{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:05:49Z","timestamp":1784775949309,"version":"3.55.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.neulet.2006.03.021","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T12:52:14Z","timestamp":1143723134000},"page":"77-80","source":"Crossref","is-referenced-by-count":9,"title":["Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease"],"prefix":"10.1016","volume":"401","author":[{"given":"Gillian","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Samedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Foy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Turic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Jehu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hollingworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"O\u2019Donovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lovestone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2006.03.021_bib1","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","author":"Altshuler","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2006.03.021_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neulet.2006.03.021_bib3","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1126\/science.290.5500.2302","article-title":"Evidence for genetic linkage of Alzheimer's disease to chromosome 10q","volume":"290","author":"Bertram","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neulet.2006.03.021_bib4","unstructured":"L. Bertram, M. McQueen, K. Mullin, D. Blacker, R. Tanzi, The AlzGene Database. Alzheimer Research Forum. Available at: http:\/\/www.alzgene.org. Accessed [17\/02\/06]."},{"key":"10.1016\/j.neulet.2006.03.021_bib5","first-page":"1","article-title":"Towards compendia of negative genetic association studies: an example for Alzheimer disease","author":"Blomqvist","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neulet.2006.03.021_bib6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2337\/diabetes.51.4.1028","article-title":"Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice","volume":"51","author":"Butler","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.neulet.2006.03.021_bib7","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng1669","article-title":"Efficiency and power in genetic association studies","volume":"37","author":"de Bakker","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2006.03.021_bib8","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1126\/science.290.5500.2303","article-title":"Linkage of plasma A[beta]42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees","volume":"290","author":"Ertekin-Taner","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neulet.2006.03.021_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","article-title":"Restriction isotyping of human apolipoprotein-E by gene amplification and cleavage with HhaI","volume":"31","author":"Hixson","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neulet.2006.03.021_bib10","doi-asserted-by":"crossref","first-page":"U85","DOI":"10.1096\/fj.03-0978fje","article-title":"Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease","volume":"18","author":"Ho","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2006.03.021_bib11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s004390000397","article-title":"Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools","volume":"107","author":"Hoogendoorn","year":"2000","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neulet.2006.03.021_bib12","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1242\/dev.126.23.5365","article-title":"PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development","volume":"126","author":"Huang","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.neulet.2006.03.021_bib13","first-page":"154","article-title":"Design of optimal primers for SNP genotyping assays based on primer extension","volume":"130B","author":"Ivanov","year":"2004","journal-title":"Am. J. Med. Genet. Part B: Neuropsychiatr. Genet."},{"key":"10.1016\/j.neulet.2006.03.021_bib14","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1126\/science.290.5500.2304","article-title":"Susceptibility locus for Alzheimer's disease on chromosome 10","volume":"290","author":"Myers","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neulet.2006.03.021_bib15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00439-002-0706-6","article-title":"Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools","volume":"110","author":"Norton","year":"2002","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neulet.2006.03.021_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"Purcell","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neulet.2006.03.021_bib17","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rosen","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neulet.2006.03.021_bib18","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrg930","article-title":"DNA pooling: a tool for large-scale association studies","volume":"3","author":"Sham","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neulet.2006.03.021_bib19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.exphem.2003.09.011","article-title":"SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide","volume":"31","author":"Sly","year":"2003","journal-title":"Exp. Hematol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439400600262X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439400600262X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T07:45:56Z","timestamp":1627199156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439400600262X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":19,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S030439400600262X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2006.03.021","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}