{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:31:15Z","timestamp":1787059875195,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuint.2026.106223","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:02:48Z","timestamp":1784246568000},"page":"106223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated input-output connectomics at single-neuron resolution reveals parallel projection streams in the mouse ventral posterolateral nucleus"],"prefix":"10.1016","volume":"199","author":[{"given":"Hengzheng","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1161-5313","authenticated-orcid":false,"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2026.106223_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.12-01-00319.1992","article-title":"Correlation between intrinsic firing patterns and thalamocortical synaptic responses of neurons in mouse barrel cortex","volume":"12","author":"Agmon","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.neuro.21.1.47","article-title":"Local circuits in primary visual cortex of the macaque monkey","volume":"21","author":"Callaway","year":"1998","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib3","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2062-23.2024","article-title":"Insula\u2192Amygdala and insula\u2192thalamus pathways are involved in Comorbid chronic pain and depression-like behavior in mice","volume":"44","author":"Chen","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib4","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel? Interoception: the sense of the physiological condition of the body","volume":"3","author":"Craig","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0165-0173(98)00017-4","article-title":"The organization of corticothalamic projections: reciprocity versus parity","volume":"28","author":"Desch\u00eanes","year":"1998","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuint.2026.106223_bib6","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/j.neuron.2025.03.007","article-title":"Single-neuron projectome reveals organization of somatosensory ascending pathways in the mouse brain","volume":"113","author":"Ding","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2026.106223_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.neuro.27.070203.144152","article-title":"Neuronal circuits of the neocortex","volume":"27","author":"Douglas","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnana.2012.00024","article-title":"Excitatory neuronal connectivity in the barrel cortex","volume":"6","author":"Feldmeyer","year":"2012","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neuint.2026.106223_bib9","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1152\/jn.01206.2007","article-title":"Proprioceptive and cutaneous representations in the rat ventral posterolateral thalamus","volume":"99","author":"Francis","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2026.106223_bib10","doi-asserted-by":"crossref","first-page":"14488","DOI":"10.1073\/pnas.222546799","article-title":"The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate","volume":"99","author":"Fremeau","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuint.2026.106223_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41593-022-01041-5","article-title":"Single-neuron projectome of mouse prefrontal cortex","volume":"25","author":"Gao","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib12","series-title":"Neuroanatomy, Thalamocortical Radiations, StatPearls","author":"George","year":"2026"},{"key":"10.1016\/j.neuint.2026.106223_bib13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/280120a0","article-title":"Morphology and intracortical projections of functionally characterised neurones in the cat visual cortex","volume":"280","author":"Gilbert","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2026.106223_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12142","article-title":"High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level","volume":"7","author":"Gong","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2026.106223_bib15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/cne.902510405","article-title":"Morphology of physiologically identified thalamocortical relay neurons in the rat ventrobasal thalamus","volume":"251","author":"Harris","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuint.2026.106223_bib16","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/cercor\/bhv099","article-title":"Thalamocortical innervation pattern in mouse auditory and visual cortex: Laminar and cell-type specificity","volume":"26","author":"Ji","year":"2016","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuint.2026.106223_bib17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ajp.22065","article-title":"Cortical networks for ethologically relevant behaviors in primates","volume":"75","author":"Kaas","year":"2013","journal-title":"Am. J. Primatol."},{"key":"10.1016\/j.neuint.2026.106223_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnint.2017.00027","article-title":"Role for the ventral posterior medial\/posterior lateral thalamus and anterior cingulate cortex in affective\/motivation pain induced by Varicella Zoster virus","volume":"11","author":"Kramer","year":"2017","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib19","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1523\/JNEUROSCI.10-03-00952.1990","article-title":"The organization and connections of somatosensory cortex in marmosets","volume":"10","author":"Krubitzer","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib20","first-page":"317","article-title":"Connections of the fronto-parietal operculum and the postcentral gyrus with the posterior ventral thalamic nucleus, especially its medial nucleus, in monkeys","volume":"26","author":"Kusama","year":"1985","journal-title":"J. Hirnforsch."},{"key":"10.1016\/j.neuint.2026.106223_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brainresbull.2020.06.008","article-title":"Coexpression of VGLUT1 and VGLUT2 in precerebellar neurons in the lateral reticular nucleus of the rat","volume":"162","author":"Li","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2026.106223_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/cne.901970208","article-title":"The structural organization of the ventral posterolateral nucleus in the rat","volume":"197","author":"McAllister","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuint.2026.106223_bib23","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1093\/cercor\/bhq069","article-title":"Cell type-specific thalamic innervation in a column of rat vibrissal cortex","volume":"20","author":"Meyer","year":"2010","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuint.2026.106223_bib24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/cne.902350403","article-title":"Morphology and laminar organization of electrophysiologically identified neurons in the primary auditory cortex in the cat","volume":"235","author":"Mitani","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuint.2026.106223_bib25","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1038\/s41598-020-59042-y","article-title":"A robust image registration interface for large volume brain atlas","volume":"10","author":"Ni","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2026.106223_bib26","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1093\/cercor\/bhr356","article-title":"A morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: a single neuron tracing study with viral vectors","volume":"22","author":"Ohno","year":"2012","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.neuint.2026.106223_bib27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-021-03941-1","article-title":"Morphological diversity of single neurons in molecularly defined cell types","volume":"598","author":"Peng","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2026.106223_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2004.04.008","article-title":"The thalamic reticular nucleus: structure, function and concept","volume":"46","author":"Pinault","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuint.2026.106223_bib29","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1096-24.2024","article-title":"Beyond barrels: diverse thalamocortical projection motifs in the mouse ventral posterior complex","volume":"44","author":"Rubio-Teves","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106223_bib30","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1152\/jn.00429.2011","article-title":"Distinct functions for direct and transthalamic corticocortical connections","volume":"106","author":"Sherman","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2026.106223_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.2001.86.1.1","article-title":"Impact of network activities on neuronal properties in corticothalamic systems","volume":"86","author":"Steriade","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuint.2026.106223_bib32","first-page":"171","article-title":"The somatosensory system","author":"ten Donkelaar","year":"2020"},{"key":"10.1016\/j.neuint.2026.106223_bib33","first-page":"13","article-title":"Neocortical layer 6, a review","volume":"4","author":"Thomson","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neuint.2026.106223_bib34","series-title":"Neuroanatomy, Thalamus, StatPearls","author":"Torrico","year":"2026"},{"key":"10.1016\/j.neuint.2026.106223_bib35","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.cell.2020.04.007","article-title":"The Allen mouse brain common coordinate framework: a 3D reference atlas","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2026.106223_bib36","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1109\/TPAMI.1982.4767203","article-title":"Threshold selection using quadtrees","volume":"4","author":"Wu","year":"1982","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"10.1016\/j.neuint.2026.106223_bib37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF00228842","article-title":"The mode of synaptic activation of pyramidal neurons in the cat primary somatosensory cortex: an intracellular HRP study","volume":"80","author":"Yamamoto","year":"1990","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuint.2026.106223_bib38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pneurobio.2018.09.006","article-title":"Vesicular glutamate transporter isoforms: the essential players in the somatosensory systems","volume":"171","author":"Zhang","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuint.2026.106223_bib39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41592-021-01074-x","article-title":"High-definition imaging using line-illumination modulation microscopy","volume":"18","author":"Zhong","year":"2021","journal-title":"Nat. Methods"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:18:15Z","timestamp":1787059095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626001142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0197018626001142"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106223","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated input-output connectomics at single-neuron resolution reveals parallel projection streams in the mouse ventral posterolateral nucleus","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106223"}}