{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:30:36Z","timestamp":1787059836711,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901912"],"award-info":[{"award-number":["81901912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuint.2026.106220","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:21:05Z","timestamp":1783639265000},"page":"106220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hyperbaric oxygen alleviates CFS-like cognitive impairment via PLA2G4A-linked glycerophospholipid metabolism"],"prefix":"10.1016","volume":"199","author":[{"given":"Houyu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianpeng","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2026.106220_bib1","article-title":"Brain-targeted autoimmunity is strongly associated with long COVID and its chronic fatigue syndrome as well as its affective symptoms","author":"Almulla","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.neuint.2026.106220_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.molmed.2024.02.003","article-title":"Unravelling shared mechanisms: insights from recent ME\/CFS research to illuminate long COVID pathologies","volume":"30","author":"Annesley","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuint.2026.106220_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.678543","article-title":"Integrative role of hyperbaric oxygen therapy on healthspan, age-related vascular cognitive impairment, and dementia","volume":"2","author":"Balasubramanian","year":"2021","journal-title":"Front. Aging"},{"key":"10.1016\/j.neuint.2026.106220_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12883-025-04133-4","article-title":"Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption","volume":"25","author":"Chaganti","year":"2025","journal-title":"BMC Neurol."},{"key":"10.1016\/j.neuint.2026.106220_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12967-024-05055-4","article-title":"PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid metabolism in platinum-resistant gastric cancer","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.neuint.2026.106220_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177943","article-title":"6-Gingerol exerts antidepressant effect through regulating the PPAR\u03b3 signaling pathway","author":"Cheng","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2026.106220_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tins.2013.10.003","article-title":"The neuroimmune basis of fatigue","volume":"37","author":"Dantzer","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuint.2026.106220_bib8","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2426874122","article-title":"Patient-reported treatment outcomes in ME\/CFS and long COVID","volume":"122","author":"Eckey","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2026.106220_bib9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1039\/C6MB00600K","article-title":"Metabolic profiling of a myalgic encephalomyelitis\/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism","volume":"13","author":"Germain","year":"2017","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.neuint.2026.106220_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/biom11101520","article-title":"Hyperbaric oxygen treatment-from mechanisms to cognitive improvement","volume":"11","author":"Gottfried","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuint.2026.106220_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1275827","article-title":"The importance of estimating prevalence of ME\/CFS in future epidemiological studies of long COVID","volume":"11","author":"Grabowska","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.neuint.2026.106220_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26136214","article-title":"Immunomodulatory mechanisms underlying neurological manifestations in long COVID: implications for immune-mediated neurodegeneration","volume":"26","author":"Hein","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2026.106220_bib13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.expneurol.2006.04.011","article-title":"Neuroprotective effect of hyperbaric oxygen therapy monitored by MR-imaging after embolic stroke in rats","volume":"201","author":"Henninger","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2026.106220_bib14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.chest.2021.01.082","article-title":"Insights from invasive cardiopulmonary exercise testing of patients with Myalgic Encephalomyelitis\/Chronic fatigue syndrome","volume":"160","author":"Joseph","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.neuint.2026.106220_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097750","article-title":"Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function","volume":"9","author":"Kraitsy","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2026.106220_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/498405","article-title":"Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury","volume":"2015","author":"Lavrnja","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.neuint.2026.106220_bib17","article-title":"Regulation of Nrf2\/GPX4 signaling pathway by hyperbaric oxygen protects against depressive behavior and cognitive impairment in a spinal cord injury rat model","volume":"31","author":"Li","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuint.2026.106220_bib18","article-title":"Systems modeling reveals shared metabolic dysregulation and potential treatments in ME\/CFS and long COVID","volume":"26","author":"Li","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2026.106220_bib19","doi-asserted-by":"crossref","first-page":"16933","DOI":"10.1021\/acs.jafc.5c02557","article-title":"Gut microbiota-driven metabolic alterations reveal the gut-brain communication of ergothioneine in ameliorating cognitive impairment in APP\/PS1 mice","volume":"73","author":"Li","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neuint.2026.106220_bib20","article-title":"Role of glycerophospholipid metabolism in