{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:17:04Z","timestamp":1781187424144,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.neulet.2008.01.023","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T07:14:49Z","timestamp":1202714089000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mitochondrial DNA in patients with essential tremor"],"prefix":"10.1016","volume":"434","author":[{"given":"Young-Mi","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Joong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uhn","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2008.01.023_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2008.01.023_bib2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1212\/01.wnl.0000216134.88617.de","article-title":"Elderly-onset essential tremor is associated with dementia","volume":"66","author":"Benito-Le\u00f3n","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2008.01.023_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S0074-02761993000100030","article-title":"A simple protocol for the physical cleavage of trypanosome cruzi kinetoplast DNA present in blood samples and its use in polymerase chain reaction (PCR)-based diagnosis of chronic chagas disease","volume":"88","author":"Britto","year":"1993","journal-title":"Mem. Inst. Oswaldo. Cruz."},{"key":"10.1016\/j.neulet.2008.01.023_bib4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1212\/WNL.47.1.264","article-title":"Accuracy of reported family histories of essential tremor","volume":"47","author":"Busenbark","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2008.01.023_bib5","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/mds.870120621","article-title":"Agreement among movement disorder specialists on the clinical diagnosis of essential tremor","volume":"12","author":"Chouinard","year":"1997","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2008.01.023_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(82)90049-6","article-title":"Replication of animal mitochondrial DNA","volume":"28","author":"Clayton","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2008.01.023_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/archneur.1962.04210020051006","article-title":"Heredofamilial tremor abolition by chemothalamectomy","volume":"7","author":"Cooper","year":"1962","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2008.01.023_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/jnnp.35.3.365","article-title":"Clinical manifestation of essential tremor","volume":"35","author":"Critchley","year":"1972","journal-title":"J. Neurol. Neurosur. Psychiatry"},{"key":"10.1016\/j.neulet.2008.01.023_bib9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/00000441-188710000-00005","article-title":"Hereditary tremor, hitherto undescribed form of motor neurosis","volume":"94","author":"Dana","year":"1887","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.neulet.2008.01.023_bib10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/00019052-199608000-00009","article-title":"Genetic of movement disorders","volume":"9","author":"Drr","year":"1996","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neulet.2008.01.023_bib11","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1212\/WNL.43.11.2212","article-title":"Familial essential tremor and idiopathic torsion dystonia are different genetic entities","volume":"43","author":"Drr","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2008.01.023_bib12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s004150050100","article-title":"Advances in the genetics of movement disorders: implications for molecular diagnosis","volume":"244","author":"Gasser","year":"1997","journal-title":"J. Neurol."},{"key":"10.1016\/j.neulet.2008.01.023_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/ng0997-84","article-title":"Mapping of a familial essential tremor gene, FET1, to chromosome 3q13","volume":"17","author":"Gulcher","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2008.01.023_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00019052-199708000-00012","article-title":"Movement disorders and mitochondrial dysfunction","volume":"10","author":"Hanna","year":"1997","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neulet.2008.01.023_bib15","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/mds.870130621","article-title":"Evidence that a gene for essential tremor maps to chromosome 2p in four families","volume":"13","author":"Higgins","year":"1998","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2008.01.023_bib16","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/331717a0","article-title":"Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies","volume":"331","author":"Holt","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2008.01.023_bib17","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1093\/nar\/17.12.4465","article-title":"Deletions of muscle mitochondrial DNA in mitochondrial myopathies: sequence analysis and possible mechanisms","volume":"17","author":"Holt","year":"1989","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.neulet.2008.01.023_bib18","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/mds.870120620","article-title":"Clinical expression of essential tremor: effects of gender and age","volume":"12","author":"Hubble","year":"1997","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2008.01.023_bib19","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1073\/pnas.92.15.6892","article-title":"A mitochondrial DNA clone is associated with increased risk for Alzheimer disease","volume":"92","author":"Hutchin","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2008.01.023_bib20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1101\/gr.6.10.965","article-title":"An expanded CAG repeat sequence in spinocerebellar ataxia type 7","volume":"6","author":"Lindbald","year":"1996","journal-title":"Genome Res."},{"key":"10.1016\/j.neulet.2008.01.023_bib21","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1212\/WNL.46.5.1200","article-title":"How familial is familial tremor?","volume":"46","author":"Louis","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2008.01.023_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0027-5107(98)00220-6","article-title":"Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin","volume":"423","author":"Lu","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.neulet.2008.01.023_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0303-8467(98)00003-1","article-title":"Familial cortical tremor with epilepsy: an under-recognized familial tremor","volume":"100","author":"Okuma","year":"1998","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.neulet.2008.01.023_bib24","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/mds.870120520","article-title":"Concordance of common movement disorders among familial cases","volume":"12","author":"Rajput","year":"1997","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2008.01.023_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ng0693-135","article-title":"Direct detection of novel expanded trinucleotide repeats in the human genome","volume":"4","author":"Schalling","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2008.01.023_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00019052-199408000-00010","article-title":"Mitochondrial dysfunction in movement disorders","volume":"7","author":"Schulz","year":"1994","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neulet.2008.01.023_bib27","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/brain\/awl120","article-title":"Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23","volume":"129","author":"Shatunov","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2008.01.023_bib28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1046\/j.1432-1327.2000.00990.x","article-title":"The D-loop structure of human mtDNA is destabilized directly by 1-methyl-4-phenylpyridinium ion (MPP+), a parkinsonism-causing toxin","volume":"267","author":"Umeda","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neulet.2008.01.023_bib29","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.1533953","article-title":"Mitochondrial genetics: a paradigm for aging and degenerative disease?","volume":"156","author":"Wallace","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neulet.2008.01.023_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.parkreldis.2006.12.004","article-title":"Essential tremor: phenotypic expression in a clinical cohort","volume":"13","author":"Whaley","year":"2007","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neulet.2008.01.023_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4269\/ajtmh.1994.51.771","article-title":"Use of a simplified polymerase chain reaction procedure to detect trypanosoma cruzi in blood samples from chronic chagasic patients in a rural endemic area","volume":"51","author":"Wincker","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.neulet.2008.01.023_bib32","first-page":"324","article-title":"Genetic considerations in movement disorders","volume":"5","author":"Wszolek","year":"1992","journal-title":"Curr. Opin. Neurol. Neurosur."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008000761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394008000761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:08:14Z","timestamp":1759608494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394008000761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0304394008000761"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2008.01.023","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial DNA in patients with essential tremor","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2008.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}