{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:36:19Z","timestamp":1790710579924,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.neulet.2007.05.018","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T07:45:12Z","timestamp":1179992712000},"page":"42-46","source":"Crossref","is-referenced-by-count":13,"title":["Association between A218C polymorphism of the tryptophan-hydroxylase-1 gene, harm avoidance and binge eating behavior in bulimia nervosa"],"prefix":"10.1016","volume":"421","author":[{"given":"Palmiero","family":"Monteleone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Tortorella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Martiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismene","family":"Serino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Di Filippo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2007.05.018_bib1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.addbeh.2004.11.002","article-title":"The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology","volume":"30","author":"Anghelescu","year":"2005","journal-title":"Addict. Behav."},{"key":"10.1016\/j.neulet.2007.05.018_bib2","first-page":"17","article-title":"The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies","volume":"53","author":"Barr","year":"1992","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archpsyc.55.1.33","article-title":"Association between the tryptophan hydroxylase gene and manic-depressive illness","volume":"55","author":"Bellivier","year":"1998","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0195-6663(86)80051-4","article-title":"Serotonin manipulations and the structure of feeding behavior","volume":"7","author":"Blundell","year":"1986","journal-title":"Appetite"},{"key":"10.1016\/j.neulet.2007.05.018_bib5","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1126\/science.8209250","article-title":"Genes, environment, and personality","volume":"264","author":"Bouchard","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.neulet.2007.05.018_bib6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00005053-199509000-00006","article-title":"Temperament, character, and personality disorder in bulimia nervosa","volume":"183","author":"Bulik","year":"1995","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.neulet.2007.05.018_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/1098-108X(199309)14:2<213::AID-EAT2260140211>3.0.CO;2-P","article-title":"The tridimensional personality questionnaire in eating disorders","volume":"14","author":"Brewerton","year":"1993","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.neulet.2007.05.018_bib8","series-title":"The Temperament and Character Inventory (TCI): a Guide to its Development and Use. Center for Psychobiology and Personality","author":"Cloninger","year":"1994"},{"key":"10.1016\/j.neulet.2007.05.018_bib9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/archpsyc.1993.01820240059008","article-title":"A psychobiological model of temperament and characters","volume":"50","author":"Cloninger","year":"1993","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib10","series-title":"Handbook of Psychiatric Genetics","first-page":"235","article-title":"Polygenic inheritance in psychiatric disorders","author":"Comings","year":"1997"},{"key":"10.1016\/j.neulet.2007.05.018_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1521\/pedi.2000.14.4.352","article-title":"A study of temperament and personality in anorexia and bulimia nervosa","volume":"4","author":"Diaz-Marsa","year":"2000","journal-title":"J. Personal. Disord."},{"key":"10.1016\/j.neulet.2007.05.018_bib12","series-title":"BMDP Statistical Software","year":"1985"},{"key":"10.1016\/j.neulet.2007.05.018_bib13","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorders SCID-I","year":"1995"},{"key":"10.1016\/j.neulet.2007.05.018_bib14","series-title":"Structured Clinical Interview for DSM-IV Axis II Personality Disorders SCID-II","year":"1997"},{"key":"10.1016\/j.neulet.2007.05.018_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00041444-200010010-00004","article-title":"Search for association between suicide attempt and serotonergic polymorphism","volume":"10","author":"Geijer","year":"2000","journal-title":"Psychiat. Genet."},{"key":"10.1016\/j.neulet.2007.05.018_bib16","series-title":"Clinical Handbook of Eating Disorders-An Integrated Approach","first-page":"323","article-title":"Molecular biology of anorexia nervosa, bulimia nervosa, binge eating disorder and obesity","author":"Grice","year":"2004"},{"key":"10.1016\/j.neulet.2007.05.018_bib17","series-title":"Personality and Psychopathology","first-page":"67","article-title":"Personality correlates of eating disorder subtypes","author":"Halmi","year":"1999"},{"key":"10.1016\/j.neulet.2007.05.018_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1192\/bjp.150.1.18","article-title":"A self-rating scale for bulimia: the BITE","volume":"150","author":"Henderson","year":"1987","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF02922258","article-title":"Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphism: relationships to monoamine metabolite concentrations in CSF of healthy volunteers","volume":"247","author":"Jonsson","year":"1997","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neulet.2007.05.018_bib20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.pnpbp.2006.05.017","article-title":"Tryptophan hydroxylase and serotonin transporter gene polymorphism does not affect the diagnosis, clinical features and treatment outcome of panic disorder in the Korean population","volume":"30","author":"Kim","year":"2006","journal-title":"Progr. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0924-9338(97)83296-8","article-title":"The mini international neuropsychiatric interview M.I.N.I. A short diagnostic structured interview: reliability and validity according to the CIDI","volume":"12","author":"Lecrubier","year":"1997","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1071","article-title":"Metaanalysis of genetic association studies supports a contribution of common variants to susceptibility to common disease","volume":"33","author":"Lohmueller","year":"2003","journal-title":"Nature Genet."},{"key":"10.1016\/j.neulet.2007.05.018_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0006-3223(98)00139-5","article-title":"The spectrum of behaviors influenced by serotonin","volume":"44","author":"Lucki","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib24","doi-asserted-by":"crossref","first-page":"99S","DOI":"10.1016\/S0893-133X(99)00040-8","article-title":"Role of serotonergic system in the pathogenesis of major depression and suicidal behavior","volume":"21","author":"Mann","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2007.05.018_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.psy.0000195746.52074.63","article-title":"Investigation of the serotonin transporter regulatory region polymorphism in bulimia nervosa: relationships to harm avoidance, nutritional parameters, and psychiatric comorbidity","volume":"68","author":"Monteleone","year":"2006","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.neulet.2007.05.018_bib26","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1523\/JNEUROSCI.1835-05.2006","article-title":"Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels","volume":"26","author":"Nakamura","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2007.05.018_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0169-328X(96)00304-X","article-title":"Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7.","volume":"45","author":"Nielsen","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neulet.2007.05.018_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/sj.mp.4000647","article-title":"Identification and analysis of new sequence variants in the human tryptophan hydroxylase (Tph) gene","volume":"5","author":"Paoloni-Giacobbino","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ajmg.b.20158","article-title":"Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits","volume":"127B","author":"Sen","year":"2004","journal-title":"Am. J. Med. Genet. Part B Neuropsychiat. Genet."},{"key":"10.1016\/j.neulet.2007.05.018_bib30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2006.04.020","article-title":"No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population","volume":"403","author":"Tochigi","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2007.05.018_bib31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000072879","article-title":"Allelic Variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits","volume":"48","author":"Tsai","year":"2003","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neulet.2007.05.018_bib32","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1086\/430507","article-title":"Rational inferences about departures from Hardy-Weinberg equilibrium","volume":"76","author":"Wittke-Thompson","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neulet.2007.05.018_bib33","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/sj.mp.4001525","article-title":"SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression","volume":"9","author":"Zill","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2007.05.018_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.euroneuro.2003.10.002","article-title":"Regional mRNA expression of a second tryptophan hydroxylase isoform in post-mortem tissue samples of two human brains","volume":"14","author":"Zill","year":"2004","journal-title":"Eur. Neuropsychopharmacol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394007005770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394007005770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T07:22:33Z","timestamp":1546845753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394007005770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0304394007005770"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2007.05.018","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}