{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:39:08Z","timestamp":1792431548641,"version":"4.5.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neuint.2026.106279","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:45:09Z","timestamp":1792230309000},"page":"106279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Implementation rules and research status of acupuncture therapy for anxiety disorders"],"prefix":"10.1016","volume":"201","author":[{"given":"Hailun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2026.106279_bib4","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.21037\/apm-21-925","article-title":"Clinical observation of warming acupuncture and moxibustion at the temples combined with Deanxit in the treatment of tension headache with anxiety and depression: a retrospective study","volume":"10","author":"A","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib1","article-title":"Electroacupuncture and acupuncture in the treatment of anxiety - a double blinded randomized parallel clinical trial","volume":"46","author":"Amorim","year":"2022","journal-title":"Compl. Ther. Clin. Pract."},{"key":"10.1016\/j.neuint.2026.106279_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.35946\/arcr.v40.1.03","article-title":"Co-Occurring alcohol use disorder and anxiety: bridging psychiatric, psychological, and neurobiological perspectives","volume":"40","author":"Anker","year":"2019","journal-title":"ARCR"},{"key":"10.1016\/j.neuint.2026.106279_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1142\/S0192415X07004606","article-title":"Effect of acupuncture treatment on the immune function impairment found in anxious women","volume":"35","author":"Arranz","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib5","series-title":"Anxiety Disorders, Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/978-981-32-9705-0_20","article-title":"Role of benzodiazepines in anxiety disorders","author":"Balon","year":"2020"},{"key":"10.1016\/j.neuint.2026.106279_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.31887\/DCNS.2017.19.2\/bbandelow","article-title":"Treatment of anxiety disorders","volume":"19","author":"Bandelow","year":"2017","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neuint.2026.106279_bib7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1037\/cou0000417","article-title":"Processes of therapeutic change: results from the Cornell-Penn Study of Psychotherapies for Panic Disorder","volume":"67","author":"Barber","year":"2020","journal-title":"J. Counsel. Psychol."},{"key":"10.1016\/j.neuint.2026.106279_bib8","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/cncr.34542","article-title":"Acupuncture during gynecological oncology surgery: a randomized controlled trial assessing the impact of integrative therapies on perioperative pain and anxiety","volume":"129","author":"Ben\u2010Arye","year":"2023","journal-title":"Cancer"},{"key":"10.1016\/j.neuint.2026.106279_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neuint.2026.106279_bib10","series-title":"The Observation in the Therapeutic Effectiveness of Acupuncture Five-Emotion Point Accompanied with Anxiety and Depression (M)","author":"Cao","year":"2019"},{"key":"10.1016\/j.neuint.2026.106279_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neulet.2007.10.026","article-title":"Effect of acupuncture on anxiety-like behavior during nicotine withdrawal and relevant mechanisms","volume":"430","author":"Chae","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2026.106279_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101583","article-title":"Sleep and anxiety: from mechanisms to interventions","volume":"61","author":"Chellappa","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuint.2026.106279_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41467-024-44704-6","article-title":"Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuint.2026.106279_bib13","first-page":"865","article-title":"Electric acupuncture plus fire acupuncture improves facial nerve function and anxiety state in patients with obstinate facial palsy","volume":"18","author":"Chen","year":"2019"},{"key":"10.1016\/j.neuint.2026.106279_bib15","first-page":"21","article-title":"Guideline for the diagnosis and treatment of generalized anxiety disorder with integrated Traditional Chinese and Western Medicine","volume":"30","year":"2023","journal-title":"zggx"},{"key":"10.1016\/j.neuint.2026.106279_bib16","series-title":"Anxiety Disorders, Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-981-32-9705-0_14","article-title":"Comorbid anxiety and depression: clinical and conceptual consideration and transdiagnostic treatment","author":"Choi","year":"2020"},{"key":"10.1016\/j.neuint.2026.106279_bib17","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.7150\/thno.106751","article-title":"Acupuncture alleviates CSDS-induced depressive-like