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Cell Mol. Med."},{"issue":"22","key":"10.1016\/j.neuint.2026.106258_bib119","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"6\u20137","key":"10.1016\/j.neuint.2026.106258_bib120","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0531-5565(00)00148-0","article-title":"Heme oxygenase-1: role in brain aging and neurodegeneration","volume":"35","author":"Schipper","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neuint.2026.106258_bib121","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1742-2094-7-86","article-title":"Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells","volume":"7","author":"Shih","year":"2010","journal-title":"J. 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