{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:42:43Z","timestamp":1774867363215,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.neulet.2004.11.010","type":"journal-article","created":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T12:16:49Z","timestamp":1107433009000},"page":"187-191","source":"Crossref","is-referenced-by-count":7,"title":["A synthetic human proline-rich-polypeptide enhances hydroxyl radical generation and fails to protect dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced toxicity in mice"],"prefix":"10.1016","volume":"375","author":[{"given":"Varduhi H.","family":"Knaryan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriti","family":"Samantaray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armen A.","family":"Galoyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kochupurackal P.","family":"Mohanakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2004.11.010_bib1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1023\/A:1013915306403","article-title":"Immunohistochemical study of immunophilin 1-15 fragment in intact frog brain, and in the brain and spinal cord of intact and hemisectioned rats","volume":"26","author":"Abrahamyan","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1023\/B:NERE.0000018840.19073.0b","article-title":"Survival of trauma-injured neurons in rat brain by treatment with proline-rich peptide (PRP-1): an immunohistochemical study","volume":"29","author":"Abrahamyan","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/ja00418a001","article-title":"Quantitative proton affinities, ionization potentials, and hydrogen affinities of alkylamines","volume":"98","author":"Aue","year":"1976","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.neulet.2004.11.010_bib4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0891-5849(97)00014-2","article-title":"Antioxidant and prooxidant properties of captopril and enalapril","volume":"23","author":"Bartosz","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neulet.2004.11.010_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JAD-2004-6103","article-title":"Colostrinin (a naturally occurring, proline-rich, polypeptide mixture) in the treatment of Alzheimer's disease","volume":"6","author":"Bilikiewicz","year":"2004","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.neulet.2004.11.010_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/1389450043490596","article-title":"Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson's disease","volume":"5","author":"Chen","year":"2004","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.neulet.2004.11.010_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0165-1781(79)90006-4","article-title":"Chronic Parkinsonism secondary to intravenous injection of meperidine analogues","volume":"1","author":"Davis","year":"1979","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3940(93)90274-O","article-title":"Correlation between 1-methyl-4-phenylpyridinium ion (MPP+) levels, ascorbic acid oxidation and glutathione levels in the striatal synaptosomes of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated rat","volume":"161","author":"Desole","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2004.11.010_bib9","doi-asserted-by":"crossref","first-page":"17131","DOI":"10.1073\/pnas.262544899","article-title":"Glutamine\/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity","volume":"99","author":"Faber","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2004.11.010_bib10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1353-8020(02)00005-6","article-title":"Effects of fibroblast growth factor and glial-derived neurotrophic factor on akinesia, F-DOPA uptake and dopamine cells in parkinsonian primates","volume":"8","author":"Fontan","year":"2002","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neulet.2004.11.010_bib11","series-title":"Biochemistry of Novel Cardioactive Hormones and Immunomodulators of the Functional System Neurosecretory Hypothalamus-Endocrine Heart","author":"Galoyan","year":"1997"},{"key":"10.1016\/j.neulet.2004.11.010_bib12","series-title":"Brain Neurosecretory Cytokines: Immune Response and Neuronal Survival","author":"Galoyan","year":"2004"},{"key":"10.1016\/j.neulet.2004.11.010_bib13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1023\/A:1012353005489","article-title":"Protective effect of a new hypothalamic peptide against cobra venom and trauma-induced neuronal injury","volume":"26","author":"Galoyan","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib14","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1023\/A:1026662318816","article-title":"Comparison of the protection against neuronal injury by hypothalamic peptides and by dexamethasone","volume":"25","author":"Galoyan","year":"2000","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1023\/B:NERE.0000026396.77459.1f","article-title":"Hypothalamic proline-rich polypeptide protects brain neurons in aluminum