{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:14:52Z","timestamp":1778735692007,"version":"3.51.4"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007923","name":"Yangtze University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.neuint.2026.106164","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:30:20Z","timestamp":1777073420000},"page":"106164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mitofusin 2 in central nervous system disorders: Roles in mitochondrial dynamics and therapeutic Implications"],"prefix":"10.1016","volume":"196","author":[{"given":"Li","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2026.106164_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144854","article-title":"The distinctive role of tau and amyloid beta in mitochondrial dysfunction through alteration in Mfn2 and Drp1 mRNA levels: a comparative study in Drosophila melanogaster","volume":"754","author":"Abtahi","year":"2020","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib2","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1096\/fj.201601309","article-title":"On the pathogenesis of Alzheimer's disease: the MAM hypothesis","volume":"31","author":"Area-Gomez","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.neuint.2026.106164_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1144896","article-title":"The complexities of investigating mitochondrial dynamics in multiple sclerosis and mouse models of MS","volume":"17","author":"Atkinson","year":"2023","journal-title":"Front. Neurosci."},{"issue":"25","key":"10.1016\/j.neuint.2026.106164_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2421806122","article-title":"Decreased mitochondrial activity in the demyelinating cerebellum of progressive multiple sclerosis and chronic EAE contributes to Purkinje cell loss","volume":"122","author":"Atkinson","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib5","first-page":"37","article-title":"Mitochondrial dysfunction and multiple sclerosis","volume":"8","author":"Barcelos","year":"2019","journal-title":"Biol. (Basel)"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12974-021-02099-x","article-title":"Interleukin-1\u03b2 mediates alterations in mitochondrial fusion\/fission proteins and memory impairment induced by amyloid-\u03b2 oligomers","volume":"18","author":"Batista","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"10291","key":"10.1016\/j.neuint.2026.106164_bib7","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"issue":"48","key":"10.1016\/j.neuint.2026.106164_bib8","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2517552122","article-title":"Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells","volume":"122","author":"Bora","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"5","key":"10.1016\/j.neuint.2026.106164_bib9","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1097\/ALN.0b013e318289bc9b","article-title":"Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain","volume":"118","author":"Boscolo","year":"2013","journal-title":"Anesthesiology"},{"issue":"11","key":"10.1016\/j.neuint.2026.106164_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259903","article-title":"The PINK1-Parkin mitophagy signaling pathway is not functional in peripheral blood mononuclear cells","volume":"16","author":"Bradshaw","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2026.106164_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106015","article-title":"Early derangement of axonal mitochondria occurs in a mouse model of progressive but not relapsing-remitting multiple sclerosis","volume":"178","author":"Buonvicino","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.neuint.2026.106164_bib13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib14","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/s41467-023-36945-8","article-title":"TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport","volume":"14","author":"Canty","year":"2023","journal-title":"Nat. Commun."},{"issue":"7641","key":"10.1016\/j.neuint.2026.106164_bib15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature21077","article-title":"MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion","volume":"542","author":"Cao","year":"2017","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.neuint.2026.106164_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/jmg.2009.072488","article-title":"Phenotypic spectrum of MFN2 mutations in the Spanish population","volume":"47","author":"Casasnovas","year":"2010","journal-title":"J. Med. Genet."},{"issue":"6131","key":"10.1016\/j.neuint.2026.106164_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1231031","article-title":"PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria","volume":"340","author":"Chen","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neuint.2026.106164_bib18","article-title":"The multifaceted roles of natural products in mitochondrial dysfunction","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuint.2026.106164_bib19","article-title":"New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases, Biomed","volume":"178","author":"Chen","year":"2024","journal-title":"Pharmacol"},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib20","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/ptr.8118","article-title":"20(R)-ginsenoside Rg3 attenuates cerebral ischemia-reperfusion injury by mitigating mitochondrial oxidative stress via the Nrf2\/HO-1 signaling pathway","volume":"38","author":"Chen","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.neuint.2026.106164_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1611958","article-title":"MFN2-a multifaceted guardian against Parkinson's pathophysiology: Mitochondria, ferroptosis, inflammation, and oxidative stress","volume":"17","author":"Cheng","year":"2025","journal-title":"Front. Aging Neurosci."