behaviors by modulating synaptic plasticity in vCA1","volume":"15","author":"Cong","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.neuint.2026.106279_bib18","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1016\/S0140-6736(16)30381-6","article-title":"Anxiety","volume":"388","author":"Craske","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2026.106279_bib19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/wps.20089","article-title":"Adding psychotherapy to antidepressant medication in depression and anxiety disorders: a meta-analysis","volume":"13","author":"Cuijpers","year":"2014","journal-title":"World Psychiatry"},{"key":"10.1016\/j.neuint.2026.106279_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/da.22580","article-title":"Melancholic and atypical depression as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression","volume":"34","author":"Cuijpers","year":"2017","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.neuint.2026.106279_bib21","first-page":"625","article-title":"Effect of warm-acupuncture on anxiety-depression-like behavior and BDNF\/TrkB pathway in chronic restraint stress rats","volume":"41","author":"Diao","year":"2018","journal-title":"Int. J. Immunol."},{"key":"10.1016\/j.neuint.2026.106279_bib22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1755-5949.2011.00254.x","article-title":"Acupuncture for anxiety","volume":"18","author":"Errington\u2010Evans","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuint.2026.106279_bib23","first-page":"1700","article-title":"Clinical observation on the treatment of vitiligo with anxiety and depression using modified Xiaoyao powder combined with thumbtack needling therapy","volume":"45","author":"Feng","year":"2024","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib24","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s43440-025-00782-x","article-title":"The cortisol axis and psychiatric disorders: an updated review","volume":"77","author":"George","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuint.2026.106279_bib26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13020-025-01307-7","article-title":"Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice","volume":"21","author":"Gong","year":"2026","journal-title":"Chin. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib25","article-title":"Research progress on the neural circuits mechanisms of anxiety","volume":"19","author":"Gong","year":"2025","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.neuint.2026.106279_bib27","series-title":"CLINICAL OBSERVATION ON THE CURATIVE EFFECT OF COGNITIVE BEHAVIOR THERAPY COMBINED WITH ACUPUNCTURE IN TREATING MILD AND MODERATE DEPRESSION SYNDROME OF LIVER QI STAGNATION BASED ON PSYCHOLOGY OF TRADITIONAL CHINESE MEDICINE (M)","author":"Guo","year":"2021"},{"key":"10.1016\/j.neuint.2026.106279_bib28","first-page":"55","article-title":"Effect of electroacupuncture at Neiguan and Yanglingquan Points on anxiety-like behavior and energy metabolism in the hippocampus in mice with posttraumatic stress disorder","volume":"44","author":"Guo","year":"2025","journal-title":"ahzy"},{"key":"10.1016\/j.neuint.2026.106279_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99882-w","article-title":"A systematic review and meta-analysis of acceptance- and mindfulness-based interventions for DSM-5 anxiety disorders","volume":"11","author":"Haller","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2026.106279_bib30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-2236(02)00006-1","article-title":"Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies","volume":"26","author":"Han","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuint.2026.106279_bib32","first-page":"61","article-title":"Clinical effect of Wendan Decoction combined with acupuncture patients on with generalized anxiety disorder of phlegm-dampness constitution","volume":"44","author":"Han","year":"2025"},{"key":"10.1016\/j.neuint.2026.106279_bib31","first-page":"154","article-title":"Effect of moxibustion on shenque and acupuncture at different acupoints on neurotransmitters in different brain regions of depression rats","volume":"20","author":"Han","year":"2018"},{"key":"10.1016\/j.neuint.2026.106279_bib33","first-page":"599","article-title":"Relevant research of iNOS and electric-acupuncture adjusting comorbid anxiety and depression","volume":"45","author":"He","year":"2018"},{"key":"10.1016\/j.neuint.2026.106279_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2826.2006.01429.x","article-title":"Do corticosteroids damage the brain?","volume":"18","author":"Herbert","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neuint.2026.106279_bib35","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(21)02141-3","article-title":"Time for united action on depression: a Lancet\u2013World Psychiatric Association