{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:31:34Z","timestamp":1787059894306,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2021ZD0204403"],"award-info":[{"award-number":["2021ZD0204403"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82221001"],"award-info":[{"award-number":["82221001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471254"],"award-info":[{"award-number":["82471254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130034"],"award-info":[{"award-number":["82130034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuint.2026.106231","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:38:09Z","timestamp":1785253089000},"page":"106231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Involvement of the GABAergic pathway from lateral hypothalamic area to paraventricular thalamic nucleus in nociceptive modulation in mice"],"prefix":"10.1016","volume":"199","author":[{"given":"Jin","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ping","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.neuint.2026.106231_bib1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/cne.24557","article-title":"Midline thalamic inputs to the amygdala: ultrastructure and synaptic targets","volume":"527","author":"Amir","year":"2019","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuint.2026.106231_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61135","article-title":"A spinoparabrachial circuit defined by Tacr1 expression drives pain","volume":"10","author":"Barik","year":"2021","journal-title":"eLife"},{"issue":"43","key":"10.1016\/j.neuint.2026.106231_bib3","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0539-25.2025","article-title":"Convergence and segregation of excitatory and inhibitory afferents in the paraventricular thalamic nucleus","volume":"45","author":"Bir\u00f3","year":"2025","journal-title":"J. Neurosci."},{"issue":"22","key":"10.1016\/j.neuint.2026.106231_bib4","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1113\/JP271946","article-title":"Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour","volume":"594","author":"Bonnavion","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2026.106231_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpain.2025.105336","article-title":"Effects of manual therapy combined with therapeutic exercise on brain structure in patients with chronic nonspecific neck pain: a randomized controlled trial","volume":"29","author":"Chaikla","year":"2025","journal-title":"J. Pain"},{"issue":"14","key":"10.1016\/j.neuint.2026.106231_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells14141042","article-title":"The integrated function of the lateral hypothalamus in energy homeostasis","volume":"14","author":"Chen","year":"2025","journal-title":"Cells"},{"issue":"34","key":"10.1016\/j.neuint.2026.106231_bib7","article-title":"Distinct thalamo-subcortical circuits underlie painful behavior and depression-like behavior following nerve injury","volume":"11","author":"Deng","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"2","key":"10.1016\/j.neuint.2026.106231_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41593-019-0572-3","article-title":"Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus","volume":"23","author":"Gao","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"22","key":"10.1016\/j.neuint.2026.106231_bib9","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1523\/JNEUROSCI.2850-20.2021","article-title":"Reciprocal lateral hypothalamic and raphe GABAergic projections promote wakefulness","volume":"41","author":"Gazea","year":"2021","journal-title":"J. Neurosci."},{"issue":"34","key":"10.1016\/j.neuint.2026.106231_bib10","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1523\/JNEUROSCI.5167-13.2014","article-title":"Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms","volume":"34","author":"Goforth","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106231_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106155","article-title":"Contribution of activating lateral hypothalamus-lateral habenula circuit to nerve trauma-induced neuropathic pain in mice","volume":"182","author":"Gu","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"12","key":"10.1016\/j.neuint.2026.106231_bib12","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1007\/s00213-020-05651-4","article-title":"The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues","volume":"237","author":"Haight","year":"2020","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.neuint.2026.106231_bib13","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/j.pain.0000000000003116","article-title":"Assessing spontaneous sensory neuron activity using in vivo calcium imaging","volume":"165","author":"Ingram","year":"2024","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.neuint.2026.106231_bib14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1248\/bpb.b23-00700","article-title":"Combined experiments with in vivo fiber photometry and behavior tests can facilitate the measurement of neuronal activity in the primary somatosensory cortex and Hyperalgesia in an inflammatory pain mice model","volume":"47","author":"Ishikawa","year":"2024","journal-title":"Biol. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.neuint.2026.106231_bib15","first-page":"851","article-title":"Intra-accumbal Orexin-1 receptors are involved in antinociception induced by stimulation of the lateral hypothalamus in the formalin test as an animal model of persistent inflammatory pain","volume":"15","author":"Jahangirvand","year":"2016","journal-title":"Iran. J. Pharm. Res."},{"issue":"1","key":"10.1016\/j.neuint.2026.106231_bib16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41598-018-19145-z","article-title":"Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice","volume":"8","author":"Jang","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.neuint.2026.106231_bib17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/1099800408325053","article-title":"Lateral hypothalamic-induced alpha-adrenoceptor modulation occurs in a model of inflammatory pain in rats","volume":"10","author":"Jeong","year":"2009","journal-title":"Biol. Res. Nurs."},{"issue":"5","key":"10.1016\/j.neuint.2026.106231_bib18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/s41593-025-01919-0","article-title":"Projectome-based characterization of hypothalamic peptidergic neurons in male mice","volume":"28","author":"Jiao","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuint.2026.106231_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2024.100172","article-title":"Neurotensin-expressing lateral hypothalamic neurons alleviate neuropathic and inflammatory pain via neurotensin receptor signaling","volume":"16","author":"Khan","year":"2024","journal-title":"Neurobiol Pain"},{"issue":"1","key":"10.1016\/j.neuint.2026.106231_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19562-1","article-title":"Repetitive nociceptive stimulation increases spontaneous neural activation similar to nociception-induced activity in mouse insular cortex","volume":"12","author":"Kobayashi","year":"2022","journal-title":"Sci. Rep."