{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:39:45Z","timestamp":1793911185329,"version":"4.8.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24H00630"],"award-info":[{"award-number":["24H00630"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H02792"],"award-info":[{"award-number":["22H02792"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K02432"],"award-info":[{"award-number":["25K02432"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02840"],"award-info":[{"award-number":["21H02840"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["SHW 2023-03"],"award-info":[{"award-number":["SHW 2023-03"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.neuint.2025.106082","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:45:11Z","timestamp":1761810311000},"page":"106082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Oral administration of arginine suppresses A\u03b2 pathology in animal models of Alzheimer's disease"],"prefix":"10.1016","volume":"191","author":[{"given":"Kanako","family":"Fujii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-8009","authenticated-orcid":false,"given":"Toshihide","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko N.","family":"Minakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2025.106082_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0006-291X(03)00578-3","article-title":"The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation","volume":"304","author":"Arakawa","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2025.106082_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10545-012-9494-x","article-title":"Creatine metabolism in urea cycle defects","volume":"35","author":"Boenzi","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.neuint.2025.106082_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4161\/pri.28938","article-title":"The therapeutic potential of chemical chaperones in protein folding diseases","volume":"8","author":"Cortez","year":"2014","journal-title":"Prion"},{"key":"10.1016\/j.neuint.2025.106082_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001176","article-title":"Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key","volume":"2","author":"Das","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2025.106082_bib5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nsmb.1437","article-title":"EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers","volume":"15","author":"Ehrnhoefer","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuint.2025.106082_bib6","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41598-018-23718-3","article-title":"Small molecules attenuate the interplay between conformational fluctuations, early oligomerization and amyloidosis of alpha synuclein","volume":"8","author":"Ghosh","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2025.106082_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nn1422","article-title":"19F and 1H MRI detection of amyloid beta plaques in vivo","volume":"8","author":"Higuchi","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2025.106082_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102952","article-title":"L-arginine in patients with spinocerebellar ataxia type 6: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"78","author":"Ishihara","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.neuint.2025.106082_bib9","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1016\/j.cell.2023.08.021","article-title":"Alzheimer's disease: from immunotherapy to immunoprevention","volume":"186","author":"Jucker","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2025.106082_bib10","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.1038\/s41598-021-86098-1","article-title":"Characterization of design grammar of peptides for regulating liquid droplets and aggregates of FUS","volume":"11","author":"Kamagata","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2025.106082_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1001\/jamaneurol.2015.5072","article-title":"Recommendations for the management of strokelike episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes","volume":"73","author":"Koenig","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neuint.2025.106082_bib12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1212\/WNL.58.5.827","article-title":"Effects of L-arginine on the acute phase of strokes in three patients with MELAS","volume":"58","author":"Koga","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2025.106082_bib13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neulet.2017.05.054","article-title":"Chronic sleep fragmentation exacerbates amyloid beta deposition in Alzheimer's disease model mice","volume":"653","author":"Minakawa","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2025.106082_bib14","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/brain\/awaa115","article-title":"Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation","volume":"143","author":"Minakawa","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2025.106082_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.neuint.2025.106082_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-2094-2-9","article-title":"Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease","volume":"2","author":"Patel","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2025.106082_bib17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single App knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2025.106082_bib18","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2025.106082_bib19","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.neuint.2025.106082_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci7100128","article-title":"Protein misfolding and aggregation as a therapeutic target for polyglutamine diseases","volume":"7","author":"Takeuchi","year":"2017","journal-title":"Brain Sci."},{"key":"10.1016\/j.neuint.2025.106082_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer's Disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuint.2025.106082_bib22","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1242\/jeb.01501","article-title":"Allometric scaling of mammalian metabolism","volume":"208","author":"White","year":"2005","journal-title":"J. Exp. Biol."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701862500155X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701862500155X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:37:27Z","timestamp":1773308247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019701862500155X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":22,"alternative-id":["S019701862500155X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2025.106082","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral administration of arginine suppresses A\u03b2 pathology in animal models of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2025.106082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106082"}}