{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:05:21Z","timestamp":1782230721853,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2006CB500700"],"award-info":[{"award-number":["2006CB500700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30370494"],"award-info":[{"award-number":["30370494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30470615"],"award-info":[{"award-number":["30470615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.neulet.2006.06.072","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T07:13:23Z","timestamp":1155885203000},"page":"33-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Chinese Presenilin-1 V97L mutation enhanced A\u03b242 levels in SH-SY5Y neuroblastoma cells"],"prefix":"10.1016","volume":"406","author":[{"given":"Boyan","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2006.06.072_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","article-title":"Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42\/1-40 ratio in vitro and in vivo","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2006.06.072_bib2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","article-title":"Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum","volume":"65","author":"Campion","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2006.06.072_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nm0197-67","article-title":"Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice","volume":"3","author":"Citron","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2006.06.072_bib4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.1064638","article-title":"A portrait of Alzheimer secretases-new features and familiar faces","volume":"293","author":"Elsler","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neulet.2006.06.072_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrm910","article-title":"Gamma-secretase-mediated proteolysis in cell-surface-receptor signaling","volume":"3","author":"Fortini","year":"2002","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.neulet.2006.06.072_bib6","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ng1204-1243","article-title":"In genetic control of disease, does \u2018race\u2019 matter?","volume":"36","author":"Goldstein","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2006.06.072_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nm0198-097","article-title":"Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes","volume":"4","author":"Holcomb","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2006.06.072_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2006.06.072_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/JAD-2005-7204","article-title":"One novel presenilin-1 gene mutation in a Chinese pedigree of familial Alzheimer's disease","volume":"7","author":"Jia","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2006.06.072_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.18388\/abp.2005_3454","article-title":"Molecular mechanisms initiating amyloid beta-fibril formation in Alzheimer's disease","volume":"52","author":"Kirkitadze","year":"2005","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.neulet.2006.06.072_bib11","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/nm1096-1146","article-title":"The E280A presenilin 1 Alzheimer mutation produces increased Abeta 42 deposition and severe cerebellar pathology","volume":"2","author":"Lemere","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2006.06.072_bib12","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neulet.2006.06.072_bib13","unstructured":"Marc Cruts and Roos Rademakers, http:\/\/www.molgen.ua.ac.be\/ADMutations\/."},{"key":"10.1016\/j.neulet.2006.06.072_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00187-1","article-title":"Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease","volume":"265","author":"Murayama","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2006.06.072_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1046\/j.1471-4159.1998.71010313.x","article-title":"Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain","volume":"71","author":"Oyama","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2006.06.072_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1749-6632.2000.tb06920.x","article-title":"The value of transgenic models for the study of neurodegenerative diseases","volume":"920","author":"Price","year":"2000","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2006.06.072_bib17","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1021\/bi0267590","article-title":"Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells","volume":"42","author":"Qi","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.neulet.2006.06.072_bib18","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2006.06.072_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0896-6273(04)00182-5","article-title":"Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration","volume":"42","author":"Saura","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2006.06.072_bib20","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","article-title":"Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2006.06.072_bib21","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2006.06.072_bib22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2006.06.072_bib23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.0953-816X.2003.03135.x","article-title":"Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2","volume":"19","author":"Takeda","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2006.06.072_bib24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/19077","article-title":"Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394006006689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394006006689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:04:48Z","timestamp":1759608288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394006006689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":24,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0304394006006689"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2006.06.072","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chinese Presenilin-1 V97L mutation enhanced A\u03b242 levels in SH-SY5Y neuroblastoma cells","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2006.06.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}