Commission","volume":"399","author":"Herrman","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2026.106279_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.rbmo.2022.02.002","article-title":"Effect of acupuncture on IVF-related anxiety: a systematic review and meta-analysis","volume":"45","author":"Hullender Rubin","year":"2022","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.neuint.2026.106279_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1682400","article-title":"Efficacy of acupuncture versus sham acupuncture on generalized anxiety disorder: a meta-analysis of randomized controlled trials","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuint.2026.106279_bib38","first-page":"1825","article-title":"300 cases of scalp acupuncture combined with Chinese herbal medicine for the treatment of anxiety and depression","volume":"27","author":"Jiao","year":"2012"},{"key":"10.1016\/j.neuint.2026.106279_bib40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2009.05.008","article-title":"The effects of acupuncture stimulation at PC6 (Neiguan) on chronic mild stress-induced biochemical and behavioral responses","volume":"460","author":"Kim","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2026.106279_bib39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0006-8993(03)03087-7","article-title":"Expression of neuropeptide Y and cholecystokinin in the rat brain by chronic mild stress","volume":"983","author":"Kim","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2026.106279_bib41","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3390\/jcm10081575","article-title":"Efficacy and underlying mechanism of acupuncture in the treatment of posttraumatic stress disorder: a systematic review of animal studies","volume":"10","author":"Kwon","year":"2021","journal-title":"JCM"},{"key":"10.1016\/j.neuint.2026.106279_bib43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neulet.2009.01.076","article-title":"Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats","volume":"453","author":"Lee","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2026.106279_bib42","series-title":"Clinical Observation the Therapeutic Effect of Navel Acupuncture on Generalized Anxiety Disorder (D)","author":"Lee","year":"2019"},{"key":"10.1016\/j.neuint.2026.106279_bib44","first-page":"55","article-title":"Clinical effect of dredging-regulating balance acupuncture on chronic insomnia with anxiety and depression","volume":"39","author":"Lei","year":"2022","journal-title":"Information on TCM"},{"key":"10.1016\/j.neuint.2026.106279_bib46","series-title":"The Study of the Clinical Effect of Tiaoshen Acupuncture Method of Jin's three-needle on the Treatment of Sudden Deafness with anxiety-depression (M)","author":"Li","year":"2022"},{"key":"10.1016\/j.neuint.2026.106279_bib45","series-title":"Clinical Study on jinsanzhen-acupuncture in the Treatment of Generalized Anxiety (D)","author":"Li","year":"2006"},{"key":"10.1016\/j.neuint.2026.106279_bib47","series-title":"Clinical Observation of Jin's three-needle-regulating-shen Therapy on Patients with Post-stroke Anxiety (M)","author":"Li","year":"2023"},{"key":"10.1016\/j.neuint.2026.106279_bib50","first-page":"57","article-title":"Efficacy of the spirit-regulation method of Jin's three-needle therapy for post-stroke anxiety and its effect on the hypothalamus-pituitary-adrenal axis","volume":"49","author":"Li","year":"2024","journal-title":"Acupunct. Res."},{"key":"10.1016\/j.neuint.2026.106279_bib48","first-page":"1147","article-title":"A study of effects of music therapy on anxiety and pain in the treatment of children with cerebral palsy with acupuncture","volume":"27","author":"Li","year":"2008","journal-title":"Int. J. Nurs."},{"key":"10.1016\/j.neuint.2026.106279_bib49","article-title":"The effect of acupuncture at the umbilical ring point combined with warm needle at Yongquan point on sleep quality, depression, and anxiety scores in patients with heart-kidney Disharmony Insomnia","volume":"40","author":"Li","year":"2018"},{"key":"10.1016\/j.neuint.2026.106279_bib51","first-page":"265","article-title":"Influences of different acupuncture methods on hypothalamic CRH mRNA expression and serum ACTH and CORT in rats with chronic stress depression","volume":"35","author":"Liang","year":"2012"},{"key":"10.1016\/j.neuint.2026.106279_bib52","series-title":"Jin's Three Needle Acupuncture Technique for Anxiety and Depression State of Patients with Chronic Fatigue Syndrome: a Non-blind Randomized Controlled Trial (M)","author":"Lin","year":"2019"},{"key":"10.1016\/j.neuint.2026.106279_bib54","article-title":"Randomized controlled trial of acupuncture for anxiety and depression in patients with chronic insomnia","volume":"9","author":"Liu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib55","article-title":"Efficacy of acupuncture (Jin's three-needle) on motor symptoms and anxiety in patients with Parkinson's