{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:16:26Z","timestamp":1777864586473,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.neuint.2026.106137","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:19:51Z","timestamp":1771949991000},"page":"106137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Degradation of alpha-synuclein\/SNCA mRNA by RNautophagy"],"prefix":"10.1016","volume":"195","author":[{"given":"Chihana","family":"Kabuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Hakuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ichiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-2596","authenticated-orcid":false,"given":"Tomohiro","family":"Kabuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2026.106137_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/15548627.2016.1145325","article-title":"Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes","volume":"12","author":"Aizawa","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2026.106137_bib2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3389\/fneur.2018.01021","article-title":"A meta-analysis of \u03b1-Synuclein multiplication in familial parkinsonism","volume":"9","author":"Book","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuint.2026.106137_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbadis.2011.10.002","article-title":"Alpha-synuclein misfolding and Parkinson's disease","volume":"1822","author":"Breydo","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2026.106137_bib4","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1038\/s41467-021-21937-3","article-title":"The release of toxic oligomers from alpha-synuclein fibrils induces dysfunction in neuronal cells","volume":"12","author":"Cascella","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2026.106137_bib5","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"Alpha-synuclein locus duplication as a cause of familial Parkinson's disease","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2026.106137_bib6","first-page":"E1994","article-title":"Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2026.106137_bib7","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1242\/jcs.202481","article-title":"Lysosomal targeting of SIDT2 via multiple YxxPhi motifs is required for SIDT2 function in the process of RNautophagy","volume":"130","author":"Contu","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neuint.2026.106137_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2022.12.090","article-title":"Nucleic acid uptake occurs independent of lysosomal acidification but dependent on ATP consumption during RNautophagy\/DNautophagy","volume":"644","author":"Contu","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2026.106137_bib9","doi-asserted-by":"crossref","first-page":"12726","DOI":"10.1074\/jbc.M109.086827","article-title":"Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153","volume":"285","author":"Doxakis","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2026.106137_bib10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4161\/auto.23002","article-title":"Discovery of a novel type of autophagy targeting RNA","volume":"9","author":"Fujiwara","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2026.106137_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105243","article-title":"Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with lewy bodies patients","volume":"152","author":"Fujiwara","year":"2022","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2026.106137_bib12","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/nar\/gkn084","article-title":"Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease","volume":"36","author":"Gr\u00fcndemann","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuint.2026.106137_bib13","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1093\/nar\/gkv579","article-title":"RNautophagy\/DNautophagy possesses selectivity for RNA\/DNA substrates","volume":"43","author":"Hase","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuint.2026.106137_bib14","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.0906277106","article-title":"Repression of alpha-synuclein expression and toxicity by microRNA-7","volume":"106","author":"Junn","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2026.106137_bib15","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.160022","article-title":"Constitutive translation of human alpha-synuclein is mediated by the 5'-untranslated region","volume":"6","author":"Koukouraki","year":"2016","journal-title":"Open Biol."},{"key":"10.1016\/j.neuint.2026.106137_bib16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","article-title":"Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease","volume":"18","author":"Kruger","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuint.2026.106137_bib17","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03029","article-title":"The role of autophagy during the early neonatal starvation period","volume":"432","author":"Kuma","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2026.106137_bib18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.nbd.2014.05.009","article-title":"Immunotherapy targeting alpha-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] alpha-synuclein mice","volume":"69","author":"Lindstrom","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2026.106137_bib19","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1093\/nar\/gkx1048","article-title":"Discovering the 3' UTR-mediated regulation of alpha-synuclein","volume":"45","author":"Marchese","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuint.2026.106137_bib20","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","article-title":"Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal","volume":"8","author":"Maroteaux","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106137_bib21","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/mds.26141","article-title":"Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease","volume":"30","author":"Murphy","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuint.2026.106137_bib22","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1074\/jbc.M115.695379","article-title":"Phosphorylation of TAR DNA-binding protein of 43 kDa (TDP-43) by truncated Casein kinase 1delta triggers mislocalization and accumulation of TDP-43","volume":"291","author":"Nonaka","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2026.106137_bib23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.parkreldis.2015.06.005","article-title":"Early-onset parkinsonism caused by alpha-synuclein gene triplication: clinical and genetic findings in a novel family","volume":"21","author":"Olgiati","year":"2015","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.neuint.2026.106137_bib24","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuint.2026.106137_bib25","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1038\/s41467-023-39335-2","article-title":"Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity","volume":"14","author":"Qian","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2026.106137_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00702-010-0513-5","article-title":"The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen","volume":"118","author":"Rogers","year":"2011","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neuint.2026.106137_bib27","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"alpha-Synuclein locus triplication causes Parkinson's disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuint.2026.106137_bib28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2026.106137_bib29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41422-023-00889-x","article-title":"Human SIDT1 mediates dsRNA uptake via its phospholipase activity","volume":"34","author":"Sun","year":"2024","journal-title":"Cell Res."},{"key":"10.1016\/j.neuint.2026.106137_bib30","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ana.10795","article-title":"The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia","volume":"55","author":"Zarranz","year":"2004","journal-title":"Ann. Neurol."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626000288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626000288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:44:28Z","timestamp":1777527868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626000288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"alternative-id":["S0197018626000288"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106137","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Degradation of alpha-synuclein\/SNCA mRNA by RNautophagy","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106137"}}