bib34","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1007\/s10571-023-01390-0","article-title":"Unraveling the potential of EphA4: a breakthrough target and beacon of hope for neurological diseases","volume":"43","author":"Verma","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2025.106048_bib35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2025.106048_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41421-020-0141-7","article-title":"Lysosome biology in autophagy","volume":"6","author":"Yim","year":"2020","journal-title":"Cell. Discov."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018625001214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018625001214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:45:19Z","timestamp":1780407919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018625001214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":36,"alternative-id":["S0197018625001214"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2025.106048","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired lysosomal proteolysis in developing neurons induces protein aggregation and disrupts morphogenesis and neuromaturation","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2025.106048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106048"}}