epilepsy","author":"Li","year":"2025","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neuint.2026.106220_bib21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3325\/cmj.2012.53.586","article-title":"Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats","volume":"53","author":"Parabucki","year":"2012","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.neuint.2026.106220_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12974-020-01809-1","article-title":"MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia","volume":"17","author":"Plastira","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2026.106220_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2282790","article-title":"Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP\/PS1 mice","volume":"15","author":"Qian","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neuint.2026.106220_bib24","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/15548627.2019.1628538","article-title":"PLA2G4A\/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma","volume":"16","author":"Sarkar","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2026.106220_bib25","article-title":"PKM2 accelerated the progression of chronic fatigue syndrome via promoting the H4K12la\/NF-\u03baB induced neuroinflammation and mitochondrial damage","volume":"15","author":"Sun","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2026.106220_bib26","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1007\/s12035-015-9314-z","article-title":"Epigenetic regulation of cytosolic phospholipase A2 in SH-SY5Y human neuroblastoma cells","volume":"53","author":"Tan","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2026.106220_bib27","article-title":"Efficacy and safety of hyperbaric oxygen therapy for Parkinson's disease with cognitive dysfunction: protocol for a systematic review and meta-analysis","volume":"14","author":"Tan","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.neuint.2026.106220_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119994","article-title":"Exploring the pharmacological mechanism of Bu-Wang San on Alzheimer's disease through multiple GEO datasets of the human hippocampus, network pharmacology, and metabolomics based on GC-MS and UPLC-Q\/TOF-MS","volume":"350","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neuint.2026.106220_bib29","article-title":"Hyperbaric oxygen therapy alleviates Paclitaxel-Induced peripheral neuropathy involving suppressing TLR4-MyD88-NF-\u03baB signaling pathway","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2026.106220_bib30","article-title":"Zileuton protects against arachidonic acid\/5-lipoxygenase\/leukotriene axis-mediated neuroinflammation in experimental traumatic brain injury","volume":"16","author":"Xu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuint.2026.106220_bib31","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1038\/s41380-018-0200-8","article-title":"Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders","volume":"25","author":"Yu","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2026.106220_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70422","article-title":"Blood-Brain barrier (BBB) dysfunction in CNS diseases: paying attention to pericytes","volume":"31","author":"Yu","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuint.2026.106220_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157018","article-title":"Gan-Mai-Da-Zao decoction ameliorates depressive-like behaviors in CUMS mice via the microbiota-metabolism-inflammation axis","volume":"145","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuint.2026.106220_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12974-023-02690-4","article-title":"Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization","volume":"20","author":"Zhang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2026.106220_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155798","article-title":"AnGong NiuHuang (AGNH) pill attenuated traumatic brain injury through regulating NF-\u03baB\/Nlrp3 axis and glycerophospholipid metabolism","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuint.2026.106220_bib36","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.4103\/0366-6999.169105","article-title":"Hyperbaric oxygen and Ginkgo Biloba extract ameliorate cognitive and memory impairment via nuclear factor Kappa-B pathway in rat model of Alzheimer's Disease","volume":"128","author":"Zhang","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.neuint.2026.106220_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156459","article-title":"Exploring the anti-fatigue properties of ginseng stem and leaf saponins: using UHPLC-MS metabolomics and neurotransmitter analysis","volume":"139","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuint.2026.106220_bib38","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4103\/NRR.NRR-D-24-01412","article-title":"Regulation of synaptic function and lipid metabolism","volume":"21","author":"Zhang","year":"2026","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuint.2026.106220_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120219","article-title":"The protective effects and mechanisms of Polygonatum sibiricum polysaccharides in chronic stress-induced neural damage","volume":"352","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neuint.2026.106220_bib40","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.2147\/JMDH.S517708","article-title":"Analysis of prognostic risk factors in children with disorders of consciousness undergoing hyperbaric oxygen therapy","volume":"18","author":"Zhao","year":"2025","journal-title":"J. Multidiscip. Healthc."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:15:41Z","timestamp":1787058941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626001117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"alternative-id":["S0197018626001117"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106220","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperbaric oxygen alleviates CFS-like cognitive impairment via PLA2G4A-linked glycerophospholipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106220"}}