},{"issue":"12","key":"10.1016\/j.neuint.2026.106164_bib22","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.7150\/ijms.24702","article-title":"B355252, a novel small molecule, confers neuroprotection against cobalt chloride toxicity in mouse hippocampal cells through altering mitochondrial dynamics and limiting autophagy induction","volume":"15","author":"Chimeh","year":"2018","journal-title":"Int. J. Med. Sci."},{"issue":"13","key":"10.1016\/j.neuint.2026.106164_bib23","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1021\/acs.jmedchem.0c00366","article-title":"Discovery of 6-phenylhexanamide derivatives as potent stereoselective mitofusin activators for the treatment of mitochondrial diseases","volume":"63","author":"Dang","year":"2020","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.neuint.2026.106164_bib24","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3390\/cells11061053","article-title":"Mitochondrial phenotypes in genetically diverse neurodegenerative diseases and their response to mitofusin activation","volume":"11","author":"Dang","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.neuint.2026.106164_bib25","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/hmg\/ddac287","article-title":"Activating mitofusins interrupts mitochondrial degeneration and delays disease progression in SOD1 mutant amyotrophic lateral sclerosis","volume":"32","author":"Dang","year":"2023","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.neuint.2026.106164_bib26","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100361R","article-title":"PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension","volume":"35","author":"Dasgupta","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.neuint.2026.106164_bib27","article-title":"Advances in neurological therapies: a review of clinical trials in Alzheimer's, Parkinson's, and multiple sclerosis","volume":"27","author":"de Souza","year":"2025","journal-title":"Am. J. Med."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib28","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/s41467-018-05722-3","article-title":"HUWE1 E3 ligase promotes PINK1\/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKK\u03b1","volume":"9","author":"Di Rita","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib29","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1038\/s41467-025-61808-9","article-title":"RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer","volume":"16","author":"Ding","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2026.106164_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113045","article-title":"Salvinorin A moderates postischemic brain injury by preserving endothelial mitochondrial function via AMPK\/Mfn2 activation","volume":"322","author":"Dong","year":"2019","journal-title":"Exp. Neurol."},{"issue":"11","key":"10.1016\/j.neuint.2026.106164_bib31","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.4103\/1673-5374.310684","article-title":"Mitofusin activation enhances mitochondrial motility and promotes neuroregeneration in CMT2A","volume":"16","author":"Dorn","year":"2021","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib32","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41531-025-01115-8","article-title":"Methodological validation of Miro1 retention as a candidate Parkinson's disease biomarker","volume":"11","author":"Drwesh","year":"2025","journal-title":"npj Parkinson's Dis."},{"issue":"8","key":"10.1016\/j.neuint.2026.106164_bib33","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3390\/biomedicines9080881","article-title":"Structural and functional alterations in mitochondria-associated membranes (MAMs) and in mitochondria activate stress response mechanisms in an in vitro model of Alzheimer's disease","volume":"9","author":"Fernandes","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41392-023-01730-y","article-title":"Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled","volume":"9","author":"Franchino","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.neuint.2026.106164_bib35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61119","article-title":"Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A","volume":"9","author":"Franco","year":"2020","journal-title":"eLife"},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1124\/jpet.122.001332","article-title":"Mitochondrial dysfunction and pharmacodynamics of mitofusin activation in murine Charcot-Marie-Tooth disease type 2A","volume":"383","author":"Franco","year":"2022","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s44319-023-00009-1","article-title":"MTCH2 cooperates with MFN2 and lysophosphatidic acinthesis to sustain mitochondrial fusion","volume":"25","author":"Goldman","year":"2024","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.neuint.2026.106164_bib38","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/15548627.2024.2440843","article-title":"Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy","volume":"21","author":"Gordaliza-Alaguero","year":"2025","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1474-4422(22)00184-3","article-title":"Ageing and multiple sclerosis","volume":"22","author":"Graves","year":"2023","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.2507-13.2014","article-title":"\u03b1-Synuclein is localized to mitochondria-associated ER membranes","volume":"34","author":"Guardia-Laguarta","year":"2014","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.neuint.2026.106164_bib41","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41589-022-01224-y","article-title":"Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction","volume":"19","author":"Guo","year":"2023","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(00)80319-0","article-title":"Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase","volume":"90","author":"Hales","year":"1997","journal-title":"Cell."