neurotoxicosis","volume":"29","author":"Galoyan","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib16","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1096\/fj.03-0203fje","article-title":"Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease","volume":"17","author":"Gao","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2004.11.010_bib17","doi-asserted-by":"crossref","first-page":"37908","DOI":"10.1074\/jbc.274.53.37908","article-title":"A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems","volume":"274","author":"Giesemann","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2004.11.010_bib18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1046\/j.1471-4159.2001.t01-1-00227.x","article-title":"Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss","volume":"77","author":"Grunblatt","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2004.11.010_bib19","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1046\/j.1471-4159.1999.731683.x","article-title":"Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease","volume":"73","author":"Han","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2004.11.010_bib20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1385\/JMN:17:3:379","article-title":"Towards an understanding of biological role of colostrinin peptides","volume":"17","author":"Kruzel","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2004.11.010_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0006-8993(96)00917-1","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level","volume":"741","author":"Kupsch","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib22","first-page":"851","article-title":"Neuropeptide processing in regional brain slices: effect of conformation and sequence","volume":"253","author":"Li","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2004.11.010_bib23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0197-0186(03)00170-0","article-title":"Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats","volume":"44","author":"Maharaj","year":"2004","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2004.11.010_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(01)01507-5","article-title":"Effects of p-chlorophenylalanine on striatal acetylcholinesterase activity and on biogenic amine levels in raphe, tuberculum olfactorium and caudate-putamen during physostigmine-induced tremor in rats","volume":"299","author":"Mehta","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2004.11.010_bib25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1081\/IPH-120026447","article-title":"Proline-rich polypeptide complex (PRP) from ovine colostrums. Studies on the effect of PRP on nitric oxide (NO) production induced by LPS in THP-1 cells","volume":"25","author":"Mikulska","year":"2003","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.neulet.2004.11.010_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0891-0618(98)00032-5","article-title":"Neuroprotection by nitric oxide against hydroxyl radical-induced nigral neurotoxicity","volume":"14","author":"Mohanakumar","year":"1998","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neulet.2004.11.010_bib27","series-title":"Neurotoxic Factors in Parkinson's Disease and Related Disorders","article-title":"Neurochemical mechanisms underlying neuroprotective actions of bromocriptine, salicylate, d- and l-deprenyl in neurodegeneration caused by MPTP","author":"Mohanakumar","year":"2000"},{"key":"10.1016\/j.neulet.2004.11.010_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/syn.10239","article-title":"d-Deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity","volume":"50","author":"Muralikrishnan","year":"2003","journal-title":"Synapse"},{"key":"10.1016\/j.neulet.2004.11.010_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2003.09.004","article-title":"Heat shock protects PC12 cells against MPP+ toxicity","volume":"993","author":"Quigney","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<58::AID-SYN7>3.0.CO;2-G","article-title":"S-Nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo","volume":"23","author":"Rauhala","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.neulet.2004.11.010_bib31","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/0024-3205(87)90291-8","article-title":"Partial protection from the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Pro-Leu-Gly-NH2(PLG; MIF-1)","volume":"40","author":"Sheng","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2004.11.010_bib32","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1097-2765(00)80142-2","article-title":"SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates","volume":"2","author":"Sittler","year":"1998","journal-title":"Mol. Cell."},{"key":"10.1016\/j.neulet.2004.11.010_bib33","series-title":"The Merck Index","year":"1996"},{"key":"10.1016\/j.neulet.2004.11.010_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0006-8993(99)02202-7","article-title":"In vivo hydroxyl radical generation in the striatum following systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice","volume":"852","author":"Thomas","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2004.11.010_bib35","doi-asserted-by":"crossref","first-page":"16504","DOI":"10.1016\/S0021-9258(19)85448-0","article-title":"Generation of reactive oxygen species during the monoamine oxidase-catalyzed oxidation of the neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"268","author":"Zang","year":"1993","journal-title":"J. Biol. Chem."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004014065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394004014065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T16:16:45Z","timestamp":1625415405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394004014065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0304394004014065"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2004.11.010","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}