{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:20:12Z","timestamp":1783102812912,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2021MC003"],"award-info":[{"award-number":["ZR2021MC003"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020QH135"],"award-info":[{"award-number":["ZR2020QH135"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.neuint.2026.106179","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T14:25:10Z","timestamp":1778423110000},"page":"106179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TRIM31 attenuates microglia-mediated neuroinflammation via targeting TAK1 in vitro and in vivo"],"prefix":"10.1016","volume":"197","author":[{"given":"Xueying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diange","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingde","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2026.106179_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.107133","article-title":"Dual role of microglia in neuroinflammation and neurodegenerative diseases","volume":"216","author":"Ajoolabady","year":"2025","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.neuint.2026.106179_bib2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/hep.31295","article-title":"Tripartite motif\u2010containing 27 attenuates liver Ischemia\/Reperfusion Injury by suppressing transforming growth factor \u03b2\u2013Activated kinase 1 (TAK1) by TAK1 binding protein 2\/3 degradation","volume":"73","author":"Chen","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.neuint.2026.106179_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103101","article-title":"Aerobic exercise attenuates LPS-induced cognitive dysfunction by reducing oxidative stress, glial activation, and neuroinflammation","volume":"71","author":"Choi","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.neuint.2026.106179_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116846","article-title":"E3 ubiquitin ligase TRIM31: a potential therapeutic target","volume":"176","author":"Deng","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.neuint.2026.106179_bib5","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1007\/s10753-024-02217-w","article-title":"Loss of Trim31 worsens cardiac remodeling in a mouse model of heart failure by enhancing the activation of the NLRP3 inflammasome","volume":"48","author":"Duan","year":"2024","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.neuint.2026.106179_bib6","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1074\/jbc.M109.076976","article-title":"Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor \u03b1- and Interleukin-1\u03b2-induced IKK\/NF-\u03baB and JNK\/AP-1 activation","volume":"285","author":"Fan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2026.106179_bib7","article-title":"TRIM67 suppresses TNFalpha-Triggered NF-kB activation by competitively binding Beta-TrCP to IkBa","volume":"13","author":"Fan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuint.2026.106179_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110287","article-title":"Parthenolide alleviates microglia\u2010mediated neuroinflammation via MAPK\/TRIM31\/NLRP3 signaling to ameliorate cognitive disorder","volume":"120","author":"Fan","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106179_bib9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.neuint.2026.106179_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2019.109684","article-title":"MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4\/NF-\u03baB pathway in vitro and in vivo","volume":"95","author":"Guan","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"10","key":"10.1016\/j.neuint.2026.106179_bib11","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/s41419-021-04208-3","article-title":"Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53","volume":"12","author":"Guo","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuint.2026.106179_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1047177","article-title":"TRIM31: a molecule with a dual role in cancer","volume":"12","author":"Guo","year":"2022","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.neuint.2026.106179_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110225","article-title":"Microglial TAK1 promotes neurotoxic astrocytes and cognitive impairment in LPS-induced hippocampal neuroinflammation","volume":"301","author":"Han","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2026.106179_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-015-0332-6","article-title":"Systemic inflammation and microglial activation: systematic review of animal experiments","volume":"12","author":"Hoogland","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.neuint.2026.106179_bib15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41419-025-07922-4","article-title":"TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification","volume":"16","author":"Li","year":"2025","journal-title":"Cell Death Dis."},{"issue":"7638","key":"10.1016\/j.neuint.2026.106179_bib16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.neuint.2026.106179_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ni.3641","article-title":"The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination","volume":"18","author":"Liu","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neuint.2026.106179_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102638","article-title":"Glial polarization in neurological diseases: molecular mechanisms and therapeutic opportunities","volume":"104","author":"Liu","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"5","key":"10.1016\/j.neuint.2026.106179_bib19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10787-016-0283-2","article-title":"LPS and neuroinflammation: a matter of timing","volume":"24","author":"Lopes","year":"2016","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.neuint.2026.106179_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cellsig.2010.09.006","article-title":"TAK1 lysine 158 is required for TGF-\u03b2-induced TRAF6-mediated Smad-independent IKK\/NF-\u03baB and JNK\/AP-1 activation","volume":"23","author":"Mao","year":"2011","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.neuint.2026.106179_bib21","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1172\/JCI130272","article-title":"Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia","volume":"130","author":"Mathew","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neuint.2026.106179_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176850","article-title":"Anti-inflammatory and antioxidant mechanisms of coniferaldehyde in lipopolysaccharide-induced neuroinflammation: