{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:39:32Z","timestamp":1778895572408,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.neulet.2006.06.063","type":"journal-article","created":{"date-parts":[[2006,7,30]],"date-time":"2006-07-30T02:01:00Z","timestamp":1154224860000},"page":"52-56","source":"Crossref","is-referenced-by-count":29,"title":["Neuroprotection of \u03b1-phenyl-n-tert-butyl-nitrone on the neonatal white matter is associated with anti-inflammation"],"prefix":"10.1016","volume":"405","author":[{"given":"Shuying","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen J.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2006.06.063_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1053\/j.semperi.2004.10.010","article-title":"Emerging concepts in periventricular white matter injury","volume":"28","author":"Back","year":"2004","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.neulet.2006.06.063_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(00)81318-5","article-title":"1996 NF-kappa B: ten years after","volume":"87","author":"Baeuerle","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2006.06.063_bib3","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/00004647-200209000-00004","article-title":"Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury","volume":"22","author":"Berti","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2006.06.063_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(03)02545-9","article-title":"Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat","volume":"975","author":"Cai","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0006-8993(94)91689-6","article-title":"Alpha-phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia","volume":"644","author":"Cao","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0891-5849(90)90110-5","article-title":"HPLC procedure for the pharmacokinetic study of the spin-trapping agent, alpha-phenyl-N-tert-butyl nitrone (PBN)","volume":"9","author":"Chen","year":"1990","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neulet.2006.06.063_bib7","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.freeradbiomed.2005.01.019","article-title":"Reactive oxygen species and the modulation of stroke","volume":"38","author":"Crack","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neulet.2006.06.063_bib8","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/S0024-3205(99)00443-9","article-title":"Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps","volume":"65","author":"Floyd","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2006.06.063_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/01.wco.0000162851.44897.8f","article-title":"Effect of inflammation on central nervous system development and vulnerability","volume":"18","author":"Hagberg","year":"2005","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neulet.2006.06.063_bib10","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.2174\/092986705774462923","article-title":"Therapeutic targets in inflammatory disease","volume":"12","author":"Hume","year":"2005","journal-title":"Curr. Med. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.neulet.2006.06.063_bib11","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/S0301-2115(03)00175-1","article-title":"Perinatal brain damage\u2014from pathophysiology to prevention","volume":"110","author":"Jensen","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.neulet.2006.06.063_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0167-4889(98)00126-8","article-title":"Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN)","volume":"1448","author":"Kotake","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2006.06.063_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2005.09.042","article-title":"IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat","volume":"1063","author":"Lin","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.brainres.2004.01.074","article-title":"Alpha-phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain","volume":"1007","author":"Lin","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2460\/ajvr.2004.65.289","article-title":"Assessment of leukotriene B4 production in leukocytes from horses with recurrent airway obstruction","volume":"65","author":"Lindberg","year":"2004","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib16","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1097\/00004647-200111000-00002","article-title":"Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats","volume":"21","author":"Marklund","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2006.06.063_bib17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/bbrc.1995.2440","article-title":"Spin trapping agent, phenyl-N-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice","volume":"215","author":"Miyajima","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2006.06.063_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/152308602753625951","article-title":"Alpha-phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice","volume":"4","author":"Naito","year":"2002","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.neulet.2006.06.063_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","article-title":"NF-kappa B: a crucial transcription factor for glial and neuronal cell function","volume":"20","author":"O\u2019Neill","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2006.06.063_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-3806(02)00606-5","article-title":"Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide","volume":"140","author":"Pang","year":"2003","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0006-8993(99)02010-7","article-title":"Effects of combined postischemic hypothermia and delayed N-tert-butyl-alpha-pheylnitrone (PBN) administration on histopathologicaland behavioral deficits associated with transient global ischemia in rats","volume":"846","author":"Pazos","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/abbi.1998.1086","article-title":"Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl-N-tert-butylnitrone (PBN)","volume":"363","author":"Sang","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neulet.2006.06.063_bib23","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/6458","article-title":"NF-kappaB is activated and promotes cell death in focal cerebral ischemia","volume":"5","author":"Schneider","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2006.06.063_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/abbi.1999.1159","article-title":"Phenyl-N-tert-butylnitrone demonstrates broad-spectrum inhibition of apoptosis-associated gene expression in endotoxin-treated rats","volume":"365","author":"Stewart","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neulet.2006.06.063_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1203\/01.pdr.0000196807.10122.5f","article-title":"Selective inhibition of nuclear factor-kappaB activation after hypoxia\/ischemia in neonatal rats is not neuroprotective","volume":"59","author":"van den Tweel","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neulet.2006.06.063_bib26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1196\/annals.1344.019","article-title":"Circulatory arrest as a model for studies of global ischemic injury and neuroprotection","volume":"1053","author":"Wiklund","year":"2005","journal-title":"Ann. NY Acad. Sci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394006006227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394006006227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T13:52:29Z","timestamp":1547473949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394006006227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":26,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0304394006006227"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2006.06.063","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}