{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:50:01Z","timestamp":1770976201386,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.neulet.2007.04.051","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T14:23:29Z","timestamp":1178547809000},"page":"213-218","source":"Crossref","is-referenced-by-count":15,"title":["Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions"],"prefix":"10.1016","volume":"419","author":[{"given":"Shinji","family":"Higashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eizo","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Minegishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshiro","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Togo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omi","family":"Katsuse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotake","family":"Uchikado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heii","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2007.04.051_bib1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"Arai","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2007.04.051_bib2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2007.04.051_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0006-8993(91)90681-K","article-title":"Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease","volume":"539","author":"Bancher","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2007.04.051_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.neuro.26.010302.081142","article-title":"Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders","volume":"26","author":"Caughey","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2007.04.051_bib5","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2007.04.051_bib6","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-006-0189-y","article-title":"Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43","author":"Davidson","year":"2007","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.neulet.2007.04.051_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1440-1789.2003.00538.x","article-title":"Ubiquitin and ubiquitin-related proteins in neurons and dendrites of brains of atypical Pick's disease without Pick bodies","volume":"24","author":"Furukawa","year":"2004","journal-title":"Neuropathology"},{"key":"10.1016\/j.neulet.2007.04.051_bib8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2007.04.051_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1440-1789.2000.00270.x","article-title":"Neuropathological discrepancy between Japanese Pick's disease without Pick bodies and frontal lobe degeneration type of frontotemporal dementia proposed by Lund and Manchester Group","volume":"20","author":"Ikeda","year":"2000","journal-title":"Neuropathology"},{"key":"10.1016\/j.neulet.2007.04.051_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1440-1789.2003.00537.x","article-title":"Motor neuron disease group accompanied by inclusions of unidentified protein signaled by ubiquitin","volume":"24","author":"Ikeda","year":"2004","journal-title":"Neuropathology"},{"key":"10.1016\/j.neulet.2007.04.051_bib11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0022-510X(98)00168-3","article-title":"Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies","volume":"159","author":"Iseki","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neulet.2007.04.051_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1750-3639.2007.00055.x","article-title":"Frontotemporal lobar degeneration: current concepts in the light of recent advances","volume":"17","author":"Kumar-Singh","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neulet.2007.04.051_bib13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00401-006-0138-9","article-title":"Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype","volume":"112","author":"Mackenzie","year":"2006","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.neulet.2007.04.051_bib14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/jnnp.47.9.953","article-title":"Presenile dementia with motor neuron disease in Japan: clinico-pathological review of 26 cases","volume":"47","author":"Mitsuyama","year":"1984","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2007.04.051_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/01.jnen.0000248554.45456.58","article-title":"TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions","volume":"66","author":"Neumann","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2007.04.051_bib16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/nen.0b013e31803020b9","article-title":"TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations","volume":"66","author":"Neumann","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2007.04.051_bib17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neulet.2007.04.051_bib18","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/jnen\/62.6.644","article-title":"Accumulation of phosphorylated alpha-synuclein in aging human brain","volume":"62","author":"Saito","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2007.04.051_bib19","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2353\/ajpath.2006.060438","article-title":"Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies","volume":"169","author":"Sampathu","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neulet.2007.04.051_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awm024","article-title":"TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations","author":"Seelaar","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2007.04.051_bib21","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"Skibinski","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2007.04.051_bib22","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neulet.2007.04.051_bib23","doi-asserted-by":"crossref","DOI":"10.1212\/01.wnl.0000254460.31273.2d","article-title":"Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation","author":"Spina","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2007.04.051_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-007-0206-9","article-title":"TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation","author":"Tan","year":"2007","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.neulet.2007.04.051_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng1332","article-title":"Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein","volume":"36","author":"Watts","year":"2004","journal-title":"Nat. Genet."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394007005009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394007005009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T20:50:27Z","timestamp":1546894227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394007005009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0304394007005009"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2007.04.051","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}