{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:10:30Z","timestamp":1790755830795,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.neulet.2006.09.026","type":"journal-article","created":{"date-parts":[[2006,10,28]],"date-time":"2006-10-28T11:18:43Z","timestamp":1162034323000},"page":"134-139","source":"Crossref","is-referenced-by-count":93,"title":["Age-related changes in glycogen synthase kinase 3\u03b2 (GSK3\u03b2) immunoreactivity in the central nervous system of rats"],"prefix":"10.1016","volume":"409","author":[{"given":"Soo Joo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Hee","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeung Min","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heon Chang","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gye Sun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daejin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Bok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choong Ik","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2006.09.026_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0197-4580(00)00118-4","article-title":"Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function","volume":"21","author":"Ajmani","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2006.09.026_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/physrev.00024.2003","article-title":"Role of tau protein in both physiological and pathological conditions","volume":"84","author":"Avila","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neulet.2006.09.026_bib3","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s00018-005-5597-y","article-title":"Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance","volume":"63","author":"Balaraman","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neulet.2006.09.026_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF02815006","article-title":"Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation","volume":"29","author":"Baum","year":"1996","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.neulet.2006.09.026_bib5","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1073\/pnas.190297597","article-title":"Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration","volume":"97","author":"Bhat","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neulet.2006.09.026_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3233\/JAD-2002-4404","article-title":"Interactions between GSK3\u03b2 and caspase signaling pathways during NGF deprivation induced cell death","volume":"4","author":"Bhat","year":"2002","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.neulet.2006.09.026_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3233\/JAD-2003-5305","article-title":"Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection","volume":"5","author":"Chen","year":"2003","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.neulet.2006.09.026_bib8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0006-8993(02)03562-X","article-title":"Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats","volume":"956","author":"Chung","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2006.09.026_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2004.05.078","article-title":"Age-related changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats","volume":"1018","author":"Chung","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2006.09.026_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1471-4914(01)02266-3","article-title":"Glycogen synthase kinase 3: an emerging therapeutic target","volume":"8","author":"Eldar-Finkelman","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neulet.2006.09.026_bib11","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1523\/JNEUROSCI.0604-06.2006","article-title":"Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3","volume":"26","author":"Engel","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2006.09.026_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/1097-4547(20001101)62:3<463::AID-JNR16>3.0.CO;2-7","article-title":"Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants","volume":"62","author":"Flaherty","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2006.09.026_bib13","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1046\/j.1471-4159.2001.00495.x","article-title":"CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium","volume":"78","author":"Grimes","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2006.09.026_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0301-0082(01)00011-9","article-title":"The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling","volume":"65","author":"Grimes","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2006.09.026_bib15","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1523\/JNEUROSCI.20-07-02567.2000","article-title":"Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal","volume":"20","author":"Hetman","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2006.09.026_bib16","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1073\/pnas.93.7.2719","article-title":"Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I\/glycogen synthase kinase 3beta in brain","volume":"93","author":"Hoshi","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neulet.2006.09.026_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tibs.2003.12.004","article-title":"The glamour and gloom of glycogen synthase kinase-3","volume":"29","author":"Jope","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.neulet.2006.09.026_bib18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0959-4388(02)00320-3","article-title":"The GSK3 beta signaling cascade and neurodegenerative disease","volume":"12","author":"Kaytor","year":"2002","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neulet.2006.09.026_bib19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbadis.2004.10.011","article-title":"Phosphorylated tau and the neurodegenerative foldopathies","volume":"1739","author":"Kosik","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2006.09.026_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1196\/annals.1342.026","article-title":"Altered cellular distribution of phospho-tau proteins coincides with impaired retrograde axonal transport in neurons of aged rats","volume":"1048","author":"Niewiadomska","year":"2005","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.neulet.2006.09.026_bib21","unstructured":"G. Niewiadomska, M. Baksalerska-Pazera, I. Lenarcik, G. Riedel, Compartmental protein expression of Tau, GSK-3beta and TrkA in cholinergic neurons of aged rats, J. Neural. Transm. (in press)."},{"key":"10.1016\/j.neulet.2006.09.026_bib22","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1182\/blood.V98.5.1374","article-title":"Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax","volume":"98","author":"Somervaille","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.neulet.2006.09.026_bib23","series-title":"Brain Maps III: Structure of the Rat Brain","author":"Swanson","year":"2004"},{"key":"10.1016\/j.neulet.2006.09.026_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0304-3940(95)12257-5","article-title":"Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I\/glycogen synthase kinase-3 beta","volume":"203","author":"Takashima","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2006.09.026_bib25","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/0076-6879(91)00172-S","article-title":"cDNA cloning and properties of glycogen synthase kinase-3","volume":"200","author":"Woodgett","year":"1991","journal-title":"Methods Enzymol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394006009736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394006009736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T02:34:14Z","timestamp":1555900454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394006009736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0304394006009736"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2006.09.026","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}