{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:01:29Z","timestamp":1792735289723,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.neulet.2007.06.031","type":"journal-article","created":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T17:56:33Z","timestamp":1183139793000},"page":"12-17","source":"Crossref","is-referenced-by-count":120,"title":["Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats"],"prefix":"10.1016","volume":"423","author":[{"given":"Myoung-Chul","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mal-Soon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Kyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Gyu","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hee","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Hyuk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Pyo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2007.06.031_bib1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/0140-6736(91)92989-F","article-title":"Parkinson's disease: pathophysiology","volume":"337","author":"Agid","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2007.06.031_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF03033137","article-title":"Dopamine- or l-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease","volume":"5","author":"Asanuma","year":"2003","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neulet.2007.06.031_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2007.06.031_bib4","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1523\/JNEUROSCI.21-15-05678.2001","article-title":"Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy","volume":"21","author":"Carro","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2007.06.031_bib5","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1212\/01.WNL.0000151960.28687.93","article-title":"Physical activity and the risk of Parkinson disease","volume":"64","author":"Chen","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2007.06.031_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1471-4159.2003.01657.x","article-title":"Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF","volume":"85","author":"Cohen","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2007.06.031_bib7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","article-title":"Exercise: a behavioral intervention to enhance brain health and plasticity","volume":"25","author":"Cotman","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2007.06.031_bib8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0197-4580(03)00112-X","article-title":"Regional responses in antioxidant system to exercise training and dietary vitamin E in aging rat brain","volume":"25","author":"Devi","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2007.06.031_bib9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0014-4886(03)00028-1","article-title":"Motor training effects on recovery of function after striatal lesions and striatal grafts","volume":"184","author":"Dobrossy","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2007.06.031_bib10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molbrainres.2004.08.008","article-title":"Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism","volume":"134","author":"Faherty","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neulet.2007.06.031_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-2007-971925","article-title":"Effects of prolonged exercise on brain ammonia and amino acids","volume":"19","author":"Guezennec","year":"1998","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.neulet.2007.06.031_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0361-9230(94)90214-3","article-title":"Striatal dopamine turnover during treadmill running in the rat: relation to the speed of running","volume":"35","author":"Hattori","year":"1994","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2007.06.031_bib13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/01376517-198906000-00008","article-title":"The benefit of a home exercise regimen for ambulatory Parkinson's disease patients","volume":"21","author":"Hurwitz","year":"1989","journal-title":"J. Neurosci. Nurs."},{"key":"10.1016\/j.neulet.2007.06.031_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02741387","article-title":"Tyrosine hydroxylase and Parkinson's disease","volume":"16","author":"Haavik","year":"1998","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2007.06.031_bib15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/toxsci\/kfi241","article-title":"Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro","volume":"87","author":"Jakel","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.neulet.2007.06.031_bib16","first-page":"297","article-title":"Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease","volume":"46","author":"Jellinger","year":"1995","journal-title":"J. Neural. Transm. Suppl."},{"key":"10.1016\/j.neulet.2007.06.031_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2005.04.068","article-title":"Effect of acupuncture on 6-hydroxydopamine-induced nigrostratal dopaminergic neuronal cell death in rats","volume":"384","author":"Kim","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2007.06.031_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/exnr.1998.6848","article-title":"Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat","volume":"152","author":"Kirik","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2007.06.031_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0404.1992.tb08054.x","article-title":"Effect of physical exercise on mortality in patients with Parkinson's disease","volume":"86","author":"Kuroda","year":"1992","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.neulet.2007.06.031_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/B:MEBR.0000027416.13070.c3","article-title":"Voluntary running provides neuroprotection in rats after 6-hydroxydopamine injection into the medial forebrain bundle","volume":"19","author":"Mabandla","year":"2004","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neulet.2007.06.031_bib21","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/apmr.2000.4439","article-title":"Treadmill training with body weight support: its effect on Parkinson's disease","volume":"81","author":"Miyai","year":"2000","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.neulet.2007.06.031_bib22","first-page":"155","article-title":"Causes of neuronal death in Parkinson's disease","volume":"86","author":"Schapira","year":"2001","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neulet.2007.06.031_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00441-004-0938-y","article-title":"Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP","volume":"318","author":"Schober","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neulet.2007.06.031_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01376517-199708000-00007","article-title":"Changes in motor performance in persons with Parkinson's disease after exercise in a mountain area","volume":"29","author":"Sunvisson","year":"1997","journal-title":"J. Neurosci. Nurs."},{"key":"10.1016\/j.neulet.2007.06.031_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0969-9961(03)00030-5","article-title":"Regulation of brain function by exercise","volume":"13","author":"Sutoo","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2007.06.031_bib26","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(03)00096-4","article-title":"Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease","volume":"119","author":"Tillerson","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2007.06.031_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/373335a0","article-title":"Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo","volume":"373","author":"Tomac","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2007.06.031_bib28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1006\/nbdi.2001.0427","article-title":"Effects of exercise on gene-expression profile in the rat hippocampus","volume":"8","author":"Tong","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2007.06.031_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1474-4422(04)00934-2","article-title":"Surgical treatment for Parkinson's disease","volume":"3","author":"Walter","year":"2004","journal-title":"Lancet Neurol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394007007094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394007007094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T23:14:15Z","timestamp":1556579655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394007007094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0304394007007094"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2007.06.031","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}