},{"issue":"13","key":"10.1016\/j.neuint.2026.106231_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108197","article-title":"State-dependent changes in perception and coding in the mouse somatosensory cortex","volume":"32","author":"Lee","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuint.2026.106231_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106699","article-title":"A neural circuit from thalamic paraventricular nucleus via zona incerta to periaqueductal gray for the facilitation of neuropathic pain","volume":"202","author":"Li","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2026.106231_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.107107","article-title":"Projection from the parafascicular nucleus of the thalamus to the insular cortex mediate analgesia and anti-anxiety behaviors in mice","volume":"216","author":"Li","year":"2025","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.neuint.2026.106231_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2024.02.019","article-title":"TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice","volume":"112","author":"Li","year":"2024","journal-title":"Neuron"},{"issue":"41","key":"10.1016\/j.neuint.2026.106231_bib25","doi-asserted-by":"crossref","first-page":"7837","DOI":"10.1523\/JNEUROSCI.2487-19.2020","article-title":"A neural circuit from thalamic paraventricular nucleus to central Amygdala for the facilitation of neuropathic pain","volume":"40","author":"Liang","year":"2020","journal-title":"J. Neurosci."},{"issue":"24","key":"10.1016\/j.neuint.2026.106231_bib26","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1523\/JNEUROSCI.2298-22.2023","article-title":"Disinhibition of mesolimbic dopamine circuit by the lateral hypothalamus regulates pain sensation","volume":"43","author":"Ma","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2026.106231_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2024.100654","article-title":"Hyperexcitation of the glutamatergic neurons in lateral hypothalamus induced by chronic pain contributes to depression-like behavior and learning and memory impairment in male mice","volume":"31","author":"Meng","year":"2024","journal-title":"Neurobiol. Stress"},{"issue":"4","key":"10.1016\/j.neuint.2026.106231_bib28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41593-019-0349-8","article-title":"Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons","volume":"22","author":"Mickelsen","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"25","key":"10.1016\/j.neuint.2026.106231_bib29","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.1523\/JNEUROSCI.0155-17.2017","article-title":"Galanin-Expressing GABA neurons in the lateral hypothalamus modulate food reward and noncompulsive locomotion","volume":"37","author":"Qualls-Creekmore","year":"2017","journal-title":"J. Neurosci."},{"issue":"6413","key":"10.1016\/j.neuint.2026.106231_bib30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1126\/science.aat2512","article-title":"The paraventricular thalamus is a critical thalamic area for wakefulness","volume":"362","author":"Ren","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuint.2026.106231_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.npep.2018.03.002","article-title":"Effects of intrathecal administration of orexin-1 receptor antagonist on antinociceptive responses induced by chemical stimulation of lateral hypothalamus in an animal model of tonic nociception","volume":"69","author":"Rezaee","year":"2018","journal-title":"Neuropeptides"},{"issue":"14","key":"10.1016\/j.neuint.2026.106231_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2017.06.024","article-title":"Lateral hypothalamic GABAergic neurons encode reward predictions that are relayed to the ventral tegmental area to regulate learning","volume":"27","author":"Sharpe","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neuint.2026.106231_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66446","article-title":"An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice","volume":"10","author":"Siemian","year":"2021","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.neuint.2026.106231_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-05572-2","article-title":"Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice","volume":"15","author":"Van der Zouwen","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2026.106231_bib35","article-title":"Lateral hypothalamic orexin neurons mediate the reward effects of pain relief induced by electroacupuncture","volume":"15","author":"Wang","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.neuint.2026.106231_bib36","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41380-022-01922-y","article-title":"Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety","volume":"28","author":"Wang","year":"2023","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.neuint.2026.106231_bib37","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/0193945915610083","article-title":"Lateral hypothalamic stimulation reduces Hyperalgesia through spinally descending Orexin-A neurons in neuropathic pain","volume":"38","author":"Wardach","year":"2016","journal-title":"West. J. Nurs. Res."},{"issue":"3","key":"10.1016\/j.neuint.2026.106231_bib38","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bja.2025.05.021","article-title":"Orexinergic projections to substantia innominata mediate arousal and analgesia","volume":"135","author":"Xiang","year":"2025","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.neuint.2026.106231_bib39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.conb.2017.03.020","article-title":"Lateral hypothalamic circuits for sleep-wake control","volume":"44","author":"Yamashita","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"issue":"11","key":"10.1016\/j.neuint.2026.106231_bib40","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41583-022-00624-2","article-title":"CaMKII: a central molecular organizer of synaptic plasticity, learning and memory","volume":"23","author":"Yasuda","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2026.106231_bib41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.brainresbull.2020.06.017","article-title":"Modulatory role of hippocampal dopamine receptors in antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in an animal model of persistent inflammatory pain","volume":"162","author":"Zakeri","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2026.106231_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113492","article-title":"Role of hippocampal orexin receptors in antinociception elicited by chemical stimulation of the lateral hypothalamus in the tail-flick test","volume":"414","author":"Zargarani","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2026.106231_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106776","article-title":"Neural and molecular investigation into the paraventricular thalamic-nucleus accumbens circuit for pain sensation and non-opioid analgesia","volume":"191","author":"Zhang","year":"2023","journal-title":"Pharmacol. Res."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:19:29Z","timestamp":1787059169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626001221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"alternative-id":["S0197018626001221"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106231","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of the GABAergic pathway from lateral hypothalamic area to paraventricular thalamic nucleus in nociceptive modulation in mice","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106231","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106231"}}