},{"issue":"12","key":"10.1016\/j.neuint.2026.106164_bib43","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/j.molcel.2025.05.021","article-title":"Mitochondrial fumarate inhibits Parkin-mediated mitophagy","volume":"85","author":"Ham","year":"2025","journal-title":"Mol. Cell."},{"issue":"6","key":"10.1016\/j.neuint.2026.106164_bib44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.5483\/BMBRep.2023-0167","article-title":"Integrative analysis of microRNA-mediated mitochondrial dysfunction in hippocampal neural progenitor cell death in relation with Alzheimer's disease","volume":"57","author":"Han","year":"2024","journal-title":"BMB Rep."},{"issue":"7","key":"10.1016\/j.neuint.2026.106164_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70508","article-title":"Downregulation of Mfn2 contributes to chronic postsurgical pain via inducing the pyroptosis of GABAergic neurons in the spinal cord","volume":"31","author":"Hu","year":"2025","journal-title":"CNS Neurosci. Ther."},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib46","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jgr.2022.10.004","article-title":"Ginsenoside compound K protects against cerebral ischemia\/reperfusion injury via Mul1\/Mfn2-mediated mitochondrial dynamics and bioenergy","volume":"47","author":"Huang","year":"2023","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.neuint.2026.106164_bib47","first-page":"912","volume":"vol. 8","author":"Huang","year":"2025"},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/CIRCRESAHA.123.322914","article-title":"Mitofusin-2 regulates platelet mitochondria and function","volume":"134","author":"Jacob","year":"2024","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-018-0238-8","article-title":"Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex","volume":"13","author":"Jiang","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuint.2026.106164_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102304","article-title":"Caveolin-1 controls mitochondrial damage and ROS production by regulating fission-fusion dynamics and mitophagy","volume":"52","author":"Jiang","year":"2022","journal-title":"Redox Biol."},{"issue":"20","key":"10.1016\/j.neuint.2026.106164_bib51","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1038\/emboj.2010.223","article-title":"Inhibition of mitochondrial fusion by \u03b1-synuclein is rescued by PINK1, Parkin and DJ-1","volume":"29","author":"Kamp","year":"2010","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib52","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1038\/s41467-021-23047-6","article-title":"Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of \u03b2-catenin signaling","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.neuint.2026.106164_bib53","first-page":"2420","article-title":"Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus","volume":"43","author":"Klacanova","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"7","key":"10.1016\/j.neuint.2026.106164_bib54","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1007\/s12035-023-03329-4","article-title":"Selected biomarkers of oxidative stress and energy metabolism disorders in neurological diseases","volume":"60","author":"Korczowska-\u0141\u0105cka","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2026.106164_bib55","article-title":"Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation","author":"Lagos","year":"2025","journal-title":"bioRxiv"},{"issue":"9","key":"10.1016\/j.neuint.2026.106164_bib56","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1111\/jcmm.12863","article-title":"Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid \u03b2-peptide production","volume":"20","author":"Leal","year":"2016","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.neuint.2026.106164_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101817","article-title":"PINK1\/Parkin-mediated mitophagy in neurodegenerative diseases","volume":"84","author":"Li","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neuint.2026.106164_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111090","article-title":"Phelligridimer A enhances the expression of mitofusin 2 and protects against cerebral ischemia\/reperfusion injury","volume":"398","author":"Li","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neuint.2026.106164_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130504","article-title":"Aberrantly downregulated FENDRR by arecoline elevates ROS and myofibroblast activation via mitigating the miR-214\/MFN2 axis","volume":"264","author":"Liao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"26","key":"10.1016\/j.neuint.2026.106164_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk2913","article-title":"Regulation