{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:15:02Z","timestamp":1781154902016,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.neulet.2004.10.090","type":"journal-article","created":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T04:16:30Z","timestamp":1106712990000},"page":"143-147","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of anti-A\u03b2 antibody isotypes used for intracerebroventricular immunization in TgCRND8"],"prefix":"10.1016","volume":"375","author":[{"given":"Neelima B.","family":"Chauhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.neulet.2004.10.090_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2003.09.005","article-title":"Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain","volume":"145","author":"Andre","year":"2003","journal-title":"J. Neuroimmunol."},{"issue":"5609","key":"10.1016\/j.neulet.2004.10.090_bib2","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.299.5609.1014a","article-title":"Cerebral hemorrhage and amyloid-beta","volume":"299","author":"Atwood","year":"2003","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neulet.2004.10.090_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jnr.10286","article-title":"Reversal of amyloid beta toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid beta antibody","volume":"69","author":"Chauhan","year":"2002","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.neulet.2004.10.090_bib4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jnr.10721","article-title":"Intracerebroventricular passive immunization with anti-Abeta antibody in Tg2576","volume":"74","author":"Chauhan","year":"2003","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.neulet.2004.10.090_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jnr.1215","article-title":"Distribution of intraventricularly administered antiamyloid-beta peptide (Abeta) antibody in the mouse brain","volume":"66","author":"Chauhan","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2004.10.090_bib6","doi-asserted-by":"crossref","unstructured":"N.B. Chauhan, G.J. Siegel, T. Lichtor, Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-Abeta antibody into the third ventricle of TgCRND8 mice, J. Neurosci. Res. (2004), in press.","DOI":"10.1002\/jnr.20298"},{"issue":"6","key":"10.1016\/j.neulet.2004.10.090_bib7","first-page":"1822","article-title":"Radioimmunotherapy of intracerebral human glioma xenografts with 131I-labeled F(ab\u2019)2 fragments of monoclonal antibody Mel-14","volume":"50","author":"Colapinto","year":"1990","journal-title":"Cancer Res."},{"issue":"15","key":"10.1016\/j.neulet.2004.10.090_bib8","doi-asserted-by":"crossref","first-page":"8850","DOI":"10.1073\/pnas.151261398","article-title":"Peripheral anti-A beta antibody alters CNS and plasma A-beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease","volume":"98","author":"DeMattos","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6815","key":"10.1016\/j.neulet.2004.10.090_bib9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/35050110","article-title":"A beta peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease","volume":"408","author":"Janus","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2004.10.090_bib10","series-title":"Clinical Neurology of Aging","first-page":"3","article-title":"Neuroanatomical and neuropathological changes during aging and dementia.","author":"Kemper","year":"1994"},{"issue":"4","key":"10.1016\/j.neulet.2004.10.090_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0166-2236(00)01749-5","article-title":"Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum","volume":"24","author":"Klein","year":"2001","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.neulet.2004.10.090_bib12","first-page":"55","article-title":"Direct stereotactic intracerebral injection of monoclonal antibodies and their fragments: a potential approach to brain tumor immunotherapy","volume":"5","author":"Liebert","year":"1990","journal-title":"Am. J. Physiol. Imaging"},{"issue":"3","key":"10.1016\/j.neulet.2004.10.090_bib13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI200318104","article-title":"Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease","volume":"11","author":"Monsonego","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"6815","key":"10.1016\/j.neulet.2004.10.090_bib14","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/35050116","article-title":"A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease","volume":"408","author":"Morgan","year":"2000","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.neulet.2004.10.090_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm840","article-title":"Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report","volume":"9","author":"Nicoll","year":"2003","journal-title":"Nat. Med."},{"issue":"5597","key":"10.1016\/j.neulet.2004.10.090_bib16","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.1078259","article-title":"Cerebral hemorrhage after passive anti-Abeta immunotherapy","volume":"298","author":"Pfeifer","year":"2002","journal-title":"Science"},{"issue":"6740","key":"10.1016\/j.neulet.2004.10.090_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.neulet.2004.10.090_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0002-9440(10)61715-4","article-title":"Immunization with a nontoxic\/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice","volume":"159","author":"Sigurdsson","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.neulet.2004.10.090_bib19","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0197-4580(02)00124-0","article-title":"A safer vaccine for Alzheimer's disease","volume":"23","author":"Sigurdsson","year":"2002","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.neulet.2004.10.090_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1089\/10445490152717550","article-title":"Immunotherapeutic strategies for prevention and treatment of Alzheimer's disease","volume":"20","author":"Solomon","year":"2001","journal-title":"DNA Cell Biol."},{"issue":"8","key":"10.1016\/j.neulet.2004.10.090_bib21","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1517\/14712598.2.8.907","article-title":"Immunological approaches as therapy for Alzheimer's disease","volume":"2","author":"Solomon","year":"2002","journal-title":"Expert Opin. Biol. Ther."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2004.10.090_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-5728(02)00307-7","article-title":"Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid (1\u201342)","volume":"132","author":"Town","year":"2002","journal-title":"J. Neuroimmunol."},{"issue":"6917","key":"10.1016\/j.neulet.2004.10.090_bib23","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nature01325","article-title":"Inflammation and therapeutic vaccination in CNS diseases","volume":"420","author":"Weiner","year":"2002","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.neulet.2004.10.090_bib24","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1523\/JNEUROSCI.23-09-03745.2003","article-title":"Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation","volume":"23","author":"Wilcock","year":"2003","journal-title":"J. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004013837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004013837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T03:53:48Z","timestamp":1548820428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394004013837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0304394004013837"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2004.10.090","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}