{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:31:33Z","timestamp":1787059893631,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82575194"],"award-info":[{"award-number":["82575194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471974"],"award-info":[{"award-number":["82471974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274657"],"award-info":[{"award-number":["82274657"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005562","name":"North Carolina Biotechnology Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515010813"],"award-info":[{"award-number":["2024A1515010813"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuint.2026.106227","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:06:45Z","timestamp":1784588805000},"page":"106227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transcriptomic characterization of prefrontal cortical remodeling and glutamate changes detected by Glu-CEST MRI in rats with propofol-induced neuroadaptations"],"prefix":"10.1016","volume":"199","author":[{"given":"Zikai","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baowen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-5455","authenticated-orcid":false,"given":"Shuhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neuint.2026.106227_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70029","article-title":"The Glutamate\/GABA-Glutamine cycle: insights, updates, and advances","volume":"169","author":"Andersen","year":"2025","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.neuint.2026.106227_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0160-5402(91)90037-6","article-title":"Enhanced detection of hyperactivity after drug withdrawal with a simple modification of the open-field apparatus","volume":"26","author":"Barros","year":"1991","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.neuint.2026.106227_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fncel.2020.00051","article-title":"Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells","volume":"14","author":"Belov Kirdajova","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib4","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1038\/s41467-019-12054-3","article-title":"Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction","volume":"10","author":"Bhattacherjee","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.neuint.2026.106227_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097129","article-title":"Orexin A inhibits propofol-induced neurite retraction by a phospholipase D\/protein kinase C\u03b5-dependent mechanism in neurons","volume":"9","author":"Bj\u00f6rnstr\u00f6m","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.neuint.2026.106227_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12630-022-02382-2","article-title":"Propofol misuse in medical professions: a scoping review","volume":"70","author":"Burnett","year":"2023","journal-title":"Can. J. Anaesth."},{"issue":"2","key":"10.1016\/j.neuint.2026.106227_bib7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nm.2615","article-title":"Magnetic resonance imaging of glutamate","volume":"18","author":"Cai","year":"2012","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12871-020-01056-0","article-title":"The role of NMDA receptors in rat propofol self-administration","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.neuint.2026.106227_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2021.111329","article-title":"Nature of glutamate alterations in substance dependence: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies","volume":"315","author":"Chen","year":"2021","journal-title":"Psychiatry Res. Neuroimaging."},{"issue":"15","key":"10.1016\/j.neuint.2026.106227_bib10","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1523\/JNEUROSCI.1982-22.2023","article-title":"Differential effects of astrocyte manipulations on learned motor behavior and neuronal ensembles in the motor cortex","volume":"43","author":"Delepine","year":"2023","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.neuint.2026.106227_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13310","article-title":"The excitatory transmission from basolateral nuclues of amygdala to nucleus accumbens shell regulates propofol self-administration through AMPA receptors","volume":"28","author":"Dong","year":"2023","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuint.2026.106227_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.148841","article-title":"Propofol-induced hippocampal neurotoxicity: a mitochondrial perspective","volume":"1831","author":"Ebrahimi","year":"2024","journal-title":"Brain Res."},{"issue":"16","key":"10.1016\/j.neuint.2026.106227_bib13","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1016\/j.neuron.2024.06.011","article-title":"Propofol anesthesia destabilizes neural dynamics across cortex","volume":"112","author":"Eisen","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2026.106227_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103823","article-title":"The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system","volume":"125","author":"Emerson","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2026.106227_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-psych-122414-033457","article-title":"Drug addiction: updating actions to habits to compulsions ten years on","volume":"67","author":"Everitt","year":"2016","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.neuint.2026.106227_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-026-02385-3","article-title":"Contrasting roles of secondary motor cortex projections to the dorsolateral and dorsomedial striatum in incubation of