of blood-brain barrier integrity by Dmp1-expressing astrocytes through mitochondrial transfer","volume":"10","author":"Liu","year":"2024","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib61","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s12975-023-01228-3","article-title":"Inhibition of USP30 promotes mitophagy by regulating ubiquitination of MFN2 by Parkin to attenuate early brain injury after SAH, Transl","volume":"16","author":"Liu","year":"2025","journal-title":"Stroke Res"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib62","doi-asserted-by":"crossref","first-page":"844","DOI":"10.18632\/aging.102659","article-title":"Surgery\/anesthesia disturbs mitochondrial fission\/fusion dynamics in the brain of aged mice with postoperative delirium","volume":"12","author":"Lu","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.neuint.2026.106164_bib63","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1161\/STROKEAHA.125.052689","article-title":"MFN2 and BAG6 synergistically protect against cerebral reperfusion injury by regulating ROS levels and autophagic flux","volume":"56","author":"Lu","year":"2025","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib64","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12035-024-04264-8","article-title":"Genetic contribution to medium-term disease activity in multiple sclerosis","volume":"62","author":"Mascia","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10198","article-title":"Transcriptomic response of brain tissue to focused ultrasound-mediated blood-brain barrier disruption depends strongly on anesthesia","volume":"6","author":"Mathew","year":"2020","journal-title":"Bioeng. Transl. Med."},{"issue":"12","key":"10.1016\/j.neuint.2026.106164_bib66","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1523\/JNEUROSCI.6248-09.2010","article-title":"Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro\/milton complex","volume":"30","author":"Misko","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106164_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.727552","article-title":"MFN2 deficiency impairs mitochondrial transport and downregulates motor protein expression in human spinal motor neurons","volume":"14","author":"Mou","year":"2021","journal-title":"Front. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.neuint.2026.106164_bib68","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib69","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41467-023-44413-6","article-title":"Allosteric control of dynamin-related protein 1 through a disordered C-terminal short linear motif","volume":"15","author":"P\u00e9rez-Jover","year":"2024","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.neuint.2026.106164_bib70","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1093\/hmg\/dds311","article-title":"Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit","volume":"21","author":"Pham","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.neuint.2026.106164_bib71","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3892\/ijmm.2024.5371","article-title":"Mitochondrial dysfunction in chronic neuroinflammatory diseases","volume":"53","author":"Qin","year":"2024","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.neuint.2026.106164_bib72","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","article-title":"Determinants and outcomes of mitochondrial dynamics","volume":"83","author":"Quintana-Cabrera","year":"2023","journal-title":"Mol. Cell."},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib73","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3390\/biom14030248","article-title":"Cloflucarban illuminates specificity and context-dependent activation of the PINK1-Parkin pathway by mitochondrial complex inhibition","volume":"14","author":"Ramirez","year":"2024","journal-title":"Biomolecules"},{"issue":"6386","key":"10.1016\/j.neuint.2026.106164_bib74","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.aao1785","article-title":"MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A","volume":"360","author":"Rocha","year":"2018","journal-title":"Science"},{"issue":"Pt 8","key":"10.1016\/j.neuint.2026.106164_bib75","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1242\/jcs.115.8.1663","article-title":"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase fzo","volume":"115","author":"Rojo","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neuint.2026.106164_bib76","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuro.2022.07.006","article-title":"Effects of pramipexole on beta-amyloid1-42 memory deficits and evaluation of oxidative stress and mitochondrial function markers in the hippocampus of Wistar rat","volume":"92","author":"Salman","year":"2022","journal-title":"Neurotoxicology"},{"issue":"10284","key":"10.1016\/j.neuint.2026.106164_bib77","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"7567","key":"10.1016\/j.neuint.2026.106164_bib78","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature14601","article-title":"Regulation of mitochondrial morphology and function by stearoylation of TFR1","volume":"525","author":"Senyilmaz","year":"2015","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.neuint.2026.106164_bib79","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/biom14121649","article-title":"Alpha-synuclein effects on mitochondrial quality control in Parkinson's