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Lett."},{"issue":"12","key":"10.1016\/j.neuint.2025.106053_bib98","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1080\/15548627.2018.1513758","article-title":"BECN1 is a new driver of ferroptosis","volume":"14","author":"Kang","year":"2018","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.neuint.2025.106053_bib99","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/biom15020214","article-title":"\u03b1-Synuclein iron-responsive-element RNA and iron regulatory protein affinity is specifically reduced by iron in Parkinson's disease","volume":"15","author":"Khan","year":"2025","journal-title":"Biomolecules"},{"issue":"14","key":"10.1016\/j.neuint.2025.106053_bib100","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1073\/pnas.0501282102","article-title":"Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress","volume":"102","author":"Kim","year":"2005","journal-title":"Proc. Natl. 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