involvement of AMPK\/Nrf2 and TAK1\/MAPK\/NF-\u03baB signaling pathways","volume":"979","author":"Park","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"8006","key":"10.1016\/j.neuint.2026.106179_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-024-07167-9","article-title":"Mitochondrial complex I activity in microglia sustains neuroinflammation","volume":"628","author":"Peruzzotti-Jametti","year":"2024","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.neuint.2026.106179_bib24","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.3390\/molecules27175481","article-title":"Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use","volume":"27","author":"Skrzypczak-Wiercioch","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2026.106179_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13727","article-title":"The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3","volume":"7","author":"Song","year":"2016","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.neuint.2026.106179_bib26","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.7150\/ijbs.33323","article-title":"Tripartite motif 8 deficiency relieves hepatic Ischaemia\/reperfusion Injury via TAK1-dependent signalling pathways","volume":"15","author":"Tao","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"8","key":"10.1016\/j.neuint.2026.106179_bib27","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/s43018-024-00764-7","article-title":"Targeting TGF\u03b2-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome","volume":"5","author":"Vinnakota","year":"2024","journal-title":"Nat. Cancer"},{"issue":"4","key":"10.1016\/j.neuint.2026.106179_bib28","first-page":"1247","article-title":"TRIM31 regulates chronic inflammation via NF-\u03baB signal pathway to promote invasion and metastasis in colorectal cancer","volume":"10","author":"Wang","year":"2018","journal-title":"Am. J. Transl. Res."},{"issue":"17","key":"10.1016\/j.neuint.2026.106179_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.148375","article-title":"MG53 suppresses NF-\u03baB activation to mitigate age-related heart failure","volume":"6","author":"Wang","year":"2021","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.neuint.2026.106179_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41392-021-00711-3","article-title":"TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.neuint.2026.106179_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111749","article-title":"Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination","volume":"130","author":"Xie","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neuint.2026.106179_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.608976","article-title":"TAK1-TABs complex: a central signalosome in inflammatory responses","volume":"11","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuint.2026.106179_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112591","article-title":"Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome","volume":"138","author":"Xue","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neuint.2026.106179_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104814","article-title":"Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation","volume":"140","author":"Yang","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"12","key":"10.1016\/j.neuint.2026.106179_bib35","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.7150\/thno.23259","article-title":"Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-\u03baB signaling pathway","volume":"8","author":"Yu","year":"2018","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.neuint.2026.106179_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-022-00954-9","article-title":"The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation in Helicobacter pylori-associated gastritis by regulating ROS and autophagy","volume":"21","author":"Yu","year":"2023","journal-title":"Cell Commun. Signal."},{"issue":"7","key":"10.1016\/j.neuint.2026.106179_bib37","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/s41591-018-0051-5","article-title":"Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease","volume":"24","author":"Yun","year":"2018","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.neuint.2026.106179_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113050","article-title":"TRIM9-Mediated resolution of neuroinflammation confers neuroprotection upon ischemic stroke in mice","volume":"42","author":"Zeng","year":"2023","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.neuint.2026.106179_bib39","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00109-020-01916-9","article-title":"Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke","volume":"98","author":"Zeyen","year":"2020","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"18","key":"10.1016\/j.neuint.2026.106179_bib40","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2423134122","article-title":"Understanding TAK1 deficiency in microglia: dual mechanisms for photoreceptor protection in a mouse model of retinitis pigmentosa","volume":"122","author":"Zhang","year":"2025","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"8","key":"10.1016\/j.neuint.2026.106179_bib41","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1161\/CIRCULATIONAHA.125.076514","article-title":"Macrophage-specific E3 ubiquitin ligase TRIM31 reduces atherosclerotic plaque formation by targeting LOX-1","volume":"153","author":"Zhang","year":"2026","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.neuint.2026.106179_bib42","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s41418-024-01334-1","article-title":"E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's disease model","volume":"31","author":"Zhao","year":"2024","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.neuint.2026.106179_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12974-019-1538-9","article-title":"Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4\/NF-kB pathway","volume":"16","author":"Zusso","year":"2019","journal-title":"J. Neuroinflammation"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626000707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626000707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:51:14Z","timestamp":1783101074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626000707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":43,"alternative-id":["S0197018626000707"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106179","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRIM31 attenuates microglia-mediated neuroinflammation via targeting TAK1 in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106179"}}