disease: protocol for a multicentre, randomised, assessor-blinded clinical trial","volume":"14","author":"Liu","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.neuint.2026.106279_bib53","article-title":"Observation Study on the efficacy of needle warming moxibustion in edema of the upper extremity and anxiety-depression of mammary cancer after operation","volume":"14","author":"Liu","year":"2019"},{"key":"10.1016\/j.neuint.2026.106279_bib56","first-page":"55","article-title":"Clinical observation of Jiaji acupuncture combined with traditional Chinese medicine in the treatment of post-stroke depression","volume":"27","author":"Lu","year":"2019"},{"key":"10.1016\/j.neuint.2026.106279_bib57","series-title":"Chinese Journal of Intergrated Tradtional And Western Medicine","first-page":"201","article-title":"Clinical Study on\u201cJin's three-needling\u201din treatment of generalized anxiety disorder","author":"Luo","year":"2007"},{"key":"10.1016\/j.neuint.2026.106279_bib58","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuron.2021.12.015","article-title":"A functional subdivision within the somatosensory system and its implications for pain research","volume":"110","author":"Ma","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2026.106279_bib59","series-title":"CLINICAL OBSERVATION ON TREATMENT OF POSTPARTUM DEPRESSION (STAGNATION OF LIVER QI) WITH JIN THREE NEEDLES COMBINED WITH BURYING NEEDLES (M)","author":"Ma","year":"2024"},{"key":"10.1016\/j.neuint.2026.106279_bib60","first-page":"1055","article-title":"Effect of electroacupuncture on E\/I balance of prefrontal cortex and hippocampal pyramidal neurons in anxiety-like mice","volume":"50","author":"Ma","year":"2025","journal-title":"Acupunct. Res."},{"key":"10.1016\/j.neuint.2026.106279_bib61","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2026.106279_bib62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1176\/appi.psychotherapy.20190021","article-title":"Mentalizing in interpersonal psychotherapy","volume":"72","author":"Markowitz","year":"2019","journal-title":"APT"},{"key":"10.1016\/j.neuint.2026.106279_bib63","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00702-017-1709-8","article-title":"Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis","volume":"125","author":"Naoi","year":"2018","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neuint.2026.106279_bib64","first-page":"728","article-title":"Central mechanism of acupuncture intervention in anxiety and depression under fMRI","volume":"47","author":"Ni","year":"2022","journal-title":"Acupunct. Res."},{"key":"10.1016\/j.neuint.2026.106279_bib65","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1118\/1.3157204","article-title":"In vivo detection and imaging of low-density foreign body with microwave-induced thermoacoustic tomography: in vivo foreign body detection with thermoacoustic tomography","volume":"36","author":"Nie","year":"2009","journal-title":"Med. Phys."},{"key":"10.1016\/j.neuint.2026.106279_bib66","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neulet.2004.11.097","article-title":"The effect of acupuncture on anxiety and neuropeptide Y expression in the basolateral amygdala of maternally separated rats","volume":"377","author":"Park","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2026.106279_bib67","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0140-6736(09)60660-7","article-title":"Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001-05: an epidemiological survey","volume":"373","author":"Phillips","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2026.106279_bib68","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41380-019-0615-x","article-title":"Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model","volume":"25","author":"Price","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neuint.2026.106279_bib69","first-page":"156","article-title":"Impacts on serum ACTH and CORT in the rat models of chronic stress depression treated with electroacupuncture at baihui(GV20) ,Shenmen (HT7) and taichong(LR3)","volume":"9","author":"Qiao","year":"2014"},{"key":"10.1016\/j.neuint.2026.106279_bib70","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.amjmed.2025.05.044","article-title":"An integrative approach to HPA axis dysfunction: from recognition to recovery","volume":"138","author":"Ring","year":"2025","journal-title":"Am. J. