{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:51:28Z","timestamp":1791953488179,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571983"],"award-info":[{"award-number":["82571983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2707705"],"award-info":[{"award-number":["2024YFC2707705"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.neuint.2026.106266","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:35:20Z","timestamp":1790033720000},"page":"106266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bilirubin impacts microglial lipophagy via the AMPK-mTOR signaling pathway"],"prefix":"10.1016","volume":"200","author":[{"given":"Shasha","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3865-6254","authenticated-orcid":false,"given":"Ziyu","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2026.106266_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1347987","article-title":"The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets","volume":"16","author":"Adamu","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuint.2026.106266_bib2","unstructured":"Aljadeed, N.M., Pambori, E., Zhang, Y., Austin, G., Olona, A., Franzoso, G., Samarajiwa, S., Tomas, A., Keung, F.W., Anand, P.K., n.d. Lipid Droplet Accumulation Drives Glutamine-dependent NLRP3 Inflammasome Activation."},{"key":"10.1016\/j.neuint.2026.106266_bib3","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/jp.2008.212","article-title":"Kernicterus in the 21st century: frequently asked questions","volume":"29","author":"Bhutani","year":"2009","journal-title":"J. Perinatol."},{"key":"10.1016\/j.neuint.2026.106266_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/j.semperi.2011.02.002","article-title":"The need for technologies to prevent bilirubin-induced neurologic dysfunction syndrome","volume":"35","author":"Bhutani","year":"2011","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.neuint.2026.106266_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2019.577067","article-title":"Dynamic expression of autophagy-related factors in autoimmune encephalomyelitis and exploration of curcumin therapy","volume":"337","author":"Boyao","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuint.2026.106266_bib6","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/glia.22642","article-title":"Age-related changes in astrocytic and ependymal cells of the subventricular zone","volume":"62","author":"Capilla-Gonzalez","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.neuint.2026.106266_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/bs.ircmb.2017.12.007","article-title":"Lipid droplets as organelles","volume":"337","author":"Cohen","year":"2018","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.neuint.2026.106266_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11011-025-01631-9","article-title":"Microglial activation as a hallmark of neuroinflammation in Alzheimer's disease","volume":"40","author":"Ebrahimi","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2026.106266_bib9","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fnins.2020.00742","article-title":"Lipid droplets in neurodegenerative disorders","volume":"14","author":"Farmer","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuint.2026.106266_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12974-018-1064-1","article-title":"Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes","volume":"15","author":"Feng","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2026.106266_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12031-007-0060-1","article-title":"Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders","volume":"33","author":"Hamilton","year":"2007","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neuint.2026.106266_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer's disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2026.106266_bib13","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41390-019-0451-3","article-title":"Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons","volume":"86","author":"He","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neuint.2026.106266_bib14","first-page":"1027","article-title":"[Role of pyroptosis in bilirubin-induced microglial injury]","volume":"22","author":"Huang","year":"2020","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"10.1016\/j.neuint.2026.106266_bib15","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1194\/jlr.M072454","article-title":"Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH","volume":"58","author":"Ioannou","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neuint.2026.106266_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cccn.2005.01.008","article-title":"Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubin","volume":"356","author":"Kaplan","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neuint.2026.106266_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2026.01.014","article-title":"Lipid droplet-induced T cell death sustains autoimmune tissue inflammation","author":"Kumar","year":"2026","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuint.2026.106266_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.neuint.2026.106266_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12974-025-03399-2","article-title":"H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes","volume":"22","author":"Li","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2026.106266_bib20","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/jnc.15984","article-title":"Bilirubin impacts microglial autophagy via the Akt\u2013mTOR signaling pathway","volume":"167","author":"Li","year":"2023","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2026.106266_bib21","doi-asserted-by":"crossref","first-page":"30042","DOI":"10.1074\/jbc.M115.673525","article-title":"The blockade of NF-\u03baB activation by a specific inhibitory peptide has a strong