cocaine-seeking","author":"G\u00f3mez-Pineda","year":"2026","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.neuint.2026.106227_bib16","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1176\/appi.ajp.159.10.1642","article-title":"Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex","volume":"159","author":"Goldstein","year":"2002","journal-title":"Am. J. Psychiatry"},{"issue":"11","key":"10.1016\/j.neuint.2026.106227_bib17","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications","volume":"12","author":"Goldstein","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2026.106227_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1161810","article-title":"Propofol inhibits neuroinflammation and metabolic reprogramming in microglia in vitro and in vivo","volume":"14","author":"Guan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuint.2026.106227_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1614362","article-title":"Exploring the correlation between Drp1 protein and the neurotoxicity of propofol","volume":"19","author":"Guo","year":"2025","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/j.neuint.2026.106227_bib21","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/mp.2017.143","article-title":"Methamphetamine abuse impairs motor cortical plasticity and function","volume":"22","author":"Huang","year":"2017","journal-title":"Mol. Psychiatr."},{"issue":"2","key":"10.1016\/j.neuint.2026.106227_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0297310","article-title":"Application of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T","volume":"19","author":"Jacobs","year":"2024","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.neuint.2026.106227_bib23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-2999(02)02035-6","article-title":"The anesthetics propofol and ketamine inhibit cocaine-induced egr-1 gene expression in rat forebrain","volume":"449","author":"Jouvert","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.neuint.2026.106227_bib24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.neuint.2026.106227_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"6","key":"10.1016\/j.neuint.2026.106227_bib26","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/mrm.21873","article-title":"Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments","volume":"61","author":"Kim","year":"2009","journal-title":"Magn. Reson. Med."},{"issue":"12","key":"10.1016\/j.neuint.2026.106227_bib27","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.biopsych.2010.07.005","article-title":"Prefrontal cortex and impulsive decision making","volume":"69","author":"Kim","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biopsych.2019.05.023","article-title":"Neurobiology of opioid addiction: opponent process, hyperkatifeia, and negative reinforcement","volume":"87","author":"Koob","year":"2020","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.neuint.2026.106227_bib29","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.neuint.2026.106227_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The open field test for measuring locomotor activity and anxiety-like behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s002130000430","article-title":"Abuse liability of the anesthetic propofol: self-administration of propofol in rats under fixed-ratio schedules of drug delivery","volume":"153","author":"LeSage","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"10.1016\/j.neuint.2026.106227_bib32","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neubiorev.2006.03.006","article-title":"Habituation in rodents: a review of behavior, neurobiology, and genetics","volume":"30","author":"Leussis","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.neuint.2026.106227_bib33","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/jmri.28921","article-title":"Glutamate chemical exchange saturation transfer (GluCEST) MRI to evaluate the rapid antidepressant effects of ketamine in the hippocampus of rat depression model","volume":"59","author":"Li","year":"2024","journal-title":"J. Magn. Reson. Imag."},{"issue":"5","key":"10.1016\/j.neuint.2026.106227_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13401","article-title":"NMDA receptor within nucleus accumbens shell regulates propofol self-administration through D1R\/ERK\/CREB signalling pathway","volume":"29","author":"Li","year":"2024","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neuint.2026.106227_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2025.115484","article-title":"The alteration of glutamate involved in the brain of Parkinson's disease patients using glutamate chemical exchange saturation transfer (GluCEST)","volume":"483","author":"Liu","year":"2025","journal-title":"Behav. Brain Res."},{"issue":"12","key":"10.1016\/j.neuint.2026.106227_bib36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.neuint.2026.106227_bib37","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neuron.2011.01.017","article-title":"Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling","volume":"69","author":"L\u00fcscher","year":"2011","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/jnc.12378","article-title":"Amphetamine stimulates movement through thalamocortical glutamate release","volume":"128","author":"Mabrouk","year":"2014","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.neuint.2026.106227_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cells8020184","article-title":"Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release","volume":"8","author":"Mahmoud","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41422-023-00864-6","article-title":"Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation","volume":"34","author":"Mao","year":"2024","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.neuint.2026.106227_bib42","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s43440-024-00653-x","article-title":"Metabotropic glutamate