{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:41:09Z","timestamp":1791204069930,"version":"4.2.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.neulet.2004.08.016","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T21:03:33Z","timestamp":1095195813000},"page":"151-154","source":"Crossref","is-referenced-by-count":59,"title":["Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease"],"prefix":"10.1016","volume":"370","author":[{"given":"Cecilia","family":"Huerta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio F.","family":"Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliecer","family":"Coto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Ribacoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bl\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Guisasola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H.","family":"Lahoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2004.08.016_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0304-3940(01)02235-2","article-title":"Early-onset Parkinson's disease associated with a new Parkin mutation in Spanish family","volume":"313","author":"\u00c1lvarez","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2004.08.016_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ajmg.10515","article-title":"Association between the TNF\u03b1-308 A\/G polymorphism and the onset-age of Alzheimer disease","volume":"114","author":"\u00c1lvarez","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neulet.2004.08.016_bib3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0166-2236(99)01453-8","article-title":"Chemokines in the CNS: plurifunctional mediators in diverse states","volume":"22","author":"Asensio","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2004.08.016_bib4","first-page":"165","article-title":"Immune processes in the pathogenesis of Parkinson's disease\u2014a potential role for microglia and nitric oxide Med","volume":"8","author":"Cztonkowska","year":"2002","journal-title":"Sci. Monit."},{"key":"10.1016\/j.neulet.2004.08.016_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1096\/fasebj.13.1.63","article-title":"TNF\u03ac plus IFN\u03b3 induce the production of Alzheimer-amyloid peptide and decrease the secretion of APPs","volume":"12","author":"Blasko","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2004.08.016_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2004.01.035","article-title":"No evidence for association of the monocyte chemoattractant protein-1 (\u22122518) gene polymorphism and Alzheimer disease","volume":"360","author":"Combarros","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2004.08.016_bib7","doi-asserted-by":"crossref","unstructured":"O. Combarros, J. Infante, J. Llorca, N. Pe\u00f1a, C. Fern\u00e1ndez_Viadero, J. Berciano, The chemokine receptor CCR5\u2013D32 gene mutation is not protective against Alzheimer disease, Neurosci. Lett. 366 (2004) 312\u2013314.","DOI":"10.1016\/j.neulet.2004.05.058"},{"key":"10.1016\/j.neulet.2004.08.016_bib8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0306-4522(00)00024-5","article-title":"Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons","volume":"97","author":"Coughlan","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2004.08.016_bib9","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","article-title":"Molecular pathways of neurodegeneration in Parkinson's disease","volume":"302","author":"Dawson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neulet.2004.08.016_bib10","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nm1296-1293","article-title":"Chemokines and HIV-1 second receptors","volume":"2","author":"D'Souza","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2004.08.016_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/84209","article-title":"Chemokines and disease","volume":"2","author":"Gerard","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neulet.2004.08.016_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/13550289909029741","article-title":"Chemokines and chemokine receptor expression in the central nervous system","volume":"5","author":"Hesselgesser","year":"1999","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.neulet.2004.08.016_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1034\/j.1600-065X.2000.17709.x","article-title":"Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation","volume":"177","author":"Huang","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.neulet.2004.08.016_bib14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/ana.10481","article-title":"Neuroinflammatory processes in Parkinson's disease","volume":"53","author":"Hunot","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2004.08.016_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s100489900083","article-title":"Progress in the clinical and molecular genetics of familial Parkinsonism","volume":"2","author":"Kitada","year":"2000","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neulet.2004.08.016_bib16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","article-title":"Chemokines\u2014chemotactic cytokines that mediate inflammation","volume":"338","author":"Luster","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neulet.2004.08.016_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3940(02)00619-5","article-title":"Single-nucleotide polymorphisms in the promoter region of the PARKIN gene and Parkinson's disease","volume":"329","author":"Mata","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2004.08.016_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/hmg\/ddh089","article-title":"Parkin genetics: one model for Parkinson's disease","volume":"13","author":"Mata","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2004.08.016_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-5728(98)00188-X","article-title":"Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with B-amyloid 25\u201335","volume":"43","author":"Meda","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neulet.2004.08.016_bib20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0736-5748(00)00012-5","article-title":"Induction of cytokines in glial cell surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology","volume":"18","author":"Mehlhorn","year":"2000","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neulet.2004.08.016_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0304-3940(99)00761-2","article-title":"Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03","volume":"275","author":"Neill","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2004.08.016_bib22","first-page":"143","article-title":"Cytokines in Parkinson's disease","volume":"58","author":"Nagatsu","year":"2000","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.neulet.2004.08.016_bib23","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/1531-8249(199905)45:5<666::AID-ANA18>3.0.CO;2-3","article-title":"A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease","volume":"45","author":"Papassotiropoulos","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2004.08.016_bib24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1086\/344266","article-title":"The chemokyne system in neuroinflammation: an update","volume":"186","author":"Ransohoff","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.neulet.2004.08.016_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.18.1.217","article-title":"The biology of chemokines and their receptors","volume":"18","author":"Rossi","year":"2000","journal-title":"Ann. Rev. Immunol."},{"key":"10.1016\/j.neulet.2004.08.016_bib26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.48.3.626","article-title":"Risk of Alzheimer's disease and duration of NSAID use","volume":"48","author":"Stewart","year":"1997","journal-title":"Neurology"},{"issue":"Suppl. 1","key":"10.1016\/j.neulet.2004.08.016_bib27","doi-asserted-by":"crossref","first-page":"I35","DOI":"10.1007\/s00415-003-1107-x","article-title":"Inflammation in Parkinson's disease","volume":"250","author":"W\u00fcllner","year":"2003","journal-title":"J. Neurol."},{"key":"10.1016\/j.neulet.2004.08.016_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0002-9440(10)65542-3","article-title":"Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer disease brains","volume":"153","author":"Xia","year":"1998","journal-title":"Am. J. Pathol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004010055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004010055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T23:21:08Z","timestamp":1549236068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394004010055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":28,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0304394004010055"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2004.08.016","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}