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib71","doi-asserted-by":"crossref","DOI":"10.1177\/03331024221132800","article-title":"Effects of acupuncture and medical training therapy on depression, anxiety, and quality of life in patients with frequent tension-type headache: a randomized controlled study","volume":"43","author":"Schiller","year":"2023","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuint.2026.106279_bib72","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.3390\/ijms22084037","article-title":"Acupuncture alleviates anxiety and 22-kHz ultrasonic vocalizations in rats subjected to repeated Alcohol administration by modulating the brain-derived neurotrophic Factor\/Corticotropin-Releasing hormone signaling pathway","volume":"22","author":"Seo","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.neuint.2026.106279_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67702-2","article-title":"Electroacupuncture intervention of visceral hypersensitivity is involved in PAR-2-activation and CGRP-release in the spinal cord","volume":"10","author":"Shah","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuint.2026.106279_bib74","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11726-017-1037-4","article-title":"Clinical study on acupuncture for primary insomnia","volume":"15","author":"Shao","year":"2017","journal-title":"J. Acupunct. Tuina. Sci."},{"key":"10.1016\/j.neuint.2026.106279_bib75","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0140-6736(18)31793-8","article-title":"Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis","volume":"393","author":"Slee","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.neuint.2026.106279_bib76","first-page":"741","article-title":"Protective effects on hippocampal neurons and the influence on hippocampal monoamine neurotransmitters with acupuncture for promoting the circulation of the governor vessel and regulating the mental state in rats with post-stroke depression","volume":"39","author":"Sun","year":"2019","journal-title":"Chin. Acupunct. Moxibustion"},{"key":"10.1016\/j.neuint.2026.106279_bib77","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1001\/jama.2022.22744","article-title":"Anxiety disorders: a review","volume":"328","author":"Szuhany","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.neuint.2026.106279_bib78","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.joim.2020.10.007","article-title":"Can acupuncture therapy reduce preoperative anxiety? A systematic review and meta-analysis","volume":"19","author":"Tong","year":"2021","journal-title":"J.Integrative Med."},{"key":"10.1016\/j.neuint.2026.106279_bib79","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/00207144.2019.1613863","article-title":"The efficacy of hypnosis as a treatment for anxiety: a Meta-Analysis","volume":"67","author":"Valentine","year":"2019","journal-title":"IJCEH (Int. J. Clin. Exp. Hypn.)"},{"key":"10.1016\/j.neuint.2026.106279_bib80","series-title":"Cross-Sectional Survey on Generalized Anxiety Disorder in Macao and Interventional Study of Press Needle Combined with Electroacupuncture (D)","author":"WAI","year":"2024"},{"key":"10.1016\/j.neuint.2026.106279_bib82","first-page":"923","article-title":"Acupuncture and moxibustion combined with umbilical therapy for 30 cases of anxiety and depression in patients with neurogenic bladder after spinal cord injury","volume":"45","author":"Wang","year":"2025","journal-title":"Chin. Acupunct. Moxibustion"},{"key":"10.1016\/j.neuint.2026.106279_bib81","first-page":"97","article-title":"Clinical observation of Zhu's scalp acupuncture for treating migraines with anxiety and depression","volume":"14","author":"Wang","year":"2022"},{"key":"10.1016\/j.neuint.2026.106279_bib83","series-title":"International Clinical Practice Guideline of Chinese Medicine Anxiety(2020-10-11))","year":"2021"},{"key":"10.1016\/j.neuint.2026.106279_bib84","first-page":"1100","article-title":"Research progress on the mechanism of acupuncture on depression based on signaling pathway regulation","volume":"49","author":"Xiao","year":"2024","journal-title":"Acupunct. Res."},{"key":"10.1016\/j.neuint.2026.106279_bib85","first-page":"681","article-title":"Effect of acupuncture combined with cognitive behavior therapy on insomnia","volume":"28","author":"Xie","year":"2021"},{"key":"10.1016\/j.neuint.2026.106279_bib86","series-title":"Study on Clinical Efficacy of Zhuang MedicineAcupuncture Treating Generalized Anxiety Disorder (M)","author":"Xu","year":"2021"},{"key":"10.1016\/j.neuint.2026.106279_bib87","series-title":"Clinical Study on Warming Acupuncture in Improving Constipation Anxiety and Depression of Postoperative Chemotherapy Patients with Colorectal Cancer (M)","author":"Yang","year":"2020"},{"key":"10.1016\/j.neuint.2026.106279_bib88","first-page":"124","article-title":"Analysis of the efficacy of thirteen governing vessel acupuncture points combined with Chinese medicine in the treatment of anxiety insomnia. Inner Mongolia","volume":"39","author":"Yang","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib89","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.joim.2025.07.002","article-title":"Electroacupuncture alleviates behaviors associated with posttraumatic stress disorder by modulating lipocalin-2-mediated neuroinflammation and neuronal activity in the prefrontal cortex","volume":"23","author":"Yang","year":"2025","journal-title":"J.Integrative Med."