neuroprotective role in a sprague-dawley rat Kernicterus model","volume":"290","author":"Li","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2026.106266_bib22","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1080\/15548627.2023.2213984","article-title":"Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment","volume":"19","author":"Li","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2026.106266_bib23","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1021\/acschemneuro.1c00287","article-title":"Depression of pyroptosis by inhibiting Caspase-1 activation improves neurological outcomes of Kernicterus model rats","volume":"12","author":"Li","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuint.2026.106266_bib24","article-title":"Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuint.2026.106266_bib25","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.it.2021.07.005","article-title":"Lipid regulation of NLRP3 inflammasome activity through organelle stress","volume":"42","author":"Liang","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.neuint.2026.106266_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/15548627.2025.2581217","article-title":"Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders","volume":"22","author":"Lu","year":"2026","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2026.106266_bib27","article-title":"Lipophagy: a new player in CNS disorders","volume":"32","author":"M","year":"2021","journal-title":"Trends Endocrinol. Metabol.: TEM"},{"key":"10.1016\/j.neuint.2026.106266_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.apsb.2024.10.009","article-title":"Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy","volume":"15","author":"Mao","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.neuint.2026.106266_bib29","doi-asserted-by":"crossref","first-page":"699","DOI":"10.12968\/hmed.2017.78.12.699","article-title":"Neonatal jaundice: aetiology, diagnosis and treatment","volume":"78","author":"Mitra","year":"2017","journal-title":"Br. J. Hosp. Med."},{"key":"10.1016\/j.neuint.2026.106266_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuint.2026.106266_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2026.106266_bib32","doi-asserted-by":"crossref","DOI":"10.1007\/s11910-022-01204-8","article-title":"Bilirubin encephalopathy","author":"Qian","year":"2022","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.neuint.2026.106266_bib33","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202102136","article-title":"Lipid droplets in the nervous system","volume":"220","author":"Ralhan","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neuint.2026.106266_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbi.2024.09.027","article-title":"Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides","volume":"123","author":"Robb","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuint.2026.106266_bib35","series-title":"Chronic Bilirubin Encephalopathy: Diagnosis and Outcome","author":"Shapiro","year":"2010"},{"key":"10.1016\/j.neuint.2026.106266_bib36","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2026.106266_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/antiox11010022","article-title":"Pathophysiology of lipid droplets in neuroglia","volume":"11","author":"Smoli\u010d","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.neuint.2026.106266_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer's 1907 paper, \u201cUber eine eigenartige Erkankung der Hirnrinde.\u201d","volume":"8","author":"Stelzmann","year":"1995","journal-title":"Clin. Anat."},{"key":"10.1016\/j.neuint.2026.106266_bib39","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jnutbio.2018.02.017","article-title":"Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic \u03b2-cell dysfunction through AMPK\/mTOR-mediated lipophagy","volume":"57","author":"Varshney","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neuint.2026.106266_bib40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12974-021-02309-6","article-title":"The semantics of microglia activation: neuroinflammation, homeostasis, and stress","volume":"18","author":"Woodburn","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuint.2026.106266_bib41","doi-asserted-by":"crossref","DOI":"10.1039\/D4FO00185K","article-title":"Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state","author":"Xie","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.neuint.2026.106266_bib42","article-title":"Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading","volume":"118","author":"Y","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuint.2026.106266_bib43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13578-022-00828-0","article-title":"Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases","volume":"12","author":"Yang","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.neuint.2026.106266_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103978","article-title":"Acetylation of fatty acid synthase regulates microglial lipid droplets accumulation and pro-inflammatory activity following traumatic brain injury","volume":"89","author":"Zhang","year":"2026","journal-title":"Redox Biol."},{"key":"10.1016\/j.neuint.2026.106266_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12974-025-03334-5","article-title":"Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases","volume":"22","author":"Zhang","year":"2025","journal-title":"J. Neuroinflammation"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:39:43Z","timestamp":1791952783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626001579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":45,"alternative-id":["S0197018626001579"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106266","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bilirubin impacts microglial lipophagy via the AMPK-mTOR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106266"}}