receptors-guardians and gatekeepers in neonatal hypoxic-ischemic brain injury","volume":"76","author":"Mielecki","year":"2024","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuint.2026.106227_bib43","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","article-title":"An integrative theory of prefrontal cortex function","volume":"24","author":"Miller","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.neuint.2026.106227_bib41","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s11064-016-2137-0","article-title":"Glutamate and brain glutaminases in drug addiction","volume":"42","author":"M\u00e1rquez","year":"2017","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib44","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1038\/s41598-024-60759-3","article-title":"Model of negative affect induced by withdrawal from acute and chronic morphine administration in male mice","volume":"14","author":"Ozdemir","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib45","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1038\/s41467-023-40285-y","article-title":"Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex","volume":"14","author":"Rompala","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.neuint.2026.106227_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020383","article-title":"Distinctive neuroanatomic regions involved in cocaine-induced behavioral sensitization in mice","volume":"11","author":"Santos-Baldaia","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13195-025-01672-3","article-title":"CEST imaging combined with (1)H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice","volume":"17","author":"Shen","year":"2025","journal-title":"Alzheimers Res. Ther."},{"issue":"6700","key":"10.1016\/j.neuint.2026.106227_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/science.adn0886","article-title":"A master regulator of opioid reward in the ventral prefrontal cortex","volume":"384","author":"Smith","year":"2024","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.neuint.2026.106227_bib49","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1038\/s41380-020-00986-y","article-title":"Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study","volume":"26","author":"Sydnor","year":"2021","journal-title":"Mol. Psychiatr."},{"issue":"2","key":"10.1016\/j.neuint.2026.106227_bib50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4097\/kja.24707","article-title":"A comprehensive analysis of propofol abuse, addiction and neuropharmacological aspects: an updated review","volume":"78","author":"Uzbay","year":"2025","journal-title":"Korean J. Anesthesiol."},{"issue":"4","key":"10.1016\/j.neuint.2026.106227_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042276","article-title":"Pathological interplay between inflammation and mitochondria aggravates glutamate toxicity","volume":"25","author":"Vaglio-Garro","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuint.2026.106227_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173447","article-title":"Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats","volume":"219","author":"Wang","year":"2022","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.neuint.2026.106227_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci8020036","article-title":"Neurobiology of propofol addiction and supportive evidence: what is the new development?","volume":"8","author":"Xiong","year":"2018","journal-title":"Brain Sci."},{"key":"10.1016\/j.neuint.2026.106227_bib54","article-title":"Glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging of rat brain with acute carbon monoxide poisoning","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.neuint.2026.106227_bib55","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41380-021-01092-3","article-title":"Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications","volume":"27","author":"Yan","year":"2022","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2026.106227_bib56","article-title":"Factors associated with euphoria in a large subset of cases using propofol sedation during gastrointestinal endoscopy","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Psychiatr."},{"issue":"33","key":"10.1016\/j.neuint.2026.106227_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2123146119","article-title":"The neuropeptide landscape of human prefrontal cortex","volume":"119","author":"Zhong","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"24","key":"10.1016\/j.neuint.2026.106227_bib58","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1021\/acschemneuro.3c00539","article-title":"Repurposing of the PET probe prototype PiB for label and radiation-free CEST MRI molecular imaging of amyloid","volume":"14","author":"Zhuang","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuint.2026.106227_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111512","article-title":"Abnormal brain functional activity and changes in c-Fos expression of propofol dependence in rats","volume":"230","author":"Zhuang","year":"2025","journal-title":"Brain Res. Bull."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701862600118X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701862600118X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:19:21Z","timestamp":1787059161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019701862600118X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":59,"alternative-id":["S019701862600118X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106227","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic characterization of prefrontal cortical remodeling and glutamate changes detected by Glu-CEST MRI in rats with propofol-induced neuroadaptations","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106227","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106227"}}