{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:27:48Z","timestamp":1771493268714,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.neulet.2004.04.083","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T19:32:24Z","timestamp":1087327944000},"page":"180-185","source":"Crossref","is-referenced-by-count":20,"title":["Roles of cyclin-dependent kinase 4 and p53 in neuronal cell death induced by doxorubicin on cerebellar granule neurons in mouse"],"prefix":"10.1016","volume":"365","author":[{"given":"Yuko","family":"Otsuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daigaku","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naokatsu","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Tatsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2004.04.083_BIB1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0959-437X(96)90004-0","article-title":"p53 in signaling checkpoint arrest or apoptosis","volume":"6","author":"Bates","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.neulet.2004.04.083_BIB2","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1523\/JNEUROSCI.18-08-02801.1998","article-title":"Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer\u2019s disease brain","volume":"18","author":"Busser","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB3","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1038\/sj.onc.1202577","article-title":"The role of ATM in DNA damage responses and cancer","volume":"17","author":"Canman","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.neulet.2004.04.083_BIB4","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1126\/science.281.5383.1677","article-title":"Activation of the ATM kinase by ionizing radiation and phosphorylation of p53","volume":"281","author":"Canman","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neulet.2004.04.083_BIB5","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1523\/JNEUROSCI.19-18-07860.1999","article-title":"Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons","volume":"19","author":"Cregan","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/jcbfm.1994.119","article-title":"Attenuation of p53 expression protects against focal ischemic damage in transgenic mice","volume":"14","author":"Crumrine","year":"1994","journal-title":"J. Cerebral Blood Flow Metab."},{"key":"10.1016\/j.neulet.2004.04.083_BIB7","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/0955-0674(94)90054-X","article-title":"Mammalian G1 cyclins","volume":"6","author":"Draetta","year":"1994","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neulet.2004.04.083_BIB8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(95)12247-8","article-title":"p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons","volume":"203","author":"Enokido","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2004.04.083_BIB9","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1460-9568.1996.tb01325.x","article-title":"Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons","volume":"8","author":"Enokido","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1006\/excr.1995.1271","article-title":"Induction of cyclin B and H1 kinase activity in apoptotic PC12 cells","volume":"219","author":"Gao","year":"1995","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.neulet.2004.04.083_BIB11","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1101\/gad.12.19.2973","article-title":"The complexity of p53 modulation: emerging patterns from divergent signals","volume":"12","author":"Giaccia","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.neulet.2004.04.083_BIB12","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1172\/JCI1130","article-title":"Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle","volume":"101","author":"Gill","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2004.04.083_BIB13","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1074\/jbc.275.16.11553","article-title":"E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3","volume":"275","author":"Giovanni","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2004.04.083_BIB14","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.280.5366.1089","article-title":"Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system","volume":"280","author":"Herzog","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neulet.2004.04.083_BIB15","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1523\/JNEUROSCI.19-08-02996.1999","article-title":"Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation","volume":"19","author":"Johnson","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1523\/JNEUROSCI.16-02-00486.1996","article-title":"Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo","volume":"16","author":"Lawrence","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB17","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1523\/JNEUROSCI.21-17-06687.2001","article-title":"Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status","volume":"21","author":"Lee","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1023\/A:1009637512917","article-title":"ATM dependent apoptosis in the nervous system","volume":"5","author":"Lee","year":"2000","journal-title":"Apoptosis"},{"key":"10.1016\/j.neulet.2004.04.083_BIB19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s004410100396","article-title":"Neuronal apoptosis at the G1\/S cell cycle checkpoint","volume":"305","author":"Liu","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neulet.2004.04.083_BIB20","first-page":"1933","article-title":"Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer\u2019s disease","volume":"150","author":"McShea","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neulet.2004.04.083_BIB21","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1523\/JNEUROSCI.21-14-05017.2001","article-title":"Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage","volume":"21","author":"Morris","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4615-0123-7_2","article-title":"Neuronal survival and cell death signaling pathways","volume":"513","author":"Morrison","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neulet.2004.04.083_BIB23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1021687810103","article-title":"p53-dependent cell death signaling in neurons","volume":"28","author":"Morrison","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2004.04.083_BIB24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.bi.61.070192.002301","article-title":"Animal cell cycles and their control (review) (261 references)","volume":"61","author":"Norbury","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neulet.2004.04.083_BIB25","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0092-8674(00)00073-8","article-title":"p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53","volume":"102","author":"Oda","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2004.04.083_BIB26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1097-2765(01)00284-2","article-title":"p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis","volume":"8","author":"Okamura","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neulet.2004.04.083_BIB27","doi-asserted-by":"crossref","first-page":"10254","DOI":"10.1073\/pnas.170144197","article-title":"Cyclin-dependent kinases as a therapeutic target for stroke","volume":"97","author":"Osuga","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2004.04.083_BIB28","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1523\/JNEUROSCI.20-09-03104.2000","article-title":"Involvement of retinoblastoma family members and E2F\/DP complexes in the death of neurons evoked by DNA damage","volume":"20","author":"Park","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB29","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1523\/JNEUROSCI.17-04-01256.1997","article-title":"G1\/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis","volume":"17","author":"Park","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.143.2.457","article-title":"Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents","volume":"143","author":"Park","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2004.04.083_BIB31","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1523\/JNEUROSCI.18-03-00830.1998","article-title":"Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress","volume":"18","author":"Park","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0092-8674(89)90936-7","article-title":"Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2","volume":"58","author":"Pines","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2004.04.083_BIB33","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase (comment)","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neulet.2004.04.083_BIB34","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0092-8674(94)90540-1","article-title":"G1 phase progression: cycling on cue","volume":"79","author":"Sherr","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2004.04.083_BIB35","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0092-8674(93)90636-5","article-title":"Mammalian G1 cyclins","volume":"73","author":"Sherr","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2004.04.083_BIB36","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1101\/gad.9.10.1149","article-title":"Inhibitors of mammalian cyclin-dependent kinases","volume":"9","author":"Sherr","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.neulet.2004.04.083_BIB37","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0092-8674(90)90504-8","article-title":"Cyclin activation of p34cdc2","volume":"63","author":"Solomon","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2004.04.083_BIB38","doi-asserted-by":"crossref","first-page":"26772","DOI":"10.1074\/jbc.273.41.26772","article-title":"Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression","volume":"273","author":"Tanaka","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2004.04.083_BIB39","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1523\/JNEUROSCI.20-08-02852.2000","article-title":"Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition","volume":"20","author":"Tanaka","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB40","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1460-9568.1999.00434.x","article-title":"Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?","volume":"11","author":"Timsit","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB41","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1523\/JNEUROSCI.17-10-03588.1997","article-title":"Aberrant expression of mitotic cdc2\/cyclin B1 kinase in degenerating neurons of Alzheimer\u2019s disease brain","volume":"17","author":"Vincent","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB42","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1523\/JNEUROSCI.16-21-06753.1996","article-title":"Evidence for p53-mediated modulation of neuronal viability","volume":"16","author":"Xiang","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2004.04.083_BIB43","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1523\/JNEUROSCI.18-04-01363.1998","article-title":"Bax involvement in p53-mediated neuronal cell death","volume":"18","author":"Xiang","year":"1998","journal-title":"J. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004005488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004005488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T03:51:40Z","timestamp":1549511500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394004005488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0304394004005488"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2004.04.083","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}