disease","volume":"14","author":"Shen","year":"2024","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib80","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1515\/revneuro-2022-0056","article-title":"Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases","volume":"34","author":"Shi","year":"2023","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neuint.2026.106164_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102321","article-title":"Advances in gene therapy approaches targeting neuro-inflammation in neurodegenerative diseases","volume":"98","author":"Singh","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib82","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/jcm9010126","article-title":"Back to the fusion: Mitofusin-2 in Alzheimer's disease","volume":"9","author":"Sita","year":"2020","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib83","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"T\u00e1bara","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"21","key":"10.1016\/j.neuint.2026.106164_bib84","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1021\/acschemneuro.4c00339","article-title":"Alzheimer's disease: exploring the landscape of cognitive decline","volume":"15","author":"Tenchov","year":"2024","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib85","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s44318-025-00604-z","article-title":"A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy","volume":"45","author":"Thayer","year":"2026","journal-title":"EMBO J."},{"key":"10.1016\/j.neuint.2026.106164_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.730342","article-title":"Teriflunomide treatment of multiple sclerosis selectively modulates CD8 memory T cells","volume":"12","author":"Tilly","year":"2021","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.neuint.2026.106164_bib87","doi-asserted-by":"crossref","first-page":"8395","DOI":"10.3390\/cimb45100529","article-title":"Mitochondrial dysfunction in dopaminergic neurons derived from patients with LRRK2- and SNCA-associated genetic forms of Parkinson's disease","volume":"45","author":"Vetchinova","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"19","key":"10.1016\/j.neuint.2026.106164_bib88","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1523\/JNEUROSCI.1356-22.2023","article-title":"Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons","volume":"43","author":"Vevea","year":"2023","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.neuint.2026.106164_bib89","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(21)00061-2","article-title":"Progress towards therapies for disease modification in Parkinson's disease","volume":"20","author":"Vijiaratnam","year":"2021","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib90","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210255","article-title":"Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria","volume":"12","author":"Vranas","year":"2022","journal-title":"Open Biol."},{"issue":"9","key":"10.1016\/j.neuint.2026.106164_bib91","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/jama.2022.1420","article-title":"What is acute ischemic stroke?","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib92","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cmet.2018.06.011","article-title":"Mitofusin 2 regulates axonal transport of calpastatin to prevent neuromuscular synaptic elimination in skeletal muscles","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib93","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3233\/JAD-215175","article-title":"Mitochondrial fusion suppresses tau pathology-induced neurodegeneration and cognitive decline","volume":"84","author":"Wang","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib94","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12974-024-03072-0","article-title":"Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson's disease through Mfn2-cGAS signaling","volume":"21","author":"Wang","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib95","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12967-025-06384-8","article-title":"Mfn2 regulates calcium homeostasis and suppresses PASMCs proliferation via interaction with IP3R3 to mitigate pulmonary arterial hypertension","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib96","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1124\/jpet.124.002258","article-title":"Sensory-motor neuropathy in Mfn2 T105M knock-in mice and its reversal by a novel piperine-derived mitofusin activator","volume":"391","author":"Weigele","year":"2024","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"10","key":"10.1016\/j.neuint.2026.106164_bib97","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1007\/s12035-022-02981-6","article-title":"Mitofusin 2 integrates mitochondrial network remodelling, mitophagy and renewal of respiratory chain proteins in neurons after oxygen and glucose deprivation","volume":"59","author":"Wojtyniak","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"9 Pt B","key":"10.1016\/j.neuint.2026.106164_bib98","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.bbadis.2018.05.018","article-title":"MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1\u03b1","volume":"1864","author":"Xi","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"6","key":"10.1016\/j.neuint.2026.106164_bib99","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1007\/s12035-024-04466-0","article-title":"Mitofusin 2 mediates the protective effect of NR6A1 silencing against neuronal injury in experimental stroke