},{"key":"10.1016\/j.neuint.2026.106279_bib90","first-page":"45","article-title":"Effect of electroacupuncture at Neiguan Point on anxiety-like and fear-like behaviors and neuronal activity in the prelimbic cortex in mice with post traumatic stress disorder","volume":"45","author":"Yang","year":"2026","journal-title":"J. Anhui Tradit. Chin. Med. Coll."},{"key":"10.1016\/j.neuint.2026.106279_bib91","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40659-022-00396-0","article-title":"Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice","volume":"55","author":"Yeom","year":"2022","journal-title":"Biol. Res."},{"key":"10.1016\/j.neuint.2026.106279_bib92","doi-asserted-by":"crossref","DOI":"10.1111\/jebm.70047","article-title":"Effects and neuroimaging findings of acupuncture for amnestic mild cognitive impairment: a randomized controlled trial","volume":"18","author":"Yin","year":"2025","journal-title":"J.Evidence Based Med."},{"key":"10.1016\/j.neuint.2026.106279_bib93","first-page":"3","article-title":"Exploring the central mechanism of mind-regulation electroacupuncture in treatment of chronic fatigue syndrome with anxiety and depression comorbidity based on functional magnetic resonance imaging","volume":"44","author":"Zeng","year":"2024","journal-title":"Chin. Acupunct. Moxibustion"},{"key":"10.1016\/j.neuint.2026.106279_bib98","first-page":"62","article-title":"Clinical observation of Anshen Dingzhi pills combined with acupuncture in the treatment of anxiety disorder","volume":"33","author":"Zhang","year":"2025"},{"key":"10.1016\/j.neuint.2026.106279_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2024.100661","article-title":"Quantitative evaluation of microenvironmental changes and efficacy of cupping therapy under different pressures based on photoacoustic imaging","volume":"40","author":"Zhang","year":"2024","journal-title":"Photoacoustics"},{"key":"10.1016\/j.neuint.2026.106279_bib95","first-page":"106","article-title":"Effect of interactive dynamic scalp acupuncture on post-stroke cognitive function, depression, and anxiety: a multicenter, randomized, controlled trial. Chin","volume":"28","author":"Zhang","year":"2022","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.neuint.2026.106279_bib94","article-title":"Case Study on Treating Insomnia with Thirteen Du Meridian Needles","volume":"23","author":"Zhang","year":"2015"},{"key":"10.1016\/j.neuint.2026.106279_bib97","first-page":"927","article-title":"Clinical observation on the treatment of insomnia with anxiety primarily using warm acupuncture","volume":"43","author":"Zhang","year":"2024","journal-title":"Gansu Med. J."},{"key":"10.1016\/j.neuint.2026.106279_bib101","article-title":"Acupuncture for comorbid depression and insomnia in perimenopause: a feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial","volume":"11","author":"Zhao","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.neuint.2026.106279_bib100","first-page":"241","article-title":"Clinical research on the effect of abdominal Tuina and acupuncture in treating Swiss generalized anxiety disorder","volume":"32","author":"Zhao","year":"2010","journal-title":"Int. J. Translat. Community Med."},{"key":"10.1016\/j.neuint.2026.106279_bib99","first-page":"587","article-title":"Experiences from Treating Depressive Insomnia with Thirteen Du Meridian Acupuncture Points Combined with Chinese Herbal Medicine","volume":"31","author":"Zhao","year":"2012"},{"key":"10.1016\/j.neuint.2026.106279_bib102","first-page":"50","article-title":"Effect of self-formulated traditional Chinese medicine combined with scalp acupuncture on post-stroke anxiety and depression and its impact on psychological State","volume":"18","author":"Zheng","year":"2025"},{"key":"10.1016\/j.neuint.2026.106279_bib103","series-title":"Clinical Observation on the Treatment of Post-stroke Anxiety Disorder with Jin's Three Needle mind-regulating Acupunture (M)","author":"Zhou","year":"2024"},{"key":"10.1016\/j.neuint.2026.106279_bib104","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0033-3182(71)71479-0","article-title":"A rating instrument for anxiety disorders","volume":"12","author":"Zung","year":"1971","journal-title":"Psychosomatics"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018626001701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:39:04Z","timestamp":1792427944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018626001701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":104,"alternative-id":["S0197018626001701"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106279","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implementation rules and research status of acupuncture therapy for anxiety disorders","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2026.106279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106279"}}