models","volume":"62","author":"Xu","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib100","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chembiol.2023.02.002","article-title":"Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction","volume":"30","author":"Yang","year":"2023","journal-title":"Cell Chem. Biol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib101","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41419-017-0020-9","article-title":"IL-1 receptor antagonism attenuates renal fibrosis via RNF182-driven MFN2 destabilization and mitochondrial dysfunction","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.neuint.2026.106164_bib102","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/1873-3468.14077","article-title":"Mitochondrial dynamics in health and disease","volume":"595","author":"Yapa","year":"2021","journal-title":"FEBS Lett."},{"issue":"23","key":"10.1016\/j.neuint.2026.106164_bib103","doi-asserted-by":"crossref","first-page":"e2404","DOI":"10.1212\/WNL.0000000000009582","article-title":"Effect of ApoE isoforms on mitochondria in Alzheimer disease","volume":"94","author":"Yin","year":"2020","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.neuint.2026.106164_bib104","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2174\/0115665240310818240531080353","article-title":"Astragaloside IV protects against podocyte injury by upregulating mitophagy via Mfn2\/Pink1\/Parkin axis","volume":"25","author":"Yuan","year":"2025","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.neuint.2026.106164_bib105","first-page":"246","article-title":"Prolonged treatment with trans-ferulic acid mitigates bioenergetics loss and restores mitochondrial dynamics in streptozotocin-induced sporadic dementia of Alzheimer's type","volume":"73","author":"Zafeer","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2026.106164_bib106","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.858286","article-title":"The role of impaired mitochondrial dynamics in MFN2-mediated pathology","volume":"10","author":"Zaman","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.neuint.2026.106164_bib107","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3390\/biom15030433","article-title":"The balance of MFN2 and OPA1 in mitochondrial dynamics, cellular homeostasis, and disease","volume":"15","author":"Zanfardino","year":"2025","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib108","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41392-020-00447-6","article-title":"Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity","volume":"6","author":"Zeng","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"7\u20139","key":"10.1016\/j.neuint.2026.106164_bib109","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/ars.2024.0837","article-title":"Uric acid stimulates PINK1\/Parkin-mediated mitophagy via Nrf2\/HO-1 pathway to protect against neuronal apoptosis in Alzheimer's disease","volume":"43","author":"Zhang","year":"2025","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neuint.2026.106164_bib110","article-title":"5-HMF plays an intervention role in ischemic stroke by regulating GluR2 to improve mitochondrial function and promote angiogenesis","volume":"44","author":"Zhang","year":"2025","journal-title":"Biochem. Biophys. Rep."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-025-02906-x","article-title":"Melatonin orchestrates mitochondrial fusion dynamics-mediated WNT\/\u03b2-catenin signaling to promote dopaminergic neuronal differentiation of human iPS and nerve regeneration in a MPTP-induced mouse model of Parkinson's disease","volume":"12","author":"Zhang","year":"2025","journal-title":"Cell Death Discov."},{"issue":"Suppl. 7","key":"10.1016\/j.neuint.2026.106164_bib112","article-title":"Restoration of mitochondrial dynamics protects against neurodegeneration in a mouse model of Alzheimer's disease","volume":"21","author":"Zhao","year":"2025","journal-title":"Alzheimer's Dement."},{"issue":"2","key":"10.1016\/j.neuint.2026.106164_bib113","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3390\/ijms22020601","article-title":"Mfn2 overexpression attenuates MPTP neurotoxicity in vivo","volume":"22","author":"Zhao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.neuint.2026.106164_bib114","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1186\/s12964-024-01843-z","article-title":"Mitochondrion-based organellar therapies for central nervous system diseases","volume":"22","author":"Zhao","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.neuint.2026.106164_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114807","article-title":"Mfn2 regulates mitochondria and mitochondria-associated endoplasmic reticulum membrane function in neurodegeneration induced by repeated sevoflurane exposure","volume":"377","author":"Zhu","year":"2024","journal-title":"Exp. Neurol."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626000550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626000550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:06:20Z","timestamp":1778735180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626000550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":115,"alternative-id":["S0197018626000550"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106164","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitofusin 2 in central nervous system disorders: Roles in mitochondrial dynamics and therapeutic Implications","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106164"}}